{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:02:16Z","timestamp":1791277336687,"version":"4.1.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2007,1,20]],"date-time":"2007-01-20T00:00:00Z","timestamp":1169251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"},{"start":{"date-parts":[[2007,1,20]],"date-time":"2007-01-20T00:00:00Z","timestamp":1169251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1007\/s00401-006-0191-4","type":"journal-article","created":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T10:11:09Z","timestamp":1169201469000},"page":"389-402","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Intraneuronal A\u03b2 immunoreactivity is not a predictor of brain amyloidosis-\u03b2 or neurofibrillary degeneration"],"prefix":"10.1007","volume":"113","author":[{"given":"Jerzy","family":"Wegiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Kuchna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Nowicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Frackowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozena","family":"Mazur-Kolecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humi","family":"Imaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarek","family":"Wegiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj D.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne P.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Reisberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mony","family":"deLeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wisniewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Pirttilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terho","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarmo","family":"Kivim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank E.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Kamphorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Potempska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bolton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia R.","family":"Currie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,1,20]]},"reference":[{"key":"191_CR1","first-page":"255","volume":"136","author":"D Allsop","year":"1990","unstructured":"Allsop D, Haga S, Bruton C, Ishii T, Roberts GW (1990) Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid beta protein of Alzheimer\u2019s disease. Am J Pathol 136:255\u2013260","journal-title":"Am J Pathol"},{"key":"191_CR2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/(SICI)1096-9861(19980720)397:1<139::AID-CNE10>3.0.CO;2-K","volume":"397","author":"BA Bahr","year":"1998","unstructured":"Bahr BA, Hoffman KB, Yang AJ, Hess US, Glabe CG, Lynch G (1998) Amyloid \u03b2-protein is internalized selectively by hippocampal field CA1 and neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein. J Comp Neurol 397:139\u2013147","journal-title":"J Comp Neurol"},{"key":"191_CR3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/ng1197-263","volume":"17","author":"KR Bales","year":"1997","unstructured":"Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ, Piccardo P, Ghetti B, Paul SM (1997) Lack of apolipoprotein E dramatically reduces amyloid \u03b2-peptide deposition. Nat Genet 17:263\u2013264","journal-title":"Nat Genet"},{"key":"191_CR4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0197-4580(89)90021-3","volume":"10","author":"C Bancher","year":"1989","unstructured":"Bancher C, Grundke-Iqbal I, Kim KS, Wisniewski HM (1989) Immunoreactivity of neuronal lipofuscin, with monoclonal antibodies to the amyloid \u03b2-protein. Neurobiol Aging 10:125\u2013132","journal-title":"Neurobiol Aging"},{"key":"191_CR5","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/00005072-199704000-00010","volume":"56","author":"M Bobinski","year":"1997","unstructured":"Bobinski M, Wegiel J, Tarnawski M, Bobinski M, Reisberg B, de Leon MJ, Miller DC, Wisniewski HM (1997) Relationships between regional neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer disease. J Neuropathol Exp Neurol 56:414\u2013420","journal-title":"J Neuropathol Exp Neurol"},{"key":"191_CR6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82:239\u2013269","journal-title":"Acta Neuropathol"},{"key":"191_CR7","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","volume":"16","author":"H Braak","year":"1995","unstructured":"Braak H, Braak E (1995) Staging of Alzheimer\u2019s disease-related neurofibrillary changes. Neurobiol Aging 16:271\u2013284","journal-title":"Neurobiol Aging"},{"key":"191_CR8","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1073\/pnas.90.5.2092","volume":"90","author":"J Busciglio","year":"1993","unstructured":"Busciglio J, Gabuzda DH, Matsudaira P, Yankner BA (1993) Generation of \u03b2-amyloid in the secretory pathway in neuronal and non neuronal cells. Proc Natl Acad Sci USA 90:2092\u20132096","journal-title":"Proc Natl Acad Sci USA"},{"key":"191_CR9","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/8438","volume":"5","author":"DH Chui","year":"1999","unstructured":"Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, Ueda O, Suzuki H, Araki W, Inoue H, Shirotani K, Takahashi K, Gallyas F, Tabira T (1999) Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat Med 5:560\u2013564","journal-title":"Nat Med"},{"key":"191_CR10","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/nm0997-1021","volume":"3","author":"DG Cook","year":"1997","unstructured":"Cook DG, Forman MS, Sung JC, Leight S, Kolson DL, Iwatsubo T, Lee VM, Doms RW (1997) Alzheimer\u2019s A\u03b2 (1\u201342) is generated in the endoplasmic reticulum\/intermediate compartment of NT2N cells. Nat Med 3:1021\u20131023","journal-title":"Nat Med"},{"key":"191_CR11","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1046\/j.1365-2559.2001.01082.x","volume":"38","author":"MR D\u2019Andrea","year":"2001","unstructured":"D\u2019Andrea MR, Nagele RG, Wang H-Y, Peterson PA, Lee DHS (2001) Evidence that neurons accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer\u2019s disease. Histopathology 38:120\u2013134","journal-title":"Histopathology"},{"key":"191_CR12","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/00005072-199411000-00011","volume":"53","author":"J Frackowiak","year":"1994","unstructured":"Frackowiak J, Zoltowska A, Wisniewski H (1994) Non-fibrillar \u03b2-amyloid protein is associated with smooth muscle cells of vessel wlls in Alzheimer disease. J Neuropathol Exp Neurol 53:637\u2013645","journal-title":"J Neuropathol Exp Neurol"},{"key":"191_CR13","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/jnen\/62.6.685","volume":"62","author":"J Frackowiak","year":"2003","unstructured":"Frackowiak J, Miller DL, Potempska A, Sukontasup T, Mazur-Kolecka B (2003) Secretion and accumulation of A\u03b2 by brain vascular smooth muscle cells from A\u03b2PP-Swedish transgenic mice. J Neuropathol Exp Neurol 62:685\u2013696","journal-title":"J Neuropathol Exp Neurol"},{"key":"191_CR14","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.brainres.2003.12.015","volume":"1002","author":"J Frackowiak","year":"2004","unstructured":"Frackowiak J, Sukontasup T, Potempska A, Mazur-Kolecka B (2004) Lysosomal deposition of A\u03b2 in cultures of brain vascular smooth muscle cells is enhanced by iron. Brain Res 1002:67\u201375","journal-title":"Brain Res"},{"key":"191_CR15","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1385\/JMN:17:2:137","volume":"17","author":"C Glabe","year":"2001","unstructured":"Glabe C (2001) Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer\u2019s disease. J Mol Neurosci 17:137\u2013145","journal-title":"J Mol Neurosci"},{"key":"191_CR16","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/0896-6273(89)90210-9","volume":"3","author":"M Goedert","year":"1989","unstructured":"Goedert M, Spillantini M, Jakes R, Rutherford D, Crowther R (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer\u2019s disease. Neuron 3:519\u2013526","journal-title":"Neuron"},{"key":"191_CR17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0002-9440(10)64700-1","volume":"156","author":"GK