{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:28:38Z","timestamp":1791350918950,"version":"4.3.1"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,3,14]],"date-time":"2010-03-14T00:00:00Z","timestamp":1268524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1007\/s00401-010-0665-2","type":"journal-article","created":{"date-parts":[[2010,3,13]],"date-time":"2010-03-13T03:39:25Z","timestamp":1268451565000},"page":"703-713","source":"Crossref","is-referenced-by-count":266,"title":["Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson\u2019s disease"],"prefix":"10.1007","volume":"119","author":[{"given":"Kelly","family":"Del Tredici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"Hawkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estifanos","family":"Ghebremedhin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Braak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,14]]},"reference":[{"key":"665_CR1","first-page":"213","volume":"22","author":"H Bagheri","year":"1999","unstructured":"Bagheri H, Damase-Michel C, Lapeyre-Mestre M et al (1999) A study of salivary secretion in Parkinson\u2019s disease. Clin Neuropharmacol 22:213\u2013215","journal-title":"Clin Neuropharmacol"},{"key":"665_CR2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/01.wco.0000183114.76056.0e","volume":"18","author":"R Baltadzhieva","year":"2005","unstructured":"Baltadzhieva R, Gurevich T, Korczyn AD (2005) Autonomic impairment in amyotrophic lateral sclerosis. Curr Opin Neurol 18:487\u2013493","journal-title":"Curr Opin Neurol"},{"key":"665_CR3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/PL00009546","volume":"13","author":"G Bassotti","year":"1998","unstructured":"Bassotti G, Germani U, Pagliaricci S et al (1998) Esophageal manometric abnormalities in Parkinson\u2019s disease. Dysphagia 13:28\u201341","journal-title":"Dysphagia"},{"key":"665_CR4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1001\/archneur.1973.00490280086013","volume":"29","author":"MC Bateson","year":"1973","unstructured":"Bateson MC, Gibberd FB, Wilson RSE (1973) Salivary symptoms in Parkinson\u2019s disease. Arch Neurol 29:274\u2013275","journal-title":"Arch Neurol"},{"key":"665_CR5","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/B978-012547626-3\/50016-8","volume-title":"The human nervous system","author":"WW Blessing","year":"2004","unstructured":"Blessing WW (2004) Lower brain stem regulation of visceral, cardiovascular, and respiratory function. In: Paxinos G, Mai JK (eds) The human nervous system, 2nd edn. Elsevier, London, pp 464\u2013478","edition":"2"},{"key":"665_CR6","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1365-2990.2006.00727.x","volume":"32","author":"A Bloch","year":"2006","unstructured":"Bloch A, Probst A, Bissig H, Adams H, Tolnay M (2006) Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neurobiol Appl Neurol 32:284\u2013295","journal-title":"Neurobiol Appl Neurol"},{"key":"665_CR7","first-page":"89","volume":"39","author":"HW Boyce","year":"2005","unstructured":"Boyce HW, Bakheet MR (2005) Sialorrhea: a review of a vexing, often unrecognized sign of oropharyngeal and esophageal disease. J Clin Gastroenterol 39:89\u201397","journal-title":"J Clin Gastroenterol"},{"key":"665_CR8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82:239\u2013259","journal-title":"Acta Neuropathol"},{"key":"665_CR9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici K, R\u00fcb U et al (2003) Staging of brain pathology related to sporadic Parkinson\u2019s disease. Neurobiol Aging 24:197\u2013211","journal-title":"Neurobiol Aging"},{"key":"665_CR10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2005.11.012","volume":"39","author":"H Braak","year":"2006","unstructured":"Braak H, de Vos RAI, Bohl J, Del Tredici K (2006) Gastric \u03b1-synuclein immunoreactive inclusions in Meissner\u2019s and Auerbach\u2019s plexuses in cases staged for Parkinson\u2019s disease-related brain pathology. Neurosci Lett 39:67\u201372","journal-title":"Neurosci Lett"},{"key":"665_CR11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00401-007-0193-x","volume":"113","author":"H Braak","year":"2007","unstructured":"Braak H, Sastre M, Bohl