{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:30:34Z","timestamp":1792510234457,"version":"4.5.0"},"reference-count":126,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T00:00:00Z","timestamp":1269302400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1007\/s00401-010-0672-3","type":"journal-article","created":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T01:29:21Z","timestamp":1269221361000},"page":"657-667","source":"Crossref","is-referenced-by-count":138,"title":["Papp\u2013Lantos inclusions and the pathogenesis of multiple system atrophy: an update"],"prefix":"10.1007","volume":"119","author":[{"given":"Kurt A.","family":"Jellinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Lantos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,23]]},"reference":[{"key":"672_CR1","first-page":"273","volume":"84","author":"H Abe","year":"1992","unstructured":"Abe H, Yagishita S, Amano N, Iwabuchi K, Hasegawa K, Kowa K (1992) Argyrophilic glial intracytoplasmic inclusions in multiple system atrophy: immunocytochemical and ultrastructural study. Acta Neuropathol 84:273\u2013277","journal-title":"Acta Neuropathol"},{"key":"672_CR2","doi-asserted-by":"crossref","first-page":"e7114","DOI":"10.1371\/journal.pone.0007114","volume":"4","author":"A Al-Chalabi","year":"2009","unstructured":"Al-Chalabi A, Durr A, Wood NW, Parkinson MH, Camuzat A, Hulot JS, Morrison KE, Renton A, Sussmuth SD, Landwehrmeyer BG, Ludolph A, Agid Y, Brice A, Leigh PN, Bensimon G (2009) Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy. PLoS One 4:e7114. doi: 7110.1371\/journal.pone.0007114","journal-title":"PLoS One"},{"key":"672_CR3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1365-2990.2007.00888.x","volume":"34","author":"J Alegre-Abarrategui","year":"2008","unstructured":"Alegre-Abarrategui J, Ansorge O, Esiri M, Wade-Martins R (2008) LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson\u2019s disease. Neuropathol Appl Neurobiol 34:272\u2013283","journal-title":"Neuropathol Appl Neurobiol"},{"key":"672_CR4","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1074\/jbc.M102981200","volume":"277","author":"MA Alim","year":"2002","unstructured":"Alim MA, Hossain MS, Arima K, Takeda K, Izumiyama Y, Nakamura M, Kaji H, Shinoda T, Hisanaga S, Ueda K (2002) Tubulin seeds alpha-synuclein fibril formation. J Biol Chem 277:2112\u20132117","journal-title":"J Biol Chem"},{"key":"672_CR5","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3233\/JAD-2004-6412","volume":"6","author":"MA Alim","year":"2004","unstructured":"Alim MA, Ma QL, Takeda K, Aizawa T, Matsubara M, Nakamura M, Asada A, Saito T, Kaji H, Yoshii M, Hisanaga S, Ueda K (2004) Demonstration of a role for alpha-synuclein as a functional microtubule-associated protein. J Alzheimers Dis 6:435\u2013442 (discussion 443\u2013439)","journal-title":"J Alzheimers Dis"},{"key":"672_CR6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0022-510X(92)90101-P","volume":"109","author":"N Arai","year":"1992","unstructured":"Arai N, Nishimura M, Oda M, Morimatsu Y, Ohe R, Nagatomo H (1992) Immunohistochemical expression of microtubule-associated protein 5 (MAP5) in glial cells in multiple system atrophy. J Neurol Sci 109:102\u2013106","journal-title":"J Neurol Sci"},{"key":"672_CR7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF00310020","volume":"83","author":"K Arima","year":"1992","unstructured":"Arima K, Murayama S, Mukoyama M, Inose T (1992) Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy. 1. Neuronal cytoplasmic inclusions. Acta Neuropathol 83:453\u2013460","journal-title":"Acta Neuropathol"},{"key":"672_CR8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.parkreldis.2006.02.005","volume":"12","author":"RA Armstrong","year":"2006","unstructured":"Armstrong RA, Cairns NJ, Lantos PL (2006) Multiple system atrophy (MSA): topographic distribution of the alpha-synuclein-associated pathological changes. Parkinsonism Relat Disord 12:356\u2013362","journal-title":"Parkinsonism Relat Disord"},{"key":"672_CR9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00401-005-0008-x","volume":"111","author":"KG Baker","year":"2006","unstructured":"Baker KG, Huang Y, McCann H, Gai WP, Jensen PH, Halliday GM (2006) P25alpha immunoreactive but alpha-synuclein immunonegative neuronal inclusions in multiple system atrophy. Acta Neuropathol 111:193\u2013195","journal-title":"Acta Neuropathol"},{"key":"672_CR10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1046\/j.1365-2990.2003.00432.x","volume":"29","author":"H Braak","year":"2003","unstructured":"Braak H, Rub U, Del Tredici K (2003) Involvement of precerebellar nuclei in multiple system atrophy. Neuropathol Appl Neurobiol 29:60\u201376","journal-title":"Neuropathol Appl Neurobiol"},{"key":"672_CR11","doi-asserted-by":"crossref","unstructured":"Brooks JA, Houlden H, Melchers A, Islam AJ, Ding J, Li A, Paudel R, Revesz T, Holton JL, Wood N, Lees A, Singleton AB, Scholz SW (2010) Mutational analysis of parkin and PINK1 in multiple system atrophy. Neurobiol Aging (in press). doi: 10.1016\/j.neurobiolaging.2009.11.020","DOI":"10.1016\/j.neurobiolaging.2009.11.020"},{"key":"672_CR12","first-page":"419","volume":"54","author":"DJ Burn","year":"2001","unstructured":"Burn DJ, Jaros E (2001) Multiple system atrophy: cellular and molecular pathology. Mol Pathol 54:419\u2013426","journal-title":"Mol Pathol"},{"key":"672_CR13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1471-4159.2001.00021.x","volume":"76","author":"BC Campbell","year":"2001","unstructured":"Campbell BC, McLean CA, Culvenor JG, Gai WP, Blumbergs PC, Jakala P, Beyreuther K, Masters CL, Li QX (2001) The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson\u2019s disease. J Neurochem 76:87\u201396","journal-title":"J Neurochem"},{"key":"672_CR14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00401-006-0119-z","volume":"112","author":"E Croisier","year":"2006","unstructured":"Croisier E, Graeber MB (2006) Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration. Acta Neuropathol 