{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:10:34Z","timestamp":1762917034370},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,10,12]],"date-time":"2006-10-12T00:00:00Z","timestamp":1160611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1007\/s00401-006-0144-y","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T12:01:16Z","timestamp":1160568076000},"page":"1-12","source":"Crossref","is-referenced-by-count":72,"title":["Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience"],"prefix":"10.1007","volume":"113","author":[{"given":"Panteleimon","family":"Giannakopoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enik\u00f6","family":"K\u00f6vari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"von Gunten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouk","family":"Imhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Bouras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick R.","family":"Hof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,10,12]]},"reference":[{"key":"144_CR1","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1212\/WNL.42.9.1681","volume":"42","author":"PV Arriagada","year":"1992","unstructured":"Arriagada PV, Marzloff K, Hyman BT (1992) Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer\u2019s disease. Neurology 42:1681\u20131688","journal-title":"Neurology"},{"key":"144_CR2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF00692056","volume":"37","author":"MJ Ball","year":"1977","unstructured":"Ball MJ (1977) Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta Neuropathol (Berl) 37:111\u2013118","journal-title":"Acta Neuropathol (Berl)"},{"key":"144_CR3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF02189115","volume":"246","author":"C Bancher","year":"1996","unstructured":"Bancher C, Jellinger K, Lassmann H, Fischer P, Leblhuber F (1996) Correlations between mental state and quantitative neuropathology in the Vienna Longitudinal Study on Dementia. Eur Arch Psychiatry Clin Neurosci 246:137\u2013146","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"144_CR4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00687751","volume":"78","author":"M Barcikowska","year":"1989","unstructured":"Barcikowska M, Wisniewski HM, Bancher C, Grundke-Iqbal I (1989) About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation. Acta Neuropathol (Berl) 78:225\u2013231","journal-title":"Acta Neuropathol (Berl)"},{"key":"144_CR5","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1212\/01.wnl.0000219668.47116.e6","volume":"66","author":"DA Bennett","year":"2006","unstructured":"Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS (2006) Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology 66:1837\u20131844","journal-title":"Neurology"},{"key":"144_CR6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/archneur.55.3.326","volume":"55","author":"L Berg","year":"1998","unstructured":"Berg L, McKeel DW Jr, Miller JP, Storandt M, Rubin EH, Morris JC, Baty J, Coats M, Norton J, Goate AM, Price JL, Gearing M, Mirra SS, Saunders AM (1998) Clinicopathologic studies in cognitively healthy aging and Alzheimer\u2019s disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch Neurol 55:326\u2013335","journal-title":"Arch Neurol"},{"key":"144_CR7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/archneur.1995.00540250089017","volume":"52","author":"LM Bierer","year":"1995","unstructured":"Bierer LM, Hof PR, Purohit KP, Carlin L, Schmeidler J, Davis KL, Perl DP (1995) Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer\u2019s disease. Arch Neurol 52:81\u201388","journal-title":"Arch Neurol"},{"key":"144_CR8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/cercor\/4.2.138","volume":"4","author":"C Bouras","year":"1994","unstructured":"Bouras C, Hof PR, Giannakopoulos P, Michel JP, Morrison JH (1994) Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital. Cereb Cortex 4:138\u2013150","journal-title":"Cereb Cortex"},{"key":"144_CR9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0304-3940(93)90305-5","volume":"153","author":"C Bouras","year":"1993","unstructured":"Bouras C, Hof PR, Morrison JH (1993) Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathologic changes. Neurosci Lett 153:131\u2013135","journal-title":"Neurosci Lett"},{"key":"144_CR10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/01.jnen.0000203077.53080.2c","volume":"65","author":"C Bouras","year":"2006","unstructured":"Bouras C, K\u00f6vari E, Herrmann FR, Rivara CB, Bailey TL, von Gunten A, Hof PR, Giannakopoulos P (2006) Stereologic analysis of microvascular morphology in the elderly: Alzheimer disease pathology and cognitive status. J Neuropathol Exp Neurol 65:235\u2013244","journal-title":"J Neuropathol Exp Neurol"},{"key":"144_CR11","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s00401-006-0127-z","volume":"112","author":"H Braak","year":"2006","unstructured":"Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol (Berl) 112:388\u2013403","journal-title":"Acta Neuropathol (Berl)"},{"key":"144_CR12","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1016\/S0197-4580(97)00062-6","volume":"18","author":"H