{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:15:49Z","timestamp":1777709749494,"version":"3.51.4"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Herzschr Elektrophys"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Arrhythmogenic cardiomyopathy (AC) is a\u00a0rare heart muscle disease with a\u00a0genetic background and autosomal dominant mode of transmission. The clinical manifestation is characterized by ventricular arrhythmias (VA), heart failure (HF) and the risk of sudden cardiac death (SCD). Pregnancy in young female patients with AC represents a\u00a0challenging condition for the life and family planning of young affected women. In addition to genetic mechanisms that influence the complex pathophysiology of AC, experimental and clinical data have confirmed the pathogenetic role of strenuous exercise and competitive sports in the early onset and rapid progression of AC symptoms and complications. Pregnancy and exercise share a number of physiological aspects of adaptation. In AC, both result in ventricular volume overload and myocardial stretch. Therefore, pregnancy has been postulated as a\u00a0potential risk factor for HF, VA, SCD, and pregnancy-related obstetric complications in patients with AC. However, the available evidence on pregnancy in AC does not confirm this hypothesis. In most women with AC, pregnancies are well tolerated, uneventful, and follow a\u00a0benign course. Pregnancy-related symptoms (VA, syncope, HF) and mortality, as well as obstetric complications, are uncommon in AC patients and range in the order of background populations and cohorts with AC and no pregnancy. The number of completed pregnancies is not associated with an acceleration of AC pathology or an increased risk of VA or HF during pregnancy and follow-up. Accordingly, there is no medical indication to advise against pregnancy in patients with AC. Preconditions include stability of rhythm and hemodynamics at baseline, as well as clinical follow-ups and the availability of multidisciplinary expert consultation during pregnancy and postpartum. Genetic counseling is recommended prior to pregnancy for all couples and their families affected by AC.<\/jats:p>","DOI":"10.1007\/s00399-021-00770-7","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T12:03:10Z","timestamp":1621944190000},"page":"186-198","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pregnancy in arrhythmogenic cardiomyopathy","Schwangerschaft bei Arrhythmogener Kardiomyopathie"],"prefix":"10.1007","volume":"32","author":[{"given":"Thomas","family":"Wichter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Milberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry D.","family":"Wichter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk G.","family":"Dechering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"770_CR1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1536\/ihj.13-255","volume":"55","author":"A Agir","year":"2014","unstructured":"Agir\u00a0A, Bozyel\u00a0S, Celikyurt\u00a0U et\u00a0al (2014) Arrhythmogenic right ventricular cardiomyopathy in pregnancy. Int Heart\u00a0J 55:372\u2013376","journal-title":"Int Heart J"},{"key":"770_CR2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01.NPR.0000367931.62740.dc","volume":"35","author":"TD Andrews","year":"2010","unstructured":"Andrews\u00a0TD, Cook\u00a0SS, Baumeister\u00a0M, Hickey\u00a0KT (2010) ARVC: help prevent sudden death. Nurse Pract 35:27\u201333","journal-title":"Nurse Pract"},{"key":"770_CR3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.11604\/pamj.2014.19.246.3773","volume":"19","author":"J Anouar","year":"2014","unstructured":"Anouar\u00a0J, Mohamed\u00a0S, Kamel\u00a0K (2014) Management of a\u00a0rare case of arrhythmogenic right ventricular dysplasia in pregnancy: a\u00a0case report. Pan Afr Med\u00a0J 19:246","journal-title":"Pan Afr Med J"},{"key":"770_CR4","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/CIRCEP.111.962035","volume":"5","author":"C Basso","year":"2012","unstructured":"Basso\u00a0C, Corrado\u00a0D, Bauce\u00a0B, Thiene\u00a0G (2012) Arrhythmogenic right ventricular cardiomyopathy. Circ Arrhythm Electrophysiol 5:1233\u20131246","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"770_CR5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ejogrb.2005.10.011","volume":"127","author":"B Bauce","year":"2006","unstructured":"Bauce\u00a0B, Daliento\u00a0L, Frigo\u00a0G et\u00a0al (2006) Pregnancy in women with arrhythmogenic right ventricular cardiomyopathy\/dysplasia. Eur J Obstet Gynecol Reprod Biol 127:186\u2013189","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"770_CR6","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/eurheartj\/ehu509","volume":"36","author":"A Bhonsale","year":"2015","unstructured":"Bhonsale\u00a0A, Groeneweg\u00a0JA, James\u00a0CA et al (2015) Impact of genotype on clinical course in arrhythmogenic right ventricular dysplasia\/cardiomyopathy-associated mutation carriers. Eur Heart\u00a0J 36:847\u2013855","journal-title":"Eur Heart J"},{"key":"770_CR7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.acvd.2017.05.010","volume":"111","author":"G Billebeau","year":"2018","unstructured":"Billebeau\u00a0G, Etienne\u00a0M, Cheikh-Khelifa\u00a0R et al (2018) Pregnancy in women with a\u00a0cardiomyopathy: outcomes and predictors from a\u00a0retrospective cohort. Arch Cardiovasc Dis 111:199\u2013209","journal-title":"Arch Cardiovasc Dis"},{"key":"770_CR8","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/europace\/euaa039","volume":"22","author":"LP Bosman","year":"2020","unstructured":"Bosman\u00a0LP, Cadrin-Tourigny\u00a0J, Bourfiss\u00a0M et al (2020) Diagnosis of arrhythmogenic right ventricular cardiomyopathy by 2010 task force criteria: clinical performance and simplified practical implementation. Europace 22:787\u2013796","journal-title":"Europace"},{"key":"770_CR9","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1093\/europace\/euu036","volume":"16","author":"S Boul\u00e9","year":"2014","unstructured":"Boul\u00e9\u00a0S, Ovart\u00a0L, Marqui\u00e9\u00a0C et al (2014) Pregnancy in women with an implantable cardioverter-defibrillator: is it safe? Europace 16:1587\u20131594","journal-title":"Europace"},{"key":"770_CR10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1161\/CIRCEP.120.008509","volume":"14","author":"J Cadrin-Tourigny","year":"2021","unstructured":"Cadrin-Tourigny\u00a0J, Bosman\u00a0LP, Wang\u00a0W et al (2021) Sudden cardiac death prediction in arrhythmogenic right ventricular cardiomyopathy (ARVC): a\u00a0multinational collaboration. Circ Arrhythm Electrophysiol 14:30\u201340","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"770_CR11","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1161\/CIRCULATIONAHA.117.030792","volume":"136","author":"H Calkins","year":"2017","unstructured":"Calkins\u00a0H, Corrado\u00a0D, Marcus\u00a0FI (2017) Risk stratification in arrhythmogenic right ventricular cardiomyopathy. Circulation 136:2068\u20132082","journal-title":"Circulation"},{"key":"770_CR12","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1161\/CIRCULATIONAHA.106.686534","volume":"117","author":"C Carbucicchio","year":"2008","unstructured":"Carbucicchio\u00a0C, Santamaria\u00a0M, Trevis\u00a0N et al (2008) Catheter ablation for the treatment of electrical storm in patients with implantable cardioverter-defibrillators: short and long-term outcomes in a\u00a0prospective single-center study. Circulation 117:462\u2013469","journal-title":"Circulation"},{"key":"770_CR13","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/ehjci\/jey061","volume":"20","author":"AI Castrini","year":"2019","unstructured":"Castrini\u00a0AI, Lie\u00a0OH, Leren\u00a0IS et al (2019) Number of pregnancies and subsequent phenotype in a\u00a0cross-sectional cohort of women with arrhythmogenic right ventricular cardiomyopathy. Eur Heart J Cardiovasc Imaging 20:192\u2013198","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"770_CR14","first-page":"32","volume":"95","author":"G Chen","year":"2016","unstructured":"Chen\u00a0G, Sun\u00a0G, Xu\u00a0R et al (2016) Zero fluoroscopy catheter ablation of severe drug-resistant arrhythmia guided by Ensite NavX system during pregnancy. Medicine 95:32","journal-title":"Medicine"},{"key":"770_CR15","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.prp.2017.07.015","volume":"213","author":"HYG Choung","year":"2017","unstructured":"Choung\u00a0HYG, Vyas\u00a0M, Jacoby\u00a0D et\u00a0al (2017) Arrhythmogenic right ventricular cardiomyopathy (ARVC) in a\u00a0young female athlete at 36\u00a0weeks gestation: a\u00a0case report. Pathol Pract 213:1302\u20131305","journal-title":"Pathol Pract"},{"key":"770_CR16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra1509267","volume":"376","author":"D Corrado","year":"2017","unstructured":"Corrado\u00a0D, Link\u00a0MS, Calkins\u00a0H (2017) Arrhythmogenic right ventricular cardiomyopathy. N\u00a0Engl J Med 376:61\u201372","journal-title":"N Engl J Med"},{"key":"770_CR17","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ijcard.2020.06.005","volume":"319","author":"D Corrado","year":"2020","unstructured":"Corrado\u00a0D, Marra\u00a0MP, Zorzi\u00a0A et\u00a0al (2020) Diagnosis of arrhythmogenic cardiomyopathy: the Padua criteria. Int J Cardiol 319:106\u2013114","journal-title":"Int J Cardiol"},{"key":"770_CR18","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1093\/eurheartj\/ehaa003","volume":"41","author":"D Corrado","year":"2020","unstructured":"Corrado\u00a0D, van Tintelen\u00a0JP, McKenna\u00a0WJ, The International Experts et\u00a0al (2020) Arrhythmogenic right ventricular cardiomyopathy: evaluation of the current diagnostic criteria and differential diagnosis. Eur Heart\u00a0J 41:1414\u20131427","journal-title":"Eur Heart J"},{"key":"770_CR19","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehv183","volume":"36","author":"D Corrado","year":"2015","unstructured":"Corrado\u00a0D, Wichter\u00a0T, Link\u00a0MS et\u00a0al (2015) Treatment of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: an international task force consensus statement. Eur Heart\u00a0J 36:3227\u20133237","journal-title":"Eur Heart J"},{"key":"770_CR20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/CIRCGEN.120.003047","volume":"14","author":"S Costa","year":"2021","unstructured":"Costa\u00a0S, Medeiros-Domingo\u00a0A, Gasparetti\u00a0A et al (2021) Impact of genetic variant reassessment on the diagnosis of arrhythmogenic right ventricular cardiomyopathy based on the 2010 task force criteria. Circ Genom Precis Med 14:49\u201356","journal-title":"Circ Genom Precis Med"},{"key":"770_CR21","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1161\/CIRCULATIONAHA.110.988287","volume":"123","author":"MG Cox","year":"2011","unstructured":"Cox\u00a0MG, van der Zwaag\u00a0PA, van der Werf\u00a0C et al (2011) Arrhythmogenic right ventricular dysplasia\/cardiomyopathy: pathogenic desmosome mutations in index-patients predict outcome of family screening. Circulation 123:2690\u20132700","journal-title":"Circulation"},{"key":"770_CR22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000364870","volume":"78","author":"M Cozzolina","year":"2014","unstructured":"Cozzolina\u00a0M, Perelli\u00a0F, Corioni\u00a0S et\u00a0al (2014) Successful obstetric management of arrhythmogenic right ventricular cardiomyopathy. Gynecol Obstet Invest 78:266\u2013271","journal-title":"Gynecol Obstet Invest"},{"key":"770_CR23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/14767050500226500","volume":"18","author":"NM Doyle","year":"2005","unstructured":"Doyle\u00a0NM, Monga\u00a0M, Montgomery\u00a0B et\u00a0al (2005) Arrhythmogenic right ventricular cardiomyopathy with implantable cardioverter defibrillator placement in pregnancy. J\u00a0Matern Fetal Neonatal Med 18:141\u2013144","journal-title":"J Matern Fetal Neonatal Med"},{"key":"770_CR24","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/ejhf.1534","volume":"21","author":"PM Elliott","year":"2019","unstructured":"Elliott\u00a0PM, Anastasakis\u00a0A, Asimaki\u00a0A et\u00a0al (2019) Definition and treatment of arrhythmogenic cardiomyopathy: an