Gouras","year":"2000","unstructured":"Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, Greenfield JP, Haroutunian V, Buxbaum JD, Xu H, Greengard P, Relkin NR (2000) Intraneuronal A\u03b242 accumulation in human brain. Am J Pathol 156:15\u201320","journal-title":"Am J Pathol"},{"key":"191_CR18","doi-asserted-by":"crossref","first-page":"10987","DOI":"10.1016\/S0021-9258(19)78080-6","volume":"269","author":"E Gowing","year":"1994","unstructured":"Gowing E, Roher AE, Woods AS, Cotter RJ, Chaney M, Little SP, Ball MJ (1994) Chemical characterization of A\u03b217\u201342 peptide, a component of diffuse amyloid deposits of Alzheimer disease. J Biol Chem 269:10987\u201310990","journal-title":"J Biol Chem"},{"key":"191_CR19","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1073\/pnas.96.2.742","volume":"96","author":"JP Greenfield","year":"1999","unstructured":"Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H (1999) Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer \u03b2-amyloid peptides. Proc Natl Acad Sci USA 96:742\u2013747","journal-title":"Proc Natl Acad Sci USA"},{"key":"191_CR20","doi-asserted-by":"publisher","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","volume":"83","author":"I Grundke-Iqbal","year":"1986","unstructured":"Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule associated protein \u03c4 (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 83:4913\u20134917","journal-title":"Proc Natl Acad Sci USA"},{"key":"191_CR21","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/BF00304141","volume":"86","author":"DC Guiroy","year":"1993","unstructured":"Guiroy DC, Mellini M, Miyazaki M, Hilbich C, Safar J, Garruto RM, Yanagihara R, Beyreuther K, Gajdusek DC (1993) Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism dementia, and neuropathologically normal Guamanians contain a 4\u20134.5\u00a0kDa protein which is immunorective to anti-amyloid beta\/A4 protein antibodies. Acta Neuropathol 86:265\u2013274","journal-title":"Acta Neuropathol"},{"key":"191_CR22","doi-asserted-by":"crossref","first-page":"489","DOI":"10.5858\/2001-125-0489-IAAPDO","volume":"125","author":"KA Gyure","year":"2001","unstructured":"Gyure KA, Durham R, Stewart WF, Smialek JE, Troncoso JC (2001) Intraneuronal A\u03b2-amyloid precedes development of amyloid plaques in Down syndrome. Arch Pathol Lab Med 125:489\u2013492","journal-title":"Arch Pathol Lab Med"},{"key":"191_CR23","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/359322a0","volume":"359","author":"C Haass","year":"1992","unstructured":"Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DL, Selkoe DJ (1992) Amyloid \u03b2-peptide is produced by cultured cells during normal metabolism. Nature 359:322\u2013325","journal-title":"Nature"},{"key":"191_CR24","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1016\/S0021-9258(18)53650-4","volume":"268","author":"C Haass","year":"1993","unstructured":"Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ (1993) \u03b2-amyloid peptide and 3\u00a0kDa fragment are derived by distinct cellular mechanisms. J Biol Chem 268:3021\u20133024","journal-title":"J Biol Chem"},{"key":"191_CR25","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1038\/nm0997-1016","volume":"3","author":"T Hartmann","year":"1997","unstructured":"Hartmann T, Bieger SC, Bruhl B, Tienari PJ, Ida N, Allsop D, Roberts GW, Masters CL, Dotti CG, Unsicker K, Beyreuther K (1997) Distinct sites of intracellular production for Alzheimer\u2019s disease A\u03b240\/42 amyloid peptides. Nat Med 3:1016\u20131020","journal-title":"Nat Med"},{"key":"191_CR26","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/0304-3940(89)90559-4","volume":"101","author":"BT Hyman","year":"1989","unstructured":"Hyman BT, Van Hoesen GW, Beyreuther K, Masters CL (1989) A4 amyloid protein immunoreactivity is present in Alzheimer\u2019s disease neurofibrillary tangles. Neurosci Lett 101:352\u2013355","journal-title":"Neurosci Lett"},{"key":"191_CR27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2990.1991.tb00736.x","volume":"17","author":"H Ito","year":"1991","unstructured":"Ito H, Hirano A, Yen S-H, Katao S (1991) Demonstration of \u03b2 amyloid protein containing neurofibrillary tangles in parkinsonism-dementia complex of Guam. Neuropathol Appl Neurobiol 17:365\u2013373","journal-title":"Neuropathol Appl Neurobiol"},{"key":"191_CR28","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1179\/his.1993.16.4.335","volume":"16","author":"K Iqbal","year":"1993","unstructured":"Iqbal K, Braak H, Braak E, Grundke-Iqbal I (1993) Silver labeling of Alzheimer neurofibrillary changes and brain \u03b2-amyloid. J Histotech 16:335\u2013342","journal-title":"J Histotech"},{"key":"191_CR29","first-page":"121","volume":"2","author":"KS Kim","year":"1988","unstructured":"Kim KS, Miller DL, Sapienza VJ, Chen CMJ, Bai C, Grundke-Iqbal I, Currie J, Wisniewski HM (1988) Neurosci Res Commun 2:121\u2013130","journal-title":"Neurosci Res Commun"},{"key":"191_CR30","first-page":"113","volume":"7","author":"KS Kim","year":"1990","unstructured":"Kim KS, Wen GY, Bancher C, Chen CMJ, Sapienza VJ, Hong H, Wisniewski HM (1990) Detection, quantitation of amyloid \u03b2-peptide with 2 monoclonal antibodies. Neurosci Res Comm 7:113\u2013122","journal-title":"Neurosci Res Comm"},{"key":"191_CR31","first-page":"230","volume":"57","author":"T Kitamoto","year":"1987","unstructured":"Kitamoto T, Ogomori K, Tateishi J, Prusiner S (1987) Methods in laboratory investigation. Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest 57:230\u2013236","journal-title":"Lab Invest"},{"key":"191_CR32","first-page":"545","volume":"60","author":"I Kuchna","year":"2001","unstructured":"Kuchna I, Wegiel J, Tarnawski M, Badmaev E, Kozlowski P, Pirttila T, Kivimaki T, Lehtimaki T, Visser F, Devenny D, Silverman W (2001) Alzheimer type pathology in the memory system of people with Down syndrome. J Neuropathol Exp Neurol 60:545","journal-title":"J Neuropathol Exp Neurol"},{"key":"191_CR33","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1006\/nbdi.1996.0003","volume":"3","author":"CA Lemere","year":"1996","unstructured":"Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ (1996) Sequence of deposition of heterogenous amyloid \u03b2 peptides and APOE in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis 3:16\u201332","journal-title":"Neurobiol Dis"},{"key":"191_CR34","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1002\/j.1460-2075.1985.tb04000.x","volume":"4","author":"CL Masters","year":"1985","unstructured":"Masters CL, Multhaup G, Simms G, Pottgiesser J, Martins RN, Beyreuther K (1985) Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer\u2019s disease contain the same protein as the amyloid plaque cores and blood vessels. EMBO J 4:2757\u20132763","journal-title":"EMBO J"},{"key":"191_CR35","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1002\/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M","volume":"46","author":"CA McLean","year":"1999","unstructured":"McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL (1999) Soluble pool of A\u03b2 amyloid as a determinant of severity of neurodegeneration in Alzheimer\u2019s disease. Ann Neurol 46:860\u2013866","journal-title":"Ann Neurol"},{"key":"191_CR36","doi-asserted-by":"publisher","first-page":"11682","DOI":"10.1021\/bi030100s","volume":"42","author":"DL Miller","year":"2003","unstructured":"Miller DL, Currie JR, Mehta PD, Potempska A, Hwang Yu-Wen, Wegiel J (2003) Humoral immune response to fibrillar \u03b2-amyloid peptide. Biochemistry 42:11682\u201311692","journal-title":"Biochemistry"},{"key":"191_CR37","doi-asserted-by":"crossref","unstructured":"Miller DL, Potempska A, Mehta PD (2007) Humoral immune responses to peptides derived from the \u03b2-amyloid peptide C-terminal sequence. Amyloid (in press)","DOI":"10.1080\/13506120601116500"},{"key":"191_CR38","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/S0140-6736(99)04937-5","volume":"355","author":"A