Braak","year":"1997","unstructured":"Braak H, Braak E (1997) Diagnostic criteria for neuropathologic assessment of Alzheimer\u2019s disease. Neurobiol Aging 18:S85\u2013S88","journal-title":"Neurobiol Aging"},{"key":"144_CR13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82:239\u2013259","journal-title":"Acta Neuropathol (Berl)"},{"key":"144_CR14","doi-asserted-by":"crossref","unstructured":"Braak H, Braak E (1997) Staging of Alzheimer-related cortical destruction. Int Psychogeriatr 9(Suppl 1):257\u2013261 (discussion 269\u2013272)","DOI":"10.1017\/S1041610297004973"},{"key":"144_CR15","doi-asserted-by":"crossref","unstructured":"Braak H, Braak E (1995) Staging of Alzheimer\u2019s disease-related neurofibrillary changes. Neurobiol Aging 16:271\u2013278 (discussion 278\u2013284)","DOI":"10.1016\/0197-4580(95)00021-6"},{"key":"144_CR16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1159\/000116984","volume":"33","author":"H Braak","year":"1993","unstructured":"Braak H, Braak E, Bohl J (1993) Staging of Alzheimer-related cortical destruction. Eur Neurol 33:403\u2013408","journal-title":"Eur Neurol"},{"key":"144_CR17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0022-510X(93)90263-X","volume":"120","author":"L Bracco","year":"1993","unstructured":"Bracco L, Campani D, Baratti E, Lippi A, Inzitari D, Pracucci G, Amaducci L (1993) Relation between MRI features and dementia in cerebrovascular disease patients with leukoaraiosis: a longitudinal study. J Neurol Sci 120:131\u2013136","journal-title":"J Neurol Sci"},{"key":"144_CR18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1159\/000088562","volume":"20","author":"L Bracco","year":"2005","unstructured":"Bracco L, Piccini C, Moretti M, Mascalchi M, Sforza A, Nacmias B, Cellini E, Bagnoli S, Sorbi S (2005) Alzheimer\u2019s disease: role of size and location of white matter changes in determining cognitive deficits. Dement Geriatr Cogn Disord 20:358\u2013366","journal-title":"Dement Geriatr Cogn Disord"},{"key":"144_CR19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0306-4522(02)00056-8","volume":"112","author":"T Bussi\u00e8re","year":"2002","unstructured":"Bussi\u00e8re T, Friend PD, Sadeghi N, Wicinski B, Lin GI, Bouras C, Giannakopoulos P, Robakis NK, Morrison JH, Perl DP, Hof PR (2002) Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer\u2019s disease. Neuroscience 112:75\u201391","journal-title":"Neuroscience"},{"key":"144_CR20","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/jnen\/61.5.384","volume":"61","author":"LM Callahan","year":"2002","unstructured":"Callahan LM, Vaules WA, Coleman PD (2002) Progressive reduction of synaptophysin message in single neurons in Alzheimer disease. J Neuropathol Exp Neurol 61:384\u2013395","journal-title":"J Neuropathol Exp Neurol"},{"key":"144_CR21","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1212\/WNL.38.11.1682","volume":"38","author":"H Crystal","year":"1988","unstructured":"Crystal H, Dickson D, Fuld P, Masur D, Scott R, Mehler M, Masdeu J, Kawas C, Aronson M, Wolfson L (1988) Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer\u2019s disease. Neurology 38:1682\u20131687","journal-title":"Neurology"},{"key":"144_CR22","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0197-4580(96)00170-4","volume":"17","author":"BJ Cummings","year":"1996","unstructured":"Cummings BJ, Pike CJ, Shankle R, Cotman CW (1996) Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer\u2019s disease. Neurobiol Aging 17:921\u2013933","journal-title":"Neurobiol Aging"},{"key":"144_CR23","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1001\/archneur.1993.00540080076020","volume":"50","author":"JL Cummings","year":"1993","unstructured":"Cummings JL (1993) Frontal-subcortical circuits and human behavior. Arch Neurol 50:873\u2013880","journal-title":"Arch Neurol"},{"key":"144_CR24","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/00005072-199904000-00008","volume":"58","author":"DG Davis","year":"1999","unstructured":"Davis DG, Schmitt FA, Wekstein DR, Markesbery WR (1999) Alzheimer neuropathologic alterations in aged cognitively normal subjects. J Neuropathol Exp Neurol 58:376\u2013388","journal-title":"J Neuropathol Exp Neurol"},{"key":"144_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-510X(90)90052-O","volume":"96","author":"T Ser Del","year":"1990","unstructured":"Del Ser T, Bermejo F, Portera A, Arredondo JM, Bouras C, Constantinidis J (1990) Vascular dementia. A clinicopathological study. J Neurol Sci 96:1\u201317","journal-title":"J Neurol Sci"},{"key":"144_CR26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jns.2004.08.016","volume":"231","author":"T Ser Del","year":"2005","unstructured":"Del Ser T, Hachinski V, Merskey H, Munoz DG (2005) Alzheimer\u2019s disease with and without cerebral infarcts. J Neurol Sci 231:3\u201311","journal-title":"J Neurol Sci"},{"key":"144_CR27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0197-4580(93)90096-T","volume":"14","author":"P Delaere","year":"1993","unstructured":"Delaere P, He Y, Fayet G, Duyckaerts C, Hauw JJ (1993) Beta A4 