{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:09:45Z","timestamp":1791079785349,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,5,26]],"date-time":"2005-05-26T00:00:00Z","timestamp":1117065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1007\/s00401-005-1021-9","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T14:21:27Z","timestamp":1117030887000},"page":"48-56","source":"Crossref","is-referenced-by-count":65,"title":["Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 gene"],"prefix":"10.1007","volume":"110","author":[{"given":"Shoichi","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Warita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,5,26]]},"reference":[{"key":"1021_CR1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1083\/jcb.147.3.531","volume":"147","author":"Beaulieu","year":"1999","unstructured":"Beaulieu JM, Nguyen MD, Julien J-P (1999) Late onset death of motor neurons in mice overexpressing wild-type peripherin. J Cell Biol 147:531\u2013544","journal-title":"J Cell Biol"},{"key":"1021_CR2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/brain\/96.2.247","volume":"6","author":"Bradley","year":"1973","unstructured":"Bradley WG, Jaros E (1973) Axoplasmic flow in axonal neuropathies. II. Axoplasmic flow in mice with motor neuron disease and muscular dystrophy. Brain 6:247\u2013258","journal-title":"Brain"},{"key":"1021_CR3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ana.410140304","volume":"14","author":"Bradley","year":"1983","unstructured":"Bradley WG, Good P, Rasool CG, Adelman LS (1983) Morphometric and biochemical studies of peripheral nerves in amyotrophic lateral sclerosis. Ann Neurol 14:267\u2013277","journal-title":"Ann Neurol"},{"key":"1021_CR4","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1212\/WNL.37.5.738","volume":"37","author":"Breuer","year":"1987","unstructured":"Breuer AC, Lynn MP, Atkinson MB, et al (1987) Fast axonal transport in amyotrophic lateral sclerosis: an intra-axonal organelle traffic analysis. Neurology 37:738\u2013748","journal-title":"Neurology"},{"key":"1021_CR5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0896-6273(00)80272-X","volume":"18","author":"Bruijn","year":"1997","unstructured":"Bruijn LI, Becher MW, Lee MK, Anderson KL, Jenkins NA, Copeland NG, Sisodia SS, Rothstein JD, Borchelt DR, Price DL, Cleveland DW (1997) ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron 18:327\u2013338","journal-title":"Neuron"},{"key":"1021_CR6","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1212\/WNL.18.9.841","volume":"18","author":"Carpenter","year":"1968","unstructured":"Carpenter S (1968) Proximal axonal enlargement in motor neuron disease. Neurology 18:841\u2013851","journal-title":"Neurology"},{"key":"1021_CR7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)81133-2","volume":"26","author":"Catterall","year":"2000","unstructured":"Catterall WA (2000) From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26:13\u201325","journal-title":"Neuron"},{"key":"1021_CR8","doi-asserted-by":"crossref","unstructured":"Chow SM, Hartmann HA (1964) Axonal lesions and waltzing syndrome after IDPN administration in rats with a concept \u201caxostasis.\u201d Acta Neuropathol (Berl) 3:428\u2013450","DOI":"10.1007\/BF00688453"},{"key":"1021_CR9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0896-6273(00)81108-3","volume":"24","author":"Cleveland","year":"1999","unstructured":"Cleveland DW (1999) From Charcot to SOD1: mechanisms of selective motor neuron death in ALS. Neuron 24:515\u2013520","journal-title":"Neuron"},{"key":"1021_CR10","first-page":"1271","volume":"145","author":"Dal","year":"1994","unstructured":"Dal Canto MC, Gurney ME (1994) Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis. Am J Pathol 145:1271\u20131280","journal-title":"Am J Pathol"},{"key":"1021_CR11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0006-8993(95)00063-V","volume":"676","author":"Dal","year":"1995","unstructured":"Dal Canto MC, Gurney ME (1995) Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu, Zn SOD, and in mice overexpressing wild-type human SOD: a model of familial amyotrophic