{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:43:48Z","timestamp":1791056628880,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,12,2]],"date-time":"2006-12-02T00:00:00Z","timestamp":1165017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,12,2]],"date-time":"2006-12-02T00:00:00Z","timestamp":1165017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1007\/s00401-006-0169-2","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T12:27:44Z","timestamp":1164976064000},"page":"187-194","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Absence of aquaporin-4 expression in lesions of neuromyelitis optica but increased expression in multiple sclerosis lesions and normal-appearing white matter"],"prefix":"10.1007","volume":"113","author":[{"given":"Colin","family":"Sinclair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Herron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Una","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"McQuaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,12,2]]},"reference":[{"key":"169_CR1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/jnen\/62.1.25","volume":"62","author":"F Aboul-Enein","year":"2003","unstructured":"Aboul-Enein F, Rauschka H, Kornek B, Stadelmann C, Stefferl A, Bruck W, Lucchinetti C, Schmidbauer M, Jellinger K, Lassmann H (2003) Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases. J Neuropathol Exp Neurol 62:25\u201333","journal-title":"J Neuropathol Exp Neurol"},{"key":"169_CR2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/oxfordjournals.bmb.a071388","volume":"33","author":"CWM Adams","year":"1977","unstructured":"Adams CWM (1977) Pathology of multiple sclerosis: progression of the lesion. British Med Bull 33:15\u201320","journal-title":"British Med Bull"},{"key":"169_CR3","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00401-005-1052-2","volume":"110","author":"K Aoki-Yoshino","year":"2005","unstructured":"Aoki-Yoshino K, Uchihara T, Duyckaerts C, Nakamura A, Hauw JJ, Wakayama Y (2005) Enhanced expression of aquaporin 4 in human brain with inflammatory diseases. Acta Neuropathol (Berl) 110:281\u2013288","journal-title":"Acta Neuropathol (Berl)"},{"key":"169_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00401-003-0709-y","volume":"106","author":"K Aoki","year":"2003","unstructured":"Aoki K, Uchihara T, Tsuchiya K, Nakamura A, Ikeda K, Wakayama Y (2003) Enhanced expression of aquaporin 4 in human brain with infarction. Acta Neuropathol (Berl) 106:121\u2013124","journal-title":"Acta Neuropathol (Berl)"},{"key":"169_CR5","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1098\/rstb.1999.0511","volume":"354","author":"F Barkhof","year":"1999","unstructured":"Barkhof F, van Walderveen M (1999) Characterization of tissue damage in multiple sclerosis by nuclear magnetic resonance. Philos Trans R Soc Lond B Biol Sci. 354:1675\u20131686","journal-title":"Philos Trans R Soc Lond B Biol Sci."},{"key":"169_CR6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1600-0404.1993.tb04100.x","volume":"87","author":"P Christiansen","year":"1993","unstructured":"Christiansen P, Gideon P, Thomsen C, Stubgaard M, Henriksen O, Larsson HB (1993) Increased water self-diffusion in chronic plaques and in apparently normal white matter in patients with multiple sclerosis. Acta Neurol Scand 87:195\u2013199","journal-title":"Acta Neurol Scand"},{"key":"169_CR7","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1046\/j.1469-7580.2002.00065.x","volume":"200","author":"DC Davies","year":"2002","unstructured":"Davies DC (2002) Blood-brain barrier breakdown in septic encephalopathy and brain tumours. J Anat 200:639\u2013646","journal-title":"J Anat"},{"key":"169_CR8","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1111\/j.1750-3639.2003.tb00485.x","volume":"13","author":"U Graumann","year":"2003","unstructured":"Graumann U, Reynolds R, Steck AJ, Schaeren-Wiemers N (2003) Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult. Brain Pathol 13:554\u2013573","journal-title":"Brain Pathol"},{"key":"169_CR9","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1254\/jphs.FMJ04004X5","volume":"96","author":"H Kobayashi","year":"2004","unstructured":"Kobayashi H, Yanagita T, Yokoo H, Wada A (2004) Molecular mechanisms and drug development in aquaporin water channel disease: aquaporins in the brain. J Pharmacol Sci 96:264\u2013270","journal-title":"J Pharmacol