{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:14:25Z","timestamp":1791216865846,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2005,6,29]],"date-time":"2005-06-29T00:00:00Z","timestamp":1120003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1007\/s00401-005-1043-3","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T13:00:45Z","timestamp":1119963645000},"page":"247-254","source":"Crossref","is-referenced-by-count":34,"title":["The RAGE pathway in inflammatory myopathies and limb girdle muscular dystrophy"],"prefix":"10.1007","volume":"110","author":[{"given":"K. M.","family":"Haslbeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Friess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. D.","family":"Schleicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bierhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. P.","family":"Nawroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kirchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Neund\u00f6rfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Heuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,6,29]]},"reference":[{"key":"1043_CR1","doi-asserted-by":"crossref","unstructured":"Ames PR, Alves J, Murat I, Isenberg DA, Nourooz-Zadeh J (1999) Oxidative stress in systemic lupus erythematosus and allied conditions with vascular involvement. Rheumatology (Oxford) 38:529\u2013534","DOI":"10.1093\/rheumatology\/38.6.529"},{"key":"1043_CR2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ana.410160206","volume":"16","author":"Arahata","year":"1984","unstructured":"Arahata K, Engel AG (1984) Monoclonal antibody analysis of mononuclear cells in myopathies. I. Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells. Ann Neurol 16:193\u2013208","journal-title":"Ann Neurol"},{"key":"1043_CR3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","volume":"12","author":"Baeuerle","year":"1994","unstructured":"Baeuerle PA, Henkel T (1994) Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 12:141\u2013179","journal-title":"Annu Rev Immunol"},{"key":"1043_CR4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s001090100225","volume":"79","author":"Baghdiguian","year":"2001","unstructured":"Baghdiguian S, Richard I, Martin M, Coopman P, Beckmann JS, Mangeat P, Lefranc G (2001) Pathophysiology of limb girdle muscular dystrophy type 2A: hypothesis and new insights into the IkappaBalpha\/NF-kappaB survival pathway in skeletal muscle. J Mol Med 79:254\u2013261","journal-title":"J Mol Med"},{"key":"1043_CR5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000068133","volume":"10","author":"Bierhaus","year":"2003","unstructured":"Bierhaus A, Nawroth PP (2003) Modulation of the vascular endothelium during infection\u2014the role of NF-kappa B activation. Contrib Microbiol 10:86\u2013105","journal-title":"Contrib Microbiol"},{"key":"1043_CR6","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.2337\/diab.46.9.1481","volume":"46","author":"Bierhaus","year":"1997","unstructured":"Bierhaus A, Chevion S, Chevion M, Hofmann M, Quehenberger P, Illmer T, Luther T, Berentshtein E, Tritschler H, Muller M et al. (1997) Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes 46:1481\u20131490","journal-title":"Diabetes"},{"key":"1043_CR7","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.2337\/diabetes.50.12.2792","volume":"50","author":"Bierhaus","year":"2001","unstructured":"Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert PM, Chen J, Hong M, Luther T, Henle T, Kloting I et al. (2001) Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes 50:2792\u20132808","journal-title":"Diabetes"},{"key":"1043_CR8","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1172\/JCI18058","volume":"114","author":"Bierhaus","year":"2004","unstructured":"Bierhaus A, Haslbeck KM, Humpert PM, Liliensiek B, Dehmer T, Morcos M, Sayed AA, Andrassy M, Schiekofer S, Schneider JG et al. (2004) Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily. J Clin Invest 114:1741\u20131751","journal-title":"J Clin Invest"},{"key":"1043_CR9","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJM198805193182007","volume":"318","author":"Brownlee","year":"1988","unstructured":"Brownlee M, Cerami A, Vlassara H (1988) Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med 318:1315\u20131321","journal-title":"N Engl J