updated expert panel report. Eur J Heart Fail 21:955\u2013964","journal-title":"Eur J Heart Fail"},{"key":"770_CR25","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","volume":"29","author":"PM Elliott","year":"2008","unstructured":"Elliott\u00a0PM, Andersson\u00a0B, Arbustini\u00a0E et\u00a0al (2008) Classification of the cardiomyopathies: a position statement from the European society of cardiology, working group on myocardial and pericardial diseases. Eur Heart\u00a0J 29:270\u2013276","journal-title":"Eur Heart J"},{"key":"770_CR26","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jacc.2010.09.046","volume":"57","author":"L Fabritz","year":"2011","unstructured":"Fabritz\u00a0L, Hoogendijk\u00a0MG, Scicluna\u00a0BP et al (2011) Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice. J\u00a0Am Coll Cardiol 57:740\u2013750","journal-title":"J Am Coll Cardiol"},{"key":"770_CR27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ijcard.2017.11.067","volume":"258","author":"E Gandjbakhch","year":"2018","unstructured":"Gandjbakhch\u00a0E, Varlet\u00a0E, Duthoit\u00a0G et\u00a0al (2018) Pregnancy and newborn outcomes in arrhythmogenic right ventricular cardiomyopathy\/dysplasia. Int J Cardiol 258:172\u2013178","journal-title":"Int J Cardiol"},{"key":"770_CR28","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.hrthm.2020.03.007","volume":"17","author":"A Gasparetti","year":"2020","unstructured":"Gasparetti\u00a0A, Dello Russo\u00a0A, Busana\u00a0M et\u00a0al (2020) Novel risk calculator performance in athletes with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm 17:1251\u20131259","journal-title":"Heart Rhythm"},{"key":"770_CR29","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/CIRCGENETICS.114.001003","volume":"8","author":"JA Groeneweg","year":"2015","unstructured":"Groeneweg\u00a0JA, Bhonsale\u00a0A, James\u00a0CA et al (2015) Clinical presentation, long-term follow-up and outcomes of 1001 arrhythmogenic right ventricular dysplasia\/cardiomyopathy patients and family members. Circ Cardiovasc Genet 8:437\u2013446","journal-title":"Circ Cardiovasc Genet"},{"key":"770_CR30","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/1752-1947-5-300","volume":"5","author":"N G\u00fcd\u00fcc\u00fc","year":"2011","unstructured":"G\u00fcd\u00fcc\u00fc\u00a0N, Kutay\u00a0NN, \u00d6zen\u00e7\u00a0E et\u00a0al (2011) Management of a\u00a0rare case of arrhythmogenic right ventricular dysplasia in pregnancy: a\u00a0case report. J\u00a0Med Case Rep 5:300\u2013303","journal-title":"J Med Case Rep"},{"key":"770_CR31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/heartjnl-2015-308624","volume":"102","author":"AR Hodes","year":"2016","unstructured":"Hodes\u00a0AR, Tichnell\u00a0C, Te Riele\u00a0ASJM et\u00a0al (2016) Pregnancy course and outcomes in women with arrhythmogenic right ventricular cardiomyopathy. Heart 102:303\u2013312","journal-title":"Heart"},{"key":"770_CR32","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/ped.12832","volume":"58","author":"T Honda","year":"2016","unstructured":"Honda\u00a0T, Kanai\u00a0Y, Ohno\u00a0S et\u00a0al (2016) Fetal arrhythmogenic right ventricular cardiomyopathy with double mutations in THEM43. Pediatr Int 58:409\u2013411","journal-title":"Pediatr Int"},{"key":"770_CR33","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1447-0756.2012.01954.x","volume":"39","author":"T Iriyama","year":"2013","unstructured":"Iriyama\u00a0T, Kamei\u00a0Y, Kozuma\u00a0S, Taketani\u00a0Y (2013) Management of patients with arrhythmogenic right ventricular cardiomyopathy during pregnancy. J\u00a0Obstet Gynaecol Res 39:390\u2013394","journal-title":"J Obstet Gynaecol Res"},{"key":"770_CR34","first-page":"725","volume":"51","author":"LC Lee","year":"2006","unstructured":"Lee\u00a0LC, Bathgate\u00a0SL, Macri\u00a0CJ et\u00a0al (2006) Arrhythmogenic right ventricular dysplasia in pregnancy: a\u00a0case report. J\u00a0Reprod Med 51:725\u2013728","journal-title":"J Reprod Med"},{"key":"770_CR35","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jacep.2018.01.010","volume":"4","author":"OH