{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:18:09Z","timestamp":1762100289890},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T00:00:00Z","timestamp":1103673600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1007\/s00401-004-0940-1","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T12:23:44Z","timestamp":1103718224000},"page":"272-284","source":"Crossref","is-referenced-by-count":21,"title":["New insights into the skeletal muscle phenotype of equine motor neuron disease: a quantitative approach"],"prefix":"10.1007","volume":"109","author":[{"given":"P.","family":"Palencia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Quiroz-Rothe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\ufffd-Luis L.","family":"Rivero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,12,22]]},"reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1212\/WNL.24.5.477","volume":"24","author":"Achari","year":"1974","unstructured":"Achari A, Anderson M (1974) Myopathic changes in amyotrophic lateral sclerosis. Neurology 24:477?481","journal-title":"Neurology"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00401-003-0699-9","volume":"105","author":"Berger","year":"2003","unstructured":"Berger A, Mayr JA, Meierhofer D, Fotschl U, Bittner R, Budka H, Grethen C, Huemer M, Kofler B, Sperl W (2003) Severe depletion of mitochondrial DNA in spinal muscular atrophy. Acta Neuropathol 105:621?622","journal-title":"Acta Neuropathol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/01913120252934260","volume":"26","author":"Chung","year":"2002","unstructured":"Chung MJ, Suh YL (2002) Ultrastructural changes of mitochondria in the skeletal muscle of patients with amyotrophic lateral sclerosis. Ultrastruct Pathol 26:3?7","journal-title":"Ultrastruct Pathol"},{"key":"CR4","first-page":"291","volume":"80","author":"Cummings","year":"1990","unstructured":"Cummings JF, George C, Lahunta A de, Fuhrer L, Valentine BA, Cooper BJ, Summers BA, Huxtable CK, Mohammed HO (1990) Equine motor neuron disease: a preliminary report. Cornell Vet 80:291?297","journal-title":"Cornell Vet"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0378-1119(96)00339-3","volume":"178","author":"De","year":"1996","unstructured":"De la Rua-Domenche R, Wiedmann M, Mohammed HO, Cummings JF, Divers TJ, Batt CA (1996) Equine moter neuron disease is not linked to Cu\/Zn superoxide dismutase mutations: sequence analysis of the equine Cu\/Zn superoxide dismutase cDNA. Gene 178:83?88","journal-title":"Gene"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1090-0233(97)80021-4","volume":"154","author":"De","year":"1997","unstructured":"De la Rua-Domnench R, Mohammed HO, Cummings JF, Divers TJ, Lahunta A de, Summers BA (1997) Association between plasma vitamin E concentration and the risk of equine motor neuron disease. Vet J 154:203?213","journal-title":"Vet J"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.2460\/javma.1997.211.10.1261","volume":"211","author":"De","year":"1997","unstructured":"De la Rua-Domenec R, Mohammed HO, Cummings JF, Divers TJ, Lahunta A, Summers A de (1997) Intrinsic, management, and nutritional factors associated with equine motor neuron disease. J Am Vet Med Assoc 211:1261?1267","journal-title":"J Am Vet Med Assoc"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0969-9961(03)00041-X","volume":"13","author":"Derave","year":"2003","unstructured":"Derave W, Van Den Bosch L, Lemmens G, Eijnde BO, Robberecht W, Hespel P (2003) Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: effects of creatine treatment. Neurobiol Dis 13:264?272","journal-title":"Neurobiol Dis"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.2042-3306.1994.tb04411.x","volume":"26","author":"Divers","year":"1994","unstructured":"Divers TJ, Mohammed HO, Cummings JF, Valentine BA, Lahunta A de, Jackson CA, Summers BA (1994) Equine motor neuron disease: findings in 28 horses and proposal of a pathophysiological mechanism for the disease. Equine Vet J 26:409?415","journal-title":"Equine