deposits are constant in the brain of the oldest old: an immunocytochemical study of 20 French centenarians. Neurobiol Aging 14:191\u2013194","journal-title":"Neurobiol Aging"},{"key":"144_CR28","first-page":"823","volume":"155","author":"C Derouesne","year":"1999","unstructured":"Derouesne C, Poirier J (1999) [Cerebral lacunae: still under debate]. Rev Neurol (Paris) 155:823\u2013831","journal-title":"Rev Neurol (Paris)"},{"key":"144_CR29","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1161\/01.STR.0000028235.91778.95","volume":"33","author":"DW Desmond","year":"2002","unstructured":"Desmond DW, Moroney JT, Sano M, Stern Y (2002) Incidence of dementia after ischemic stroke: results of a longitudinal study. Stroke 33:2254\u20132260","journal-title":"Stroke"},{"key":"144_CR30","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0197-4580(97)00065-1","volume":"18","author":"DW Dickson","year":"1997","unstructured":"Dickson DW (1997) Neuropathological diagnosis of Alzheimer\u2019s disease: a perspective from longitudinal clinicopathological studies. Neurobiol Aging 18:S21\u2013S26","journal-title":"Neurobiol Aging"},{"key":"144_CR31","doi-asserted-by":"crossref","unstructured":"Dickson DW, Crystal HA, Bevona C, Honer W, Vincent I, Davies P (1995) Correlations of synaptic and pathological markers with cognition of the elderly. Neurobiol Aging 16:285\u2013298 (discussion 298\u2013304)","DOI":"10.1016\/0197-4580(95)00013-5"},{"key":"144_CR32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0197-4580(92)90027-U","volume":"13","author":"DW Dickson","year":"1992","unstructured":"Dickson DW, Crystal HA, Mattiace LA, Masur DM, Blau AD, Davies P, Yen SH, Aronson MK (1992) Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging 13:179\u2013189","journal-title":"Neurobiol Aging"},{"key":"144_CR33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0197-4580(97)80306-5","volume":"18","author":"C Duyckaerts","year":"1997","unstructured":"Duyckaerts C, Bennecib M, Grignon Y, Uchihara T, He Y, Piette F, Hauw JJ (1997) Modeling the relation between neurofibrillary tangles and intellectual status. Neurobiol Aging 18:267\u2013273","journal-title":"Neurobiol Aging"},{"key":"144_CR34","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1136\/jnnp.51.8.1037","volume":"51","author":"T Erkinjuntti","year":"1988","unstructured":"Erkinjuntti T, Haltia M, Palo J, Sulkava R, Paetau A (1988) Accuracy of the clinical diagnosis of vascular dementia: a prospective clinical and post-mortem neuropathological study. J Neurol Neurosurg Psychiatry 51:1037\u20131044","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"144_CR35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1749-6632.2000.tb06373.x","volume":"903","author":"MM Esiri","year":"2000","unstructured":"Esiri MM (2000) Which vascular lesions are of importance in vascular dementia? Ann N Y Acad Sci 903:239\u2013243","journal-title":"Ann N Y Acad Sci"},{"key":"144_CR36","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(99)02355-7","volume":"354","author":"MM Esiri","year":"1999","unstructured":"Esiri MM, Nagy Z, Smith MZ, Barnetson L, Smith AD (1999) Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer\u2019s disease [letter]. Lancet 354:919\u2013920","journal-title":"Lancet"},{"key":"144_CR37","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/jnnp.63.6.749","volume":"63","author":"MM Esiri","year":"1997","unstructured":"Esiri MM, Wilcock GK, Morris JH (1997) Neuropathological assessment of the lesions of significance in vascular dementia. J Neurol Neurosurg Psychiatry 63:749\u2013753","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"144_CR38","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s00401-005-0007-y","volume":"111","author":"E Farkas","year":"2006","unstructured":"Farkas E, de Vos RA, Donka G, Jansen Steur EN, Mihaly A, Luiten PG (2006) Age-related microvascular degeneration in the human cerebral periventricular white matter. Acta Neuropathol (Berl) 111:150\u2013157","journal-title":"Acta Neuropathol (Berl)"},{"key":"144_CR39","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0301-0082(00)00068-X","volume":"64","author":"E Farkas","year":"2001","unstructured":"Farkas E, Luiten PG (2001) Cerebral microvascular pathology in aging and Alzheimer\u2019s disease. Prog Neurobiol 64:575\u2013611","journal-title":"Prog Neurobiol"},{"key":"144_CR40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jns.2004.09.004","volume":"226","author":"MS Fernando","year":"2004","unstructured":"Fernando MS, Ince PG (2004) Vascular pathologies and cognition in a population-based cohort of elderly people. J Neurol Sci 226:13\u201317","journal-title":"J Neurol Sci"},{"key":"144_CR41","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR (1975) \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189\u2013198","journal-title":"J Psychiatr Res"},{"key":"144_CR42","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0140-6736(00)02604-0","volume":"356","author":"E Garde","year":"2000","unstructured":"Garde E, Mortensen EL, Krabbe K, Rostrup E, Larsson HB (2000) Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study. Lancet 