Med"},{"key":"1043_CR10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s001250050131","volume":"37","author":"Cameron","year":"1994","unstructured":"Cameron NE, Cotter MA, Archibald V, Dines KC, Maxfield EK (1994) Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats. Diabetologia 37:449\u2013459","journal-title":"Diabetologia"},{"key":"1043_CR11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1172\/JCI10373","volume":"107","author":"Collins","year":"2001","unstructured":"Collins T, Cybulsky MI (2001) NF-kappaB: pivotal mediator or innocent bystander in atherogenesis? J Clin Invest 107:255\u2013264","journal-title":"J Clin Invest"},{"key":"1043_CR12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/32.2.6198355","volume":"32","author":"Cordell","year":"1984","unstructured":"Cordell JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, MacDonald S, Pulford KA, Stein H, Mason DY (1984) Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 32:219\u2013229","journal-title":"J Histochem Cytochem"},{"key":"1043_CR13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0960-8966(98)00126-6","volume":"9","author":"De Bleecker","year":"1999","unstructured":"De Bleecker JL, Meire VI, Declercq W, Van Aken EH (1999) Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies. Neuromuscul Disord 9:239\u2013246","journal-title":"Neuromuscul Disord"},{"key":"1043_CR14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ana.410160207","volume":"16","author":"Engel","year":"1984","unstructured":"Engel AG, Arahata K (1984) Monoclonal antibody analysis of mononuclear cells in myopathies. II. Phenotypes of autoinvasive cells in polymyositis and inclusion body myositis. Ann Neurol 16:209\u2013215","journal-title":"Ann Neurol"},{"key":"1043_CR15","unstructured":"Gempel KE, Wagner EM, Schleicher ED (1994) Production and characterization of antibodies against carboxymethyllysine-modified proteins. In: Maillard reactions in chemistry, food and health. The royal society of Chemistry, Cambridge"},{"key":"1043_CR16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00401-002-0518-8","volume":"104","author":"Haslbeck","year":"2002","unstructured":"Haslbeck KM, Schleicher ED, Friess U, Kirchner A, Neundorfer B, Heuss D (2002) N(epsilon)-Carboxymethyllysine in diabetic and non-diabetic polyneuropathies. Acta Neuropathol 104:45\u201352","journal-title":"Acta Neuropathol"},{"key":"1043_CR17","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mus.20039","volume":"29","author":"Haslbeck","year":"2004","unstructured":"Haslbeck KM, Bierhaus A, Schleicher E, Kirchner A, Nawroth P, Schlotzer U, Neundorfer B, Heuss D (2004) Receptor for advanced glycation endproduct (RAGE)-mediated nuclear factor-kappaB activation in vasculitic neuropathy. Muscle Nerve 29:853\u2013860","journal-title":"Muscle Nerve"},{"key":"1043_CR18","doi-asserted-by":"crossref","unstructured":"Hein G, Franke S (2002) Are advanced glycation end-product-modified proteins of pathogenetic importance in fibromyalgia? Rheumatology (Oxford) 41:1163\u20131167","DOI":"10.1093\/rheumatology\/41.10.1163"},{"key":"1043_CR19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1096\/fj.01-0866com","volume":"16","author":"Hunter","year":"2002","unstructured":"Hunter RB, Stevenson E, Koncarevic A, Mitchell-Felton H, Essig DA, Kandarian SC (2002) Activation of an alternative NF-kappaB pathway in skeletal muscle during disuse atrophy. FASEB J 16:529\u2013538","journal-title":"FASEB J"},{"key":"1043_CR20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/smim.2000.0210","volume":"12","author":"Karin","year":"2000","unstructured":"Karin M, Delhase M (2000) The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol 12:85\u201398","journal-title":"Semin Immunol"},{"key":"1043_CR21","first-page":"527","volume":"2","author":"Karpati","year":"1993","unstructured":"Karpati G, Carpenter S (1993) Pathology of the inflammatory myopathies. Baillieres Clin Neurol 2:527\u2013556","journal-title":"Baillieres Clin Neurol"},{"key":"1043_CR22","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1165\/ajrcmb.23.4.4117","volume":"23","author":"Kasper","year":"2000","unstructured":"Kasper M, Roehlecke C, Witt M, Fehrenbach H, Hofer A, Miyata T, Weigert C, Funk RH, Schleicher ED (2000) Induction of apoptosis by glyoxal in human embryonic lung epithelial cell line L132. Am J Respir Cell Mol Biol 