Sci"},{"key":"169_CR10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0022-510X(02)00421-5","volume":"206","author":"H Lassmann","year":"2003","unstructured":"Lassmann H (2003) Hypoxia-like tissue injury as a component of multiple sclerosis lesions. J Neurol Sci 206:187\u2013191","journal-title":"J Neurol Sci"},{"key":"169_CR11","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1093\/brain\/awg127","volume":"126","author":"H Lassmann","year":"2003","unstructured":"Lassmann H, Reindl M, Rauschka H, Berger J, Aboul-Enein F, Berger T, Zurbriggen A, Lutterotti A, Bruck W, Weber JR, Ullrich R, Schmidbauer M, Jellinger K, Vandevelde M (2003) A new paraclinical CSF marker for hypoxia-like tissue damage in multiple sclerosis lesions. Brain 126:1347\u20131357","journal-title":"Brain"},{"key":"169_CR12","first-page":"284","volume":"251","author":"C Laule","year":"2004","unstructured":"Laule C, Vavasour IM, Moore GR, Oger J, Li DK, Paty DW, McKay AL (2004) Water content and myelin water fraction in multiple sclerosis. A T2 relaxation study. J Neurol 251:284\u2013293","journal-title":"A T2 relaxation study. J Neurol"},{"key":"169_CR13","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1084\/jem.20050304","volume":"202","author":"VA Lennon","year":"2005","unstructured":"Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR (2005) IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 202:473\u2013477","journal-title":"J Exp Med"},{"key":"169_CR14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/00019052-200106000-00002","volume":"14","author":"C Lucchinetti","year":"2001","unstructured":"Lucchinetti C, Bruck W, Noseworthy J (2001) Multiple sclerosis; recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment. Curr Opin Neurol 14:259\u2013269","journal-title":"Curr Opin Neurol"},{"key":"169_CR15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11910-001-0028-4","volume":"1","author":"S Markovic-Plese","year":"2001","unstructured":"Markovic-Plese S, McFarland HF (2001) Immunopathogenesis of the multiple sclerosis lesion. Curr Neurol Neurosci Rep 1:257\u2013262","journal-title":"Curr Neurol Neurosci Rep"},{"key":"169_CR16","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1620\/tjem.209.269","volume":"209","author":"T Misu","year":"2006","unstructured":"Misu T, Fujihara K, Nakamura M, Murakami K, Endo M, Konno H, Itoyama Y (2006) Loss of aquaporin-4 in active perivascular lesions in neuromyelitis optica: a case report. Tohoku J Exp Med 209:269\u2013275","journal-title":"Tohoku J Exp Med"},{"key":"169_CR17","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.neuroscience.2004.07.055","volume":"129","author":"GP Nicchia","year":"2004","unstructured":"Nicchia GP, Nico B, Camassa LMA, Mola MG, Loh N, Dermietzel R, Spray DC, Svelto M, Frigeri A (2004) The role of aquaporin-4 in blood-brain barrier development and integrity: studies in animal and cell culture models. Neuroscience 129:935\u2013945","journal-title":"Neuroscience"},{"key":"169_CR18","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/glia.10216","volume":"42","author":"B Nico","year":"2003","unstructured":"Nico B, Frigeri A, Nicchia GP, Corsi P, Ribatti D, Quondamatteo F, Herken R, Girolamo F, Marzullo A, Svelto M, Roncali L (2003) Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice. Glia 42:235\u2013251","journal-title":"Glia"},{"key":"169_CR19","first-page":"242","volume":"69","author":"M Papadopoulos","year":"2002","unstructured":"Papadopoulos M (2002) Aquaporin water channels and brain edema. Mount Sinai J Med 69:242\u2013248","journal-title":"Mount Sinai J Med"},{"key":"169_CR20","first-page":"258","volume":"2","author":"CM Poser","year":"1994","unstructured":"Poser CM (1994) Notes on the pathogenesis of multiple sclerosis. Clin Neurosci 2:258\u2013265","journal-title":"Clin Neurosci"},{"key":"169_CR21","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1002\/jnr.20819","volume":"83","author":"MC Ribeiro","year":"2006","unstructured":"Ribeiro MC, Hirt L, Bogousslavsky J, Regli L, Badaut J (2006) Time course of aquaporin expression after transient focal cerebral ischemia in mice. J Neurosci Res 83:1231\u20131240","journal-title":"J Neurosci Res"},{"key":"169_CR22","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00401-006-0117-1","volume":"112","author":"A Rodriguez","year":"2006","unstructured":"Rodriguez A, Perez-Gracia E, Espinosa JC, Pumarola M, Torres JM, Ferrer I (2006) Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine PrP transgenic mice. Acta