{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T17:11:24Z","timestamp":1648833084774},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Herzschr Elektrophys"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s00399-021-00779-y","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T14:02:41Z","timestamp":1626098561000},"page":"335-340","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiology meets neurology: clinical presentation and management of patients with primary neurogenic disorders and orthostatic intolerance"],"prefix":"10.1007","volume":"32","author":[{"given":"Christina","family":"Haubrich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Klingenheben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"issue":"suppl 1","key":"779_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s10286-007-1001-3","volume":"18","author":"PA Low","year":"2008","unstructured":"Low\u00a0PA (2008) Prevalence of orthostatic hypotension. Clin Auton Res 18(suppl 1):8\u201313","journal-title":"Clin Auton Res"},{"key":"779_CR2","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1042\/CS20060091","volume":"112","author":"W Wieling","year":"2007","unstructured":"Wieling\u00a0W, Krediet\u00a0P, Dijk\u00a0N et\u00a0al (2007) Initial orthostatic hypotension: review of a\u00a0forgotten condition. Clin Sci 112:157\u2013165","journal-title":"Clin Sci"},{"issue":"suppl 1","key":"779_CR3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s10286-007-1004-0","volume":"18","author":"D Robertson","year":"2008","unstructured":"Robertson\u00a0D (2008) The pathophysiology and diagnosis of orthostatic hypotension. Clin Auton Res 18(suppl 1):2\u20137","journal-title":"Clin Auton Res"},{"key":"779_CR4","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1161\/01.CIR.98.20.2154","volume":"98","author":"R Furlan","year":"1998","unstructured":"Furlan\u00a0R, Jacob\u00a0G, Snell\u00a0M et\u00a0al (1998) Chronic orthostatic intolerance: a\u00a0disorder with discordant cardiac and vascular sympathetic control. Circulation 98:2154\u20132159","journal-title":"Circulation"},{"key":"779_CR5","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.amjcard.2013.04.057","volume":"112","author":"P Ptaszynski","year":"2013","unstructured":"Ptaszynski\u00a0P, Kaczmarek\u00a0K, Klingenheben\u00a0T et\u00a0al (2013) Noninvasive assessment of autonomic cardiovascular acitivity in patients with inappropriate sinus tachycardia. Am J Cardiol 112:811\u2013815","journal-title":"Am J Cardiol"},{"issue":"1","key":"779_CR6","doi-asserted-by":"publisher","first-page":"e20171673","DOI":"10.1542\/peds.2017-1673","volume":"141","author":"JM Stewart","year":"2018","unstructured":"Stewart\u00a0JM, Boris\u00a0JR, Chelimsky\u00a0G et\u00a0al (2018) Pediatric disorders of orthostatic intolerance. Pediatrics 141(1):e20171673","journal-title":"Pediatrics"},{"key":"779_CR7","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1016\/j.hrthm.2015.03.029","volume":"12","author":"RS Sheldon","year":"2015","unstructured":"Sheldon\u00a0RS, Grubb\u00a0BP, Olshansky\u00a0B et\u00a0al (2015) 2015 HRS expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm 12:e41\u2013e63","journal-title":"Heart Rhythm"},{"key":"779_CR8","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1007\/s00415-012-6736-7","volume":"260","author":"M Metzler","year":"2013","unstructured":"Metzler\u00a0M, Duerr\u00a0S, Granata\u00a0R et\u00a0al (2013) Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management. J\u00a0Neurol 260:2212\u20132219","journal-title":"J Neurol"},{"key":"779_CR9","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.46.5.1470","author":"IJ Schatz","year":"1996","unstructured":"Schatz IJ, Bannister R, Freeman RL et\u00a0al (1996) Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. Neurology 46(5). https:\/\/doi.org\/10.1212\/wnl.46.5.1470","journal-title":"Neurology"},{"key":"779_CR10","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1161\/01.CIR.98.21.2290","volume":"98","author":"KH Masaki","year":"1998","unstructured":"Masaki\u00a0KH, Schatz\u00a0IJ, Burchfield\u00a0CM et\u00a0al (1998) Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart Program. Circulation 98:2290\u20132295","journal-title":"Circulation"},{"key":"779_CR11","unstructured":"Brignole M (2007) The syndromes of orthostatic intolerance. E\u00a0J ECS Counc Cardiol Pract 6(5). www.escardio.org\/Journals\/E-Journal-of-Cardiology-Practice\/Volume-6\/"},{"key":"779_CR12","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1007\/s00108-002-0689-3","volume":"43","author":"T Klingenheben","year":"2002","unstructured":"Klingenheben\u00a0T (2002) Autonome Dysfunktion und orthostatische Intoleranz. Internist 43:1055\u20131064","journal-title":"Internist"},{"key":"779_CR13","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1161\/CIRCULATIONAHA.108.805887","volume":"119","author":"DS Goldstein","year":"2009","unstructured":"Goldstein\u00a0DS, Sharabi\u00a0Y (2009) Neurogenic orthostatic hypotension. A pathophysiological approach. Circulation 119:139\u2013146","journal-title":"Circulation"},{"key":"779_CR14","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/eurheartj\/ehy037","volume":"39","author":"M Brignole","year":"2018","unstructured":"Brignole\u00a0M, Moya\u00a0A, de Lange\u00a0FJ et\u00a0al (2018) 2018 ESC Guidelines for the diagnosis and management of syncope. Eur Heart\u00a0J 39:1883\u20131948","journal-title":"Eur