JRE, de Vos RAI, Del Tredici K (2007) Parkinson\u2019s disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons. Acta Neuropathol 113:421\u2013429","journal-title":"Acta Neuropathol"},{"key":"665_CR12","doi-asserted-by":"crossref","first-page":"i70","DOI":"10.1093\/chemse\/bjh118","volume":"30","author":"RM Bradley","year":"2005","unstructured":"Bradley RM, Fukami H, Suwabe T (2005) Neurobiology of the gustatory\u2013salivary reflex. Chem Senses 30:i70\u2013i71","journal-title":"Chem Senses"},{"key":"665_CR13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00004836-199407000-00004","volume":"19","author":"KG Byrne","year":"1994","unstructured":"Byrne KG, Pfeiffer RM, Quigley EMM (1994) Gastrointestinal dysfunction in Parkinson\u2019s disease: a report of clinical experience at a single center. J Clin Gastroenterol 19:11\u201316","journal-title":"J Clin Gastroenterol"},{"key":"665_CR14","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/mds.22051","volume":"23","author":"MG Cers\u00f3simo","year":"2008","unstructured":"Cers\u00f3simo MG, Benarroch EE (2008) Neural control of the gastrointestinal tract: implications for Parkinson disease. Mov Disord 23:1065\u20131073","journal-title":"Mov Disord"},{"key":"665_CR15","first-page":"34","volume":"459","author":"AH Chatoo","year":"1953","unstructured":"Chatoo AH, Lee VM, Linden RA (1953) Evidence for synergism between the masticatory and gustatory parotid salivary reflexes in humans. J Physiol 459:34","journal-title":"J Physiol"},{"key":"665_CR16","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1002\/mds.21646","volume":"22","author":"KL Chou","year":"2007","unstructured":"Chou KL, Evatt M, Hinson V, Kompoliti K (2007) Sialorrhea in Parkinson\u2019s disease: a review. Mov Disord 22:2306\u20132313","journal-title":"Mov Disord"},{"key":"665_CR17","first-page":"1061","volume-title":"Physiology of the gastrointestinal tract","author":"DI Cook","year":"1994","unstructured":"Cook DI, van Lennep EW, Roberts ML, Young JA (1994) Secretion by the major salivary glands. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 3rd edn. Raven, New York, pp 1061\u20131117","edition":"3"},{"key":"665_CR18","first-page":"470","volume-title":"Basic pathology","author":"JM Crawford","year":"1997","unstructured":"Crawford JM (1997) The oral cavity and gastrointestinal tract. In: Kumar V, Cotran RS, Robbins SL (eds) Basic pathology. W.B. Saunders, Philadelphia, pp 470\u2013515"},{"key":"665_CR19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/jnen\/61.5.413","volume":"61","author":"K Del Tredici","year":"2002","unstructured":"Del Tredici K, R\u00fcb U, de Vos RAI, Bohl JRE, Braak H (2002) Where does Parkinson pathology begin in the brain? J Neuropathol Exp Neurol 61:413\u2013426","journal-title":"J Neuropathol Exp Neurol"},{"key":"665_CR20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/jnnp.23.4.283","volume":"23","author":"WA Hartog Jager den","year":"1960","unstructured":"den Hartog Jager WA, Bethlem J (1960) The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans. J Neurol Neurosurg Psychiatry 23:283\u2013290","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"665_CR21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00401-008-0345-7","volume":"115","author":"DW Dickson","year":"2008","unstructured":"Dickson DW, Fujishiro H, DelleDonne A et al (2008) Evidence that incidental Lewy body disease is pre-symptomatic Parkinson\u2019s disease. Acta Neuropathol 115:437\u2013444","journal-title":"Acta Neuropathol"},{"key":"665_CR22","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S1474-4422(09)70238-8","volume":"8","author":"DW Dickson","year":"2009","unstructured":"Dickson DW, Braak H, Duda JE et al (2009) Diagnostic criteria for the neuropathological assessment of Parkinson disease. Lancet Neurol 8:1150\u20131157","journal-title":"Lancet Neurol"},{"key":"665_CR23","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1212\/WNL.38.8.1237","volume":"38","author":"RL Doty","year":"1988","unstructured":"Doty RL, Deems D, Stellar S (1988) Olfactory dysfunction in Parkinson\u2019s disease: a general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 