356:628\u2013634","journal-title":"Lancet"},{"key":"144_CR43","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","volume":"60","author":"P Giannakopoulos","year":"2003","unstructured":"Giannakopoulos P, Herrmann FR, Bussi\u00e8re T, Bouras C, K\u00f6vari E, Perl DP, Morrison JH, Gold G, Hof PR (2003) Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease. Neurology 60:1495\u20131500","journal-title":"Neurology"},{"key":"144_CR44","first-page":"348","volume":"5","author":"P Giannakopoulos","year":"1994","unstructured":"Giannakopoulos P, Hof PR, Giannakopoulos AS, Bu\u00e9e-Scherrer V, Surini M, Delacourte A, Bouras C (1994) Dementia in the oldest\u2013old: quantitative analysis of 12 cases from a psychiatric hospital. Dementia 5:348\u2013356","journal-title":"Dementia"},{"key":"144_CR45","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1001\/archneur.1995.00540360028012","volume":"52","author":"P Giannakopoulos","year":"1995","unstructured":"Giannakopoulos P, Hof PR, Giannakopoulos AS, Herrmann FR, Michel JP, Bouras C (1995) Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of very old patients. Arch Neurol 52:1150\u20131159","journal-title":"Arch Neurol"},{"key":"144_CR46","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/00005072-199612000-00004","volume":"55","author":"P Giannakopoulos","year":"1996","unstructured":"Giannakopoulos P, Hof PR, K\u00f6vari E, Vallet PG, Bouras C (1996) Distinct patterns of neuronal loss and Alzheimer\u2019s disease lesion distribution in elderly individuals older than 90\u00a0years. J Neuropathol Exp Neurol 55:1210\u20131220","journal-title":"J Neuropathol Exp Neurol"},{"key":"144_CR47","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/jnen\/60.10.946","volume":"60","author":"G Gold","year":"2001","unstructured":"Gold G, K\u00f6vari E, Corte G, Herrmann FR, Canuto A, Bussi\u00e8re T, Hof PR, Bouras C, Giannakopoulos P (2001) Clinical validity of a beta-protein deposition staging in brain aging and Alzheimer disease. J Neuropathol Exp Neurol 60:946\u2013952","journal-title":"J Neuropathol Exp Neurol"},{"key":"144_CR48","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/01.STR.0000166052.89772.b5","volume":"36","author":"G Gold","year":"2005","unstructured":"Gold G, K\u00f6vari E, Herrmann FR, Canuto A, Hof PR, Michel JP, Bouras C, Giannakopoulos P (2005) Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia. Stroke 36:1184\u20131188","journal-title":"Stroke"},{"key":"144_CR49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.410410106","volume":"41","author":"T G\u00f3mez-Isla","year":"1997","unstructured":"G\u00f3mez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT (1997) Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer\u2019s disease. Ann Neurol 41:17\u201324","journal-title":"Ann Neurol"},{"key":"144_CR50","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1523\/JNEUROSCI.16-14-04491.1996","volume":"16","author":"T G\u00f3mez-Isla","year":"1996","unstructured":"G\u00f3mez-Isla T, Price JL, McKeel Jr DW, Morris JC, Growdon JH, Hyman BT (1996) Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer\u2019s disease. J Neurosci 16:4491\u20134500","journal-title":"J Neurosci"},{"key":"144_CR51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1212\/WNL.54.1.105","volume":"54","author":"MS Green","year":"2000","unstructured":"Green MS, Kaye JA, Ball MJ (2000) The Oregon brain aging study: neuropathology accompanying healthy aging in the oldest old. Neurology 54:105\u2013113","journal-title":"Neurology"},{"key":"144_CR52","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0197-4580(99)00063-9","volume":"20","author":"E Grober","year":"1999","unstructured":"Grober E, Dickson D, Sliwinski MJ, Buschke H, Katz M, Crystal H, Lipton RB (1999) Memory and mental status correlates of modified Braak staging. Neurobiol Aging 20:573\u2013579","journal-title":"Neurobiol Aging"},{"key":"144_CR53","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/cercor\/8.8.710","volume":"8","author":"AJ Harding","year":"1998","unstructured":"Harding AJ, Halliday GM, Kril JJ (1998) Variation in hippocampal neuron number with age and brain volume. Cereb Cortex 8:710\u2013718","journal-title":"Cereb Cortex"},{"key":"144_CR54","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1001\/archneur.1992.00530330070019","volume":"49","author":"PR Hof","year":"1992","unstructured":"Hof PR, Bierer LM, Perl DP, Delacourte A, Bu\u00e9e L, Bouras C, Morrison JH (1992) Evidence for early vulnerability of the medial and inferior aspects of the temporal lobe in an 82 year old patient with preclinical signs of dementia: regional and laminar distribution of neurofibrillary tangles and senile plaques. Arch Neurol 49:946\u2013953","journal-title":"Arch Neurol"},{"key":"144_CR55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/jnen\/62.1.55","volume":"62","author":"PR Hof","year":"2003","unstructured":"Hof PR, Bussi\u00e8re T, Gold G, K\u00f6vari E, Giannakopoulos P, Bouras C, Perl DP, Morrison JH (2003) Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease. J Neuropathol Exp