{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:20:55Z","timestamp":1790889655883,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,5,5]],"date-time":"2009-05-05T00:00:00Z","timestamp":1241481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s00401-009-0540-1","type":"journal-article","created":{"date-parts":[[2009,5,4]],"date-time":"2009-05-04T21:22:06Z","timestamp":1241472126000},"page":"391-399","source":"Crossref","is-referenced-by-count":60,"title":["Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia"],"prefix":"10.1007","volume":"118","author":[{"given":"Robin L.","family":"Haynes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca D.","family":"Folkerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia L.","family":"Trachtenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Volpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah C.","family":"Kinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,5,5]]},"reference":[{"key":"540_CR1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1203\/01.pdr.0000246226.89215.a6","volume":"60","author":"R Askalan","year":"2006","unstructured":"Askalan R, Deveber G, Ho M, Ma J, Hawkins C (2006) Astrocytic-inducible nitric oxide synthase in the ischemic developing human brain. Pediatr Res 60:687\u2013692. doi: 10.1203\/01.pdr.0000246226.89215.a6","journal-title":"Pediatr Res"},{"key":"540_CR2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/ana.20530","volume":"58","author":"SA Back","year":"2005","unstructured":"Back SA, Luo NL, Mallinson RA et al (2005) Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes. Ann Neurol 58:108\u2013120. doi: 10.1002\/ana.20530","journal-title":"Ann Neurol"},{"key":"540_CR3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1750-3639.2007.00107.x","volume":"18","author":"SS Billiards","year":"2008","unstructured":"Billiards SS, Haynes RL, Folkerth RD et al (2008) Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia. Brain Pathol 18:153\u2013163. doi: 10.1111\/j.1750-3639.2007.00107.x","journal-title":"Brain Pathol"},{"key":"540_CR4","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1042\/BST0351119","volume":"35","author":"GC Brown","year":"2007","unstructured":"Brown GC (2007) Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase. Biochem Soc Trans 35:1119\u20131121. doi: 10.1042\/BST0351166","journal-title":"Biochem Soc Trans"},{"key":"540_CR5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0165-0173(00)00018-7","volume":"32","author":"A Contestabile","year":"2000","unstructured":"Contestabile A (2000) Roles of NMDA receptor activity and nitric oxide production in brain development. Brain Res Brain Res Rev 32:476\u2013509. doi: 10.1016\/S0165-0173(00)00018-7","journal-title":"Brain Res Brain Res Rev"},{"key":"540_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.112.1.1","volume":"112","author":"SJ Counsell","year":"2003","unstructured":"Counsell SJ, Allsop JM, Harrison MC et al (2003) Diffusion-weighted imaging of the brain in preterm infants with focal and diffuse white matter abnormality. Pediatrics 112:1\u20137. doi: 10.1542\/peds.112.1.1","journal-title":"Pediatrics"},{"key":"540_CR7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/mrdd.10005","volume":"8","author":"O Dammann","year":"2002","unstructured":"Dammann O, Kuban KC, Leviton A (2002) Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children born preterm. Ment Retard Dev Disabil Res Rev 8:46\u201350. doi: 10.1002\/mrdd.10005","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"540_CR8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1055\/s-2008-1052453","volume":"18","author":"LS Vries De","year":"1987","unstructured":"De Vries LS, Connell JA, Dubowitz LM, Oozeer RC, Dubowitz V, Pennock JM (1987) Neurological, electrophysiological and MRI abnormalities in infants with extensive cystic