Lie","year":"2018","unstructured":"Lie\u00a0OH, Dejgaard\u00a0LA, Saberniak\u00a0J et\u00a0al (2018) Harmful effects of exercise intensity and exercise duration in arrhythmogenic right ventricular cardiomyopathy. JACC Clin Electrophysiol 4:744\u2013753","journal-title":"JACC Clin Electrophysiol"},{"key":"770_CR36","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1745176","author":"FY Luo","year":"2020","unstructured":"Luo\u00a0FY, Chadha\u00a0R, Osborne\u00a0C, Kealey\u00a0A (2020) Arrhythmogenic right ventricular cardiomyopathy (ARVC) in pregnancy: a\u00a0case series of nine patients and review of literature. J\u00a0Matern Fetal Neonatal Med. https:\/\/doi.org\/10.1080\/14767058.2020.1745176","journal-title":"J Matern Fetal Neonatal Med"},{"key":"770_CR37","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/01.CIR.65.2.384","volume":"65","author":"FI Marcus","year":"1982","unstructured":"Marcus\u00a0FI, Fontaine\u00a0G, Guiraudon\u00a0G et\u00a0al (1982) Right ventricular dysplasia: a\u00a0report of 24\u00a0cases. Circulation 65:384\u2013399","journal-title":"Circulation"},{"key":"770_CR38","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1161\/CIRCULATIONAHA.108.840827","volume":"121","author":"FI Marcus","year":"2010","unstructured":"Marcus\u00a0FI, McKenna\u00a0WJ, Sherrill\u00a0D et\u00a0al (2010) Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed modification of the task force criteria. Circulation 121:1533\u20131541","journal-title":"Circulation"},{"key":"770_CR39","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jacc.2013.01.073","volume":"61","author":"FI Marcus","year":"2013","unstructured":"Marcus\u00a0FI, Edson\u00a0S, Towbin\u00a0JA (2013) Genetics in arrhythmogenic right ventricular cardiomyopathy. A practical guide for physicians. J\u00a0Am Coll Cardiol 61:1945\u20131948","journal-title":"J Am Coll Cardiol"},{"key":"770_CR40","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.106.174287","volume":"113","author":"BJ Maron","year":"2006","unstructured":"Maron\u00a0BJ, Towbin\u00a0JA, Thiene\u00a0G et\u00a0al (2006) Contemporary definition and classification of cardiomyopathies: AHA scientific statement. Circulation 113:1807\u20131816","journal-title":"Circulation"},{"key":"770_CR41","first-page":"373","volume":"13","author":"K Masunuru","year":"2020","unstructured":"Masunuru\u00a0K, Hershberger\u00a0RE, Day\u00a0SM et\u00a0al (2020) Genetic testing for inherited cardiovascular diseases: a scientific statement from the American heart association. Circ Genom Precis Med 13:373\u2013385","journal-title":"Circ Genom Precis Med"},{"key":"770_CR42","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3390\/jcm9030878","volume":"9","author":"G Mattesi","year":"2020","unstructured":"Mattesi\u00a0G, Zorzi\u00a0A, Corrado\u00a0D, Capriano\u00a0A (2020) Natural history of arrhythmogenic cardiomyopathy. J\u00a0Clin Med 9:878","journal-title":"J Clin Med"},{"key":"770_CR43","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/hrt.71.3.215","volume":"71","author":"WJ McKenna","year":"1994","unstructured":"McKenna\u00a0WJ, Thiene\u00a0G, Nava\u00a0A et\u00a0al (1994) Diagnosis of arrhythmogenic right ventricular dysplasia cardiomyopathy. Br Heart\u00a0J 71:215\u2013218","journal-title":"Br Heart J"},{"key":"770_CR44","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijcard.2019.01.041","volume":"280","author":"F Migliore","year":"2019","unstructured":"Migliore\u00a0F, Viani\u00a0S, Bongiorni\u00a0MG et\u00a0al (2019) Subcutaneous implantable cardioverter defibrillator in patients with arrhythmogenic right ventricular cardiomyopathy: results from an Italian multicenter registry. Int J Cardiol 280:74\u201379","journal-title":"Int J Cardiol"},{"key":"770_CR45","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/s41436-018-0267-2","volume":"21","author":"LV Milko","year":"2019","unstructured":"Milko\u00a0LV, Funke\u00a0BH, Hershberger\u00a0RE et\u00a0al (2019) Development of clinical domain working groups for the clinical genome resource (ClinGen): lessons learned and plans for the future. Genet Med 21:987\u2013993","journal-title":"Genet Med"},{"key":"770_CR46","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1253\/circj.CJ-12-1275","volume":"77","author":"T Miyoshi","year":"2013","unstructured":"Miyoshi\u00a0T, Kamiya\u00a0CA, Katsuragi\u00a0S et al (2013) Safety and efficacy of implantable cardioverter-defibrillator during pregnancy and after delivery. Circ\u00a0J 77:1166\u20131170","journal-title":"Circ J"},{"key":"770_CR47","first-page":"3147","volume":"32","author":"P Nihoyannopoulos","year":"2018","unstructured":"Nihoyannopoulos\u00a0P, Pieper\u00a0PG, Presbitero\u00a0P et\u00a0al (2018) ESC guidelines on the management of cardiovascular diseases during pregnancy. Eur Heart\u00a0J 32:3147\u20133197","journal-title":"Eur Heart J"},{"key":"770_CR48","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/europace\/euaa136","volume":"22","author":"PG Platonov","year":"2020","unstructured":"Platonov\u00a0PG, Castrini\u00a0AI, Svensson\u00a0A et\u00a0al (2020) Pregnancies, ventricular arrhythythmias, and substrate progression in women with arrhythmogenic right ventricular cardiomyopathy in the nordic ARVC registry. Europace 22:1873\u20131879","journal-title":"Europace"},{"key":"770_CR49","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","volume":"17","author":"S Richards","year":"2015","unstructured":"Richards\u00a0S, Aziz\u00a0N, Bale\u00a0S et\u00a0al (2015) Standards and guidelines for the interpretation of sequence variants. Genet Med 17:405\u2013424","journal-title":"Genet Med"},{"key":"770_CR50","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/CIRCGENETICS.113.000288","volume":"6","author":"I Rigato","year":"2013","unstructured":"Rigato\u00a0I, Bauce\u00a0B, Rampazzo\u00a0A et al (2013) Compound and digenic heterozygosity predicts lifetime arrhythmic outcome and sudden cardiac death in desmosomal gene-related arrhythmogenic right ventricular cardiomyopathy. Circ Cardiovasc Genet 6:533\u2013542","journal-title":"Circ Cardiovasc Genet"},{"key":"770_CR51","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tcm.2014.10.007","volume":"25","author":"A Rojas","year":"2015","unstructured":"Rojas\u00a0A, Calkins\u00a0H (2015) Present understanding of the relationship between exercise and arrhythmogenic right ventricular dysplasia\/cardiomyopathy. Trends Cardiovasc Med 25:189\u2013190","journal-title":"Trends Cardiovasc Med"},{"key":"770_CR52","doi-asserted-by":"crossref","first-page":"e001471","DOI":"10.1161\/JAHA.114.001471","volume":"3","author":"AC Savant","year":"2014","unstructured":"Savant\u00a0AC, Bhonsale\u00a0A, te Riele\u00a0ASJM et\u00a0al (2014) Exercise has a\u00a0disproportionate role in the pathogenesis of arrhythmogenic right ventricular dysplasia cardiomyopathy in patients without desmosomal mutations. J\u00a0Am Heart Assoc 3:e1471","journal-title":"J Am Heart Assoc"},{"key":"770_CR53","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1136\/heartjnl-2018-313476","volume":"105","author":"M Schaufelberger","year":"2019","unstructured":"Schaufelberger\u00a0M (2019) Cardiomyopathy and pregnancy. Heart 105:1543\u20131551","journal-title":"Heart"},{"key":"770_CR54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjcr\/ytz208","volume":"3","author":"M Schiavone","year":"2019","unstructured":"Schiavone\u00a0M, Calcagnino\u00a0M, Mazzanti\u00a0A, Bonanomi\u00a0C (2019) Outcomes and management of arrhythmogenic right ventricular cardiomyopathy in pregnancy: a\u00a0case report. Eur Heart J Case Rep 3:1\u20135","journal-title":"Eur Heart J Case Rep"},{"key":"770_CR55","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1471-2261-13-58","volume":"13","author":"S Stec","year":"2013","unstructured":"Stec\u00a0S, Krynski\u00a0T, Baran\u00a0J, Kulakowski\u00a0P (2013) \u201cRescue\u201d ablation of electrical storm in arrhythmogenic right ventricular cardiomyopathy in pregnancy. BMC Cardiovasc Disord 13:58","journal-title":"BMC Cardiovasc Disord"},{"key":"770_CR56","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.jacc.2012.11.087","volume":"62","author":"ASJM