Neurol 62:55\u201367","journal-title":"J Neuropathol Exp Neurol"},{"key":"144_CR56","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2990.1990.tb00940.x","volume":"16","author":"BM Hubbard","year":"1990","unstructured":"Hubbard BM, Fenton GW, Anderson JM (1990) A quantitative histological study of early clinical and preclinical Alzheimer\u2019s disease. Neuropathol Appl Neurobiol 16:111\u2013121","journal-title":"Neuropathol Appl Neurobiol"},{"key":"144_CR57","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1192\/bjp.140.6.566","volume":"140","author":"CP Hughes","year":"1982","unstructured":"Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL (1982) A new clinical scale for the staging of dementia. Br J Psychiatry 140:566\u2013572","journal-title":"Br J Psychiatry"},{"key":"144_CR58","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1097\/00005072-199812000-00009","volume":"57","author":"CM Hulette","year":"1998","unstructured":"Hulette CM, Welsh-Bohmer KA, Murray MG, Saunders AM, Mash DC, McIntyre LM (1998) Neuropathological and neuropsychological changes in \u201cnormal\u201d aging: evidence for preclinical Alzheimer disease in cognitively normal individuals. J Neuropathol Exp Neurol 57:1168\u20131174","journal-title":"J Neuropathol Exp Neurol"},{"key":"144_CR59","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0022-510X(98)00050-1","volume":"157","author":"Y Itoh","year":"1998","unstructured":"Itoh Y, Yamada M, Suematsu N, Matsushita M, Otomo E (1998) An immunohistochemical study of centenarian brains: a comparison. J Neurol Sci 157:73\u201381","journal-title":"J Neurol Sci"},{"key":"144_CR60","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jns.2004.11.029","volume":"229\u2013230","author":"KA Jellinger","year":"2005","unstructured":"Jellinger KA (2005) Understanding the pathology of vascular cognitive impairment. J Neurol Sci 229\u2013230:57\u201363","journal-title":"J Neurol Sci"},{"key":"144_CR61","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00401-002-0634-5","volume":"105","author":"KA Jellinger","year":"2003","unstructured":"Jellinger KA, Attems J (2003) Incidence of cerebrovascular lesions in Alzheimer\u2019s disease: a postmortem study. Acta Neuropathol (Berl) 105:14\u201317","journal-title":"Acta Neuropathol (Berl)"},{"key":"144_CR62","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/ana.410230206","volume":"23","author":"R Katzman","year":"1988","unstructured":"Katzman R, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, Renbing X, Peck A (1988) Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 23:138\u2013144","journal-title":"Ann Neurol"},{"key":"144_CR63","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/jnen\/62.11.1087","volume":"62","author":"DS Knopman","year":"2003","unstructured":"Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, Smith GE, Dickson DW, Johnson KA, Petersen LE, McDonald WC, Braak H, Petersen RC (2003) Neuropathology of cognitively normal elderly. J Neuropathol Exp Neurol 62:1087\u20131095","journal-title":"J Neuropathol Exp Neurol"},{"key":"144_CR64","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/1531-8249(20010201)49:2<202::AID-ANA40>3.0.CO;2-3","volume":"49","author":"JH Kordower","year":"2001","unstructured":"Kordower JH, Chu Y, Stebbins GT, DeKosky ST, Cochran EJ, Bennett D, Mufson EJ (2001) Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Ann Neurol 49:202\u2013213","journal-title":"Ann Neurol"},{"key":"144_CR65","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/01.STR.0000110791.51378.4E","volume":"35","author":"E K\u00f6vari","year":"2004","unstructured":"K\u00f6vari E, Gold G, Herrmann FR, Canuto A, Hof PR, Michel JP, Bouras C, Giannakopoulos P (2004) Cortical microinfarcts and demyelination significantly affect cognition in brain aging. Stroke 35:410\u2013414","journal-title":"Stroke"},{"key":"144_CR66","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00401-001-0477-5","volume":"103","author":"JJ Kril","year":"2002","unstructured":"Kril JJ, Patel S, Harding AJ, Halliday GM (2002) Neuron loss from the hippocampus of Alzheimer\u2019s disease exceeds extracellular neurofibrillary tangle formation. Acta Neuropathol (Berl) 103:370\u2013376","journal-title":"Acta Neuropathol (Berl)"},{"key":"144_CR67","first-page":"1474","volume":"57","author":"JH Lee","year":"2000","unstructured":"Lee JH, Olichney JM, Hansen LA, Hofstetter CR, Thal LJ (2000) Small concomitant vascular lesions do not influence rates of cognitive decline in patients with alzheimer disease. Arch Neurol 57:1474\u20131479","journal-title":"Arch Neurol"},{"key":"144_CR68","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1523\/JNEUROSCI.07-06-01799.1987","volume":"7","author":"DA Lewis","year":"1987","unstructured":"Lewis DA, Campbell MJ, Terry RD, Morrison JH (1987) Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer\u2019s disease: a quantitative study of visual and auditory cortices. J Neurosci 7:1799\u20131808","journal-title":"J Neurosci"},{"key":"144_CR69","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0248-8663(96)80691-6","volume":"16","author":"D