Mochizuki","year":"2000","unstructured":"Mochizuki A, Tamaoka A, Shimohata A, Komatsuzaki Y, Shoji S (2000) A\u03b242-positive non-pyramidal neurons around amyloid plaques in Alzheimer\u2019s disease. Lancet 355:42","journal-title":"Lancet"},{"key":"191_CR39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/13506120208995241","volume":"9","author":"C Mori","year":"2002","unstructured":"Mori C, Spooner ET, Wisniewski KE, Wisniewski TM, Yamaguchi H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA (2002) Intraneuronal A\u03b242 accumulation in Down syndrome brain. Amyloid J Protein Fold Disord 9:88\u2013102","journal-title":"Amyloid J Protein Fold Disord"},{"key":"191_CR40","first-page":"1082","volume":"144","author":"GM Murphy","year":"1994","unstructured":"Murphy GM, Forno LS, Higgins L, Scardina JM, Eng LF, Cordell B (1994) Development of monoclonal antibody specific for the COOH-terminal of A\u03b2-amyloid 1\u201342 and its immunohistochemical reactivity in Alzheimer\u2019s disease and related disorders. Am J Pathol 144:1082\u20131088","journal-title":"Am J Pathol"},{"key":"191_CR41","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/BF00966798","volume":"17","author":"IL Payan","year":"1992","unstructured":"Payan IL, Chou S-J, Fisher GH, Man EH, Emory C, Frey WH (1992) Altered aspartate in Alzheimer neurofibrillary tangles. Neurochem Res 17:187\u2013191","journal-title":"Neurochem Res"},{"key":"191_CR42","first-page":"283","volume":"140","author":"G Perry","year":"1992","unstructured":"Perry G, Cras P, Siedlak SL, Tabaton M, Kawai M (1992) \u03b2 protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer\u2019s disease. Am J Pathol 140:283\u2013290","journal-title":"Am J Pathol"},{"key":"191_CR43","doi-asserted-by":"publisher","first-page":"23895","DOI":"10.1074\/jbc.270.41.23895","volume":"270","author":"CJ Pike","year":"1995","unstructured":"Pike CJ, Overman MJ, Cotman CW (1995) Amino-terminal deletions enhance aggregation of \u03b2-amyloid peptides in vitro. J Biol Chem 270:23895\u201323898","journal-title":"J Biol Chem"},{"key":"191_CR44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3109\/13506129908993283","volume":"6","author":"A Potempska","year":"1999","unstructured":"Potempska A, Mack K, Mehta P, Kim KS, Miller DL (1999) Quantification of sub-femtomole amount of Alzheimer amyloid \u03b2 peptides. Amyloid 6:14\u201321","journal-title":"Amyloid"},{"key":"191_CR45","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1176\/ajp.139.9.1136","volume":"139","author":"B Reisberg","year":"1982","unstructured":"Reisberg B, Ferris SH, DeLeon MJ, Crook T (1982) The global deterioration scale for the assessment of promary degenerative dementia. Am J Psychol 139:1136\u20131139","journal-title":"Am J Psychol"},{"key":"191_CR46","first-page":"653","volume":"24","author":"B Reisberg","year":"1988","unstructured":"Reisberg B (1988) Functional assessment staging (FAST). Psychopharmacol Bull 24:653\u2013659","journal-title":"Psychopharmacol Bull"},{"key":"191_CR47","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00005072-199906000-00001","volume":"58","author":"WI Rosenblum","year":"1999","unstructured":"Rosenblum WI (1999) The presence, origin, and significance of A\u03b2 peptide in the cell bodies of neurons. J Neuropathol Exp Neurol 58:575\u2013581","journal-title":"J Neuropathol Exp Neurol"},{"key":"191_CR48","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/0896-6273(95)90301-1","volume":"14","author":"TC Saido","year":"1995","unstructured":"Saido TC, Iwatsubo T, Mann DMA, Shimada H, Ihara Y, Kawashima S (1995) Dominant and differential deposition of distinct \u03b2-amyloid peptide species, A\u03b2N3(pE), in senile plaques. Neuron 14:457\u2013466","journal-title":"Neuron"},{"key":"191_CR49","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/00005072-199812000-00004","volume":"57","author":"C Schwab","year":"1998","unstructured":"Schwab C, Akiyama H, McGeer EG, McGeer PL (1998) Extracellular neurofibrillary tangles are immunopositive for the 40 carboxy-terminal sequence of \u03b2-amyloid protein. J Neuropathol Exp Neurol 57:1131\u20131137","journal-title":"J Neuropathol Exp Neurol"},{"key":"191_CR50","doi-asserted-by":"crossref","first-page":"24290","DOI":"10.1016\/S0021-9258(19)51080-8","volume":"269","author":"O Schweers","year":"1994","unstructured":"Schweers O, Schonbrunn-Hanebeck E, Marx A, Mandelkow E (1994) Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta structure. J Biol Chem 269:24290\u201324297","journal-title":"J Biol Chem"},{"key":"191_CR51","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1046\/j.1471-4159.2003.01818.x","volume":"85","author":"N Sergeant","year":"2003","unstructured":"Sergeant N, Bombois S, Ghestem A, Drobecq H, Kostanjevecki V, Missiaen C, Wattez A, David J-P, Vanmechelen E, Sergheraert C, Delacourte A (2003) Truncated beta-amyloid peptide species in pre-clinical Alzheimer\u2019s disease as new targets for the vaccination approach. J Neurochem 85:1581\u20131591","journal-title":"J Neurochem"},{"key":"191_CR52","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1471-4159.1988.tb13231.x","volume":"50","author":"R Shapira","year":"1988","unstructured":"Shapira R, Austin GE, Mirra SS (1988) Neuritic plaque amyloid is highly racemized. J Neurochem 50:69\u201374","journal-title":"J Neurochem"},{"key":"191_CR53","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0969-9961(03)00069-X","volume":"14","author":"JG Sheng","year":"2003","unstructured":"Sheng JG, Bora SH, Xu G, Borchelt DR, Price DL, Koliatsos VE (2003) Lipopolisaccharide -induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid \u03b2 peptide in APPswe transgenic mice. Neurobiol Dis 14:133\u2013145","journal-title":"Neurobiol Dis"},{"key":"191_CR54","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1177\/08830738060210062201","volume":"21","author":"DK Sokol","year":"2006","unstructured":"Sokol DK, Chen D, Farlow MR, Dunn DW, Maloney B, Zimmer JA, Lahiri DK (2006) High levels of Alzheimer beta- amyloid precursor protein (APP) in children with severely autistic behavior and aggression. J Child Neurol 21:444\u2013449","journal-title":"J Child Neurol"},{"key":"191_CR55","first-page":"973","volume":"134","author":"RA Stern","year":"1989","unstructured":"Stern RA, Otvos L Jr, Trojanowski JQ, Lee VM (1989) Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer\u2019s diease beta-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system. Am J Pathol 134:973\u2013978","journal-title":"Am J Pathol"},{"key":"191_CR56","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1073\/pnas.88.6.2098","volume":"88","author":"M Tabaton","year":"1991","unstructured":"Tabaton M, Cammarata S, Mancardi G, Manetto V, Autilio-Gambetti L, Perry G, Gambetti P (1991) Ultrastructural localization of \u03b2-amyloid, tau and ubiquitin epitopes in extracellular neurofibrillary tangles. Proc Natl Acad Sci USA 88:2098\u20132102","journal-title":"Proc Natl Acad Sci USA"},{"key":"191_CR57","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0002-9440(10)64463-X","volume":"161","author":"RH Takahashi","year":"2002","unstructured":"Takahashi RH, Milner TA, Li F, Nam EN, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK (2002) Intraneuronal Alzheimer A\u03b242 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol 161:1869\u20131879","journal-title":"Am J Pathol"},{"key":"191_CR58","first-page":"239","volume":"17","author":"RH Takahashi","year":"2002","unstructured":"Takahashi RH, Nam EE, Edgar M, Gouras GK (2002) Alzheimer \u03b2-amyloid peptides: normal and abnormal localization. Histol Histopathol 17:239\u2013246","journal-title":"Histol Histopathol"},{"key":"191_CR59","doi-asserted-by":"publisher","first-page":"31894","DOI":"10.1074\/jbc.271.50.31894","volume":"271","author":"R Wang","year":"1996","unstructured":"Wang R, Sweeney D, Gandy SE, Sisodia S (1996) The profile of soluble amyloid \u03b2 protein in cultured media. J Biol Chem 