{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:10:01Z","timestamp":1769094601592,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,12,27]],"date-time":"2009-12-27T00:00:00Z","timestamp":1261872000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1007\/s00401-009-0629-6","type":"journal-article","created":{"date-parts":[[2009,12,26]],"date-time":"2009-12-26T06:46:56Z","timestamp":1261810016000},"page":"715-722","source":"Crossref","is-referenced-by-count":39,"title":["\u03b1-Synuclein pathology in the spinal cord autonomic nuclei associates with \u03b1-synuclein pathology in the brain: a population-based Vantaa 85+ study"],"prefix":"10.1007","volume":"119","author":[{"given":"Minna","family":"Oinas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Paetau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa","family":"Myllykangas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma-Leena","family":"Notkola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Kalimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomo","family":"Polvikoski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,12,27]]},"reference":[{"key":"629_CR1","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1212\/01.wnl.0000277459.83543.99","volume":"69","author":"F Barkhof","year":"2007","unstructured":"Barkhof F, Polvikoski TM, van Straaten EC, Kalaria RN, Sulkava R, Aronen HJ, Niinisto L, Rastas S, Oinas M, Scheltens P, Erkinjuntti T (2007) The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old. Neurology 69:1521\u20131527","journal-title":"Neurology"},{"key":"629_CR2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00401-009-0538-8","volume":"117","author":"TG Beach","year":"2009","unstructured":"Beach TG, Adler CH, Lue L, Sue LI, Bachalakuri J, Henry-Watson J, Sasse J, Boyer S, Shirohi S, Brooks R, Eschbacher J, White CL III, Akiyama H, Caviness J, Shill HA, Connor DJ, Sabbagh MN, Walker DG, Arizona Parkinson\u2019s Disease Consortium (2009) Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol (Berl) 117:613\u2013634","journal-title":"Acta Neuropathol (Berl)"},{"key":"629_CR3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00401-008-0409-8","volume":"116","author":"TG Beach","year":"2008","unstructured":"Beach TG, White CL, Hamilton RL, Duda JE, Iwatsubo T, Dickson DW, Leverenz JB, Roncaroli F, Buttini M, Hladik CL, Sue LI, Noorigian JV, Adler CH (2008) Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol (Berl) 116:277\u2013288","journal-title":"Acta Neuropathol (Berl)"},{"key":"629_CR4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1365-2990.2006.00727.x","volume":"32","author":"A Bloch","year":"2006","unstructured":"Bloch A, Probst A, Bissig H, Adams H, Tolnay M (2006) Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol Appl Neurobiol 32:284\u2013295","journal-title":"Neuropathol Appl Neurobiol"},{"key":"629_CR5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82:239\u2013259","journal-title":"Acta Neuropathol (Berl)"},{"key":"629_CR6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E (2003) Staging of brain pathology related to sporadic Parkinson\u2019s disease. Neurobiol Aging 24:197\u2013211","journal-title":"Neurobiol Aging"},{"key":"629_CR7","doi-asserted-by":"crossref","unstructured":"Braak H, Muller CM, Rub U, Ackermann H, Bratzke H, de Vos RA, Del Tredici K (2006) Pathology associated with sporadic Parkinson\u2019s disease\u2014where does it end? J Neural Transm Suppl 70:89\u201397","DOI":"10.1007\/978-3-211-45295-0_15"},{"key":"629_CR8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/jnen\/61.5.413","volume":"61","author":"K Del Tredici","year":"2002","unstructured":"Del Tredici K, Rub U, De Vos RA, Bohl JR, Braak H (2002) Where does parkinson disease pathology begin in the brain? J Neuropathol Exp Neurol 61:413\u2013426","journal-title":"J Neuropathol Exp Neurol"},{"key":"629_CR9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00401-008-0344-8","volume":"115","author":"G Halliday","year":"2008","unstructured":"Halliday G, Hely M, Reid W, Morris J (2008) The progression of pathology in longitudinally followed patients with Parkinson\u2019s disease. Acta Neuropathol (Berl) 115:409\u2013415","journal-title":"Acta Neuropathol (Berl)"},{"key":"629_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-008-0406-y","volume":"116","author":"KA Jellinger","year":"2008","unstructured":"Jellinger KA (2008) A critical reappraisal of current staging of Lewy-related pathology in human brain. Acta Neuropathol (Berl) 116:1\u201316","journal-title":"Acta Neuropathol (Berl)"},{"key":"629_CR11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-2004-817719","volume":"23","author":"H Kaufmann","year":"2003","unstructured":"Kaufmann H, Biaggioni I (2003) Autonomic failure in neurodegenerative disorders. Semin Neurol 23:351\u2013363","journal-title":"Semin Neurol"},{"key":"629_CR12","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1212\/WNL.56.7.980","volume":"56","author":"H Kaufmann","year":"2001","unstructured":"Kaufmann H, Hague K, Perl D (2001) Accumulation of alpha-synuclein in autonomic nerves in pure autonomic failure. Neurology 56:980\u2013981","journal-title":"Neurology"},{"key":"629_CR13","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1212\/01.WNL.0000138500.73671.DC","volume":"63","author":"H Kaufmann","year":"2004","unstructured":"Kaufmann H, Nahm K, Purohit D, Wolfe D (2004) Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies. Neurology 63:1093\u20131095","journal-title":"Neurology"},{"key":"629_CR14","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1212\/01.wnl.0000204179.88955.fa","volume":"66","author":"KJ Klos","year":"2006","unstructured":"Klos KJ, Ahlskog JE, Josephs KA, Apaydin H, Parisi JE, Boeve BF, DeLucia MW, Dickson DW (2006) Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals. Neurology 66:1100\u20131102","journal-title":"Neurology"},{"key":"629_CR15","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","volume":"47","author":"IG McKeith","year":"1996","unstructured":"McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen EN, Ballard C, de Vos RA, Wilcock GK, Jellinger KA, Perry RH (1996) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47:1113\u20131124","journal-title":"Neurology"},{"key":"629_CR16","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","volume":"65","author":"IGFM McKeith","year":"2005","unstructured":"McKeith IGFM, Dickson DW, Lowe JDM, Emre M, O\u2019Brien JTDM, Feldman HCM, Cummings J, Duda JE, Lippa C, Perry EKDS, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJFRCP, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier SFRCPC, Goetz CG, GomezTortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RNFRCP, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VMY, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, MukaetovaLadinska EB, Pasquier F, Perry RHDS, Schulz JB, Trojanowski JQ, Yamada M, for the Consortium on DLB (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology 65:1863\u20131872","journal-title":"Neurology"},{"key":"629_CR17","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1212\/01.wnl.0000264429.59379.d9","volume":"68","author":"A Minguez-Castellanos","year":"2007","unstructured":"Minguez-Castellanos A, Chamorro CE, Escamilla-Sevilla F, Ortega-Moreno A, Rebollo AC, Gomez-Rio M, Concha A, Munoz DG (2007) Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders? A cohort study. Neurology 68:2012\u20132018","journal-title":"Neurology"},{"key":"629_CR18","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3233\/JAD-2009-1169","volume":"18","author":"M Oinas","year":"2009","unstructured":"Oinas M, Polvikoski T, Sulkava R, Myllykangas L, Juva K, Notkola I-L, Rastas S, Niinist\u00f6 L, Kalimo H, Paetau A (2009) Neuropathologic findings of Dementia with Lewy bodies (DLB) in a population-based Vantaa 85+ study. J Alzheimers Dis 18:677\u2013689","journal-title":"J Alzheimers Dis"},{"key":"629_CR19","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1600-0463.2007.apm_521.x","volume":"115","author":"M Oinas","year":"2007","unstructured":"Oinas M, Sulkava R, Polvikoski T, Kalimo H, Paetau A (2007) Reappraisal of a consecutive autopsy series of patients with primary degenerative dementia: Lewy-related pathology. APMIS 115:820\u2013827","journal-title":"APMIS"},{"key":"629_CR20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00401-008-0346-6","volume":"115","author":"L Parkkinen","year":"2008","unstructured":"Parkkinen L, Pirttila T, Alafuzoff I (2008) Applicability of current staging\/categorization of alpha-synuclein pathology and their clinical relevance. Acta Neuropathol (Berl) 115:399\u2013407","journal-title":"Acta Neuropathol (Berl)"},{"key":"629_CR21","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1136\/jnnp.2005.083550","volume":"77","author":"T Polvikoski","year":"2006","unstructured":"Polvikoski T, Kalaria RN, Perry R, Miller V, Kenny RA (2006) Carotid sinus hypersensitivity associated with focal alpha-synucleinopathy of the autonomic nervous system. J Neurol Neurosurg Psychiatry 77:1064\u20131066","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"629_CR22","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1212\/WNL.56.12.1690","volume":"56","author":"T Polvikoski","year":"2001","unstructured":"Polvikoski T, Sulkava R, Myllykangas L, Notkola IL, Niinisto L, Verkkoniemi A, Kainulainen K, Kontula K, Perez-Tur J, Hardy J, Haltia M (2001) Prevalence of Alzheimer\u2019s disease in very elderly people: a prospective neuropathological study. Neurology 56:1690\u20131696","journal-title":"Neurology"},{"key":"629_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1468-1331.2008.02057.x","volume":"15","author":"A Probst","year":"2008","unstructured":"Probst A, Bloch A, Tolnay M (2008) New insights into the pathology of Parkinson\u2019s disease: does the peripheral autonomic system become central? Eur J Neurol 15:1\u20134","journal-title":"Eur J Neurol"},{"key":"629_CR24","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","volume":"95","author":"MG Spillantini","year":"1998","unstructured":"Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson\u2019s disease and dementia with lewy bodies. Proc Natl Acad Sci USA 95:6469\u20136473","journal-title":"Proc Natl Acad Sci USA"},{"key":"629_CR25","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000113469","volume":"38","author":"K Wakabayashi","year":"1997","unstructured":"Wakabayashi K, Takahashi H (1997) Neuropathology of autonomic nervous system in Parkinson\u2019s disease. Eur Neurol 38:2\u20137","journal-title":"Eur Neurol"},{"key":"629_CR26","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1212\/01.wnl.0000306697.48738.b6","volume":"70","author":"Zaccai J Brayne","year":"2008","unstructured":"Zaccai J, Brayne C, McKeith I, Matthews F, Ince PG, MRC Cognitive Function, Ageing Neuropathology Study (2008) Patterns and stages of alpha-synucleinopathy: relevance in a population-based cohort. Neurology 70:1042\u20131048","journal-title":"Neurology"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-009-0629-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-009-0629-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-009-0629-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T17:24:06Z","timestamp":1559064246000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-009-0629-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,27]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["629"],"URL":"https:\/\/doi.org\/10.1007\/s00401-009-0629-6","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,27]]}}}