Leys","year":"1995","unstructured":"Leys D, Scheltens P, Vermersch P, Pruvo JP (1995) [Morphological imaging in the diagnosis of dementia. II. Vascular dementia]. Rev Med Interne 16:195\u2013200","journal-title":"Rev Med Interne"},{"key":"144_CR70","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.STR.27.8.1274","volume":"27","author":"WT Longstreth Jr","year":"1996","unstructured":"Longstreth WT Jr, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, Enright PL, O\u2019Leary D, Fried L (1996) Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke 27:1274\u20131282","journal-title":"Stroke"},{"key":"144_CR71","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2165\/00002512-200522060-00003","volume":"22","author":"MA Mackowiak-Cordoliani","year":"2005","unstructured":"Mackowiak-Cordoliani MA, Bombois S, Memin A, Henon H, Pasquier F (2005) Poststroke dementia in the elderly. Drugs Aging 22:483\u2013493","journal-title":"Drugs Aging"},{"key":"144_CR72","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1212\/WNL.43.1_Part_1.192","volume":"43","author":"E Masliah","year":"1993","unstructured":"Masliah E, Mallory M, Hansen L, DeTeresa R, Terry RD (1993) Quantitative synaptic alterations in the human neocortex during normal aging. Neurology 43:192\u2013197","journal-title":"Neurology"},{"key":"144_CR73","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1212\/WNL.46.3.707","volume":"46","author":"JC Morris","year":"1996","unstructured":"Morris JC, Storandt M, McKeel DW Jr, Rubin EH, Price JL, Grant EA, Berg L (1996) Cerebral amyloid deposition and diffuse plaques in \u201cnormal\u201d aging: evidence for presymptomatic and very mild Alzheimer\u2019s disease. Neurology 46:707\u2013719","journal-title":"Neurology"},{"key":"144_CR74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-4580(83)90048-9","volume":"4","author":"CQ Mountjoy","year":"1983","unstructured":"Mountjoy CQ, Roth M, Evans NJ, Evans HM (1983) Cortical neuronal counts in normal elderly controls and demented patients. Neurobiol Aging 4:1\u201311","journal-title":"Neurobiol Aging"},{"key":"144_CR75","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00005072-199702000-00007","volume":"56","author":"Z Nagy","year":"1997","unstructured":"Nagy Z, Esiri MM, Jobst KA, Morris JH, King EM, McDonald B, Joachim C, Litchfield S, Barnetson L, Smith AD (1997) The effects of additional pathology on the cognitive deficit in Alzheimer disease. J Neuropathol Exp Neurol 56:165\u2013170","journal-title":"J Neuropathol Exp Neurol"},{"key":"144_CR76","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jama.283.12.1571","volume":"283","author":"J Naslund","year":"2000","unstructured":"Naslund J, Haroutunian V, Mohs R, Davis KL, Davies P, Greengard P, Buxbaum JD (2000) Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 283:1571\u20131577","journal-title":"JAMA"},{"key":"144_CR77","doi-asserted-by":"crossref","unstructured":"Neuropathology Group of the Medical Research Council Cognitive Function, Ageing Study (MRC CFAS) (2001) Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 357:169\u2013175","DOI":"10.1016\/S0140-6736(00)03589-3"},{"key":"144_CR78","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1073\/pnas.82.13.4531","volume":"82","author":"RC Pearson","year":"1985","unstructured":"Pearson RC, Esiri MM, Hiorns RW, Wilcock GK, Powell TP (1985) Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease. Proc Natl Acad Sci USA 82:4531\u20134534","journal-title":"Proc Natl Acad Sci USA"},{"key":"144_CR79","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0197-4580(91)90006-6","volume":"12","author":"JL Price","year":"1991","unstructured":"Price JL, Davis PB, Morris JC, White DL (1991) The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer\u2019s disease. Neurobiol Aging 12:295\u2013312","journal-title":"Neurobiol Aging"},{"key":"144_CR80","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1001\/archneur.58.9.1395","volume":"58","author":"JL Price","year":"2001","unstructured":"Price JL, Ko AI, Wade MJ, Tsou SK, McKeel DW, Morris JC (2001) Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Arch Neurol 58:1395\u20131402","journal-title":"Arch Neurol"},{"key":"144_CR81","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","volume":"45","author":"JL Price","year":"1999","unstructured":"Price JL, Morris JC (1999) Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer\u2019s disease. Ann Neurol 45:358\u2013368","journal-title":"Ann Neurol"},{"key":"144_CR82","first-page":"493","volume":"58","author":"BR Reed","year":"2001","unstructured":"Reed BR, Eberling JL, Mungas D, Weiner M, Jagust WJ (2001) Frontal lobe hypometabolism predicts cognitive decline in patients with lacunar infarcts. Arch Neurol 58:493\u2013497","journal-title":"Arch Neurol"},{"key":"144_CR83","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neurobiolaging.2004.06.019","volume":"26","author":"KP Riley","year":"2005","unstructured":"Riley KP, Snowdon DA, Desrosiers MF, Markesbery WR (2005) Early life linguistic ability, late life cognitive function, and neuropathology: findings from the Nun Study. Neurobiol