{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:03:47Z","timestamp":1792098227815,"version":"4.4.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2005,3,10]],"date-time":"2005-03-10T00:00:00Z","timestamp":1110412800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1007\/s00401-005-0988-6","type":"journal-article","created":{"date-parts":[[2005,3,9]],"date-time":"2005-03-09T10:45:16Z","timestamp":1110365116000},"page":"483-489","source":"Crossref","is-referenced-by-count":27,"title":["Silver staining profiles distinguish Pick bodies from neurofibrillary tangles of Alzheimer type: comparison between Gallyas and Campbell-Switzer methods"],"prefix":"10.1007","volume":"109","author":[{"given":"Toshiki","family":"Uchihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniaki","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,3,10]]},"reference":[{"key":"988_CR1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ar.1090650110","volume":"65","author":"Bodian","year":"1936","unstructured":"Bodian D (1936) A new method for staining nerve fibers and nerve endings in mounted paraffin sections. Anat Res 65:89","journal-title":"Anat Res"},{"key":"988_CR2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3109\/10520299209110013","volume":"67","author":"Bolle","year":"1992","unstructured":"Bolle L, Maurer B, Janzer RC (1992) A modified Hortega-Globus stain is superior to Bielschowsky and Bodian stains for demonstrating neuritic plaques. Biotech Histochem 67:82\u201387","journal-title":"Biotech Histochem"},{"key":"988_CR3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0165-0270(98)00173-3","volume":"87","author":"Braak","year":"1999","unstructured":"Braak E, Braak H (1999) Silver staining method for demonstrating Lewy bodies in Parkinson\u2019s disease and argyrophilic oligodendrocytes in multiple system atrophy. J Neurosci Methods 87:111\u2013115","journal-title":"J Neurosci Methods"},{"key":"988_CR4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/10520298809107184","volume":"63","author":"Braak","year":"1988","unstructured":"Braak H, Braak E, Ohm TG, Bohl J (1988) Silver impregnation of Alzheimer\u2019s neurofibrillary changes counterstained for basophilic material and lipofuscin pigment. Stain Technol 63:197\u2013200","journal-title":"Stain Technol"},{"key":"988_CR5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s004010050436","volume":"91","author":"Bu","year":"1996","unstructured":"Bu\u00e9e-Scherrer V, Hof PR, Bu\u00e9e L, Leveugle B, Vermersch P, Perl DP, Olanow CW, Delacourte A (1996) Hyperphosphorylated tau proteins differentiate corticobasal degeneration and Pick\u2019s disease. Acta Neuropathol 91:351\u2013359","journal-title":"Acta Neuropathol"},{"key":"988_CR6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s004010050978","volume":"97","author":"Bussi","year":"1999","unstructured":"Bussi\u00e8re T, Hof PR, Mailliot C, Brown CD, Caillet-Boudin M-L, Perl DP, Bu\u00e9e L, Delacourte A (1999) Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration. Acta Neuropathol 97:221\u2013230","journal-title":"Acta Neuropathol"},{"key":"988_CR7","first-page":"67","volume":"13","author":"Campbell","year":"1987","unstructured":"Campbell SK, Switzer RC, Martin TL (1987) Alzheimer\u2019s plaques and tangles: a controlled and enhanced silver staining method. Soc Neurosci Abstr 13:67","journal-title":"Soc Neurosci Abstr"},{"key":"988_CR8","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/jnnp.50.9.1221","volume":"50","author":"Connolly","year":"1987","unstructured":"Connolly AAP, Anderton BA, Esiri MM (1987) A comparative study of a silver stain and monoclonal antibody reactions on Alzheimer\u2019s neurofibrillary tangles. J Neurol Neurosurg Psychiatry 50:1221\u20131224","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"988_CR9","first-page":"67","volume":"39","author":"Cross","year":"1982","unstructured":"Cross RB (1982) Demonstration of neurofibrillary tangles in paraffin sections: a quick and simple method using a modification of Palmgren\u2019s method. Med Lab Sci 39:67\u201369","journal-title":"Med Lab Sci"},{"key":"988_CR10","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1046\/j.1365-2990.2003.00463.x","volume":"29","author":"De","year":"2003","unstructured":"De Silva R, Lashley T, Gibb G, Hanger D, Hope A, Reid A, Bandopadhyay R, Utton M, Strand C, Jowett T, Khan N, Anderton B, Wood N, Holton J, Revesz T, Lee A (2003) Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies. Neuropathol Appl Neurobiol 29:288\u2013302","journal-title":"Neuropathol Appl Neurobiol"},{"key":"988_CR11","first-page":"167","volume":"Neuropathol","author":"Duyckaerts","year":"1987","unstructured":"Duyckaerts C, Brion JP, Hauw JJ, Flament-Durand J (1987) Quantitative assessment of the density of neurofibrillary tangles and senile plaques in senile dementia of the Alzheimer type. Comparison of immunocytochemistry with a specific antibody and Bodian\u2019s protargol method. Acta Neuropathol (Berl) 73:167\u2013170","journal-title":"Acta"},{"key":"988_CR12","first-page":"1","volume":"19","author":"Gallyas","year":"1971","unstructured":"Gallyas