271:31894\u201331902","journal-title":"J Biol Chem"},{"key":"191_CR60","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S0197-4580(99)00060-3","volume":"20","author":"J Wegiel","year":"1999","unstructured":"Wegiel J, Wisniewski HM, Morys J, Tarnawski M, Kuchna I, Dziewiatkowski J, Pirttil\u00e4 T, Krivim\u00e4ki T, Lehtim\u00e4ki T, Lach B (1999) Neuronal loss and amyloid-\u03b2 removal in the amygdala of people with Down syndrome. Neurobiol Aging 20:259\u2013269","journal-title":"Neurobiol Aging"},{"key":"191_CR61","first-page":"483","volume":"61","author":"J Wegiel","year":"2002","unstructured":"Wegiel J, Kuchna I, Miller D, Mehta P, Wegiel J, Wisniewski T, Reisberg B, Silverman W (2002) Intraneuronal accumulation of N-terminally truncated amyloid beta. J Neuropathol Exp Neurol 61:483","journal-title":"J Neuropathol Exp Neurol"},{"key":"191_CR62","doi-asserted-by":"publisher","first-page":"16085","DOI":"10.1074\/jbc.272.26.16085","volume":"272","author":"C Wild-Bode","year":"1997","unstructured":"Wild-Bode C, Yamazaki T, Capell A, Leimer U, Steiner H, Ihara Y, Haass C (1997) Intracellular generation and accumulation of amyloid \u03b2-peptide terminating at amino acid 42. J Biol Chem 272:16085\u201316088","journal-title":"J Biol Chem"},{"key":"191_CR63","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/00005072-199908000-00001","volume":"58","author":"CA Wilson","year":"1999","unstructured":"Wilson CA, Doms RW, Lee VM-Y (1999) Intracellular APP processing and A\u03b2 production in Alzheimer disease. J Neuropathol Exp Neurol 58:787\u2013794","journal-title":"J Neuropathol Exp Neurol"},{"key":"191_CR64","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S0304-3940(01)01876-6","volume":"306","author":"O Wirths","year":"2001","unstructured":"Wirths O, Multhaup G, Czech C, Blanchard V, Moussaoui S, Tremp G, Pradier L, Beyreuther K, Bayere TA (2001) Intraneuronal A\u03b2 accumulation precedes plaque formation in \u03b2-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosc Lett 306:116\u2013120","journal-title":"Neurosc Lett"},{"key":"191_CR65","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/BF00294218","volume":"80","author":"KE Wisniewski","year":"1990","unstructured":"Wisniewski KE, Maslinska D, Kitaguchi T, Kim KS, Goebel HH, Haltia M (1990) Topographic heterogeneity of amyloid \u03b2-protein epitopes in brains with various forms of neuronal lipofuscinoses suggesting defective processing of amyloid precursor protein. Acta Neuropathol 80:26\u201334","journal-title":"Acta Neuropathol"},{"key":"191_CR66","doi-asserted-by":"publisher","first-page":"3748","DOI":"10.1073\/pnas.94.8.3748","volume":"94","author":"H Xu","year":"1997","unstructured":"Xu H, Sweeney D, Wang R, Thinakaran G, Lo ACY, Sisodia SS, Greengard P, Gandy S (1997) Generation of Alzheimer\u2019s \u03b2-amyloid protein in the trans-Golgi in the apparent absence of vesicle formation. Proc Natl Acad Sci USA 94:3748\u20133752","journal-title":"Proc Natl Acad Sci USA"},{"key":"191_CR67","first-page":"699","volume":"138","author":"H Yamaguchi","year":"1991","unstructured":"Yamaguchi H, Nakazato Y, Shoji M, Okamoto K, Ihara Y, Morimatsu M, Hirai S (1991) Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia. Am J Pathol 138:699\u2013705","journal-title":"Am J Pathol"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-006-0191-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00401-006-0191-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-006-0191-4.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-006-0191-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T16:40:40Z","timestamp":1630428040000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00401-006-0191-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,20]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["191"],"URL":"https:\/\/doi.org\/10.1007\/s00401-006-0191-4","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,20]]},"assertion":[{"value":"28 June 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}