112:517\u2013530","journal-title":"Acta Neuropathol"},{"key":"672_CR15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1471-4159.2009.06324.x","volume":"111","author":"KM Danzer","year":"2009","unstructured":"Danzer KM, Krebs SK, Wolff M, Birk G, Hengerer B (2009) Seeding induced by \u03b1-synuclein oligomers provides evidence for spreading of \u03b1-synuclein pathology. J Neurochem 111:192\u2013203","journal-title":"J Neurochem"},{"key":"672_CR16","doi-asserted-by":"crossref","first-page":"13010","DOI":"10.1073\/pnas.0903691106","volume":"106","author":"P Desplats","year":"2009","unstructured":"Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci USA 106:13010\u201313015","journal-title":"Proc Natl Acad Sci USA"},{"key":"672_CR17","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0002-9440(10)65226-1","volume":"155","author":"DW Dickson","year":"1999","unstructured":"Dickson DW, Liu W, Hardy J, Farrer M, Mehta N, Uitti R, Mark M, Zimmerman T, Golbe L, Sage J, Sima A, D\u2019Amato C, Albin R, Gilman S, Yen SH (1999) Widespread alterations of alpha-synuclein in multiple system atrophy. Am J Pathol 155:1241\u20131251","journal-title":"Am J Pathol"},{"key":"672_CR18","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/jnen\/59.9.830","volume":"59","author":"JE Duda","year":"2000","unstructured":"Duda JE, Giasson BI, Gur TL, Montine TJ, Robertson D, Biaggioni I, Hurtig HI, Stern MB, Gollomp SM, Grossman M, Lee VM, Trojanowski JQ (2000) Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy. J Neuropathol Exp Neurol 59:830\u2013841","journal-title":"J Neuropathol Exp Neurol"},{"key":"672_CR19","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2005.07.021","volume":"47","author":"MS Forman","year":"2005","unstructured":"Forman MS, Lee VM, Trojanowski JQ (2005) Nosology of Parkinson\u2019s disease: looking for the way out of a quagmire. Neuron 47:479\u2013482","journal-title":"Neuron"},{"key":"672_CR20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00401-008-0398-7","volume":"116","author":"H Fujishiro","year":"2008","unstructured":"Fujishiro H, Ahn TB, Frigerio R, DelleDonne A, Josephs KA, Parisi JE, Eric Ahlskog J, Dickson DW (2008) Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy? Acta Neuropathol 116:269\u2013275","journal-title":"Acta Neuropathol"},{"key":"672_CR21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb841","volume":"4","author":"H Fujiwara","year":"2002","unstructured":"Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T (2002) Alpha-synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4:160\u2013164","journal-title":"Nat Cell Biol"},{"key":"672_CR22","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1046\/j.1471-4159.1999.02093.x","volume":"73","author":"WP Gai","year":"1999","unstructured":"Gai WP, Power JH, Blumbergs PC, Culvenor JG, Jensen PH (1999) Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components. J Neurochem 73:2093\u20132100","journal-title":"J Neurochem"},{"key":"672_CR23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0014-4886(03)00004-9","volume":"181","author":"WP Gai","year":"2003","unstructured":"Gai WP, Pountney DL, Power JH, Li QX, Culvenor JG, McLean CA, Jensen PH, Blumbergs PC (2003) Alpha-synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy. Exp Neurol 181:68\u201378","journal-title":"Exp Neurol"},{"key":"672_CR24","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1177\/34.12.3537114","volume":"34","author":"F Gallyas","year":"1986","unstructured":"Gallyas F, Wolff JR (1986) Metal-catalyzed oxidation renders silver intensification selective. Applications for the histochemistry of diaminobenzidine and neurofibrillary changes. J Histochem Cytochem 34:1667\u20131672","journal-title":"J Histochem Cytochem"},{"key":"672_CR25","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ana.20819","volume":"59","author":"WR Galpern","year":"2006","unstructured":"Galpern WR, Lang AE (2006) Interface between tauopathies and synucleinopathies: a tale of two proteins. Ann Neurol 59:449\u2013458","journal-title":"Ann Neurol"},{"issue":"Suppl 1","key":"672_CR26","first-page":"S426","volume":"24","author":"F Geser","year":"2009","unstructured":"Geser F, Malunda J, Wenning GK, Lee VM, Trojanowski JQ (2009) Multiple system atrophy is not a TDP-43 proteinopathy. Mov Disord 24(Suppl 1):S426","journal-title":"Mov Disord"},{"key":"672_CR27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00401-003-0726-x","volume":"106","author":"BI Giasson","year":"2003","unstructured":"Giasson BI, Mabon ME, Duda JE, Montine TJ, Robertson D, Hurtig HI, Lee VM, Trojanowski JQ (2003) Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy. Acta Neuropathol 106:243\u2013250","journal-title":"Acta Neuropathol"},{"key":"672_CR28","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0022-510X(98)00304-9","volume":"163","author":"S Gilman","year":"1999","unstructured":"Gilman S, Low PA, Quinn N, Albanese A, Ben-Shlomo Y, Fowler CJ, Kaufmann H, Klockgether T, Lang AE, Lantos PL, Litvan I, Mathias CJ, Oliver E, Robertson D, Schatz I, Wenning GK (1999) Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 163:94\u201398","journal-title":"J Neurol Sci"},{"key":"672_CR29","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","volume":"71","author":"S Gilman","year":"2008","unstructured":"Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Durr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71:670\u2013676","journal-title":"Neurology"},{"key":"672_CR30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/jnnp.32.1.28","volume":"32","author":"JG Graham","year":"1969","unstructured":"Graham JG, Oppenheimer DR (1969) Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. J Neurol Neurosurg Psychiatry 32:28\u201334","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"672_CR31","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0002-9440(10)63378-0","volume":"165","author":"SV Griffin","year":"2004","unstructured":"Griffin SV, Hiromura K, Pippin J, Petermann AT, Blonski MJ, Krofft R, Takahashi S, Kulkarni AB, Shankland SJ (2004) Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology. Am J Pathol 165:1175\u20131185","journal-title":"Am J Pathol"},{"key":"672_CR32","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.brainres.2007.04.034","volume":"1155","author":"S Higashi","year":"2007","unstructured":"Higashi S, Biskup S, West AB, Trinkaus D, Dawson VL, Faull RL, Waldvogel HJ, Arai H, Dawson TM, Moore DJ, Emson PC (2007) Localization of Parkinson\u2019s disease-associated LRRK2 in normal and pathological human brain. Brain Res 1155:208\u2013219","journal-title":"Brain Res"},{"key":"672_CR33","doi-asserted-by":"crossref","first-page":"29531","DOI":"10.1074\/jbc.M703466200","volume":"282","author":"E Hlavanda","year":"2007","unstructured":"Hlavanda E, Klement E, Kokai E, Kovacs J, Vincze O, Tokesi N, Orosz F, Medzihradszky KF, Dombradi V, Ovadi J (2007) Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases. J Biol Chem 282:29531\u201329539","journal-title":"J Biol Chem"},{"key":"672_CR34","doi-asserted-by":"crossref","first-page":"47746","DOI":"10.1074\/jbc.M408906200","volume":"279","author":"R Hodara","year":"2004","unstructured":"Hodara R, Norris EH, Giasson BI, Mishizen-Eberz AJ, Lynch DR, Lee VM, Ischiropoulos H (2004) Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. J Biol Chem 279:47746\u201347753","journal-title":"J Biol Chem"},{"key":"672_CR35","doi-asserted-by":"crossref","first-page":"309","DOI":"10.5414\/NPP27309","volume":"27","author":"Y Honjo","year":"2008","unstructured":"Honjo Y, Shirakashi Y, Kawamoto Y, Akiguchi I (2008) Anti-DARPP32 antibody-immunopositive inclusions in the brain of patients with multiple system atrophy. Clin Neuropathol 27:309\u2013316","journal-title":"Clin Neuropathol"},{"key":"672_CR36","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00401-008-0446-3","volume":"116","author":"Y Huang","year":"2008","unstructured":"Huang Y, Song YJ, Murphy K, Holton JL, Lashley T, Revesz T, Gai WP, Halliday GM (2008) LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions. Acta Neuropathol 116:639\u2013646","journal-title":"Acta Neuropathol"},{"key":"672_CR37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s004010050655","volume":"93","author":"M Inoue","year":"1997","unstructured":"Inoue M, Yagishita S, Ryo M, Hasegawa K, Amano N, Matsushita M (1997) The distribution and dynamic density of oligodendroglial cytoplasmic inclusions (GCIs) in multiple system atrophy: a correlation between the density of GCIs and the degree of involvement of striatonigral and olivopontocerebellar systems. Acta Neuropathol 93:585\u2013591","journal-title":"Acta Neuropathol"},{"key":"672_CR38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/jnen\/63.1.43","volume":"63","author":"K Ishizawa","year":"2004","unstructured":"Ishizawa K, Komori T, Sasaki S, Arai N, Mizutani T, Hirose T (2004) Microglial activation parallels system degeneration in multiple system atrophy. J Neuropathol Exp Neurol 63:43\u201352","journal-title":"J Neuropathol Exp Neurol"},{"key":"672_CR39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1440-1789.2007.00855.x","volume":"28","author":"K Ishizawa","year":"2008","unstructured":"Ishizawa K, Komori T, Arai N, Mizutani T, Hirose T (2008) Glial cytoplasmic inclusions and tissue injury in multiple system atrophy: a quantitative study in white matter (olivopontocerebellar system) and gray matter (nigrostriatal system). Neuropathology 28:249\u2013257","journal-title":"Neuropathology"},{"key":"672_CR40","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1440-1789.2007.00785.x","volume":"27","author":"T Iwatsubo","year":"2007","unstructured":"Iwatsubo T (2007) Pathological biochemistry of alpha-synucleinopathy. Neuropathology 27:474\u2013478","journal-title":"Neuropathology"},{"key":"672_CR41","first-page":"21","volume":"60","author":"KA Jellinger","year":"2000","unstructured":"Jellinger KA, Stadelmann C (2000) The enigma of cell death in neurodegenerative disorders. J Neural Transm Suppl 60:21\u201336","journal-title":"J Neural Transm Suppl"},{"key":"672_CR42","first-page":"95","volume":"59","author":"KA Jellinger","year":"2000","unstructured":"Jellinger KA, Stadelmann C (2000) Mechanisms of cell death in neurodegenerative disorders. J Neural Transm Suppl 59:95\u2013114","journal-title":"J Neural Transm Suppl"},{"issue":"Suppl 6","key":"672_CR43","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1002\/mds.10557","volume":"18","author":"KA Jellinger","year":"2003","unstructured":"Jellinger KA (2003) Neuropathological spectrum of synucleinopathies. Mov Disord 18(Suppl 6):S2\u2013S12","journal-title":"Mov Disord"},{"issue":"Suppl 12","key":"672_CR44","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1002\/mds.20537","volume":"20","author":"KA Jellinger","year":"2005","unstructured":"Jellinger KA, Seppi K, Wenning GK (2005) Grading of neuropathology in multiple system atrophy: proposal for a novel scale. Mov Disord 20(Suppl 12):S29\u2013S36","journal-title":"Mov Disord"},{"key":"672_CR45","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s00401-006-0075-7","volume":"112","author":"KA Jellinger","year":"2006","unstructured":"Jellinger KA (2006) P25alpha immunoreactivity in multiple system atrophy and Parkinson disease. Acta Neuropathol 112:112","journal-title":"Acta Neuropathol"},{"key":"672_CR46","first-page":"267","volume-title":"Degenerative diseases of the nervous system","author":"KA Jellinger","year":"2007","unstructured":"Jellinger KA (2007) Lewy body disorders. In: Youdim MBH, Riederer P, Mandel SA, Battistin L, Lajtha A (eds) Degenerative diseases of the nervous system. Springer, New York, pp 267\u2013343"},{"key":"672_CR47","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/embo-reports\/kvf109","volume":"3","author":"PJ Kahle","year":"2002","unstructured":"Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C (2002) Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. EMBO Rep 3:583\u2013588","journal-title":"EMBO Rep"},{"key":"672_CR48","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-007-0302-x","volume":"115","author":"PJ Kahle","year":"2008","unstructured":"Kahle PJ (2008) Alpha-synucleinopathy models and human neuropathology: similarities and differences. Acta Neuropathol 115:87\u201395","journal-title":"Acta Neuropathol"},{"key":"672_CR49","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/BF00294235","volume":"79","author":"S Kato","year":"1990","unstructured":"Kato S, Nakamura H (1990) Cytoplasmic argyrophilic inclusions in neurons of pontine nuclei in patients with olivopontocerebellar atrophy: immunohistochemical and ultrastructural studies. Acta Neuropathol 79:584\u2013594","journal-title":"Acta Neuropathol"},{"key":"672_CR50","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/BF00293383","volume":"82","author":"S Kato","year":"1991","unstructured":"Kato S, Nakamura H, Hirano A, Ito H, Llena JF, Yen SH (1991) Argyrophilic ubiquitinated cytoplasmic inclusions of Leu-7-positive glial cells in olivopontocerebellar atrophy (multiple system atrophy). Acta Neuropathol 82:488\u2013493","journal-title":"Acta Neuropathol"},{"key":"672_CR51","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/ana.10361","volume":"52","author":"Y Kawamoto","year":"2002","unstructured":"Kawamoto Y, Akiguchi I, Nakamura S, Budka H (2002) Accumulation of 14-3-3 proteins in glial cytoplasmic inclusions in multiple system atrophy. Ann Neurol 52:722\u2013731","journal-title":"Ann Neurol"},{"key":"672_CR52","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.brainres.2006.12.049","volume":"1136","author":"Y Kawamoto","year":"2007","unstructured":"Kawamoto Y, Akiguchi I, Shirakashi Y, Honjo Y, Tomimoto H, Takahashi R, Budka H (2007) Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy. Brain Res 1136:219\u2013227","journal-title":"Brain Res"},{"key":"672_CR53","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/NEN.0b013e31818809f4","volume":"67","author":"Y Kawamoto","year":"2008","unstructured":"Kawamoto Y, Kobayashi Y, Suzuki Y, Inoue H, Tomimoto H, Akiguchi I, Budka H, Martins LM, Downward J, Takahashi R (2008) Accumulation of HtrA2\/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies. J Neuropathol Exp Neurol 67:984\u2013993","journal-title":"J Neuropathol Exp Neurol"},{"key":"672_CR54","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1212\/01.wnl.0000271880.27321.a7","volume":"69","author":"C Klein","year":"2007","unstructured":"Klein C, Schlossmacher MG (2007) Parkinson disease, 10\u00a0years after its genetic revolution: multiple clues to a complex disorder. Neurology 69:2093\u20132104","journal-title":"Neurology"},{"key":"672_CR55","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s00401-003-0702-5","volume":"106","author":"T Komori","year":"2003","unstructured":"Komori T, Ishizawa K, Arai N, Hirose T, Mizutani T, Oda M (2003) Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy. Acta Neuropathol (Berl) 106:66\u201370","journal-title":"Acta Neuropathol (Berl)"},{"key":"672_CR56","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00401-006-0167-4","volume":"113","author":"GG Kovacs","year":"2007","unstructured":"Kovacs GG, Gelpi E, Lehotzky A, Hoftberger R, Erdei A, Budka H, Ovadi J (2007) The brain-specific protein TPPP\/p25 in pathological protein deposits of neurodegenerative diseases. Acta Neuropathol 113:153\u2013161","journal-title":"Acta Neuropathol"},{"key":"672_CR57","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/mds.21259","volume":"22","author":"AJ Langerveld","year":"2007","unstructured":"Langerveld AJ, Mihalko D, DeLong C, Walburn J, Ide CF (2007) Gene expression changes in postmortem tissue from the rostral pons of multiple system atrophy patients. Mov Disord 22:766\u2013777","journal-title":"Mov Disord"},{"key":"672_CR58","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/jnnp.57.2.129","volume":"57","author":"PL Lantos","year":"1994","unstructured":"Lantos PL, Papp MI (1994) Cellular pathology of multiple system atrophy: a review. J Neurol Neurosurg Psychiatry 57:129\u2013133","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"672_CR59","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/00005072-199812000-00001","volume":"57","author":"PL Lantos","year":"1998","unstructured":"Lantos PL (1998) The definition of multiple system atrophy: a review of recent developments. J Neuropathol Exp Neurol 57:1099\u20131111","journal-title":"J Neuropathol Exp Neurol"},{"key":"672_CR60","first-page":"188","volume-title":"Neurodegeneration: the molecular pathology of dementia and movement disorders","author":"PL Lantos","year":"2003","unstructured":"Lantos PL, Quinn N (2003) Dementia with Lewy bodies. In: Dickson DW (ed) Neurodegeneration: the molecular pathology of dementia and movement disorders. ISN Neuropath Press, Basel, pp 188\u2013199"},{"key":"672_CR61","first-page":"203","volume-title":"Neurodegeneration: the molecular. pathology of dementia and movement disorders","author":"PL Lantos","year":"2003","unstructured":"Lantos PL, Quinn N (2003) Multiple system atrophy. In: Dickson DW (ed) Neurodegeneration: the molecular. pathology of dementia and movement disorders, 1st edn. ISN Neuropath Press, Basel, pp 203\u2013214","edition":"1"},{"key":"672_CR62","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1074\/jbc.M410409200","volume":"280","author":"E Lindersson","year":"2005","unstructured":"Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH (2005) p25alpha stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. J Biol Chem 280:5703\u20135715","journal-title":"J Biol Chem"},{"key":"672_CR63","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0002-9440(10)65617-9","volume":"153","author":"A Matsuo","year":"1998","unstructured":"Matsuo A, Akiguchi I, Lee GC, McGeer EG, McGeer PL, Kimura J (1998) Myelin degeneration in multiple system atrophy detected by unique antibodies. Am J Pathol 153:735\u2013744","journal-title":"Am J Pathol"},{"key":"672_CR64","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00234-008-0381-y","volume":"50","author":"E Matsusue","year":"2008","unstructured":"Matsusue E, Fujii S, Kanasaki Y, Sugihara S, Miyata H, Ohama