leukomalacia. Neuropediatrics 18:61\u201366. doi: 10.1055\/s-2008-1052453","journal-title":"Neuropediatrics"},{"key":"540_CR9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/0006-8993(94)90683-1","volume":"651","author":"M Endoh","year":"1994","unstructured":"Endoh M, Maiese K, Wagner J (1994) Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia. Brain Res 651:92\u2013100. doi: 10.1016\/0006-8993(94)90683-1","journal-title":"Brain Res"},{"key":"540_CR10","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2214\/ajr.152.3.583","volume":"152","author":"O Flodmark","year":"1989","unstructured":"Flodmark O, Lupton B, Li D et al (1989) MR imaging of periventricular leukomalacia in childhood. AJR Am J Roentgenol 152:583\u2013590","journal-title":"AJR Am J Roentgenol"},{"key":"540_CR11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1750-3639.2004.tb00063.x","volume":"14","author":"RD Folkerth","year":"2004","unstructured":"Folkerth RD, Keefe RJ, Haynes RL, Trachtenberg FL, Volpe JJ, Kinney HC (2004) Interferon-gamma expression in periventricular leukomalacia in the human brain. Brain Pathol 14:265\u2013274","journal-title":"Brain Pathol"},{"key":"540_CR12","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/NEN.0b013e31817e5c5e","volume":"67","author":"RD Folkerth","year":"2008","unstructured":"Folkerth RD, Trachtenberg FL, Haynes RL (2008) Oxidative injury in the cerebral cortex and subplate neurons in periventricular leukomalacia. J Neuropathol Exp Neurol 67:677\u2013686. doi: 10.1097\/NEN.0b013e31817e5c5e","journal-title":"J Neuropathol Exp Neurol"},{"key":"540_CR13","first-page":"3","volume":"8","author":"LF Goncalves","year":"2002","unstructured":"Goncalves LF, Chaiworapongsa T, Romero R (2002) Intrauterine infection and prematurity. MRDD Res Rev 8:3\u201313","journal-title":"MRDD Res Rev"},{"key":"540_CR14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/jnen\/62.5.441","volume":"62","author":"RL Haynes","year":"2003","unstructured":"Haynes RL, Folkerth RD, Keefe RJ et al (2003) Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia. J Neuropathol Exp Neurol 62:441\u2013450","journal-title":"J Neuropathol Exp Neurol"},{"key":"540_CR15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/cne.20453","volume":"484","author":"RL Haynes","year":"2005","unstructured":"Haynes RL, Borenstein NS, Desilva TM et al (2005) Axonal development in the cerebral white matter of the human fetus and infant. J Comp Neurol 484:156\u2013167. doi: 10.1002\/cne.20453","journal-title":"J Comp Neurol"},{"key":"540_CR16","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1203\/PDR.0b013e31816c825c","volume":"63","author":"RL Haynes","year":"2008","unstructured":"Haynes RL, Billiards SS, Borenstein NS, Volpe JJ, Kinney HC (2008) Diffuse axonal injury in periventricular leukomalacia as determined by apoptotic marker fractin. Pediatr Res 63:656\u2013661. doi: 10.1203\/PDR.0b013e31816c825c","journal-title":"Pediatr Res"},{"key":"540_CR17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/(SICI)1097-4547(19970215)47:4<427::AID-JNR8>3.0.CO;2-G","volume":"47","author":"S Hindley","year":"1997","unstructured":"Hindley S, Juurlink BH, Gysbers JW, Middlemiss PJ, Herman MA, Rathbone MP (1997) Nitric oxide donors enhance neurotrophin-induced neurite outgrowth through a cGMP-dependent mechanism. J Neurosci Res 47:427\u2013439. doi: 10.1002\/(SICI)1097-4547(19970215)47:4<427::AID-JNR8>3.0.CO;2-G","journal-title":"J Neurosci Res"},{"key":"540_CR18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1447-0756.2000.tb01316.x","volume":"26","author":"S Ikeno","year":"2000","unstructured":"Ikeno S, Nagata N, Yoshida S, Takahashi H, Kigawa J, Terakawa N (2000) Immature brain injury via peroxynitrite production induced by inducible nitric oxide synthase after hypoxia-ischemia in rats. J Obstet Gynaecol Res 26:227\u2013234","journal-title":"J