Aging 26:341\u2013347","journal-title":"Neurobiol Aging"},{"key":"144_CR84","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1474-4422(02)00190-4","volume":"1","author":"GC Roman","year":"2002","unstructured":"Roman GC, Erkinjuntti T, Wallin A, Pantoni L, Chui HC (2002) Subcortical ischaemic vascular dementia. Lancet Neurol 1:426\u2013436","journal-title":"Lancet Neurol"},{"key":"144_CR85","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1212\/WNL.44.11.2081","volume":"44","author":"W Samuel","year":"1994","unstructured":"Samuel W, Masliah E, Hill LR, Butters N, Terry R (1994) Hippocampal connectivity and Alzheimer\u2019s dementia: effects of synapse loss and tangle frequency in a two-component model. Neurology 44:2081\u20132088","journal-title":"Neurology"},{"key":"144_CR86","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000049145","volume":"13","author":"R Schmidt","year":"2002","unstructured":"Schmidt R, Schmidt H, Kapeller P, Lechner A, Fazekas F (2002) Evolution of white matter lesions. Cerebrovasc Dis 13:16\u201320","journal-title":"Cerebrovasc Dis"},{"key":"144_CR87","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1038\/sj.jcbfm.9600159","volume":"25","author":"ML Schroeter","year":"2005","unstructured":"Schroeter ML, Bucheler MM, Preul C, Scheid R, Schmiedel O, Guthke T, von Cramon DY (2005) Spontaneous slow hemodynamic oscillations are impaired in cerebral microangiopathy. J Cereb Blood Flow Metab 25:1675\u20131684","journal-title":"J Cereb Blood Flow Metab"},{"key":"144_CR88","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/(SICI)1096-9861(19970324)379:4<482::AID-CNE2>3.0.CO;2-Z","volume":"379","author":"G Simic","year":"1997","unstructured":"Simic G, Kostovic I, Winblad B, Bogdanovic N (1997) Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer\u2019s disease. J Comp Neurol 379:482\u2013494","journal-title":"J Comp Neurol"},{"key":"144_CR89","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.1997.03540340047031","volume":"277","author":"DA Snowdon","year":"1997","unstructured":"Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR (1997) Brain infarction and the clinical expression of Alzheimer disease. The nun study. JAMA 277:813\u2013817","journal-title":"JAMA"},{"key":"144_CR90","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1212\/WNL.44.10.1885","volume":"44","author":"TK Tatemichi","year":"1994","unstructured":"Tatemichi TK, Paik M, Bagiella E, Desmond DW, Stern Y, Sano M, Hauser WA, Mayeux R (1994) Risk of dementia after stroke in a hospitalized cohort: results of a longitudinal study. Neurology 44:1885\u20131891","journal-title":"Neurology"},{"key":"144_CR91","first-page":"179","volume-title":"Alzheimer\u2019s disease","author":"RD Terry","year":"1994","unstructured":"Terry RD, Masliah E, Hansen LA (1994) Structural basis of the cognitive alterations in Alzheimer\u2019s disease. In: Terry RD, Katzman R, Bick KL (eds) Alzheimer\u2019s disease. Raven Press, New York, pp 179\u2013196"},{"key":"144_CR92","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/jnen\/59.8.733","volume":"59","author":"DR Thal","year":"2000","unstructured":"Thal DR, R\u00fcb U, Schultz C, Sassin I, Ghebremedhin E, Del Tredici K, Braak E, Braak H (2000) Sequence of Abeta-protein deposition in the human medial temporal lobe. J Neuropathol Exp Neurol 59:733\u2013748","journal-title":"J Neuropathol Exp Neurol"},{"key":"144_CR93","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0022-510X(68)90154-8","volume":"7","author":"BE Tomlinson","year":"1968","unstructured":"Tomlinson BE, Blessed G, Roth M (1968) Observations on the brains of non-demented old people. J Neurol Sci 7:331\u2013356","journal-title":"J Neurol Sci"},{"key":"144_CR94","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1749-6632.2002.tb04845.x","volume":"977","author":"F Udaka","year":"2002","unstructured":"Udaka F, Sawada H, Kameyama M (2002) White matter lesions and dementia: MRI-pathological correlation. Ann N Y Acad Sci 977:411\u2013415","journal-title":"Ann N Y Acad Sci"},{"key":"144_CR95","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/ana.410170309","volume":"17","author":"J Ulrich","year":"1985","unstructured":"Ulrich J (1985) Alzheimer changes in nondemented patients younger than sixty-five: possible early stages of Alzheimer\u2019s disease and senile dementia of Alzheimer type. Ann Neurol 17:273\u2013277","journal-title":"Ann Neurol"},{"key":"144_CR96","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2202-5-37","volume":"5","author":"O Uspenskaia","year":"2004","unstructured":"Uspenskaia O, Liebetrau M, Herms J, Danek A, Hamann GF (2004) Aging is associated with increased collagen type IV accumulation in the basal lamina of human cerebral microvessels. BMC Neurosci 5:37","journal-title":"BMC Neurosci"},{"key":"144_CR97","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1161\/01.STR.0000179092.59909.42","volume":"36","author":"WM Flier van der","year":"2005","unstructured":"van der Flier WM, van Straaten EC, Barkhof F, Verdelho A, Madureira S, Pantoni L, Inzitari D, Erkinjuntti T, Crisby M, Waldemar G, Schmidt