E, Ogawa T (2008) Putaminal lesion in multiple system atrophy: postmortem MR-pathological correlations. Neuroradiology 50:559\u2013567","journal-title":"Neuroradiology"},{"key":"672_CR65","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.3174\/ajnr.A1662","volume":"30","author":"E Matsusue","year":"2009","unstructured":"Matsusue E, Fujii S, Kanasaki Y, Kaminou T, Ohama E, Ogawa T (2009) Cerebellar lesions in multiple system atrophy: postmortem MR imaging-pathologic correlations. Am J Neuroradiol 30:1725\u20131730","journal-title":"Am J Neuroradiol"},{"key":"672_CR66","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.neuroscience.2007.05.027","volume":"147","author":"HL Melrose","year":"2007","unstructured":"Melrose HL, Kent CB, Taylor JP, Dachsel JC, Hinkle KM, Lincoln SJ, Mok SS, Culvenor JG, Masters CL, Tyndall GM, Bass DI, Ahmed Z, Andorfer CA, Ross OA, Wszolek ZK, Delldonne A, Dickson DW, Farrer MJ (2007) A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease. Neuroscience 147:1047\u20131058","journal-title":"Neuroscience"},{"key":"672_CR67","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1097\/01.jnen.0000235121.98052.54","volume":"65","author":"J Miklossy","year":"2006","unstructured":"Miklossy J, Arai T, Guo JP, Klegeris A, Yu S, McGeer EG, McGeer PL (2006) LRRK2 expression in normal and pathologic human brain and in human cell lines. J Neuropathol Exp Neurol 65:953\u2013963","journal-title":"J Neuropathol Exp Neurol"},{"key":"672_CR68","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s00702-005-0378-1","volume":"112","author":"DW Miller","year":"2005","unstructured":"Miller DW, Johnson JM, Solano SM, Hollingsworth ZR, Standaert DG, Young AB (2005) Absence of alpha-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia. J Neural Transm 112:1613\u20131624","journal-title":"J Neural Transm"},{"key":"672_CR69","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.expneurol.2008.06.004","volume":"213","author":"B Mollenhauer","year":"2008","unstructured":"Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I, Ng J, Schulz-Schaeffer W, Kretzschmar HA, McLean PJ, Trenkwalder C, Sarracino DA, Vonsattel JP, Locascio JJ, El-Agnaf OM, Schlossmacher MG (2008) Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Exp Neurol 213:315\u2013325","journal-title":"Exp Neurol"},{"key":"672_CR70","first-page":"51","volume":"19","author":"S Nakamura","year":"2000","unstructured":"Nakamura S, Kawamoto Y, Nakano S, Akiguchi I (2000) Expression of the endocytosis regulatory proteins Rab5 and Rabaptin-5 in glial cytoplasmic inclusions from brains with multiple system atrophy. Clin Neuropathol 19:51\u201356","journal-title":"Clin Neuropathol"},{"key":"672_CR71","first-page":"243","volume":"20","author":"S Nakamura","year":"2001","unstructured":"Nakamura S, Kawamoto Y, Kitajima K, Honjo Y, Matsuo A, Nakano S, Akiguchi I (2001) Immunohistochemical localization of phosphoinositide 3-kinase in brains with multiple system atrophy. Clin Neuropathol 20:243\u2013247","journal-title":"Clin Neuropathol"},{"key":"672_CR72","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2353\/ajpath.2009.080503","volume":"174","author":"K Nakayama","year":"2009","unstructured":"Nakayama K, Suzuki Y, Yazawa I (2009) Microtubule depolymerization suppresses alpha-synuclein accumulation in a mouse model of multiple system atrophy. Am J Pathol 174:1471\u20131480","journal-title":"Am J Pathol"},{"key":"672_CR73","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s00401-003-0811-1","volume":"107","author":"M Nishie","year":"2004","unstructured":"Nishie M, Mori F, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K (2004) Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathol 107:292\u2013298","journal-title":"Acta Neuropathol"},{"key":"672_CR74","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2990.2004.00564.x","volume":"30","author":"M Nishie","year":"2004","unstructured":"Nishie M, Mori F, Yoshimoto M, Takahashi H, Wakabayashi K (2004) A quantitative investigation of neuronal cytoplasmic and intranuclear inclusions in the pontine and inferior olivary nuclei in multiple system atrophy. Neuropathol Appl Neurobiol 30:546\u2013554","journal-title":"Neuropathol Appl Neurobiol"},{"key":"672_CR75","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.biolcel.2004.08.002","volume":"96","author":"F Orosz","year":"2004","unstructured":"Orosz F, Kovacs GG, Lehotzky A, Olah J, Vincze O, Ovadi J (2004) TPPP\/p25: from unfolded protein to misfolding disease: prediction and experiments. Biol Cell 96:701\u2013711","journal-title":"Biol Cell"},{"key":"672_CR76","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1523\/JNEUROSCI.04-01-00111.1984","volume":"4","author":"CC Ouimet","year":"1984","unstructured":"Ouimet CC, Miller PE, Hemmings HC Jr, Walaas SI, Greengard P (1984) DARPP-32, a dopamine- and adenosine 3\u2032:5\u2032-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization. J Neurosci 4:111\u2013124","journal-title":"J Neurosci"},{"key":"672_CR77","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1093\/brain\/awh303","volume":"127","author":"T Ozawa","year":"2004","unstructured":"Ozawa T, Paviour D, Quinn NP, Josephs KA, Sangha H, Kilford L, Healy DG, Wood NW, Lees AJ, Holton JL, Revesz T (2004) The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. Brain 127:2657\u20132671","journal-title":"Brain"},{"key":"672_CR78","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00401-007-0254-1","volume":"114","author":"T Ozawa","year":"2007","unstructured":"Ozawa T (2007) Morphological substrate of autonomic failure and neurohormonal dysfunction in multiple system atrophy: impact on determining phenotype spectrum. Acta Neuropathol (Berl) 114:201\u2013211","journal-title":"Acta Neuropathol (Berl)"},{"key":"672_CR79","doi-asserted-by":"crossref","first-page":"16895","DOI":"10.1074\/jbc.M800747200","volume":"283","author":"KE Paleologou","year":"2008","unstructured":"Paleologou KE, Schmid AW, Rospigliosi CC, Kim HY, Lamberto GR, Fredenburg RA, Lansbury PT Jr, Fernandez CO, Eliezer