Obstet Gynaecol Res"},{"key":"540_CR19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1067\/S0022-3476(03)00357-3","volume":"143","author":"TE Inder","year":"2003","unstructured":"Inder TE, Wells SJ, Mogridge NB, Spencer C, Volpe JJ (2003) Defining the nature of the cerebral abnormalities in the premature infant: a qualitative magnetic resonance imaging study. J Pediatr 143:171\u2013179. doi: 10.1067\/S0022-3476(03)00357-3","journal-title":"J Pediatr"},{"key":"540_CR20","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1212\/WNL.56.10.1278","volume":"56","author":"H Kadhim","year":"2001","unstructured":"Kadhim H, Tabarki B, Verellen G, De Prez C, Rona A-M, Sebire G (2001) Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. Neurology 56:1278\u20131284","journal-title":"Neurology"},{"key":"540_CR21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00401-002-0633-6","volume":"105","author":"H Kadhim","year":"2003","unstructured":"Kadhim H, Tabarki B, De Prez C, Sebire G (2003) Cytokine immunoreactivity in cortical and subcortical neurons in periventricular leukomalacia: are cytokines implicated in neuronal dysfunction in cerebral palsy? Acta Neuropathol 105:209\u2013216","journal-title":"Acta Neuropathol"},{"key":"540_CR22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1212\/01.wnl.0000224754.63593.c4","volume":"67","author":"H Kadhim","year":"2006","unstructured":"Kadhim H, Khalifa M, Deltenre P, Casimir G, Sebire G (2006) Molecular mechanisms of cell death in periventricular leukomalacia. Neurology 67:293\u2013299. doi: 10.1212\/01.wnl.0000224754.63593.c4","journal-title":"Neurology"},{"key":"540_CR23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1440-1789.2003.00483.x","volume":"23","author":"O Katsuse","year":"2003","unstructured":"Katsuse O, Iseki E, Kosaka K (2003) Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with dementia with Lewy bodies. Neuropathology 23:9\u201315. doi: 10.1046\/j.1440-1789.2003.00483.x","journal-title":"Neuropathology"},{"key":"540_CR24","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/j.1471-4159.2006.03964.x","volume":"98","author":"C Kaur","year":"2006","unstructured":"Kaur C, Sivakumar V, Ang LS, Sundaresan A (2006) Hypoxic damage to the periventricular white matter in neonatal brain: role of vascular endothelial growth factor, nitric oxide and excitotoxicity. J Neurochem 98:1200\u20131216. doi: 10.1111\/j.1471-4159.2006.03964.x","journal-title":"J Neurochem"},{"key":"540_CR25","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1124\/mol.106.033449","volume":"71","author":"R Korhonen","year":"2007","unstructured":"Korhonen R, Linker K, Pautz A, Forstermann U, Moilanen E, Kleinert H (2007) Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the Jun N-terminal kinase. Mol Pharmacol 71:1427\u20131434. doi: 10.1124\/mol.106.033449","journal-title":"Mol Pharmacol"},{"key":"540_CR26","doi-asserted-by":"crossref","first-page":"9936","DOI":"10.1073\/pnas.0502552102","volume":"102","author":"J Li","year":"2005","unstructured":"Li J, Baud O, Vartanian T, Volpe JJ, Rosenberg PA (2005) Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. Proc Natl Acad Sci USA 102:9936\u20139941. doi: 10.1073\/pnas.0502552102","journal-title":"Proc Natl Acad Sci USA"},{"key":"540_CR27","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/S0002-9440(10)64677-9","volume":"158","author":"JS Liu","year":"2001","unstructured":"Liu JS, Zhao ML, Brosnan CF, Lee SC (2001) Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am J Pathol 158:2057\u20132066","journal-title":"Am J Pathol"},{"key":"540_CR28","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1542\/peds.107.4.719","volume":"107","author":"EF Maalouf","year":"2001","unstructured":"Maalouf EF, Duggan PJ, Counsell S et al (2001) Comparison of findings on cranial ultrasound and magnetic resonance imaging