te Riele","year":"2013","unstructured":"te Riele\u00a0ASJM, Bhonsale\u00a0A, James\u00a0CA et\u00a0al (2013) Incremental value of cardiac magnetic resonance imaging in arrhythmic risk stratification of arrhythmogenic right ventricular dysplasia\/cardiomyopathy\u2014associated desmosomal mutation carriers. J\u00a0Am Coll Cardiol 62:1761\u20131769","journal-title":"J Am Coll Cardiol"},{"key":"770_CR57","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jacc.2014.04.044","volume":"64","author":"ASJM te Riele","year":"2014","unstructured":"te Riele\u00a0ASJM, James\u00a0CA, Rastegar\u00a0N et al (2014) Yield of serial evaluation in at-risk family members with ARVC\/D. J\u00a0Am Coll Cardiol 64:293\u2013301","journal-title":"J Am Coll Cardiol"},{"key":"770_CR58","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12968-014-0050-8","volume":"6","author":"ASJM te Riele","year":"2014","unstructured":"te Riele\u00a0ASJM, Tandri\u00a0H, Bluemke\u00a0DA (2014) Arrhythmogenic right ventricular cardiomyopathy (ARVC): cardiovascular magnetic resonance update. J\u00a0Cardiovasc Magn Reson 6:50","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"770_CR59","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJM198801213180301","volume":"318","author":"G Thiene","year":"1988","unstructured":"Thiene\u00a0G, Nava\u00a0A, Corrado\u00a0D et\u00a0al (1988) Right ventricular cardiomyopathy and sudden cardiac death in young people. N\u00a0Engl J Med 318:129\u2013133","journal-title":"N Engl J Med"},{"key":"770_CR60","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1016\/j.hrthm.2019.05.007","volume":"16","author":"JA Towbin","year":"2019","unstructured":"Towbin\u00a0JA, McKenna\u00a0WJ, Abrams\u00a0DJ et\u00a0al (2019) 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy. Heart Rhythm 16:e301\u2013e372","journal-title":"Heart Rhythm"},{"key":"770_CR61","first-page":"162","volume":"2","author":"AN Vadysinghe","year":"2017","unstructured":"Vadysinghe\u00a0AN, Jayasooriya\u00a0RP, Gunatilake\u00a0GKK, Sivasubramanium\u00a0M (2017) Unexpected sudden death in pregnancy\u2014arrhythmogenic right venticular cardiomyopathy\/dysplasia: a\u00a0case report. Forensic Sci Res 2:162\u2013163","journal-title":"Forensic Sci Res"},{"key":"770_CR62","doi-asserted-by":"crossref","first-page":"e002467","DOI":"10.1161\/CIRCGEN.119.002467","volume":"12","author":"FHM van Lint","year":"2019","unstructured":"van Lint\u00a0FHM, Murray\u00a0B, Tichnell\u00a0C et\u00a0al (2019) Arrhythmogenic right ventricular cardiomyopathy\u2014associated desmosomal variants are rarely de novo. Circ Genom Precis Med 12:e2467","journal-title":"Circ Genom Precis Med"},{"key":"770_CR63","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/europace\/euaa105","volume":"22","author":"W Wang","year":"2020","unstructured":"Wang\u00a0W, Tichnell\u00a0C, Murray\u00a0BA et al (2020) Exercise restriction is protective for genotype-positive family members of arrhythmogenic right ventricular cardiomyopathy patients. Europace 22:1270\u20131278","journal-title":"Europace"},{"key":"770_CR64","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s12181-013-0495-2","volume":"8","author":"T Wichter","year":"2014","unstructured":"Wichter\u00a0T, Paul\u00a0M (2014) Arrhythmogene rechtsventrikul\u00e4re Kardiomyopathie. Teil 1: Pathophysiologie, Klinik und Diagnostik [Arrhythmogenic right ventricular cardiomyopathy. Part 1: Pathophysiology, clinical presentation and diagnosis. Kardiologe 8:85\u201398","journal-title":"Kardiologe"},{"key":"770_CR65","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12181-014-0556-1","volume":"8","author":"T Wichter","year":"2014","unstructured":"Wichter\u00a0T, Paul\u00a0M (2014) Arrhythmogene rechtsventrikul\u00e4re Kardiomyopathie. Teil 2: Risikostratifikation und Therapie [Arrhythmogenic right ventricular cardiomyopathy. Part 2: Risk stratification and therapeutic management. Kardiologe 8:179\u2013196","journal-title":"Kardiologe"},{"key":"770_CR66","isbn-type":"print","first-page":"79","volume-title":"Current