lateral sclerosis (FALS). Brain Res 676:25\u201340","journal-title":"Brain Res"},{"key":"1021_CR12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1006\/nbdi.2000.0292","volume":"7","author":"Dupuis","year":"1997","unstructured":"Dupuis L, Tapia M de, Rene F, Lutz-Bucher B, Gordon JW, Mercken L, Pradier L, Loeffler JP (1997) Differential screening of mutated SOD1 transgenic mice reveals early up-regulation of a fast axonal transport component in spinal cord motor neurons. Neurobiol Dis 7:274\u2013285","journal-title":"Neurobiol Dis"},{"key":"1021_CR13","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1126\/science.81524","volume":"202","author":"Griffin","year":"1978","unstructured":"Griffin JW, Hoffman PN, Clark AW, Carrol PT, Price DL (1978) Slow axonal transport of neurofilament proteins: impairment by \u03b2,\u03b2\u2019-iminodiproprionitrile administration. Science 202:633\u2013635","journal-title":"Science"},{"key":"1021_CR14","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","volume":"264","author":"Gurney","year":"1994","unstructured":"Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD, Caliendo J, Hentati A, Kwon YW, Deng HX, et al (1994) Motor neuron degeneration in mice that express a human Cu\/Zn superoxide dismutase mutation. Science 264:1772\u20131775","journal-title":"Science"},{"key":"1021_CR15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0092-8674(01)00244-6","volume":"104","author":"Julien","year":"2001","unstructured":"Julien JP (2001) Amyotrophic lateral sclerosis: unfolding the toxicity of the misfolded. Cell 104:581\u2013591","journal-title":"Cell"},{"key":"1021_CR16","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/0896-6273(94)90263-1","volume":"13","author":"Lee","year":"1994","unstructured":"Lee MK, Marszalek JR, Cleveland DW (1994) A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron 13:975\u2013988","journal-title":"Neuron"},{"key":"1021_CR17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/(SICI)1096-9861(19980202)391:1<64::AID-CNE6>3.0.CO;2-P","volume":"39","author":"Morrison","year":"1998","unstructured":"Morrison BM, Janssen WG, Gordon JW, Morrison JH (1998) Time course of neuropathology in the spinal cord of G86R superoxide dismutase transgenic mice. J Comp Neurol 39:64\u201377","journal-title":"J Comp Neurol"},{"key":"1021_CR18","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/mus.880160517","volume":"16","author":"Mitsumoto","year":"1993","unstructured":"Mitsumoto H, Kurahashi K, Jacob JM, McQuarrie IG (1993) Retardation of fast axonal transport in wobbler mice. Muscle Nerve 16:542\u2013547","journal-title":"Muscle Nerve"},{"key":"1021_CR19","unstructured":"Norris FH (1979) Moving axon particles of intercostal nerve terminal in benign and malignant ALS. In: Tsubaki T, Toyokura Y (eds) Amyotrophic lateral sclerosis. University Park Press, Baltimore, pp 375\u2013385"},{"key":"1021_CR20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","volume":"362","author":"Rosen","year":"1993","unstructured":"Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O\u2019Regan JP, Deng HX, et al (1993) Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362:59\u201362","journal-title":"Nature"},{"key":"1021_CR21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1212\/WNL.47.2.535","volume":"47","author":"Sasaki","year":"1996","unstructured":"Sasaki S, Iwata M (1996) Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis. Neurology 47:535\u2013540","journal-title":"Neurology"},{"key":"1021_CR22","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0022-510X(92)90017-F","volume":"110","author":"Sasaki","year":"1992","unstructured":"Sasaki S, Maruyama S (1992) Increase in diameter of the axonal initial segment is an early change in amyotrophic lateral sclerosis. J Neurol Sci 110:114\u2013120","journal-title":"J Neurol Sci"},{"key":"1021_CR23","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ana.410250520","volume":"25","author":"Sasaki","year":"1989","unstructured":"Sasaki S, Maruyama S, Yamane K, Sakuma H, Takeishi M (1989) Swellings of proximal axons in a case of motor neuron disease. Ann Neurol 25:520\u2013522","journal-title":"Ann