23:485\u2013491","journal-title":"Am J Respir Cell Mol Biol"},{"key":"1043_CR23","doi-asserted-by":"crossref","first-page":"31740","DOI":"10.1074\/jbc.274.44.31740","volume":"274","author":"Kislinger","year":"1999","unstructured":"Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, Hofmann M, Yan SF, Pischetsrieder M, Stern D, Schmidt AM (1999) N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. J Biol Chem 274:31740\u201331749","journal-title":"J Biol Chem"},{"key":"1043_CR24","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/sj.bjp.0702937","volume":"128","author":"Liptay","year":"1999","unstructured":"Liptay S, Bachem M, Hacker G, Adler G, Debatin KM, Schmid RM (1999) Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine. Br J Pharmacol 128:1361\u20131369","journal-title":"Br J Pharmacol"},{"key":"1043_CR25","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1212\/01.WNL.0000049913.27181.51","volume":"60","author":"Monici","year":"2003","unstructured":"Monici MC, Aguennouz M, Mazzeo A, Messina C, Vita G (2003) Activation of nuclear factor-kappaB in inflammatory myopathies and Duchenne muscular dystrophy. Neurology 60:993\u2013997","journal-title":"Neurology"},{"key":"1043_CR26","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.2337\/diabetes.49.9.1561","volume":"49","author":"Quehenberger","year":"2000","unstructured":"Quehenberger P, Bierhaus A, Fasching P, Muellner C, Klevesath M, Hong M, Stier G, Sattler M, Schleicher E, Speiser W, Nawroth PP (2000) Endothelin 1 transcription is controlled by nuclear factor-kappaB in AGE-stimulated cultured endothelial cells. Diabetes 49:1561\u20131570","journal-title":"Diabetes"},{"key":"1043_CR27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1172\/JCI119180","volume":"99","author":"Schleicher","year":"1997","unstructured":"Schleicher ED, Wagner E, Nerlich AG (1997) Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest 99:457\u2013468","journal-title":"J Clin Invest"},{"key":"1043_CR28","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1172\/JCI118175","volume":"96","author":"Schmidt","year":"1995","unstructured":"Schmidt AM, Hori O, Chen JX, Li JF, Crandall J, Zhang J, Cao R, Yan SD, Brett J, Stern D (1995) Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. J Clin Invest 96:1395\u20131403","journal-title":"J Clin Invest"},{"key":"1043_CR29","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1172\/JCI200114002","volume":"108","author":"Schmidt","year":"2001","unstructured":"Schmidt AM, Yan SD, Yan SF, Stern DM (2001) The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 108:949\u2013955","journal-title":"J Clin Invest"},{"key":"1043_CR30","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1128\/MCB.23.14.4870-4881.2003","volume":"23","author":"Sorci","year":"2003","unstructured":"Sorci G, Riuzzi F, Agneletti AL, Marchetti C, Donato R (2003) S100B inhibits myogenic differentiation and myotube formation in a RAGE-independent manner. Mol Cell Biol 23:4870\u20134881","journal-title":"Mol Cell Biol"},{"key":"1043_CR31","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/jcp.10462","volume":"199","author":"Sorci","year":"2004","unstructured":"Sorci G, Riuzzi F, Agneletti AL, Marchetti C, Donato R (2004) S100B causes apoptosis in a myoblast cell line in a RAGE-independent manner. J Cell Physiol 199:274\u2013283","journal-title":"J Cell Physiol"},{"key":"1043_CR32","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1128\/MCB.24.11.4880-4894.2004","volume":"24","author":"Sorci","year":"2004","unstructured":"Sorci G, Riuzzi F, Arcuri C, Giambanco I, Donato R (2004) Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding. Mol Cell Biol 24:4880\u20134894","journal-title":"Mol Cell Biol"},{"key":"1043_CR33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/jemt.1174","volume":"55","author":"Stangel","year":"2001","unstructured":"Stangel M, Mix E, Zettl UK, Gold R (2001) Oxides and apoptosis in inflammatory myopathies. Microsc Res Tech 55:249\u2013258","journal-title":"Microsc Res Tech"},{"key":"1043_CR34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","volume":"107","author":"Tak","year":"2001","unstructured":"Tak PP, Firestein GS (2001) NF-kappaB: a key role in inflammatory diseases. J Clin Invest 107:7\u201311","journal-title":"J Clin