thinking on arrhythmogenic right ventricular cardiomyopathy","author":"T Wichter","year":"2014","unstructured":"Wichter\u00a0T (2014) Drug therapy in arrhythmogenic right ventricular cardiomyopathy: when and how to use which drugs? In: Duru\u00a0F, Brunckhorst\u00a0C (eds) Current thinking on arrhythmogenic right ventricular cardiomyopathy. Cardiotext Publishing, Minneapolis, pp 79\u201391. ISBN 978-1-935395-92\u20118","ISBN":"https:\/\/id.crossref.org\/isbn\/9781935395928"},{"key":"770_CR67","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1161\/01.CIR.0000121738.88273.43","volume":"109","author":"T Wichter","year":"2004","unstructured":"Wichter\u00a0T, Paul\u00a0M, Wollmann\u00a0C et al (2004) Implantable cardioverter-defibrillator therapy in arrhythmogenic right ventricular cardiomyopathy: single-center experience of long-term follow-up and complications in 60\u00a0patients. Circulation 109:1503\u20131508","journal-title":"Circulation"},{"key":"770_CR68","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/europace\/eul053","volume":"8","author":"EK Wlodarska","year":"2006","unstructured":"Wlodarska\u00a0EK, Wozniak\u00a0O, Konka\u00a0M et\u00a0al (2006) Thromboembolic complications in arrhythmogenic right ventricular dysplasia\/cardiomyopathy. Europace 8:596\u2013600","journal-title":"Europace"},{"key":"770_CR69","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.amjcard.2019.11.008","volume":"125","author":"L Wu","year":"2020","unstructured":"Wu\u00a0L, Liang\u00a0E, Fan\u00a0S et\u00a0al (2020) Effect of pregnancy in arrhythmogenic right ventricular cardiomyopathy. Am J Cardiol 125:613\u2013617","journal-title":"Am J Cardiol"},{"key":"770_CR70","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1111\/jce.12501","volume":"25","author":"L Wu","year":"2014","unstructured":"Wu\u00a0L, Yao\u00a0Y, Chen\u00a0G et\u00a0al (2014) Intracardiac thrombosis in patients with arrhythmogenic right ventricular cardiomyopathy. J\u00a0Cardiovasc Electrophysiol 25:1359\u20131362","journal-title":"J Cardiovasc Electrophysiol"},{"key":"770_CR71","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jacc.2009.11.020","volume":"55","author":"T Xu","year":"2010","unstructured":"Xu\u00a0T, Yang\u00a0Z, Vatta\u00a0M et\u00a0al (2010) Compound and digenic heterozygosity contributes to arrhythmogenic right ventricular cardiomyopathy. J\u00a0Am Coll Cardiol 55:587\u2013597","journal-title":"J Am Coll Cardiol"},{"key":"770_CR72","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780198784906.001.0001","volume-title":"ESC CardioMed","author":"V Zagrosek-Regitz","year":"2018","unstructured":"Zagrosek-Regitz\u00a0V (2018) Pregnancy and heart disease. In: Camm\u00a0AJ, L\u00fcscher\u00a0TF et al (eds) ESC CardioMed, 3rd\u00a0edn. Oxford University Press, https:\/\/doi.org\/10.1093\/med\/9780198784906.001.0001","edition":"3"}],"container-title":["Herzschrittmachertherapie + Elektrophysiologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00399-021-00770-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00399-021-00770-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00399-021-00770-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T13:44:43Z","timestamp":1672235083000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00399-021-00770-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["770"],"URL":"https:\/\/doi.org\/10.1007\/s00399-021-00770-7","relation":{},"ISSN":["0938-7412","1435-1544"],"issn-type":[{"value":"0938-7412","type":"print"},{"value":"1435-1544","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]},"assertion":[{"value":"11 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"T.\u00a0Wichter, P.\u00a0Milberg, H.D.\u00a0Wichter, and D.G.\u00a0Dechering declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this article no studies with human participants or animals were performed by any of the authors. All studies performed were in accordance with the ethical standards indicated in each case.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}