Neurol"},{"key":"1021_CR24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0022-510X(90)90221-8","volume":"97","author":"Sasaki","year":"1990","unstructured":"Sasaki S, Maruyama S, Yamane K, Sakuma H, Takeishi M (1990) Ultrastructure of swollen proximal axons of anterior horn neurons in motor neuron disease. J Neurol Sci 97:233\u2013240","journal-title":"J Neurol Sci"},{"key":"1021_CR25","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s00401-004-0838-y","volume":"107","author":"Sasaki","year":"2004","unstructured":"Sasaki S, Warita H, Abe K, Iwata M (2004) Slow component of axonal transport is impaired in the proximal axon of transgenic mice with a G93A mutant SOD1 gene. Acta Neuropathol 107:452\u2013460","journal-title":"Acta Neuropathol"},{"key":"1021_CR26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00401-004-0837-z","volume":"107","author":"Sasaki","year":"2004","unstructured":"Sasaki S, Warita H, Murakami T, Abe K, Iwata M (2004) Ultrastructural study of mitochondria in the spinal cord of transgenic mice with a G93A mutant SOD1 gene. Acta Neuropathol 107:461\u2013474","journal-title":"Acta Neuropathol"},{"key":"1021_CR27","doi-asserted-by":"crossref","unstructured":"Sasaki S, Warita H, Murakami T, Shibata N, Komori T, Abe K, Kobayashi M, Iwata M (2005) Ultrastructural study of aggregates in the spinal cord of transgenic mice with a G93A mutant SOD1 gene. Acta Neuropathol (in press)","DOI":"10.1007\/s00401-004-0939-7"},{"key":"1021_CR28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0166-2236(96)10075-8","volume":"20","author":"Stuart","year":"1997","unstructured":"Stuart G, Spruston N, Sakmann B, H\u00e4usser M (1997) Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends Neurosci 20:125\u2013131","journal-title":"Trends Neurosci"},{"key":"1021_CR29","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1073\/pnas.93.7.3155","volume":"93","author":"Tu","year":"1996","unstructured":"Tu P-H, Raju P, Robinson KA, Gurney ME, Trojanowski JQ, Lee VM-Y (1996) Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis. Proc Natl Aca Sci USA 93:3155\u20133160","journal-title":"Proc Natl Aca Sci USA"},{"key":"1021_CR30","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0006-8993(98)01351-1","volume":"819","author":"Warita","year":"1999","unstructured":"Warita H, Itoyama Y, Abe K (1999) Selective impairment of fast anterograde axonal transport in the peripheral nerves of asymptomatic transgenic mice with a G93A mutant SOD1 gene. Brain Res 819:120\u2013131","journal-title":"Brain Res"},{"key":"1021_CR31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/4553","volume":"2","author":"Williamson","year":"1999","unstructured":"Williamson TL, Cleveland DW (1999) Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat Neurosci 2:50\u201356","journal-title":"Nat Neurosci"},{"key":"1021_CR32","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0896-6273(95)90259-7","volume":"14","author":"Wong","year":"1995","unstructured":"Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL (1995) An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14:1105\u20131116","journal-title":"Neuron"},{"key":"1021_CR33","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1083\/jcb.139.5.1307","volume":"139","author":"Zhang","year":"1997","unstructured":"Zhang B, Tu P-H, Abtahian F, Trojanowski JQ, Lee VM-Y (1997) Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation. J Cell Biol 139:1307\u20131315","journal-title":"J Cell Biol"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-005-1021-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-005-1021-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-005-1021-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T13:23:02Z","timestamp":1559049782000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-005-1021-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,26]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["1021"],"URL":"https:\/\/doi.org\/10.1007\/s00401-005-1021-9","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1027203.327643","asserted-by":"object"}]},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,26]]}}}