Vet J"},{"key":"CR10","first-page":"180","volume":"42","author":"Divers","year":"1996","unstructured":"Divers TJ, Valentine BA, Jackson CA, Van Metre DC, Mohammed HO (1996) Simple and practical muscle biopsy test for equine motor neuron disease. Proc Am Ass Equine Practnrs 42:180?181","journal-title":"Proc Am Ass Equine Practnrs"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0749-0739(17)30258-4","volume":"13","author":"Divers","year":"1997","unstructured":"Divers TJ, Mohammed HO, Cummings JF (1997) Equine motor neuron disease. Vet Clin N Am Equine Prac 13:97?105","journal-title":"Vet Clin N Am Equine Prac"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1097\/00002060-200211001-00014","volume":"81","author":"Edgerton","year":"2002","unstructured":"Edgerton VR, Roy RR, Allen DL, Monti RJ (2002) Adaptations in skeletal muscle disuse or decreased-use atrophy. Am J Physiol Med Rehabil 81:S127?S147","journal-title":"Am J Physiol Med Rehabil"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.2042-3306.1980.tb03420.x","volume":"12","author":"Ess","year":"1980","unstructured":"Ess\u00e9n B, Lindholm A, Thornton JR (1980) Histochemical properties of muscle fiber types and enzyme activities on skeletal muscles of Standardbred trotters of different ages. Equine Vet J 12:175?180","journal-title":"Equine Vet J"},{"key":"CR14","unstructured":"Ess\u00e9n-Gustavsson B, Lindholm a, McMiken D, Persson SGB, Thornton J (1983) Skeletal muscle characteristics of young Standardbreds in relation to growth and early training. In: Snow DH, Persson SGB, Rose RJ (eds) Equine exercise physiology. Granta Editions, Cambridge, pp 200?210"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1152\/japplphysiol.00673.2001","volume":"92","author":"Germinario","year":"2002","unstructured":"Germinario E, Esposito A, Megighian A, Midrio M, Biral D, Betto R, Danieli-Betto D (2002) Early changes of type 2B fibers after denervation of rat EDL skeletal muscle. J Appl Physiol 92: 2045?2052","journal-title":"J Appl Physiol"},{"key":"CR16","first-page":"480","volume":"49","author":"Green","year":"1999","unstructured":"Green SL, Tolwani RJ (1999) Animal models for motor neuron disease. Lab Anim Sci 49:480?486","journal-title":"Lab Anim Sci"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/(SICI)1097-4598(199606)19:6<728::AID-MUS7>3.0.CO;2-C","volume":"19","author":"Grimby","year":"1996","unstructured":"Grimby L, Tollback A, Muller U, Larsson L (1996) Fatigue of chronically overused motor units in prior polio patients. Muscle Nerve 19:728?737","journal-title":"Muscle Nerve"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.2042-3306.1996.tb03775.x","volume":"28","author":"Jackson","year":"1996","unstructured":"Jackson CA, Lahunta A de, Cummings TJ, Divers TJ, Mohammed HO, Valentine BA, Hackett RP (1996) Spinal accessory nerve biopsy as an ante mortem diagnostic test for equine motor neuron disease. Equine Vet J 28:215?219","journal-title":"Equine Vet J"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/mus.880131107","volume":"13","author":"Jiang","year":"1990","unstructured":"Jiang B, Roy RR, Edgerton VR (1990) Expression of a fast fiber enzyme profile in the cat soleus after spinalization. Muscle Nerve 13:1037?1049","journal-title":"Muscle Nerve"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/mus.10257","volume":"26","author":"Krivickas","year":"2002","unstructured":"Krivickas LS, Yang J-I, Kim S-K, Frontera WR (2002) Skeletal muscle fiber function and rate of disease progression in amyotrophic lateral sclerosis. Muscle Nerve 26:636?643","journal-title":"Muscle Nerve"},{"key":"CR21","first-page":"1","volume":"181","author":"L","year":"1992","unstructured":"L\u00f3pez-Rivero JL, Serrano AL, Diz AM, Galisteo AM (1992) Variability of muscle fiber composition and fiber size in the horse gluteus medius: an enzyme-histochemical and morphometric study. J Anat 181:1?10","journal-title":"J