{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:53:32Z","timestamp":1791417212103,"version":"4.3.3"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,11,18]],"date-time":"2008-11-18T00:00:00Z","timestamp":1226966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1007\/s00401-008-0458-z","type":"journal-article","created":{"date-parts":[[2008,11,17]],"date-time":"2008-11-17T06:20:25Z","timestamp":1226902825000},"page":"19-29","source":"Crossref","is-referenced-by-count":23,"title":["Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"117","author":[{"given":"Adele","family":"Woodhouse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E.","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sokolova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria L.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda M.","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey C.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Vickers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,11,18]]},"reference":[{"key":"458_CR1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00401-001-0476-6","volume":"103","author":"H Akiyama","year":"2002","unstructured":"Akiyama H, Schwab C, Kondo H et al (2002) Morphologically distinct plaque types differentially affect dendritic structure and organization in the early and late stages of Alzheimer\u2019s disease. Acta Neuropathol 103:377\u2013383","journal-title":"Acta Neuropathol"},{"key":"458_CR2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000017051","volume":"9","author":"RA Armstrong","year":"1998","unstructured":"Armstrong RA (1998) \u03b2-Amyloid plaques: stages in life history or independent origin? Dement Geriatr Cogn Disord 9:227\u2013238","journal-title":"Dement Geriatr Cogn Disord"},{"key":"458_CR3","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1091\/mbc.02-03-0046","volume":"13","author":"J Biernat","year":"2002","unstructured":"Biernat J, Wu Y-Z, Timm T et al (2002) Protein kinase MARK\/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Mol Biol Cell 13:4013\u20134028","journal-title":"Mol Biol Cell"},{"key":"458_CR4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0014-4886(03)00252-8","volume":"184","author":"V Blanchard","year":"2003","unstructured":"Blanchard V, Moussaoui S, Czech C et al (2003) Time sequence of maturation of dystrophic neurites associated with A\u03b2 deposits in APP\/PS1 transgenic mice. Exp Neurol 184:247\u2013263","journal-title":"Exp Neurol"},{"key":"458_CR5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","volume":"17","author":"DR Borchelt","year":"1996","unstructured":"Borchelt DR, Thinakaran G, Eckman CB et al (1996) Familial Alzheimer\u2019s disease-linked presenilin 1 variants elevate Abeta1-42\/1-40 ratio in vitro and in vivo. Neuron 17:1005\u20131013","journal-title":"Neuron"},{"key":"458_CR6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239\u2013259","journal-title":"Acta Neuropathol"},{"key":"458_CR7","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0896-6273(95)90232-5","volume":"14","author":"J Busciglio","year":"1995","unstructured":"Busciglio J, Lorenzo A, Yeh J, Yanker BA (1995) \u03b2-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 14:879\u2013888","journal-title":"Neuron"},{"key":"458_CR8","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/302553","volume":"65","author":"D Campion","year":"1999","unstructured":"Campion D, Dumanchin C, Hannequin D et al (1999) Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum. Am J Hum Genet 65:664\u2013670","journal-title":"Am J Hum Genet"},{"key":"458_CR9","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/jnr.21601","volume":"86","author":"Q Chen","year":"2008","unstructured":"Chen Q, Nakajima A, Choi SH, Xiong X, Tang YP (2008) Loss of presenilin function causes Alzheimer\u2019s disease-like neurodegeneration in the mouse. J Neurosci Res 86:1615\u20131626","journal-title":"J Neurosci Res"},{"key":"458_CR10","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nm0498-452","volume":"4","author":"R Crook","year":"1998","unstructured":"Crook R, Verkkoniemi A, Perez-Tur J et al (1998) A variant of Alzheimer\u2019s disease with spastic paraparesis