38:1237\u20131244","journal-title":"Neurology"},{"key":"665_CR24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1136\/jnnp.55.2.138","volume":"55","author":"RL Doty","year":"1992","unstructured":"Doty RL, Stern MB, Pfeiffer C, Gollomp SM, Hurtig HI (1992) Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 55:138\u2013142","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"665_CR25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/mds.870060211","volume":"6","author":"LL Edwards","year":"1991","unstructured":"Edwards LL, Pfeiffer RF, Quigley EMM, Hofman R, Balluff M (1991) Gastrointestinal symptoms in Parkinson\u2019s disease. Mov Disord 6:151\u2013156","journal-title":"Mov Disord"},{"key":"665_CR26","first-page":"15","volume":"1","author":"LL Edwards","year":"1994","unstructured":"Edwards LL, Quigley EM, Harned RK, Hofmann R, Pfeiffer RF (1994) Characterization of swallowing and defecation in Parkinson\u2019s disease. Am J Gastroenterol 1:15\u201325","journal-title":"Am J Gastroenterol"},{"key":"665_CR27","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/00220345870660022101","volume":"66","author":"N Emmelin","year":"1987","unstructured":"Emmelin N (1987) Nerve interactions in salivary glands. J Dent Res 66:509\u2013517","journal-title":"J Dent Res"},{"key":"665_CR28","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/mds.22260","volume":"24","author":"ML Evatt","year":"2009","unstructured":"Evatt ML, Chaudhuri KR, Chou KL et al (2009) Dysautonomia rating scales in Parkinson\u2019s disease: sialorrhea, dysphagia, and constipation\u2014critique and recommendations by Movement Disorders Task Force on Rating Scales for Parkinson\u2019s disease. Mov Disord 24:635\u2013646","journal-title":"Mov Disord"},{"key":"665_CR29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00688674","volume":"34","author":"LS Forno","year":"1976","unstructured":"Forno LS, Norville RL (1976) Ultrastructure of Lewy bodies in the stellate ganglion. Acta Neuropathol 34:183\u2013197","journal-title":"Acta Neuropathol"},{"key":"665_CR30","doi-asserted-by":"crossref","unstructured":"Frigerio R, Fujishiro H, Ahn TB et al (2009) Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies? Neurobiol Aging. doi: 10.1016\/j.neurobiolaging.2009.05.019","DOI":"10.1016\/j.neurobiolaging.2009.05.019"},{"key":"665_CR31","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/mds.21989","volume":"23","author":"H Fujishiro","year":"2008","unstructured":"Fujishiro H, Frigerio R, Burnett M et al (2008) Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson\u2019s disease. Mov Disord 23:1085\u20131092","journal-title":"Mov Disord"},{"key":"665_CR32","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/nen.0b013e3180517454","volume":"66","author":"Y Fumimura","year":"2007","unstructured":"Fumimura Y, Ikemura M, Saito Y et al (2007) Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease. J Neuropathol Exp Neurol 66:354\u2013362","journal-title":"J Neuropathol Exp Neurol"},{"key":"665_CR33","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0003-9969(67)90179-3","volume":"12","author":"JR Garrett","year":"1967","unstructured":"Garrett JR (1967) The innervation of normal human submandibular and parotid salivary glands. Arch Oral Biol 12:1417","journal-title":"Arch Oral Biol"},{"key":"665_CR34","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/00220345870660020201","volume":"66","author":"JR Garrett","year":"1987","unstructured":"Garrett JR (1987) The proper role of nerves in salivatory secretion\u2014a review. J Dent Res 66:387\u2013397","journal-title":"J Dent Res"},{"key":"665_CR35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/01.tp.0000296060.39823.a4","volume":"85","author":"G Gerling","year":"2008","unstructured":"Gerling G, Garrett JR, Paterson KL et al (2008) Innervation and secretory function of transplanted human submandibular salivary glands. Transplantation 85:135\u2013140","journal-title":"Transplantation"},{"key":"665_CR36","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00401-009-0596-y","volume":"118","author":"E Ghebremedhin","year":"2009","unstructured":"Ghebremedhin E, Del Tredici K, Langston JW, Braak H (2009) Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson\u2019s