D, Zweckstetter M, Lashuel HA (2008) Phosphorylation at Ser-129 but not the phosphomimics S129E\/D inhibits the fibrillation of alpha-synuclein. J Biol Chem 283:16895\u201316905","journal-title":"J Biol Chem"},{"key":"672_CR80","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1523\/JNEUROSCI.5922-09.2010","volume":"30","author":"KE Paleologou","year":"2010","unstructured":"Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, Lashuel HA (2010) Phosphorylation at S87 is enhanced in synucleinopathies, inhibits \u03b1-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci 30:3184\u20133198","journal-title":"J Neurosci"},{"key":"672_CR81","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0022-510X(89)90219-0","volume":"94","author":"MI Papp","year":"1989","unstructured":"Papp MI, Kahn JE, Lantos PL (1989) Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sci 94:79\u2013100","journal-title":"J Neurol Sci"},{"key":"672_CR82","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0022-510X(92)90286-T","volume":"107","author":"MI Papp","year":"1992","unstructured":"Papp MI, Lantos PL (1992) Accumulation of tubular structures in oligodendroglial and neuronal cells as the basic alteration in multiple system atrophy. J Neurol Sci 107:172\u2013182","journal-title":"J Neurol Sci"},{"issue":"Pt 2","key":"672_CR83","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/brain\/117.2.235","volume":"117","author":"MI Papp","year":"1994","unstructured":"Papp MI, Lantos PL (1994) The distribution of oligodendroglial inclusions in multiple system atrophy and its relevance to clinical symptomatology. Brain 117(Pt 2):235\u2013243","journal-title":"Brain"},{"key":"672_CR84","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s004010000292","volume":"101","author":"YS Piao","year":"2001","unstructured":"Piao YS, Hayashi S, Hasegawa M, Wakabayashi K, Yamada M, Yoshimoto M, Ishikawa A, Iwatsubo T, Takahashi H (2001) Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathol 101:285\u2013293","journal-title":"Acta Neuropathol"},{"key":"672_CR85","unstructured":"Pountney DL, Dickson TC, Power JH, Vickers JC, West AJ, Gai WP (2009) Association of metallothionein-III with oligodendroglial cytoplasmic inclusions in multiple system atrophy. Neurotox Res. doi: 10.1007\/s12640-12009-19146-12646"},{"key":"672_CR86","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1097\/00005072-199809000-00002","volume":"57","author":"S Probst-Cousin","year":"1998","unstructured":"Probst-Cousin S, Rickert CH, Schmid KW, Gullotta F (1998) Cell death mechanisms in multiple system atrophy. J Neuropathol Exp Neurol 57:814\u2013821","journal-title":"J Neuropathol Exp Neurol"},{"issue":"Suppl","key":"672_CR87","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/jnnp.52.Suppl.78","volume":"52","author":"N Quinn","year":"1989","unstructured":"Quinn N (1989) Multiple system atrophy\u2014the nature of the beast. J Neurol Neurosurg Psychiatry 52(Suppl):78\u201389","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"672_CR88","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/1097-4547(20001001)62:1<9::AID-JNR2>3.0.CO;2-U","volume":"62","author":"C Richter-Landsberg","year":"2000","unstructured":"Richter-Landsberg C, Gorath M, Trojanowski JQ, Lee VM (2000) Alpha-synuclein is developmentally expressed in cultured rat brain oligodendrocytes. J Neurosci Res 62:9\u201314","journal-title":"J Neurosci Res"},{"key":"672_CR89","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s12031-009-9190-y","volume":"39","author":"M Riedel","year":"2009","unstructured":"Riedel M, Goldbaum O, Richter-Landsberg C (2009) Alpha-synuclein promotes the recruitment of tau to protein inclusions in oligodendroglial cells: effects of oxidative and proteolytic stress. J Mol Neurosci 39:226\u2013234","journal-title":"J Mol Neurosci"},{"key":"672_CR90","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/mds.21385","volume":"22","author":"K Sato","year":"2007","unstructured":"Sato K, Kaji R, Matsumoto S, Goto S (2007) Cell type-specific neuronal loss in the putamen of patients with multiple system atrophy. Mov Disord 22:738\u2013742","journal-title":"Mov Disord"},{"key":"672_CR91","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0002-9440(10)61113-3","volume":"160","author":"MG Schlossmacher","year":"2002","unstructured":"Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS (2002) Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol 160:1655\u20131667","journal-title":"Am J Pathol"},{"key":"672_CR92","first-page":"184","volume-title":"The dementias 2","author":"MG Schlossmacher","year":"2007","unstructured":"Schlossmacher MG (2007) Alpha-synuclein and synucleinopathies. In: Growdon J, Rossor MN (eds) The dementias 2. Butterworth Heinemann, London, pp 184\u2013213"},{"key":"672_CR93","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/ana.21685","volume":"65","author":"SW Scholz","year":"2009","unstructured":"Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R, Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ, Arepalli S, Zonozi RR, Revesz T, Holton J, Wood N, Lees A, Oertel W, Wullner U, Goldwurm S, Pellecchia MT, Illig T, Riess O, Fernandez HH, Rodriguez RL, Okun MS, Poewe W, Wenning GK, Hardy JA, Singleton AB, Gasser T (2009) SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol 65:610\u2013614","journal-title":"Ann Neurol"},{"key":"672_CR94","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s00401-003-0675-4","volume":"105","author":"K Shibuya","year":"2003","unstructured":"Shibuya K, Uchihara T, Nakamura A, Ishiyama M, Yamaoka K, Yagishita S, Iwabuchi K, Kosaka K (2003) Reversible conformational change of tau2 epitope on exposure to detergent in glial cytoplasmic inclusions of multiple system atrophy. Acta Neuropathol 105:508\u2013514","journal-title":"Acta Neuropathol"},{"key":"672_CR95","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1523\/JNEUROSCI.3527-05.2005","volume":"25","author":"CW Shults","year":"2005","unstructured":"Shults CW, Rockenstein E, Crews L, Adame A, Mante M, Larrea G, Hashimoto