and unusual plaques due to the deletion of exon 9 of presenilin 1. Nat Med 4:452\u2013455","journal-title":"Nat Med"},{"key":"458_CR11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0301-0082(99)00033-7","volume":"60","author":"C Czech","year":"2000","unstructured":"Czech C, Tremp G, Pradier L (2000) Presenilins and Alzheimer\u2019s disease: biological functions and pathogenic mechanisms. Prog Neurobiol 60:363\u2013384","journal-title":"Prog Neurobiol"},{"key":"458_CR12","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.neurobiolaging.2007.02.029","volume":"29","author":"FG Felice De","year":"2008","unstructured":"De Felice FG, Wu D, Lambert MP et al (2008) Alzheimer\u2019s disease-type neuronal tau hyperphosphorylation induced by Abeta oligomers. Neurobiol Aging 29:1334\u20131347","journal-title":"Neurobiol Aging"},{"key":"458_CR13","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.nbd.2004.10.001","volume":"18","author":"TC Dickson","year":"2005","unstructured":"Dickson TC, Chuckowree JA, Chuah MI, West AK, Vickers JC (2005) Novel Alzheimer\u2019s disease pathology reflects variable neuronal vulnerability and demonstrates the role of \u03b2-amyloid plaques in neurodegeneration. Neurobiol Dis 18:286\u2013295","journal-title":"Neurobiol Dis"},{"key":"458_CR14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0306-4522(01)00169-5","volume":"105","author":"TC Dickson","year":"2001","unstructured":"Dickson TC, Vickers JC (2001) The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer\u2019s disease. Neuroscience 105:99\u2013107","journal-title":"Neuroscience"},{"key":"458_CR15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/exnr.1998.7010","volume":"156","author":"TC Dickson","year":"1999","unstructured":"Dickson TC, King CE, McCormack GH, Vickers JC (1999) Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer\u2019s disease. Exp Neurol 156:100\u2013110","journal-title":"Exp Neurol"},{"key":"458_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(00)00550-9","volume":"103","author":"WK Dowjat","year":"2001","unstructured":"Dowjat WK, Wisniewski H, Wisniewski T (2001) Alzheimer\u2019s disease presenilin-1 expression modulates the assembly of neurofilaments. Neuroscience 103:1\u20138","journal-title":"Neuroscience"},{"key":"458_CR17","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1152\/jn.00088.2001","volume":"87","author":"J Evans","year":"2002","unstructured":"Evans J, Sumners C, Moore J et al (2002) Characterisation of mitotic neurons derived from adult rat hypothalamus and brain stem. J Neurophysiol 87:1076\u20131085","journal-title":"J Neurophysiol"},{"key":"458_CR18","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/mcne.1997.0615","volume":"9","author":"A Ferreira","year":"1997","unstructured":"Ferreira A, Lu Q, Orecchio L, Kosik KS (1997) Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Abeta. Mol Cell Neurosci 9:220\u2013234","journal-title":"Mol Cell Neurosci"},{"key":"458_CR19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/neur.1996.0002","volume":"5","author":"H Fukumoto","year":"1996","unstructured":"Fukumoto H, Asami-Odaka AS, Uzuki N, Iwatsubo T (1996) Association of A\u03b240-positive senile plaques with microglial cells in the brains of patients with Alzheimer\u2019s disease and in non-demented aged individuals. Neurodegeneration 5:13\u201317","journal-title":"Neurodegeneration"},{"key":"458_CR20","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","volume":"60","author":"P Giannakopoulos","year":"2003","unstructured":"Giannakopoulos P, Herrmann FR, Bussiere T et al (2003) Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease. Neurology 60:1495\u20131500","journal-title":"Neurology"},{"key":"458_CR21","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/brain\/122.9.1709","volume":"122","author":"T Gomez-Isla","year":"1999","unstructured":"Gomez-Isla T, Growdon WB, McNamara MJ et al (1999) The impact of different presenilin 1 and presenilin 2 mutation on amyloid deposition neurofibrillary changes and neuronal loss in familial Alzheimer\u2019s disease brain: evidence for other phenotype-modifying factors. Brain 