disease: an anatomical study. Acta Neuropathol 118:777\u2013784","journal-title":"Acta Neuropathol"},{"key":"665_CR37","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1007\/s00415-002-0820-3","volume":"249","author":"R Giess","year":"2002","unstructured":"Giess R, Werner E, Beck M et al (2002) Impaired salivary gland function reveals autonomic dysfunction in amyotrophic lateral sclerosis. J Neurol 249:1246\u20131249","journal-title":"J Neurol"},{"key":"665_CR38","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","volume":"71","author":"S Gilman","year":"2008","unstructured":"Gilman S, Wenning GK, Low PA et al (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71:670\u2013676","journal-title":"Neurology"},{"key":"665_CR39","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/mds.20213","volume":"19","author":"CG Goetz","year":"2004","unstructured":"Goetz CG, Power W, Rascol O et al (2004) Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov Disord 19:1020\u20131028","journal-title":"Mov Disord"},{"key":"665_CR40","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1212\/WNL.58.8.1247","volume":"58","author":"DS Goldstein","year":"2002","unstructured":"Goldstein DS, Holmes CS, Dendi R, Bruce SR, Li ST (2002) Orthostatic hypotension from sympathetic denervation in Parkinson\u2019s disease. Neurology 58:1247\u20131255","journal-title":"Neurology"},{"key":"665_CR41","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/jnnp.62.5.436","volume":"62","author":"CH Hawkes","year":"1997","unstructured":"Hawkes CH, Shephard BC, Daniel SE (1997) Olfactory dysfunction in Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 62:436\u2013444","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"665_CR42","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/mds.21956","volume":"23","author":"MA Hely","year":"2008","unstructured":"Hely MA, Reid WG, Adena MA, Halliday GM, Morris JG (2008) The Sydney multicenter study of Parkinson\u2019s disease: the inevitability of dementia at 20\u00a0years. Mov Disord 23:837\u2013844","journal-title":"Mov Disord"},{"issue":"Suppl 4","key":"665_CR43","doi-asserted-by":"crossref","first-page":"90S","DOI":"10.1016\/S0002-9343(99)00345-9","volume":"108","author":"PJ Hornby","year":"2000","unstructured":"Hornby PJ, Abrahams TP (2000) Central control of lower esophageal sphincter relaxation. Am J Med 108(Suppl 4):90S\u201398S","journal-title":"Am J Med"},{"key":"665_CR44","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1212\/WNL.52.6.1269","volume":"52","author":"K Iwanaga","year":"1999","unstructured":"Iwanaga K, Wakabayashi K, Yoshimoto M et al (1999) Lewy body type degeneration in cardiac plexus in Parkinson\u2019s and incidental Lewy body diseases. Neurology 52:1269\u20131271","journal-title":"Neurology"},{"key":"665_CR45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF01354542","volume":"9","author":"MD Kaplan","year":"1993","unstructured":"Kaplan MD, Baum BJ (1993) The function of saliva. Dysphagia 9:225\u2013229","journal-title":"Dysphagia"},{"key":"665_CR46","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/41.3.8429209","volume":"41","author":"P Klosen","year":"1993","unstructured":"Klosen P, Maessen X, de Aguilar P (1993) PEG embedding for immunocytochemistry: application to the analysis of immunoreactivity loss during histological processing. J Histochem Cytochem 41:455\u2013463","journal-title":"J Histochem Cytochem"},{"key":"665_CR47","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/jnen\/62.12.1241","volume":"62","author":"E Kuusisto","year":"2003","unstructured":"Kuusisto E, Parkkinen L, Alafuzoff I (2003) Morphogenesis of Lewy bodies: dissimilar incorporation of \u03b1-synuclein, ubiquitin, and p62. J Neuropathol Exp Neurol 62:1241\u20131253","journal-title":"J Neuropathol Exp Neurol"},{"key":"665_CR48","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0003-9969(88)90190-2","volume":"33","author":"K Kyriacou","year":"1988","unstructured":"Kyriacou K, Garrett JR (1988) Morphological changes in the rabbit submandibular gland after parasympathetic or sympathetic denervation. Arch Oral Biol 33:281\u2013290","journal-title":"Arch Oral