M, Song D, Iwatsubo T, Tsuboi K, Masliah E (2005) Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. J Neurosci 25:10689\u201310699","journal-title":"J Neurosci"},{"key":"672_CR96","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1002\/mds.22046","volume":"23","author":"H Soma","year":"2008","unstructured":"Soma H, Yabe I, Takei A, Fujiki N, Yanagihara T, Sasaki H (2008) Associations between multiple system atrophy and polymorphisms of SLC1A4, SQSTM1, and EIF4EBP1 genes. Mov Disord 23:1161\u20131167","journal-title":"Mov Disord"},{"key":"672_CR97","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00401-005-1013-9","volume":"110","author":"M Sone","year":"2005","unstructured":"Sone M, Yoshida M, Hashizume Y, Hishikawa N, Sobue G (2005) Alpha-synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy. Acta Neuropathol 110:19\u201326","journal-title":"Acta Neuropathol"},{"key":"672_CR98","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2353\/ajpath.2007.070201","volume":"171","author":"YJ Song","year":"2007","unstructured":"Song YJ, Lundvig DM, Huang Y, Gai WP, Blumbergs PC, Hojrup P, Otzen D, Halliday GM, Jensen PH (2007) p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy. Am J Pathol 171:1291\u20131303","journal-title":"Am J Pathol"},{"issue":"Suppl.1","key":"672_CR99","first-page":"S266","volume":"23","author":"YJC Song","year":"2008","unstructured":"Song YJC, Huang Y, Gai WP, Jensen PH, Halliday GM (2008) Correlations between striatal oligodendroglial abnormalities and neuron loss in multiple system atrophy (abstract). Mov Disord 23(Suppl.1):S266","journal-title":"Mov Disord"},{"key":"672_CR100","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0304-3940(98)00504-7","volume":"251","author":"MG Spillantini","year":"1998","unstructured":"Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M (1998) Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson\u2019s disease and dementia with Lewy bodies. Neurosci Lett 251:205\u2013208","journal-title":"Neurosci Lett"},{"key":"672_CR101","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.tins.2005.07.002","volume":"28","author":"N Stefanova","year":"2005","unstructured":"Stefanova N, Tison F, Reindl M, Poewe W, Wenning GK (2005) Animal models of multiple system atrophy. Trends Neurosci 28:501\u2013506","journal-title":"Trends Neurosci"},{"key":"672_CR102","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/mds.21671","volume":"22","author":"N Stefanova","year":"2007","unstructured":"Stefanova N, Reindl M, Neumann M, Kahle PJ, Poewe W, Wenning GK (2007) Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy. Mov Disord 22:2196\u20132203","journal-title":"Mov Disord"},{"key":"672_CR103","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S1474-4422(09)70288-1","volume":"8","author":"N Stefanova","year":"2009","unstructured":"Stefanova N, Bucke P, Duerr S, Wenning GK (2009) Multiple system atrophy: an update. Lancet Neurol 8:1172\u20131178","journal-title":"Lancet Neurol"},{"key":"672_CR104","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.expneurol.2009.05.016","volume":"219","author":"N Stefanova","year":"2009","unstructured":"Stefanova N, Hainzer M, Stemberger S, Couillard-Despres S, Aigner L, Poewe W, Wenning GK (2009) Striatal transplantation for multiple system atrophy\u2014are grafts affected by alpha-synucleinopathy? Exp Neurol 219:368\u2013371","journal-title":"Exp Neurol"},{"key":"672_CR105","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0014-5793(91)80903-G","volume":"289","author":"M Takahashi","year":"1991","unstructured":"Takahashi M, Tomizawa K, Ishiguro K, Sato K, Omori A, Sato S, Shiratsuchi A, Uchida T, Imahori K (1991) A novel brain-specific 25\u00a0kDa protein (p25) is phosphorylated by a Ser\/Thr-Pro kinase (TPK II) from tau protein kinase fractions. FEBS Lett 289:37\u201343","journal-title":"FEBS Lett"},{"key":"672_CR106","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1471-4159.1993.tb05842.x","volume":"60","author":"M Takahashi","year":"1993","unstructured":"Takahashi M, Tomizawa K, Fujita SC, Sato K, Uchida T, Imahori K (1993) A brain-specific protein p25 is localized and associated with oligodendrocytes, neuropil, and fiber-like structures of the CA3 hippocampal region in the rat brain. J Neurochem 60:228\u2013235","journal-title":"J Neurochem"},{"key":"672_CR107","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/(SICI)1097-4644(19980101)68:1<128::AID-JCB13>3.0.CO;2-D","volume":"68","author":"XM Tang","year":"1998","unstructured":"Tang XM, Strocchi P, Cambi F (1998) Changes in the activity of cdk2 and cdk5 accompany differentiation of rat primary oligodendrocytes. J Cell Biochem 68:128\u2013137","journal-title":"J Cell Biochem"},{"key":"672_CR108","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/exnr.2000.7489","volume":"166","author":"NA Tatton","year":"2000","unstructured":"Tatton NA (2000) Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson\u2019s disease. Exp Neurol 166:29\u201343","journal-title":"Exp Neurol"},{"key":"672_CR109","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00401-006-0192-3","volume":"113","author":"B Terni","year":"2007","unstructured":"Terni B, Rey MJ, Boluda S, Torrejon-Escribano B, Sabate MP, Calopa M, van Leeuwen FW, Ferrer I (2007) Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer\u2019s disease. Acta Neuropathol 113:403\u2013416","journal-title":"Acta Neuropathol"},{"key":"672_CR110","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/brain\/awp282","volume":"133","author":"J Tong","year":"2010","unstructured":"Tong J, Wong H, Guttman M, Ang LC, Forno LS, Shimadzu M, Rajput AH, Muenter MD, Kish SJ, Hornykiewicz O, Furukawa Y (2010) Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson\u2019s disease and progressive supranuclear palsy: a comparative investigation. Brain 133:172\u2013188","journal-title":"Brain"},{"key":"672_CR111","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1365-2990.2007.00907.x","volume":"33","author":"JQ Trojanowski","year":"2007","unstructured":"Trojanowski JQ, Revesz