in preterm infants. Pediatrics 107:719\u2013727. doi: 10.1542\/peds.107.4.719","journal-title":"Pediatrics"},{"key":"540_CR29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cne.903170308","volume":"317","author":"CM Muller","year":"1992","unstructured":"Muller CM (1992) Astrocytes in cat visual cortex studied by GFAP and S-100 immunocytochemistry during postnatal development. J Comp Neurol 317:309\u2013323. doi: 10.1002\/cne.903170308","journal-title":"J Comp Neurol"},{"key":"540_CR30","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1084\/jem.183.5.2293","volume":"183","author":"S Nicholson","year":"1996","unstructured":"Nicholson S, Bonecini-Almeida Mda G, Lapa e Silva JR et al (1996) Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis. J Exp Med 183:2293\u20132302. doi: 10.1084\/jem.183.5.2293","journal-title":"J Exp Med"},{"key":"540_CR31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2176\/nmc.41.63","volume":"41","author":"M Niwa","year":"2001","unstructured":"Niwa M, Inao S, Takayasu M et al (2001) Time course of expression of three nitric oxide synthase isoforms after transient middle cerebral artery occlusion in rats. Neurol Med Chir (Tokyo) 41:63\u201373. doi: 10.2176\/nmc.41.63","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"540_CR32","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1128\/CDLI.5.4.438-445.1998","volume":"5","author":"EL Oleszak","year":"1998","unstructured":"Oleszak EL, Zaczynska E, Bhattacharjee M, Butunoi C, Legido A, Katsetos CD (1998) Inducible nitric oxide synthase and nitrotyrosine are found in monocytes\/macrophages and\/or astrocytes in acute, but not in chronic, multiple sclerosis. Clin Diagn Lab Immunol 5:438\u2013445","journal-title":"Clin Diagn Lab Immunol"},{"key":"540_CR33","doi-asserted-by":"crossref","first-page":"32294","DOI":"10.1074\/jbc.M603915200","volume":"281","author":"A Pautz","year":"2006","unstructured":"Pautz A, Linker K, Hubrich T, Korhonen R, Altenhofer S, Kleinert H (2006) The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression. J Biol Chem 281:32294\u201332302. doi: 10.1074\/jbc.M603915200","journal-title":"J Biol Chem"},{"key":"540_CR34","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00401-007-0295-5","volume":"114","author":"CR Pierson","year":"2007","unstructured":"Pierson CR, Folkerth RD, Billiards SS et al (2007) Gray matter injury associated with periventricular leukomalacia in the premature infant. Acta Neuropathol 114:619\u2013631. doi: 10.1007\/s00401-007-0295-5","journal-title":"Acta Neuropathol"},{"key":"540_CR35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/(SICI)1097-4695(199604)29:4<415::AID-NEU1>3.0.CO;2-B","volume":"29","author":"RC Renteria","year":"1996","unstructured":"Renteria RC, Constantine-Paton M (1996) Exogenous nitric oxide causes collapse of retinal ganglion cell axonal growth cones in vitro. J Neurobiol 29:415\u2013428. doi: 10.1002\/(SICI)1097-4695(199604)29:4<415::AID-NEU1>3.0.CO;2-B","journal-title":"J Neurobiol"},{"key":"540_CR36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0928-4257(02)00005-0","volume":"96","author":"N Rochefort","year":"2002","unstructured":"Rochefort N, Quenech\u2019du N, Watroba L, Mallat M, Giaume C, Milleret C (2002) Microglia and astrocytes may participate in the shaping of visual callosal projections during postnatal development. J Physiol (Paris) 96:183\u2013192. doi: 10.1016\/S0928-4257(02)00005-0","journal-title":"J Physiol (Paris)"},{"key":"540_CR37","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.devbrainres.2005.09.011","volume":"160","author":"N Rochefort","year":"2005","unstructured":"Rochefort N, Quenech\u2019du N, Ezan P, Giaume C, Milleret C (2005) Postnatal development of GFAP, connexin43 and connexin30 in cat visual cortex. Brain Res Dev Brain Res 160:252\u2013264. doi: 10.1016\/j.devbrainres.2005.09.011","journal-title":"Brain