F (1971) Silver staining of Alzheimer\u2019s neurofibrillary changes by means of physical development. Acta Morphol Acad Scient Hung 19:1\u20138","journal-title":"Acta Morphol Acad Scient Hung"},{"key":"988_CR13","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1126\/science.6169146","volume":"213","author":"Gambetti","year":"1981","unstructured":"Gambetti P, Autilio-Gambetti L, Papasozomenos SC (1981) Bodian\u2019s silver method stains neurofilament polypeptides. Science 213:1521\u20131522","journal-title":"Science"},{"key":"988_CR14","first-page":"1375","volume":"31","author":"Hicks","year":"1946","unstructured":"Hicks SP (1946) A rapid pyridine silver stain for nervous tissue and reticular fibers. J Lab Clin Med 31:1375\u20131377","journal-title":"J Lab Clin Med"},{"key":"988_CR15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1001\/archneur.1962.00450200028003","volume":"6","author":"Hirano","year":"1962","unstructured":"Hirano A, Zimmerman HM (1962) Silver impregnation of nerve cells and fibers in celloidin sections. A simple impregnation technique. Arch Neurol 6:114\u2013122","journal-title":"Arch Neurol"},{"key":"988_CR16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0197-4580(91)90022-C","volume":"12","author":"Iqbal","year":"1991","unstructured":"Iqbal K, Braak E, Braak H, Zaidi T, Grundke-Iqbal I (1991) A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Neurobiol Aging 12:357\u2013361","journal-title":"Neurobiol Aging"},{"key":"988_CR17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3109\/10520299309104677","volume":"68","author":"Kondoh","year":"1993","unstructured":"Kondoh H, Matsushita M, Kosaka K, Miyazaki N (1993) Staining senile plaques using Bodian\u2019s method modified with methenamine. Biotech Histochem 68:113\u2013116","journal-title":"Biotech Histochem"},{"key":"988_CR18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2990.1989.tb01255.x","volume":"15","author":"Lamy","year":"1989","unstructured":"Lamy C, Duyckaerts C, Dela\u00e8re P, Payan C, Fermanian J, Poulain V, Hauw JJ (1989) Comparison of seven staining methods for senile plaques and neurofibrillary tangles in a prospective series of 15 elderly patients. Neuropathol Appl Neurobiol 15:563\u2013578","journal-title":"Neuropathol Appl Neurobiol"},{"key":"988_CR19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0014-5793(98)00910-7","volume":"433","author":"Mailliot","year":"1998","unstructured":"Mailliot C, Sergeant N, Bussi\u00e8re T, Caillet-Boudin M-L, Delacourte A, Bu\u00e9e L (1998) Phosphorylation of specific sets of tau isoforms reflects different neurofibrillary degeneration processes. FEBS Lett 433:201\u2013204","journal-title":"FEBS Lett"},{"key":"988_CR20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF00227819","volume":"84","author":"Mercken","year":"1992","unstructured":"Mercken M, Vandermeern M, L\u00fcbke U, Six J, Boons J, Van de Voorde A, Martin J-J, Gheuens J (1992) Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes. Acta Neuropathol 84:265\u2013272","journal-title":"Acta Neuropathol"},{"key":"988_CR21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","volume":"42","author":"Mirra","year":"1991","unstructured":"Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Hughes JP, Belle G van, Berg L (1991) The consortium to establish a registry for Alzheimer\u2019s disease (CERAD). II. Standardization of the neuropathologic assessment of Alzheimer\u2019s disease. Neurology 42:479\u2013486","journal-title":"Neurology"},{"key":"988_CR22","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0344-0338(11)81084-8","volume":"187","author":"Reusche","year":"1991","unstructured":"Reusche E (1991) Silver staining of senile plaques and neurofibrillary tangles in paraffin sections. A simple and effective method. Pathol Res Pract 187:1045\u20131049","journal-title":"Pathol Res Pract"},{"key":"988_CR23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/BF00334887","volume":"86","author":"Rosenwald","year":"1993","unstructured":"Rosenwald A, Reusche E, Ogomori K, Teichert H-M (1993) Comparison of silver staining and immunohistology for the detection of neurofibrillary tangles and extracellular cerebral amyloid in paraffin sections. Acta Neuropathol 86:182\u2013186","journal-title":"Acta Neuropathol"},{"key":"988_CR24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/exnr.2002.7961","volume":"177","author":"Sakamoto","year":"2002","unstructured":"Sakamoto M, Uchihara T, Hayashi M, Nakamura A, Kikuchi E, Mizutani T, Mizusawa H, Hirai S (2002) Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red. Exp Neurol 177:88\u201394","journal-title":"Exp Neurol"},{"key":"988_CR25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1749-6632.1993.tb18319.x","volume":"679","author":"Switzer","year":"1993","unstructured":"Switzer RC 3rd (1993) Silver staining methods: their role in detecting neurotoxicity. Ann N Y Acad Sci 679:341\u2013348","journal-title":"Ann N Y Acad Sci"},{"key":"988_CR26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1365-2990.1999.00182.x","volume":"25","author":"Tolnay","year":"1999","unstructured":"Tolnay