T (2007) Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy. Neuropathol Appl Neurobiol 33:615\u2013620","journal-title":"Neuropathol Appl Neurobiol"},{"key":"672_CR112","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/ana.410440324","volume":"44","author":"PH Tu","year":"1998","unstructured":"Tu PH, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski JQ, Lee VM (1998) Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Ann Neurol 44:415\u2013422","journal-title":"Ann Neurol"},{"key":"672_CR113","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1002\/jnr.22089","volume":"87","author":"K Ubhi","year":"2009","unstructured":"Ubhi K, Lee PH, Adame A, Inglis C, Mante M, Rockenstein E, Stefanova N, Wenning GK, Masliah E (2009) Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy. J Neurosci Res 87:2728\u20132739","journal-title":"J Neurosci Res"},{"key":"672_CR114","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.molbrainres.2004.11.014","volume":"134","author":"VN Uversky","year":"2005","unstructured":"Uversky VN, Yamin G, Munishkina LA, Karymov MA, Millett IS, Doniach S, Lyubchenko YL, Fink AL (2005) Effects of nitration on the structure and aggregation of alpha-synuclein. Brain Res Mol Brain Res 134:84\u2013102","journal-title":"Brain Res Mol Brain Res"},{"key":"672_CR115","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1097\/NEN.0b013e3181b67678","volume":"68","author":"N Uyama","year":"2009","unstructured":"Uyama N, Uchihara T, Mochizuki Y, Nakamura A, Takahashi R, Mizutani T (2009) Selective nuclear shrinkage of oligodendrocytes lacking glial cytoplasmic inclusions in multiple system atrophy: a 3-dimensional volumetric study. J Neuropathol Exp Neurol 68:1084\u20131091","journal-title":"J Neuropathol Exp Neurol"},{"issue":"Suppl 1","key":"672_CR116","first-page":"S429","volume":"24","author":"F Viallet","year":"2009","unstructured":"Viallet F, Maues De Paula A, Bonnefoi B, Gayraud D, Julou M, Sault M-C, Pellissier J-F (2009) Preclinical multiple system atrophy: a neuropathological case report in a 81-year-old man with isolated REM sleep behavioral disorder (abstr). Mov Disord 24(Suppl 1):S429","journal-title":"Mov Disord"},{"key":"672_CR117","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00401-005-1029-1","volume":"110","author":"K Wakabayashi","year":"2005","unstructured":"Wakabayashi K, Mori F, Nishie M, Oyama Y, Kurihara A, Yoshimoto M, Kuroda N (2005) An autopsy case of early (\u201cminimal change\u201d) olivopontocerebellar atrophy (multiple system atrophy-cerebellar). Acta Neuropathol 110:185\u2013190","journal-title":"Acta Neuropathol"},{"key":"672_CR118","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1440-1789.2006.00713.x","volume":"26","author":"K Wakabayashi","year":"2006","unstructured":"Wakabayashi K, Takahashi H (2006) Cellular pathology in multiple system atrophy. Neuropathology 26:338\u2013345","journal-title":"Neuropathology"},{"key":"672_CR119","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/mds.870090206","volume":"9","author":"GK Wenning","year":"1994","unstructured":"Wenning GK, Quinn N, Magalhaes M, Mathias C, Daniel SE (1994) \u201cMinimal change\u201d multiple system atrophy. Mov Disord 9:161\u2013166","journal-title":"Mov Disord"},{"key":"672_CR120","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00401-004-0935-y","volume":"109","author":"GK Wenning","year":"2005","unstructured":"Wenning GK, Jellinger KA (2005) The role of alpha-synuclein in the pathogenesis of multiple system atrophy. Acta Neuropathol 109:129\u2013140","journal-title":"Acta Neuropathol"},{"key":"672_CR121","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ana.21465","volume":"64","author":"GK Wenning","year":"2008","unstructured":"Wenning GK, Stefanova N, Jellinger KA, Poewe W, Schlossmacher MG (2008) Multiple system atrophy: a primary oligodendrogliopathy. Ann Neurol 64:239\u2013246","journal-title":"Ann Neurol"},{"key":"672_CR122","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1007\/s00415-009-5173-8","volume":"256","author":"GK Wenning","year":"2009","unstructured":"Wenning GK, Stefanova N (2009) Recent developments in multiple system atrophy. J Neurol 256:1791\u20131808","journal-title":"J Neurol"},{"key":"672_CR123","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.neuron.2005.01.032","volume":"45","author":"I Yazawa","year":"2005","unstructured":"Yazawa I, Giasson BI, Sasaki R, Zhang B, Joyce S, Uryu K, Trojanowski JQ, Lee VM (2005) Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron 45:847\u2013859","journal-title":"Neuron"},{"key":"672_CR124","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1440-1789.2007.00841.x","volume":"27","author":"M Yoshida","year":"2007","unstructured":"Yoshida M (2007) Multiple system atrophy: alpha-synuclein and neuronal degeneration. Neuropathology 27:484\u2013493","journal-title":"Neuropathology"},{"key":"672_CR125","first-page":"1051","volume":"61","author":"M Yoshida","year":"2009","unstructured":"Yoshida M, Sone M (2009) Mechanism of neuronal degeneration of multiple system atrophy. Brain Nerve 61:1051\u20131060","journal-title":"Brain Nerve"},{"key":"672_CR126","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/ana.20928","volume":"60","author":"X Zhu","year":"2006","unstructured":"Zhu X, Siedlak SL, Smith MA, Perry G, Chen SG (2006) LRRK2 protein is a component of Lewy bodies. Ann Neurol 60:617\u2013618 (author reply 618\u2013619)","journal-title":"Ann Neurol"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-010-0672-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-010-0672-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-010-0672-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T03:30:42Z","timestamp":1711337442000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-010-0672-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,23]]},"references-count":126,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["672"],"URL":"https:\/\/doi.org\/10.1007\/s00401-010-0672-3","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,23]]}}}