122:1709\u20131719","journal-title":"Brain"},{"key":"458_CR22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/1565","volume":"1","author":"J Hardy","year":"1998","unstructured":"Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (1998) Genetic dissection of Alzheimer\u2019s disease and related dementias: amyloid and its relationship to tau. Nat Neurosci 1:355\u2013358","journal-title":"Nat Neurosci"},{"key":"458_CR23","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/1531-8249(200011)48:5<806::AID-ANA18>3.0.CO;2-F","volume":"48","author":"H Houlden","year":"2000","unstructured":"Houlden H, Baker M, McGowan E et al (2000) Variant Alzheimer\u2019s disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations. Ann Neurol 48:806\u2013808","journal-title":"Ann Neurol"},{"key":"458_CR24","doi-asserted-by":"crossref","first-page":"6026","DOI":"10.1523\/JNEUROSCI.21-16-06026.2001","volume":"21","author":"T Ishihara","year":"2001","unstructured":"Ishihara T, Higuchi M, Zhang B et al (2001) Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments. J Neurosci 21:6026\u20136035","journal-title":"J Neurosci"},{"key":"458_CR25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(97)00347-9","volume":"228","author":"K Ishii","year":"1997","unstructured":"Ishii K, Ii K, Hasegawa T, Shoji S, Doi A, Mori H (1997) Increased Abeta 42(43)-plaque deposition in early-onset familial Alzheimer\u2019s disease brains with the deletion of exon 9 and the missense point mutation (H163R) in the PS-1 gene. Neurosci Lett 228:17\u201320","journal-title":"Neurosci Lett"},{"key":"458_CR26","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1471-4159.2007.05038.x","volume":"104","author":"H Karlstrom","year":"2008","unstructured":"Karlstrom H, Brooks WS, Kwok JBJ et al (2008) Variable phenotype of Alzheimer\u2019s disease with spastic paraparesis. J Neurochem 104:573\u2013583","journal-title":"J Neurochem"},{"key":"458_CR27","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1074\/jbc.M211827200","volume":"278","author":"JBJ Kwok","year":"2003","unstructured":"Kwok JBJ, Halliday GM, Brooks WS et al (2003) Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer\u2019s disease with non-cored plaques and no neuritic dystrophy. J Biol Chem 278:6748\u20136754","journal-title":"J Biol Chem"},{"key":"458_CR28","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1523\/JNEUROSCI.4272-06.2007","volume":"27","author":"O Lazarov","year":"2007","unstructured":"Lazarov O, Morfini GA, Pigino G et al (2007) Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer\u2019s Disease-linked mutant presenilin 1. J Neurosci 27:7011\u20137020","journal-title":"J Neurosci"},{"key":"458_CR29","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1212\/WNL.46.2.406","volume":"46","author":"CF Lippa","year":"1996","unstructured":"Lippa CF, Saunders AM, Smith TW et al (1996) Familial and sporadic Alzheimer\u2019s disease: neuropathology cannot exclude a final common pathway. Neurology 46:406\u2013412","journal-title":"Neurology"},{"key":"458_CR30","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/S0002-9440(10)64688-3","volume":"158","author":"DMA Mann","year":"2001","unstructured":"Mann DMA, Pickering-Brown SM, Takeuchi A, Iwatsubo T, Familial Alzheimer\u2019s disease pathology study group (2001) Amyloid angiopathy and variability in amyloid-\u03b2 deposition is determined by mutation position in presenilin-1-linked Alzheimer\u2019s disease. Am J Pathol 158:2165\u20132175","journal-title":"Am J Pathol"},{"key":"458_CR31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1365-2990.2001.00316.x","volume":"27","author":"DMA Mann","year":"2001","unstructured":"Mann DMA, Takeuchi A, Sato S et al (2001) Cases of Alzheimer\u2019s disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic \u03b2-amyloid pathology known as \u2018cotton wool\u2019 plaques. Neuropathol Appl Neurobiol 27:189\u2013196","journal-title":"Neuropathol Appl Neurobiol"},{"key":"458_CR32","first-page":"871","volume":"142","author":"E Masliah","year":"1993","unstructured":"Masliah E, Mallory M, Hansen L, Alford M, DeTeresa R, Terry R (1993) An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer\u2019s disease. Am J Pathol 142:871\u2013881","journal-title":"Am