M, Probst A (1999) Tau protein pathology in Alzheimer\u2019s disease and related disorders. Neuropathol Appl Neurobiol 25:171\u2013187","journal-title":"Neuropathol Appl Neurobiol"},{"key":"988_CR27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF00867417","volume":"252","author":"Uchihara","year":"1995","unstructured":"Uchihara T, Kondo H, Ikeda K, Kosaka K (1995) Alzheimer-type pathology in melanin-bleached sections of substantia nigra. J Neurol 252:485\u2013489","journal-title":"J Neurol"},{"key":"988_CR28","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s004010050934","volume":"96","author":"Uchihara","year":"1998","unstructured":"Uchihara T, Mizusawa H, Tsuchiya K, Kondo H, Oda T, Ikeda K (1998) Discrepancy between tau immunoreactivity and argyrophilia by the Bodian method in neocortical neurons of corticobasal degeneration. Acta Neuropathol 96:553\u2013557","journal-title":"Acta Neuropathol"},{"key":"988_CR29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s004010000306","volume":"101","author":"Uchihara","year":"2001","unstructured":"Uchihara T, Nakamura A, Yamazaki M, Mori O (2001) Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence. Acta Neuropathol 101:535\u2013539","journal-title":"Acta Neuropathol"},{"key":"988_CR30","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s004010100401","volume":"102","author":"Uchihara","year":"2001","unstructured":"Uchihara T, Nakamura A, Yamazaki M, Mori O, Ikeda K, Tsuchiya K (2001) Different conformation of neuronal tau deposits distinguished by double immunofluorescence with AT8 and thiazin red combined with Gallyas method. Acta Neuropathol 102:462\u2013466","journal-title":"Acta Neuropathol"},{"key":"988_CR31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1046\/j.1440-1789.2003.00523.x","volume":"23","author":"Uchihara","year":"2003","unstructured":"Uchihara T, Ikeda K, Tsuchiya K (2003) Pick body disease and Pick syndrome. Neuropathology 23:318\u2013326","journal-title":"Neuropathology"},{"key":"988_CR32","unstructured":"Uchihara T, Shibuya K, Nakamura A, Yagishita S (in press) Silver stains distinguish tau-positive structures in corticobasal degeneration\/progressive supranuclear palsy and in Alzheimer\u2019s disease: Comparison between Gallyas and Campbell-Switzer methods. Acta Neuropathol"},{"key":"988_CR33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/BF00308476","volume":"83","author":"Vallet","year":"1992","unstructured":"Vallet PG, Guntern R, Hof PR, Golaz J, Delacourte A, Robakis NK, Bouras C (1992) A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer\u2019s disease. Acta Neuropathol 83:170\u2013178","journal-title":"Acta Neuropathol"},{"key":"988_CR34","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/BF00296118","volume":"79","author":"Wilcock","year":"1990","unstructured":"Wilcock GK, Matthews SM, Moss T (1990) Comparison of three silver stains for demonstrating neurofibrillary tangles and neuritic plaques in brain tissue stored for long periods. Acta Neuropathol 79:566\u2013568","journal-title":"Acta Neuropathol"},{"key":"988_CR35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF00687398","volume":"78","author":"Wisniewski","year":"1989","unstructured":"Wisniewski HM, Wen GY, Kim KS (1989) Comparison of four staining methods on the detection of neuritic plaques. Acta Neuropathol 78:22\u201327","journal-title":"Acta Neuropathol"},{"key":"988_CR36","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/BF00296119","volume":"79","author":"Yamaguchi","year":"1990","unstructured":"Yamaguchi H, Haga C, Hirai S, Nakazato Y, Kosaka K (1990) Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brain by a new methenamine silver stain. Acta Neuropathol 79:569\u2013572","journal-title":"Acta Neuropathol"},{"key":"988_CR37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2990.1986.tb00677.x","volume":"12","author":"Yamamoto","year":"1986","unstructured":"Yamamoto T, Hirano A (1986) A comparative study of modified Bielshowsky, Bodian and Thioflavin S stains on Alzheimer\u2019s neurofibrillary tangles. Neuropathol Appl Neurobiol 12:3\u20139","journal-title":"Neuropathol Appl Neurobiol"},{"key":"988_CR38","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ana.410130211","volume":"13","author":"Yen","year":"1983","unstructured":"Yen SH, Horoupian DS, Terry RD (1983) Immunocytochemical comparison of neurofibrillary tangles in senile dementia of Alzheimer type, progressive supranuclear palsy, and postencephalitic Parkinsonism. Ann Neurol 13:172\u2013175","journal-title":"Ann Neurol"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-005-0988-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-005-0988-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-005-0988-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T07:51:57Z","timestamp":1586159517000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-005-0988-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,10]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["988"],"URL":"https:\/\/doi.org\/10.1007\/s00401-005-0988-6","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,10]]}}}