Anat"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/mus.1083","volume":"24","author":"Monti","year":"2001","unstructured":"Monti RJ, Roy RR, Edgerton VR (2001) Role of motor unit structure in defining function. Muscle Nerve 24:848?866","journal-title":"Muscle Nerve"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1152\/japplphysiol.00724.2003","volume":"96","author":"Otis","year":"2004","unstructured":"Otis JS, Roy RR, Edgerton VR, Talmadge RJ (2004) Adaptations in metabolic capacity of rat soleus after paralysis. J Appl Physiol 96:584?596","journal-title":"J Appl Physiol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1152\/jappl.2001.90.3.1119","volume":"90","author":"Pette","year":"2001","unstructured":"Pette D (2001) Plasticity in skeletal, cardiac, and smooth muscle. Historical perspectives: plasticity of mammalian skeletal muscle. J Appl Physiol 90:1119?1124","journal-title":"J Appl Physiol"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.2042-3306.1998.tb04497.x","volume":"30","author":"Polack","year":"1998","unstructured":"Polack EW, King JM, Cummings JF, Lahunta A de, Divers TJ, Mohammed HO (1998) Quantitative assessment of motor neuron loss in equine motor neuron disease (EMND). Equine Vet J 30:256?259","journal-title":"Equine Vet J"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s004180100319","volume":"116","author":"Quiroz-Rothe","year":"2001","unstructured":"Quiroz-Rothe E, Rivero JLL (2001) Co-ordinated expression of contractile and non-contractile features of control equine muscle fiber types characterised by immunostaining of myosin heavy chains. Histochem Cell Biol 116:299?312","journal-title":"Histochem Cell Biol"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2746\/042516402776767259","volume":"34","author":"Quiroz-Rothe","year":"2002","unstructured":"Quiroz-Rothe E, Novales M, Aguilera-Tejero E, Rivero JLL (2002) Polysaccharide storage myopathy in the M. longissimus lumborum of showjumpers and dressage horses with back pain. Equine Vet J 34:171?176","journal-title":"Equine Vet J"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/(SICI)1097-0185(199610)246:2<185::AID-AR5>3.0.CO;2-0","volume":"246","author":"Rivero","year":"1996","unstructured":"Rivero JLL, Talmadge RJ, Edgerton VR (1996) Myosin heavy chain isoforms in adult equine skeletal muscle: an immunohistochemical and electrophoretic study. Anat Rec 246:185?194","journal-title":"Anat Rec"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1002\/elps.1150181115","volume":"18","author":"Rivero","year":"1997","unstructured":"Rivero JLL, Talmadge RJ, Edgerton VR (1997) A sensitive electrophoretic method for the quantification of myosin heavy chain isoforms in horse skeletal muscle: histochemical and immunohistochemical verification. Electrophoresis 18:1967?1972","journal-title":"Electrophoresis"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1023\/A:1005461214800","volume":"20","author":"Rivero","year":"1999","unstructured":"Rivero JLL, Serrano AL, Barrey E, Valette JP, Jouglin M (1999) Analysis of myosin heavy chains at the protein level in horse skeletal muscle. J Muscle Res Cell Motil 20:211?221","journal-title":"J Muscle Res Cell Motil"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.2460\/javma.1998.212.08.1271","volume":"212","author":"Shelton","year":"1998","unstructured":"Shelton GD, Hopkins AL, Ginn PE, Lahunta A de, Cummings JF, Berryman FC, Hansen L (1998) Adult-onset motor neuron disease in three cats. J Am Vet Med Assoc 212:1271?1275","journal-title":"J Am Vet Med Assoc"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/(SICI)1097-4598(200005)23:5<661::AID-MUS3>3.0.CO;2-J","volume":"23","author":"Talmadge","year":"2000","unstructured":"Talmadge RJ (2000) Myosin heavy chain isoform expression following reduced neuromuscular activity: potential regulatory mechanisms. Muscle Nerve 23:661?679","journal-title":"Muscle Nerve"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1152\/jappl.1993.75.5.2337","volume":"75","author":"Talmadge","year":"1993","unstructured":"Talmadge RJ, Roy