Biol"},{"key":"665_CR49","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF00385794","volume":"11","author":"NA Leopold","year":"1995","unstructured":"Leopold NA, Kagel MC (1995) Prepharyngeal dysphagia in Parkinson\u2019s disease. Dysphagia 11:14\u201322","journal-title":"Dysphagia"},{"key":"665_CR50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/PL00009512","volume":"12","author":"NA Leopold","year":"1997","unstructured":"Leopold NA, Kagel MC (1997) Pharyngo-esophageal dysphagia in Parkinson\u2019s disease. Dysphagia 12:11\u201318","journal-title":"Dysphagia"},{"key":"665_CR51","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0079-6123(08)63055-1","volume":"87","author":"AD Loewy","year":"1991","unstructured":"Loewy AD (1991) Forebrain nuclei involved in autonomic control. Prog Brain Res 87:253\u2013268","journal-title":"Prog Brain Res"},{"key":"665_CR52","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/NEN.0b013e3181ac10a7","volume":"68","author":"WR Markesbery","year":"2009","unstructured":"Markesbery WR, Jicha GA, Liu H, Schmitt FA (2009) Lewy body pathology in normal elderly subjects. J Neuropathol Exp Neurol 68:816\u2013822","journal-title":"J Neuropathol Exp Neurol"},{"key":"665_CR53","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/00000478-198910000-00008","volume":"13","author":"F Martinez-Madrigal","year":"1989","unstructured":"Martinez-Madrigal F, Micheau C (1989) Histology of the major salivary glands. Am J Surg Pathol 13:879\u2013899","journal-title":"Am J Surg Pathol"},{"key":"665_CR54","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/mds.21586","volume":"23","author":"P Martinez-Marin","year":"2007","unstructured":"Martinez-Marin P, Schapira AHV, Stocchi F et al (2007) Prevalence of nonmotor symptoms in Parkinson\u2019s disease in an international setting: study using nonmotor symptoms questionnaire in 545 patients. Mov Disord 23:1623\u20131629","journal-title":"Mov Disord"},{"key":"665_CR55","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","volume":"65","author":"IG McKeith","year":"2005","unstructured":"McKeith IG, Dickson DW, Lowe J et al (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65:1863\u20131872","journal-title":"Neurology"},{"key":"665_CR56","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1002\/mds.22775","volume":"24","author":"Y Miki","year":"2009","unstructured":"Miki Y, Mori F, Wakabayashi K, Kuroda N, Orimo S (2009) Incidental Lewy body disease restricted to the heart and stellate ganglion. Mov Disord 24:2299\u20132301","journal-title":"Mov Disord"},{"key":"665_CR57","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1212\/01.wnl.0000264429.59379.d9","volume":"68","author":"A Minguez-Castellanos","year":"2007","unstructured":"Minguez-Castellanos A, Chamorro CE, Escamilla-Sevilla F et al (2007) Do \u03b1-synuclein aggregates in autonomic plexuses predate Lewy body disorders? A cohort study. Neurology 68:2012\u20132018","journal-title":"Neurology"},{"key":"665_CR58","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2990.2004.00564.x","volume":"30","author":"M Nishie","year":"2004","unstructured":"Nishie M, Mori F, Yoshimoto M, Takahashi H, Wakabayashi K (2004) A quantitative investigation of neuronal cytoplasmic and intranuclear inclusions in the pontine and inferior olivary nuclei in multiple system atrophy. Neuropathol Appl Neurobiol 30:546\u2013554","journal-title":"Neuropathol Appl Neurobiol"},{"key":"665_CR59","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1750-3639.2006.00032.x","volume":"17","author":"S Orimo","year":"2007","unstructured":"Orimo S, Takahashi A, Uchihara T et al (2007) Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson\u2019s disease. Brain Pathol 17:24\u201330","journal-title":"Brain Pathol"},{"key":"665_CR60","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/brain\/awm302","volume":"131","author":"S Orimo","year":"2008","unstructured":"Orimo S, Uchihara T, Nakamura A et al (2008) Axonal \u03b1-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson\u2019s disease. Brain 131:642\u2013650","journal-title":"Brain"},{"key":"665_CR61","first-page":"136","volume":"5","author":"RF Pfeiffer","year":"1998","unstructured":"Pfeiffer