Neuropathol (Berl) 112:573\u2013585","journal-title":"Acta Neuropathol (Berl)"},{"key":"169_CR23","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/jnnp.72.2.262","volume":"72","author":"S Saadoun","year":"2002","unstructured":"Saadoun S, Papadopoulos MC, Davies DC, Krishna S, Bell BA (2002) Aquaporin-4 expression is increased in oedematous human brain tumours. J Neurol Neurosurg Psych 72:262\u2013265","journal-title":"J Neurol Neurosurg Psych"},{"key":"169_CR24","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1136\/jcp.56.12.972","volume":"56","author":"S Saadoun","year":"2003","unstructured":"Saadoun S, Papadopoulos MC, Krishna S (2003) Water transport becomesuncoupled from K+ siphoning in brain contusion, bacterial meningitis, and brain tumours: immunohistochemical case review. J Clin Pathol 56:972\u2013975","journal-title":"J Clin Pathol"},{"key":"169_CR25","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/j.1365-2990.2004.00638.x","volume":"31","author":"C Sinclair","year":"2005","unstructured":"Sinclair C, Mirakhur M, Kirk J, Farrell M, McQuaid S (2005) Up-regulation of osteopontin and alphaBeta-crystallin in the normal-appearing white matter of multiple sclerosis: an immunohistochemical study utilizing tissue microarrays. Neuropathol Appl Neurobiol 31:292\u2013303","journal-title":"Neuropathol Appl Neurobiol"},{"key":"169_CR26","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/3-211-30714-1_82","volume":"96","author":"R Suzuki","year":"2006","unstructured":"Suzuki R, Okuda M, Asai J, Nagashima G, Itokawa H, Matsunaga A, Fujimoto T, Suzuki T (2006) Astrocytes co-express aquaporin-1, -4 and vascular endothelial growth factor in brain edema tissue associated with brain contusion. Acta Neurochir Suppl 96:398\u2013401","journal-title":"Acta Neurochir Suppl"},{"key":"169_CR27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s004010051194","volume":"100","author":"F Tanaka","year":"2000","unstructured":"Tanaka F, Ozawa Y, Inage Y, Deguchi K, Itoh M, Imai Y, Kohsaka S, Takashima S (2000) Association of osteopontin with ischemic axonal death in periventricular leukomalacia. Acta Neuropathol (Berl) 100:69\u201374","journal-title":"Acta Neuropathol (Berl)"},{"key":"169_CR28","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0169-328X(00)00084-X","volume":"78","author":"M Taniguchi","year":"2000","unstructured":"Taniguchi M, Yamashita T, Kumura E, Tamatani M, Kobayashi A, Yokawa T, Maruno M, Kato A, Ohnishi T, Kohmura E, Tohyama M, Yoshimine T (2000) Induction of aquaporin-4 water channel mRNA after focal ishemia in rat. Brain Res Mol Brain Res 78:131\u2013137","journal-title":"Brain Res Mol Brain Res"},{"key":"169_CR29","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S0301-0082(00)00035-6","volume":"63","author":"Venero Jl","year":"2001","unstructured":"Venero Jl, Vizuete ML, Machado A, Cano J (2001) Aquaporins in the central nervous system. Prog Neurobiol 63:321\u2013336","journal-title":"Prog Neurobiol"},{"key":"169_CR30","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1523\/JNEUROSCI.18-06-02075.1998","volume":"18","author":"X Wang","year":"1988","unstructured":"Wang X, Louden C, Yue TL, Ellison JA, Barone FC, Solleveld HA, Feurerstein GZ (1988) Delayed expression of osteopontin after focal stroke in the rat. J Neurosci 18:2075\u20132083","journal-title":"J Neurosci"},{"key":"169_CR31","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1007\/s00401-005-0984-x","volume":"109","author":"A Warth","year":"2005","unstructured":"Warth A, Mittelbronn M, Wolburg H (2005) Redistribution of the water channel protein aquaporin-4 and the K+ channel protein Kir4.1 differs in low- and high-grade human brain tumours. Acta Neuropathol (Berl) 109:418\u2013426","journal-title":"Acta Neuropathol (Berl)"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-006-0169-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00401-006-0169-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-006-0169-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-006-0169-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T02:18:02Z","timestamp":1652581082000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00401-006-0169-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["169"],"URL":"https:\/\/doi.org\/10.1007\/s00401-006-0169-2","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,2]]},"assertion":[{"value":"11 August 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}