RR (1993) Electrophoretic separation of rat skeletal muscle myosin heavy-chain isoforms. J Appl Physiol 75:2337?2340","journal-title":"J Appl Physiol"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1152\/jappl.1995.78.4.1256","volume":"78","author":"Talmadge","year":"1995","unstructured":"Talmadge RJ, Roy RR, Edgerton VR (1995) Prominence of myosin heavy chain hybrid fibers in soleus muscle of spinal cord-transected rats. J Appl Physiol 78:1256?1265","journal-title":"J Appl Physiol"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1152\/jappl.1996.80.4.1296","volume":"80","author":"Talmadge","year":"1996","unstructured":"Talmadge RJ, Roy RR, Chalmers GR, Edgerton VR (1996) MHC and sarcoplasmic reticulum protein isoforms in functionally overloaded cat plantaris muscle fibers. J Appl Physiol 80:1296?1303","journal-title":"J Appl Physiol"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/030098589403100122","volume":"31","author":"Valentine","year":"1994","unstructured":"Valentine BA, Lahunta A de, George C, Summers BA, Cummings JF, Divers TJ, Mohammed HO (1994) Acquired equine motor neuron disease. Vet Pathol 31:130?138","journal-title":"Vet Pathol"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.2042-3292.1998.tb00846.x","volume":"10","author":"Valentine","year":"1998","unstructured":"Valentine BA, Divers TJ, Murphy DJ, Todhunter PG (1998) Muscle biopsy diagnosis of equine motor neuron disease and equine polysaccharide storage myopathy. Equine Vet Educ 10:42?50","journal-title":"Equine Vet Educ"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/030098587601300604","volume":"13","author":"Vandevelde","year":"1976","unstructured":"Vandevelde M, Greene CE, Hoff EJ (1976) Lower motor neuron disease with accumulation of neurofilaments in a cat. Vet Pathol 13:428?435","journal-title":"Vet Pathol"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/brain\/123.7.1339","volume":"123","author":"Vielhaber","year":"2000","unstructured":"Vielhaber S, Kunz D, Winkler K, Wiedemann F, Kirches E, Feistner H, Heinze H, Elger C, Schibert W, Kunz W (2000) Mitochondrial DNA abnormalities in skeletal muscle of patients with sporadic amyotrophic lateral sclerosis. Brain 123:1339?1348","journal-title":"Brain"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0960-8966(03)00135-4","volume":"13","author":"Visser","year":"2003","unstructured":"Visser J, Mans E, Visser M de, Berg-Vos RM van den, Franssen H, Jong JMBV de, Berg LH van den, Wooke JHJ, Haan RJ de (2003) Comparison of maximal voluntary isometric contraction and hand-held dynamometry in measuring muscle strength of patients with progressive lower motor neuron syndrome. Neuromuscul Disord 13:744?750","journal-title":"Neuromuscul Disord"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0024-3205(98)00557-8","volume":"64","author":"Wallis","year":"1999","unstructured":"Wallis MG, Appleby GJ, Youd JM, Clark MG, Penschow JD (1999) Reduced glycogen phosphorylase activity in denervated hindlimb muscles of rats is related to muscle atrophy and fiber type. Life Sci 64:221?228","journal-title":"Life Sci"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-510X(98)00008-2","volume":"156","author":"Wiedeman","year":"1998","unstructured":"Wiedeman F, Winkler K, Kuznetsov A, Bartels C, Vielhaber S, Feistner H, Kunz W (1998) Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis. J Neurol Sci 156:65?72","journal-title":"J Neurol Sci"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-004-0940-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-004-0940-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-004-0940-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T05:05:25Z","timestamp":1705467925000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-004-0940-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,22]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["940"],"URL":"https:\/\/doi.org\/10.1007\/s00401-004-0940-1","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,22]]}}}