{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:57:01Z","timestamp":1789736221543,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2006,3,23]],"date-time":"2006-03-23T00:00:00Z","timestamp":1143072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1007\/s00401-006-0054-z","type":"journal-article","created":{"date-parts":[[2006,3,22]],"date-time":"2006-03-22T12:09:21Z","timestamp":1143029361000},"page":"430-435","source":"Crossref","is-referenced-by-count":31,"title":["Differential deposition of amyloid \u03b2 peptides in cerebral amyloid angiopathy associated with Alzheimer\u2019s disease and vascular dementia"],"prefix":"10.1007","volume":"111","author":[{"given":"Mattias","family":"Haglund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Kalaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet Y.","family":"Slade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Englund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,3,23]]},"reference":[{"key":"54_CR1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00005072-199804000-00008","volume":"57","author":"NC Alonzo","year":"1998","unstructured":"Alonzo NC, Hyman BT, Rebeck GW, Greenberg SM (1998) Progression of cerebral amyloid angiopathy: accumulation of amyloid-beta40 in affected vessels. J Neuropathol Exp Neurol 57:353\u2013359","journal-title":"J Neuropathol Exp Neurol"},{"key":"54_CR2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00401-005-1074-9","volume":"110","author":"J Attems","year":"2005","unstructured":"Attems J (2005) Sporadic cerebral amyloid angiopathy: pathology, clinical implications, and possible pathomechanisms. Acta Neuropathol 110:345\u2013359","journal-title":"Acta Neuropathol"},{"key":"54_CR3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00401-004-0822-6","volume":"107","author":"J Attems","year":"2004","unstructured":"Attems J, Lintner F, Jellinger KA (2004) Amyloid beta peptide 1\u201342 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology. Acta Neuropathol 107:283\u2013291","journal-title":"Acta Neuropathol"},{"key":"54_CR4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239\u2013259","journal-title":"Acta Neuropathol"},{"key":"54_CR5","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1365-2559.1981.tb01818.x","volume":"5","author":"A Brun","year":"1981","unstructured":"Brun A, Englund E (1981) Regional pattern of degeneration in Alzheimer\u2019s disease: neuronal loss and histopathological grading. Histopathology 5:549\u2013564","journal-title":"Histopathology"},{"key":"54_CR6","first-page":"3","volume-title":"Alzheimer\u2019s disease\u2014advances in clinical and basic research","author":"A Brun","year":"1993","unstructured":"Brun A, Gustafson L (1993) The longitudinal dementia study: a 25-year perspective on neuropathology, differential diagnosis and treatment. In: Corain B, Iqbal K, Nicolini M, Winblad B, Wisniewski H, Zatta P (eds) Alzheimer\u2019s disease\u2014advances in clinical and basic research. Wiley, New York, pp 3\u201318"},{"key":"54_CR7","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/jnen\/59.9.768","volume":"59","author":"D Cadavid","year":"2000","unstructured":"Cadavid D, Mena H, Koeller K, Frommelt RA (2000) Cerebral beta amyloid angiopathy is a risk factor for cerebral ischemic infarction. A case control study in human brain biopsies. J Neuropathol Exp Neurol 59:768\u2013773","journal-title":"J Neuropathol Exp Neurol"},{"key":"54_CR8","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/1097-4547(20000615)60:6<804::AID-JNR13>3.0.CO;2-1","volume":"60","author":"PB Eisenhauer","year":"2000","unstructured":"Eisenhauer PB, Johnson RJ, Wells JM, Davies TA, Fine RE (2000) Toxicity of various amyloid beta peptide species in cultured human blood\u2013brain barrier endothelial cells: increased toxicity of Dutch-type mutant. J Neurosci Res 60:804\u2013810","journal-title":"J Neurosci Res"},{"key":"54_CR9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jns.2004.09.004","volume":"226","author":"MS Fernando","year":"2004","unstructured":"Fernando MS, Ince PG (2004) MRC Cognitive Function and Ageing Neuropathology Study Group. Vascular pathologies and cognition in a population-based cohort of elderly people. J Neurol Sci 226:13\u201317","journal-title":"J Neurol Sci"},{"key":"54_CR10","doi-asserted-by":"crossref","first-page":"7013","DOI":"10.1074\/jbc.270.13.7013","volume":"270","author":"SA Gravina","year":"1995","unstructured":"Gravina SA, Ho L, Eckman CB, Long KE, Otvos L Jr, Younkin LH, Suzuki N, Younkin SG (1995) Amyloid beta protein (A beta) in Alzheimer\u2019s disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). J Biol Chem 270:7013\u20137016","journal-title":"J Biol Chem"},{"key":"54_CR11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/ana.410180110","volume":"18","author":"F