RF (1998) Gastrointestinal dysfunction in Parkinson\u2019s disease. Clin Neurosci 5:136\u2013146","journal-title":"Clin Neurosci"},{"key":"665_CR62","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1474-4422(03)00307-7","volume":"2","author":"RF Pfeiffer","year":"2003","unstructured":"Pfeiffer RF (2003) Gastrointestinal dysfunction in Parkinson\u2019s disease. Lancet Neurol 2:107\u2013116","journal-title":"Lancet Neurol"},{"issue":"Suppl 1","key":"665_CR63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1468-1331.2008.02057.x","volume":"15","author":"A Probst","year":"2008","unstructured":"Probst A, Bloch A, Tolnay M (2008) New insights into the pathology of Parkinson\u2019s disease: does the peripheral autonomic nervous system become central? Eur J Neurol 15(Suppl 1):1\u20134","journal-title":"Eur J Neurol"},{"key":"665_CR64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autneu.2006.10.006","volume":"133","author":"GB Proctor","year":"2007","unstructured":"Proctor GB, Carpenter GH (2007) Regulation of salivary gland function by autonomic nerves. Auton Neurosci Basic Clin 133:3\u201318","journal-title":"Auton Neurosci Basic Clin"},{"key":"665_CR65","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/mds.20189","volume":"20","author":"M Proulx","year":"2005","unstructured":"Proulx M, de Courval FP, Wiseman MA, Panisset M (2005) Salivary production in Parkinson\u2019s disease. Mov Disord 20:204\u2013207","journal-title":"Mov Disord"},{"key":"665_CR66","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/0016-5085(84)90079-9","volume":"87","author":"SJ Qualman","year":"1984","unstructured":"Qualman SJ, Haupt HM, Yang P, Hamilton SR (1984) Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson\u2019s disease. Gastroenterology 87:848\u2013856","journal-title":"Gastroenterology"},{"key":"665_CR67","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1052-3359(25)00678-7","volume":"5","author":"WG Richards","year":"1995","unstructured":"Richards WG, Sugarbaker DJ (1995) Neuronal control of esophageal function. Chest Surg Clin North Am 5:157\u2013171","journal-title":"Chest Surg Clin North Am"},{"key":"665_CR68","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/ana.410190310","volume":"19","author":"JA Robbins","year":"1986","unstructured":"Robbins JA, Logemann JA, Kirshner HS (1986) Swallowing and speech production in Parkinson\u2019s disease. Ann Neurol 19:283\u2013287","journal-title":"Ann Neurol"},{"key":"665_CR69","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1002\/mds.21076","volume":"21","author":"GW Ross","year":"2006","unstructured":"Ross GW, Petrovitch H, Abbott RD et al (2006) Association of olfactory dysfunction with incidental Lewy bodies. Mov Disord 21:2062\u20132067","journal-title":"Mov Disord"},{"key":"665_CR70","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/0021-9681(58)90006-7","volume":"8","author":"RS Schwab","year":"1958","unstructured":"Schwab RS, England AS (1958) Parkinson\u2019s disease. J Chronic Dis 8:448\u2013501","journal-title":"J Chronic Dis"},{"key":"665_CR71","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0003-9969(69)90167-8","volume":"14","author":"IL Shannon","year":"1969","unstructured":"Shannon IL, Suddick RP, Chauncey HH (1969) Effect of atropine-induced flow rate depression on composition of unstimulated human parotid fluid. Arch Oral Biol 14:761\u2013770","journal-title":"Arch Oral Biol"},{"key":"665_CR72","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1353-8020(01)00052-9","volume":"8","author":"MF Siddiqui","year":"2002","unstructured":"Siddiqui MF, Rast S, Lynn MJ, Auchus AP, Pfeiffer RF (2002) Autonomic dysfunction in Parkinson\u2019s disease: a comprehensive symptom survey. Parkinsonism Rel Disord 8:277\u2013284","journal-title":"Parkinsonism Rel Disord"},{"key":"665_CR73","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0033-8389(05)70070-1","volume":"36","author":"AR Silvers","year":"1998","unstructured":"Silvers AR, Som PM (1998) Salivary glands. Radiol Clin North Am 36:941\u2013966","journal-title":"Radiol Clin North Am"},{"key":"665_CR74","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00401-005-1013-9","volume":"110","author":"M