J Pathol"},{"key":"458_CR33","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/jnen\/60.4.357","volume":"60","author":"E Masliah","year":"2001","unstructured":"Masliah E, Sisk A, Mallory M, Games D (2001) Neurofibrillary pathology in transgenic mice overexpressing V717F \u03b2-Amyloid precursor protein. J Neuropathol Exp Neurol 60:357\u2013368","journal-title":"J Neuropathol Exp Neurol"},{"key":"458_CR34","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature06616","volume":"451","author":"M Meyer-Luehmann","year":"2008","unstructured":"Meyer-Luehmann M, Spires-Jones TL, Prada C et al (2008) Rapid appearance and local toxicity of amyloid-\u03b2 plaques in a mouse model of Alzheimer\u2019s disease. Nature 451:720\u2013724","journal-title":"Nature"},{"key":"458_CR35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","volume":"41","author":"SS Mirra","year":"1991","unstructured":"Mirra SS, Heyman A, McKeel D et al (1991) The consortium to establish a registry for Alzheimer\u2019s disease (CERAD). Part II. Standardization of the neuropathological assessment of Alzheimer\u2019s disease. Neurology 41:479\u2013486","journal-title":"Neurology"},{"key":"458_CR36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00401-008-0420-0","volume":"116","author":"M P\u00e9rez","year":"2008","unstructured":"P\u00e9rez M, Asunci\u00f3n Mor\u00e1n M, Ferrer I et al (2008) Phosphorylated tau in neuritic plaques of APPsw\/Tauvlw transgenic mice and Alzheimer disease. Acta Neuropathol 116:409\u2013418","journal-title":"Acta Neuropathol"},{"key":"458_CR37","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1523\/JNEUROSCI.21-03-00834.2001","volume":"21","author":"G Pigino","year":"2001","unstructured":"Pigino G, Pelsman A, Mori H, Busciglio J (2001) Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation. J Neurosci 21:834\u2013842","journal-title":"J Neurosci"},{"key":"458_CR38","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bbrc.2007.04.187","volume":"358","author":"R Porzig","year":"2007","unstructured":"Porzig R, Singer D, Hoffmann R (2007) Epitope mapping of mABs AT8 and Tau5 directed against hyperphosphoylated regions of the human tau protein. Biochem Biophys Res Commun 358:644\u2013649","journal-title":"Biochem Biophys Res Commun"},{"key":"458_CR39","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","volume":"45","author":"JL Price","year":"1999","unstructured":"Price JL, Morris JC (1999) Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer\u2019s disease. Ann Neurol 45:358\u2013368","journal-title":"Ann Neurol"},{"key":"458_CR40","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0306-4522(94)90490-1","volume":"60","author":"MJ Savage","year":"1994","unstructured":"Savage MJ, Iqbal M, Loh T et al (1994) Cathespin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein. Neuroscience 60:607\u2013619","journal-title":"Neuroscience"},{"key":"458_CR41","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nm0896-864","volume":"2","author":"D Scheuner","year":"1996","unstructured":"Scheuner D, Eckman C, Jensen M et al (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer\u2019s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer\u2019s disease. Nat Med 2:850\u2013852","journal-title":"Nat Med"},{"key":"458_CR42","first-page":"513","volume":"60","author":"M Schmidt","year":"1989","unstructured":"Schmidt M, Lee VM, Trojanowski JQ (1989) Analysis of epitopes shared by Hirano bodies and neurofilament proteins in normal and Alzheimer\u2019s disease hippocampus. Lab Invest 60:513\u2013522","journal-title":"Lab Invest"},{"key":"458_CR43","doi-asserted-by":"crossref","first-page":"18295","DOI":"10.1074\/jbc.271.31.18295","volume":"271","author":"DJ Selkoe","year":"1996","unstructured":"Selkoe DJ (1996) (1996) Amyloid beta-protein and the genetics of Alzheimer\u2019s disease. J Biol Chem 271:18295\u201318298","journal-title":"J Biol Chem"},{"key":"458_CR44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.nbd.2003.10.008","volume":"15","author":"CE Shepherd","year":"2004","unstructured":"Shepherd CE, Gregory GC, Vickers JC et al (2004) Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques. Neurobiol Dis 