Gray","year":"1985","unstructured":"Gray F, Dubas F, Roullet E, Escourolle R (1985) Leukoencephalopathy in diffuse hemorrhagic cerebral amyloid angiopathy. Ann Neurol 18:54\u201359","journal-title":"Ann Neurol"},{"key":"54_CR12","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1161\/01.STR.0000143224.36527.44","volume":"35","author":"SM Greenberg","year":"2004","unstructured":"Greenberg SM, Gurol ME, Rosand J, Smith EE (2004) Amyloid angiopathy-related vascular cognitive impairment. Stroke 35:2616\u20132619","journal-title":"Stroke"},{"key":"54_CR13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000063606","volume":"14","author":"M Haglund","year":"2002","unstructured":"Haglund M, Englund E (2002) Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy\u2014a histopathological assessment. Dement Geriatr Cogn Disord 14:161\u2013166","journal-title":"Dement Geriatr Cogn Disord"},{"key":"54_CR14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000079192","volume":"18","author":"M Haglund","year":"2004","unstructured":"Haglund M, Sjobeck M, Englund E (2004) Severe cerebral amyloid angiopathy characterizes an underestimated variant of vascular dementia. Dement Geriatr Cogn Disord 18:132\u2013137","journal-title":"Dement Geriatr Cogn Disord"},{"key":"54_CR15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0896-6273(94)90458-8","volume":"13","author":"T Iwatsubo","year":"1994","unstructured":"Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y (1994) Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 13:45\u201353","journal-title":"Neuron"},{"key":"54_CR16","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1021\/bi00069a001","volume":"32","author":"JT Jarrett","year":"1993","unstructured":"Jarrett JT, Berger EP, Lansbury PT (1993) The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer\u2019s disease. Biochemistry 32:4693\u20134697","journal-title":"Biochemistry"},{"key":"54_CR17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00316150","volume":"214","author":"K Jellinger","year":"1977","unstructured":"Jellinger K (1977) Cerebrovascular amyloidosis with cerebral hemorrhage. J Neurol 214:195\u2013206","journal-title":"J Neurol"},{"key":"54_CR18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jns.2004.09.019","volume":"226","author":"RN Kalaria","year":"2004","unstructured":"Kalaria RN, Kenny RA, Ballard CG, Perry R, Ince P, Polvikoski T (2004) Towards defining the neuropathological substrates of vascular dementia. J Neurol Sci 226:75\u201380","journal-title":"J Neurol Sci"},{"key":"54_CR19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2174\/1568013033483267","volume":"4","author":"RN Kalaria","year":"2003","unstructured":"Kalaria RN, Thomas A, Oakley A, Ince P, Tamaoka A, Mori H, Kenny RA, Ballard C (2003) Cerebrovascular amyloidosis and dementia. Curr Med Chem Immun Endoc Metab Agents 4:317\u2013327","journal-title":"Curr Med Chem Immun Endoc Metab Agents"},{"key":"54_CR20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0006-8993(93)90021-E","volume":"623","author":"M Kawai","year":"1993","unstructured":"Kawai M, Kalaria RN, Cras P, Siedlak SL, Velasco ME, Shelton ER, Chan HW, Greenberg BD, Perry G (1993) Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease. Brain Res 623:142\u2013146","journal-title":"Brain Res"},{"key":"54_CR21","doi-asserted-by":"crossref","first-page":"17082","DOI":"10.1016\/S0021-9258(18)41896-0","volume":"267","author":"H Mori","year":"1992","unstructured":"Mori H, Takio K, Ogawara M, Selkoe DJ (1992) Mass spectrometry of purified amyloid beta protein in Alzheimer\u2019s disease. J Biol Chem 267:17082\u201317086","journal-title":"J Biol Chem"},{"key":"54_CR22","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.neurobiolaging.2004.02.003","volume":"25","author":"JA Nicoll","year":"2004","unstructured":"Nicoll JA, Yamada M, Frackowiak J, Mazur-Kolecka B, Weller RO (2004) Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer\u2019s disease. Pro-CAA position statement. Neurobiol Aging 25:589\u2013597","journal-title":"Neurobiol Aging"},{"key":"54_CR23","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1001\/archneur.1995.00540310076019","volume":"52","author":"JM Olichney","year":"1995","unstructured":"Olichney JM, Hansen LA, Hofstetter R, Grundman R, Katzman R, Thal LJ (1995) Cerebral infarction in Alzheimer\u2019s disease is associated with severe amyloid angiopathy and hypertension. Arch Neurol 52:702\u2013708","journal-title":"Arch Neurol"},{"key":"54_CR24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.brainresrev.2003.08.001","volume":"43","author":"AA Rensink","year":"2003","unstructured":"Rensink AA, de Waal RM, Kremer B, Verbeek MM (2003) Pathogenesis of cerebral amyloid angiopathy. Brain Res Brain Res Rev 43:207\u2013223","journal-title":"Brain Res Brain Res