Heart J"},{"key":"779_CR15","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s004150050479","volume":"246","author":"CJ Mathias","year":"1999","unstructured":"Mathias\u00a0CJ, Mallipeddi\u00a0R, Bleasdale-Barr\u00a0K (1999) Symptoms associated with orthostatic hypotension in pure autonomic failure and multiple system atrophy. J\u00a0Neurol 246:893\u2013898","journal-title":"J Neurol"},{"key":"779_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1469-7793.1999.0001o.x","volume":"519","author":"AA Smit","year":"1999","unstructured":"Smit\u00a0AA, Halliwill\u00a0JR, Low\u00a0PA et\u00a0al (1999) Pathophysiological basis of orthostatic hypotension in autonomic failure. J\u00a0Physiol 519:1\u201310","journal-title":"J Physiol"},{"key":"779_CR17","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1016\/S0140-6736(86)91665-X","volume":"1","author":"RA Kenny","year":"1986","unstructured":"Kenny\u00a0RA, Ingram\u00a0A, Bayliss\u00a0J, Sutton\u00a0R (1986) Head-up tilt: a\u00a0useful test for investigating unexplained syncope. Lancet 1:1352\u20131355","journal-title":"Lancet"},{"key":"779_CR18","doi-asserted-by":"publisher","first-page":"e0128962","DOI":"10.1371\/journal.pone.0128962","volume":"10","author":"D Nilsson","year":"2015","unstructured":"Nilsson\u00a0D, Sutton\u00a0R, Tas\u00a0W et\u00a0al (2015) Orthostatic changes in hemodynamics and cardiovascular biomarkers in dysautonomic patients. PLoS ONE 10:e128962","journal-title":"PLoS ONE"},{"key":"779_CR19","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1007\/s00415-014-7339-2","volume":"261","author":"A Fanciulli","year":"2014","unstructured":"Fanciulli\u00a0A, Strano\u00a0S, Ndayisaba\u00a0JP et al (2014) Detecting nocturnal hypertension in Parkinson\u2019s disease and multiple system atrophy: proposal of a\u00a0decision-support algorithm. J\u00a0Neurol 261:1291\u20131299","journal-title":"J Neurol"},{"key":"779_CR20","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/ajh.2011.191","volume":"25","author":"S Voichanski","year":"2012","unstructured":"Voichanski\u00a0S, Grossman\u00a0C, Leibowitz\u00a0A et\u00a0al (2012) Orthostatic hypotension is associated with nocturnal change in systolic blood pressure. Am J Hypertens 25:159\u2013164","journal-title":"Am J Hypertens"},{"key":"779_CR21","series-title":"Springer Reference Medizin","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-44768-0_65-1","volume-title":"Klinische Neurologie","author":"C Haubrich","year":"2018","unstructured":"Haubrich\u00a0C (2018) Erkrankungen des autonomen Nervensystems. In: Berlit\u00a0P (ed) Klinische Neurologie. Springer Reference Medizin. Springer, Berlin, Heidelberg https:\/\/doi.org\/10.1007\/978-3-662-44768-0_65-1"},{"issue":"7","key":"779_CR22","first-page":"1099","volume":"47","author":"K Kashihara","year":"2006","unstructured":"Kashihara\u00a0K, Ohno\u00a0M, Kawada\u00a0S, Okumura\u00a0Y (2006) Reduced cardiac uptake and enhanced washout of 123 I\u2011MIBG in pure autonomic failure occurs conjointly with parkinson\u2019s disease and dementia with Lewy bodies. J\u00a0Nucl Med 47(7):1099\u20131101","journal-title":"J Nucl Med"},{"key":"779_CR23","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1001\/jama.1997.03540370036033","volume":"13","author":"PA Low","year":"1997","unstructured":"Low\u00a0PA, Gilden\u00a0JL, Freeman\u00a0R et\u00a0al (1997) Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. JAMA 13:1046\u20131051","journal-title":"JAMA"},{"issue":"suppl 1","key":"779_CR24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10286-007-1005-z","volume":"18","author":"CJ Mathias","year":"2008","unstructured":"Mathias\u00a0CJ (2008) L\u2011dihydroxphenylserine (Droxidopa) in the treatment of orthostatic hypotension. The European experience. Clin Auton Res 18(suppl 1):25\u201329","journal-title":"Clin Auton Res"},{"issue":"suppl 1","key":"779_CR25","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s10286-007-1002-2","volume":"18","author":"H Kaufmann","year":"2008","unstructured":"Kaufmann\u00a0H (2008) L\u2011dihydroxyphenylserine (Droxidopa): a\u00a0new therapy for neurogenic orthostatic hypotension: the US experience. Clin Auton Res 18(suppl 1):19\u201324","journal-title":"Clin Auton Res"}],"container-title":["Herzschrittmachertherapie + Elektrophysiologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00399-021-00779-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00399-021-00779-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00399-021-00779-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T18:33:29Z","timestamp":1630694009000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00399-021-00779-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,12]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["779"],"URL":"https:\/\/doi.org\/10.1007\/s00399-021-00779-y","relation":{},"ISSN":["0938-7412","1435-1544"],"issn-type":[{"value":"0938-7412","type":"print"},{"value":"1435-1544","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,12]]},"assertion":[{"value":"10 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"C.\u00a0Haubrich and T.\u00a0Klingenheben declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this article no studies with human participants or animals were performed by any of the authors. All studies performed were in accordance with the ethical standards indicated in each case.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}