15:115\u2013119","journal-title":"Neurobiol Dis"},{"key":"458_CR45","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1093\/brain\/awg090","volume":"126","author":"PM Stanford","year":"2003","unstructured":"Stanford PM, Shepherd CE, Halliday GM et al (2003) Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia. Brain 126:814\u2013826","journal-title":"Brain"},{"key":"458_CR46","doi-asserted-by":"crossref","first-page":"7233","DOI":"10.1074\/jbc.M007183200","volume":"276","author":"H Steiner","year":"2001","unstructured":"Steiner H, Revesz T, Neumann M et al (2001) A pathogenic presenilin-1 deletion causes aberrant A\u03b242 production in the absence of congophilic amyloid plaques. J Biol Chem 276:7233\u20137239","journal-title":"J Biol Chem"},{"key":"458_CR47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0006-8993(96)00811-6","volume":"739","author":"JH Su","year":"1996","unstructured":"Su JH, Cummings BJ, Cotman CW (1996) Plaque biogenesis in brain aging and Alzheimer\u2019s disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments. Brain Res 739:79\u201387","journal-title":"Brain Res"},{"key":"458_CR48","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s004010050920","volume":"96","author":"JH Su","year":"1998","unstructured":"Su JH, Cummings BJ, Cotman CW (1998) Plaque biogenesis in brain aging and Alzheimer\u2019s disease. II. Progressive transformation and developmental sequence of dystrophic neurites. Acta Neuropathol 96:463\u2013471","journal-title":"Acta Neuropathol"},{"key":"458_CR49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00401-002-0536-6","volume":"104","author":"M Takao","year":"2002","unstructured":"Takao M, Ghetti B, Hayakawa I et al (2002) A novel mutation (G217D) in the presenilin 1 gene (PSEN1) in a Japanese family: presenile dementia and Parkinsonism are associated with cotton wool plaques in the cortex and striatum. Acta Neuropathol 104:155\u2013170","journal-title":"Acta Neuropathol"},{"key":"458_CR50","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.1073\/pnas.95.16.9637","volume":"95","author":"A Takashima","year":"1998","unstructured":"Takashima A, Murayama M, Murayama O et al (1998) Presenilin 1 associates with glycogen synthase kinase-3\u03b2 and its substrate tau. Proc Natl Acad Sci USA 95:9637\u20139641","journal-title":"Proc Natl Acad Sci USA"},{"key":"458_CR51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0301-0082(99)00023-4","volume":"60","author":"JC Vickers","year":"2000","unstructured":"Vickers JC, Dickson TC, Adlard PA, Saunders HL, King CE, McCormack G (2000) The cause of neuronal degeneration in Alzheimer\u2019s disease. Prog Neurobiol 60:139\u2013165","journal-title":"Prog Neurobiol"},{"key":"458_CR52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(94)90310-7","volume":"62","author":"JC Vickers","year":"1994","unstructured":"Vickers JC, Riederer BM, Marugg R, Bu\u00e9e-Scherrer V, Bu\u00e9e L, Delacourtes A (1994) Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer\u2019s disease. Neuroscience 62:1\u201313","journal-title":"Neuroscience"},{"key":"458_CR53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF03033772","volume":"7","author":"A Woodhouse","year":"2005","unstructured":"Woodhouse A, West AK, Chuckowree JA, Vickers JC, Dickson TC (2005) Does \u03b2-amyloid plaque formation cause structural injury to neuronal processes? Neurotox Res 7:5\u201315","journal-title":"Neurotox Res"},{"key":"458_CR54","unstructured":"Woodhouse A, Vickers JC, Adlard PA, Dickson TC (2007) Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging. Neurobiol Aging (in press). 18 October 2007 [Epub ahead of print]"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-008-0458-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-008-0458-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-008-0458-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T14:11:18Z","timestamp":1709388678000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-008-0458-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,18]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["458"],"URL":"https:\/\/doi.org\/10.1007\/s00401-008-0458-z","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,18]]}}}