R, Fazekas F, Scheltens P (2005) Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study. Stroke 36:2116\u20132120","journal-title":"Stroke"},{"key":"144_CR98","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa022066","volume":"348","author":"SE Vermeer","year":"2003","unstructured":"Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM (2003) Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 348:1215\u20131222","journal-title":"N Engl J Med"},{"key":"144_CR99","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/jnen\/59.11.931","volume":"59","author":"HV Vinters","year":"2000","unstructured":"Vinters HV, Ellis WG, Zarow C, Zaias BW, Jagust WJ, Mack WJ, Chui HC (2000) Neuropathologic substrates of ischemic vascular dementia. J Neuropathol Exp Neurol 59:931\u2013945","journal-title":"J Neuropathol Exp Neurol"},{"key":"144_CR100","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neurobiolaging.2005.02.008","volume":"27","author":"A Gunten von","year":"2006","unstructured":"von Gunten A, K\u00f6vari E, Bussi\u00e8re T, Rivara CB, Gold G, Bouras C, Hof PR, Giannakopoulos P (2006) Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer\u2019s disease. Neurobiol Aging 27:270\u2013277","journal-title":"Neurobiol Aging"},{"key":"144_CR101","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.expneurol.2004.12.005","volume":"193","author":"A Gunten von","year":"2005","unstructured":"von Gunten A, K\u00f6vari E, Rivara CB, Bouras C, Hof PR, Giannakopoulos P (2005) Stereologic analysis of hippocampal Alzheimer\u2019s disease pathology in the oldest\u2013old: evidence for sparing of the entorhinal cortex and CA1 field. Exp Neurol 193:198\u2013206","journal-title":"Exp Neurol"},{"key":"144_CR102","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1161\/01.STR.0000133686.29320.58","volume":"35","author":"HM Wen","year":"2004","unstructured":"Wen HM, Mok VC, Fan YH, Lam WW, Tang WK, Wong A, Huang RX, Wong KS (2004) Effect of white matter changes on cognitive impairment in patients with lacunar infarcts. Stroke 35:1826\u20131830","journal-title":"Stroke"},{"key":"144_CR103","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0197-4580(93)90113-P","volume":"14","author":"MJ West","year":"1993","unstructured":"West MJ (1993) Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 14:287\u2013293","journal-title":"Neurobiol Aging"},{"key":"144_CR104","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0140-6736(94)92338-8","volume":"344","author":"MJ West","year":"1994","unstructured":"West MJ, Coleman PD, Flood DG, Troncoso JC (1994) Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer\u2019s disease. Lancet 344:769\u2013772","journal-title":"Lancet"},{"key":"144_CR105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.902960102","volume":"296","author":"MJ West","year":"1990","unstructured":"West MJ, Gundersen HJ (1990) Unbiased stereological estimation of the number of neurons in the human hippocampus. J Comp Neurol 296:1\u201322","journal-title":"J Comp Neurol"},{"key":"144_CR106","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0022-510X(82)90155-1","volume":"56","author":"GK Wilcock","year":"1982","unstructured":"Wilcock GK, Esiri MM (1982) Plaques, tangles and dementia. A quantitative study. J Neurol Sci 56:343\u2013356","journal-title":"J Neurol Sci"},{"key":"144_CR107","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/S0197-4580(97)00068-7","volume":"18","author":"HM Wisniewski","year":"1997","unstructured":"Wisniewski HM, Silverman W (1997) Diagnostic criteria for the neuropathological assessment of Alzheimer\u2019s disease: current status and major issues. Neurobiol Aging 18:S43\u2013S50","journal-title":"Neurobiol Aging"},{"key":"144_CR108","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/01.STR.26.7.1171","volume":"26","author":"A Ylikoski","year":"1995","unstructured":"Ylikoski A, Erkinjuntti T, Raininko R, Sarna S, Sulkava R, Tilvis R (1995) White matter hyperintensities on MRI in the neurologically nondiseased elderly. Analysis of cohorts of consecutive subjects aged 55 to 85 years living at home. Stroke 26:1171\u20131177","journal-title":"Stroke"},{"key":"144_CR109","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00401-001-0493-5","volume":"103","author":"D Zekry","year":"2002","unstructured":"Zekry D, Duyckaerts C, Moulias R, Belmin J, Geoffre C, Herrmann F, Hauw JJ (2002) Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly. Acta Neuropathol (Berl) 103:481\u2013487","journal-title":"Acta Neuropathol (Berl)"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-006-0144-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-006-0144-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-006-0144-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T14:33:46Z","timestamp":1587220426000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-006-0144-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,12]]},"references-count":109,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["144"],"URL":"https:\/\/doi.org\/10.1007\/s00401-006-0144-y","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,12]]}}}