Rev"},{"key":"54_CR25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1750-3639.2002.tb00449.x","volume":"12","author":"T Revesz","year":"2002","unstructured":"Revesz T, Holton JL, Lashley T, Plant G, Rostagno A, Ghiso J, Frangione B (2002) Sporadic and familial cerebral amyloid angiopathies. Brain Pathol 12:343\u2013357","journal-title":"Brain Pathol"},{"key":"54_CR26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3233\/JAD-2003-5403","volume":"5","author":"JA Rhodin","year":"2003","unstructured":"Rhodin JA, Thomas TN, Clark L, Garces A, Bryant M (2003) In vivo cerebrovascular actions of amyloid beta-peptides and the protective effect of conjugated estrogens. J Alzheimers Dis 5:275\u2013286","journal-title":"J Alzheimers Dis"},{"key":"54_CR27","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1016\/S0021-9258(18)53661-9","volume":"268","author":"AE Roher","year":"1993","unstructured":"Roher AE, Lowenson JD, Clarke S, Wolkow C, Wang R, Cotter RJ, Reardon IM, Zurcher-Neely HA, Heinrikson RL, Ball MJ, Greenberg B (1993) Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer\u2019s disease. J Biol Chem 268:3072\u20133083","journal-title":"J Biol Chem"},{"key":"54_CR28","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1023\/B:NERE.0000023612.66691.e6","volume":"29","author":"M Sadowski","year":"2004","unstructured":"Sadowski M, Pankiewicz J, Scholtzova H, Li YS, Quartermain D, Duff K, Wisniewski T (2004) Links between the pathology of Alzheimer\u2019s disease and vascular dementia. Neurochem Res 29:1257\u20131266","journal-title":"Neurochem Res"},{"key":"54_CR29","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/380168a0","volume":"380","author":"T Thomas","year":"1996","unstructured":"Thomas T, Thomas G, McLendon C, Sutton T, Mullan M (1996) Beta-amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380:168\u2013171","journal-title":"Nature"},{"key":"54_CR30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000082349","volume":"19","author":"A Thomas","year":"2005","unstructured":"Thomas A, Ballard C, Kenny RA, O\u2019Brien J, Oakley A, Kalaria R (2005) Correlation of entorhinal amyloid with memory in Alzheimer\u2019s and vascular but not lewy body dementia. Dement Geriatr Cogn Disord 19:57\u201360","journal-title":"Dement Geriatr Cogn Disord"},{"key":"54_CR31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neulet.2003.08.048","volume":"352","author":"J Tian","year":"2003","unstructured":"Tian J, Shi J, Bailey K, Mann DM (2003) Negative association between amyloid plaques and cerebral amyloid angiopathy in Alzheimer\u2019s disease. Neurosci Lett 352:137\u2013140","journal-title":"Neurosci Lett"},{"key":"54_CR32","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1046\/j.1471-4159.1997.68031135.x","volume":"68","author":"MM Verbeek","year":"1997","unstructured":"Verbeek MM, de Waal RM, Schipper JJ, Van Nostrand WE (1997) Rapid degeneration of cultured human brain pericytes by amyloid beta protein. J Neurochem 68:1135\u20131141","journal-title":"J Neurochem"},{"key":"54_CR33","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0002-9440(10)65616-7","volume":"153","author":"RO Weller","year":"1998","unstructured":"Weller RO, Massey A, Newman TA, Hutchings M, Kuo YM, Roher AE (1998) Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer\u2019s disease. Am J Pathol 153:725\u2013733","journal-title":"Am J Pathol"},{"key":"54_CR34","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1749-6632.2002.tb04812.x","volume":"977","author":"RO Weller","year":"2002","unstructured":"Weller RO, Yow HY, Preston SD, Mazanti I, Nicoll JA (2002) Cerebrovascular disease is a major factor in the failure of elimination of A beta from the aging human brain: implications for therapy of Alzheimer\u2019s disease. Ann N Y Acad Sci 977:162\u2013168","journal-title":"Ann N Y Acad Sci"},{"key":"54_CR35","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s004010050935","volume":"96","author":"WW Zhang","year":"1998","unstructured":"Zhang WW, Lempessi H, Olsson Y (1998) Amyloid angiopathy of the human brain: immunohistochemical studies using markers for components of extracellular matrix, smooth muscle actin and endothelial cells. Acta Neuropathol 96:558\u2013563","journal-title":"Acta Neuropathol"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-006-0054-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-006-0054-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-006-0054-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T03:26:43Z","timestamp":1627183603000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-006-0054-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,23]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["54"],"URL":"https:\/\/doi.org\/10.1007\/s00401-006-0054-z","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,23]]}}}