Sone","year":"2005","unstructured":"Sone M, Yoshida M, Hashizume Y, Hishikawa N, Sobue G (2005) \u03b1-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy. Acta Neuropathol 110:19\u201326","journal-title":"Acta Neuropathol"},{"key":"665_CR75","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF00369454","volume":"86","author":"S Takeda","year":"1993","unstructured":"Takeda S, Yamazaki K, Miyakawa T, Arai H (1993) Parkinson\u2019s disease with involvement of the parasympathetic ganglia. Acta Neuropathol 86:397\u2013398","journal-title":"Acta Neuropathol"},{"key":"665_CR76","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s002590050544","volume":"27","author":"J Taki","year":"2000","unstructured":"Taki J, Nakajima K, Hwang EH et al (2000) Peripheral sympathetic dysfunction in patients with Parkinson\u2019s disease without autonomic failure is heart selective and disease specific. Eur J Nucl Med 27:566\u2013573","journal-title":"Eur J Nucl Med"},{"key":"665_CR77","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/1531-8257(200101)16:1<41::AID-MDS1017>3.0.CO;2-M","volume":"16","author":"G Tissingh","year":"2001","unstructured":"Tissingh G, Berendse HW, Bergmanns P et al (2001) Loss of olfaction in de novo and treated Parkinson\u2019s disease: possible implications for early diagnosis. Mov Disord 16:41\u201346","journal-title":"Mov Disord"},{"key":"665_CR78","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/mds.20784","volume":"21","author":"OR Tumilasci","year":"2006","unstructured":"Tumilasci OR, Cers\u00f3simo MG, Belforte JE, Micheli FE, Benarroch EE, Pazo JH (2006) Quantitative study of salivary secretion in Parkinson\u2019s disease. Mov Disord 21:660\u2013667","journal-title":"Mov Disord"},{"key":"665_CR79","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1212\/01.wnl.0000266593.50534.e8","volume":"69","author":"D Verbaan","year":"2007","unstructured":"Verbaan D, Marinus J, Visser M, van Rooden SM, Stiggelbout AM, van Hilten JJ (2007) Patient-reported autonomic symptoms in Parkinson\u2019s disease. Neurology 69:333\u2013341","journal-title":"Neurology"},{"key":"665_CR80","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00687767","volume":"76","author":"K Wakabayashi","year":"1988","unstructured":"Wakabayashi K, Takahashi H, Takeda S, Ohama E, Ikuta F (1988) Parkinson\u2019s disease: the presence of Lewy bodies in Auerbach\u2019s and Meissner\u2019s plexuses. Acta Neuropathol 76:217\u2013221","journal-title":"Acta Neuropathol"},{"key":"665_CR81","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF00294234","volume":"79","author":"K Wakabayashi","year":"1990","unstructured":"Wakabayashi K, Takahashi H, Takeda S, Ohama E, Ikuta F (1990) Parkinson\u2019s disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system. Acta Neuropathol 79:581\u2013583","journal-title":"Acta Neuropathol"},{"key":"665_CR82","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0304-3940(92)90923-U","volume":"138","author":"K Wakabayashi","year":"1992","unstructured":"Wakabayashi K, Takahashi H, Obata K, Ikuta F (1992) Immunocytochemical localization of synaptic vesicle-specific protein in Lewy body-containing neurons in Parkinson\u2019s disease. Neurosci Lett 138:237\u2013240","journal-title":"Neurosci Lett"},{"key":"665_CR83","first-page":"609","volume":"60","author":"K Wakabayashi","year":"1993","unstructured":"Wakabayashi K, Takahashi H, Ohama E, Takeda S, Ikuta F (1993) Lewy bodies in the visceral autonomic nervous system in Parkinson\u2019s disease. Adv Neurol 60:609\u2013612","journal-title":"Adv Neurol"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-010-0665-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-010-0665-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-010-0665-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T12:43:46Z","timestamp":1739969026000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-010-0665-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,14]]},"references-count":83,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["665"],"URL":"https:\/\/doi.org\/10.1007\/s00401-010-0665-2","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,14]]}}}