Res Dev Brain Res"},{"key":"540_CR38","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jpeds.2008.02.033","volume":"153","author":"DK Shah","year":"2008","unstructured":"Shah DK, Doyle LW, Anderson PJ et al (2008) Adverse neurodevelopment in preterm infants with postnatal sepsis or necrotizing enterocolitis is mediated by white matter abnormalities on magnetic resonance imaging at term. J Pediatr 153:170\u2013175. doi: 10.1016\/j.jpeds.2008.02.033","journal-title":"J Pediatr"},{"key":"540_CR39","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF00315011","volume":"90","author":"J Towfighi","year":"1995","unstructured":"Towfighi J, Zec N, Yager J, Housman C, Vannucci RC (1995) Temporal evolution of neuropathologic changes in an immature rat model of cerebral hypoxia: a light microscopic study. Acta Neuropathol 90:375\u2013386. doi: 10.1007\/BF00315011","journal-title":"Acta Neuropathol"},{"key":"540_CR40","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/1097-4695(20010215)46:3<206::AID-NEU1003>3.0.CO;2-S","volume":"46","author":"S Wagenen Van","year":"2001","unstructured":"Van Wagenen S, Rehder V (2001) Regulation of neuronal growth cone filopodia by nitric oxide depends on soluble guanylyl cyclase. J Neurobiol 46:206\u2013219. doi: 10.1002\/1097-4695(20010215)46:3<206::AID-NEU1003>3.0.CO;2-S","journal-title":"J Neurobiol"},{"key":"540_CR41","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1203\/00006450-200111000-00003","volume":"50","author":"JJ Volpe","year":"2001","unstructured":"Volpe JJ (2001) Neurobiology of periventricular leukomalacia in the premature infant. Pediatr Res 50:553\u2013562. doi: 10.1203\/00006450-200111000-00003","journal-title":"Pediatr Res"},{"key":"540_CR42","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jpeds.2008.04.057","volume":"153","author":"JJ Volpe","year":"2008","unstructured":"Volpe JJ (2008) Postnatal sepsis, necrotizing entercolitis, and the critical role of systemic inflammation in white matter injury in premature infants. J Pediatr 153:160\u2013163. doi: 10.1016\/j.jpeds.2008.04.057","journal-title":"J Pediatr"},{"key":"540_CR43","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/niox.2001.0348","volume":"5","author":"MX Wang","year":"2001","unstructured":"Wang MX, Murrell DF, Szabo C, Warren RF, Sarris M, Murrell GA (2001) Nitric oxide in skeletal muscle: inhibition of nitric oxide synthase inhibits walking speed in rats. Nitric Oxide 5:219\u2013232. doi: 10.1006\/niox.2001.0348","journal-title":"Nitric Oxide"},{"key":"540_CR44","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0006-8993(01)02872-4","volume":"920","author":"A Wong","year":"2001","unstructured":"Wong A, Luth HJ, Deuther-Conrad W et al (2001) Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer\u2019s disease. Brain Res 920:32\u201340. doi: 10.1016\/S0006-8993(01)02872-4","journal-title":"Brain Res"},{"key":"540_CR45","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3940(99)00967-2","volume":"279","author":"Y You","year":"2000","unstructured":"You Y, Kaur C (2000) Expression of induced nitric oxide synthase in amoeboid microglia in postnatal rats following an exposure to hypoxia. Neurosci Lett 279:101\u2013104. doi: 10.1016\/S0304-3940(99)00967-2","journal-title":"Neurosci Lett"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-009-0540-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-009-0540-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-009-0540-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T22:41:22Z","timestamp":1589755282000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-009-0540-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,5]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["540"],"URL":"https:\/\/doi.org\/10.1007\/s00401-009-0540-1","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,5]]}}}