Invest"},{"key":"1043_CR35","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/00005072-199603000-00009","volume":"55","author":"Tews","year":"1996","unstructured":"Tews DS, Goebel HH (1996) Cytokine expression profile in idiopathic inflammatory myopathies. J Neuropathol Exp Neurol 55:342\u2013347","journal-title":"J Neuropathol Exp Neurol"},{"key":"1043_CR36","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/clin.1998.4527","volume":"87","author":"Tews","year":"1998","unstructured":"Tews DS, Goebel HH (1998) Cell death and oxidative damage in inflammatory myopathies. Clin Immunol Immunopathol 87:240\u2013247","journal-title":"Clin Immunol Immunopathol"},{"key":"1043_CR37","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/gut.45.5.693","volume":"45","author":"Thiele","year":"1999","unstructured":"Thiele K, Bierhaus A, Autschbach F, Hofmann M, Stremmel W, Thiele H, Ziegler R, Nawroth PP (1999) Cell specific effects of glucocorticoid treatment on the NF-kappaBp65\/IkappaBalpha system in patients with Crohn\u2019s disease. Gut 45:693\u2013704","journal-title":"Gut"},{"key":"1043_CR38","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1093\/brain\/119.5.1471","volume":"119","author":"Van der Kooi","year":"1996","unstructured":"Van der Kooi AJ, Barth PG, Busch HF, Haan R de, Ginjaar HB, Essen AJ van, Hooff LJ van, Howeler CJ, Jennekens FG, Jongen P et al. (1996) The clinical spectrum of limb girdle muscular dystrophy. A survey in The Netherlands. Brain 119:1471\u20131480","journal-title":"Brain"},{"key":"1043_CR39","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/(SICI)1097-4598(199805)21:5<584::AID-MUS4>3.0.CO;2-4","volume":"21","author":"Van der Kooi","year":"1998","unstructured":"Van der Kooi AJ, Ginjaar HB, Busch HF, Wokke JH, Barth PG, Visser M de (1998) Limb girdle muscular dystrophy: a pathological and immunohistochemical reevaluation. Muscle Nerve 21:584\u2013590","journal-title":"Muscle Nerve"},{"key":"1043_CR40","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1172\/JCI118397","volume":"97","author":"Wautier","year":"1996","unstructured":"Wautier JL, Zoukourian C, Chappey O, Wautier MP, Guillausseau PJ, Cao R, Hori O, Stern D, Schmidt AM (1996) Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats. J Clin Invest 97:238\u2013243","journal-title":"J Clin Invest"},{"key":"1043_CR41","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0925-4439(00)00041-7","volume":"1502","author":"Yan","year":"2000","unstructured":"Yan SD, Roher A, Chaney M, Zlokovic B, Schmidt AM, Stern D (2000) Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide. Biochim Biophys Acta 1502:145\u2013157","journal-title":"Biochim Biophys Acta"},{"key":"1043_CR42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nm831","volume":"9","author":"Yan","year":"2003","unstructured":"Yan SS, Wu ZY, Zhang HP, Furtado G, Chen X, Yan SF, Schmidt AM, Brown C, Stern A, LaFaille J et al. (2003) Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system. Nat Med 9:287\u2013293","journal-title":"Nat Med"},{"key":"1043_CR43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0304-3940(98)00657-0","volume":"254","author":"Yang","year":"1998","unstructured":"Yang CC, Askanas V, Engel WK, Alvarez RB (1998) Immunolocalization of transcription factor NF-kappaB in inclusion-body myositis muscle and at normal human neuromuscular junctions. Neurosci Lett 254:77\u201380","journal-title":"Neurosci Lett"},{"key":"1043_CR44","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.2337\/diabetes.50.6.1495","volume":"50","author":"Yeh","year":"2001","unstructured":"Yeh CH, Sturgis L, Haidacher J, Zhang XN, Sherwood SJ, Bjercke RJ, Juhasz O, Crow MT, Tilton RG, Denner L (2001) Requirement for p38 and p44\/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretion. Diabetes 50:1495\u20131504","journal-title":"Diabetes"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-005-1043-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-005-1043-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-005-1043-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T17:23:02Z","timestamp":1559064182000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-005-1043-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,29]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["1043"],"URL":"https:\/\/doi.org\/10.1007\/s00401-005-1043-3","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,29]]}}}