{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:28:58Z","timestamp":1792189738093,"version":"4.4.0"},"reference-count":132,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T00:00:00Z","timestamp":1278806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s00401-010-0718-6","type":"journal-article","created":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T23:07:36Z","timestamp":1278889656000},"page":"287-296","source":"Crossref","is-referenced-by-count":477,"title":["The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia"],"prefix":"10.1007","volume":"120","author":[{"given":"Costantino","family":"Iadecola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,7,11]]},"reference":[{"key":"718_CR1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","volume":"37","author":"NJ Abbott","year":"2010","unstructured":"Abbott NJ, Patabendige AAK, Dolman DEM, Yusof SR, Begley DJ (2010) Structure and function of the blood-brain barrier. Neurobiol Dis 37:13\u201325","journal-title":"Neurobiol Dis"},{"key":"718_CR2","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1161\/01.STR.0000248777.44128.93","volume":"37","author":"L Aho","year":"2006","unstructured":"Aho L, Jolkkonen J, Alafuzoff I (2006) Beta-amyloid aggregation in human brains with cerebrovascular lesions. Stroke 37:2940\u20132945","journal-title":"Stroke"},{"key":"718_CR3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1152\/japplphysiol.00937.2005","volume":"100","author":"J Andresen","year":"2006","unstructured":"Andresen J, Shafi NI, Bryan RM Jr (2006) Endothelial influences on cerebrovascular tone. J Appl Physiol 100:318\u2013327","journal-title":"J Appl Physiol"},{"key":"718_CR4","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1523\/JNEUROSCI.0035-09.2009","volume":"29","author":"K Arai","year":"2009","unstructured":"Arai K, Lo EH (2009) An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci 29:4351\u20134355","journal-title":"J Neurosci"},{"key":"718_CR5","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/jnr.22256","volume":"88","author":"K Arai","year":"2010","unstructured":"Arai K, Lo EH (2010) Astrocytes protect oligodendrocyte precursor cells via MEK\/ERK and PI3K\/Akt signaling. J Neurosci Res 88:758\u2013763","journal-title":"J Neurosci Res"},{"key":"718_CR6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jocn.2005.04.017","volume":"13","author":"GA Bateman","year":"2006","unstructured":"Bateman GA, Levi CR, Schofield P, Wang Y, Lovett EC (2006) Quantitative measurement of cerebral haemodynamics in early vascular dementia and Alzheimer\u2019s disease. J Clin Neurosci 13:563\u2013568","journal-title":"J Clin Neurosci"},{"key":"718_CR7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-006-0136-y","volume":"113","author":"TG Beach","year":"2007","unstructured":"Beach TG, Wilson JR, Sue LI et al (2007) Circle of Willis atherosclerosis: association with Alzheimer\u2019s disease, neuritic plaques and neurofibrillary tangles. Acta Neuropathol 113:13\u201321","journal-title":"Acta Neuropathol"},{"key":"718_CR8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ncb1819","volume":"11","author":"RD Bell","year":"2009","unstructured":"Bell RD, Deane R, Chow N et al (2009) SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol 11:143\u2013153","journal-title":"Nat Cell Biol"},{"key":"718_CR9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00401-009-0522-3","volume":"118","author":"RD Bell","year":"2009","unstructured":"Bell RD, Zlokovic BV (2009) Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer\u2019s disease. Acta Neuropathol 118:103\u2013113","journal-title":"Acta Neuropathol"},{"key":"718_CR10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0197-4580(99)00110-4","volume":"21","author":"MM Breteler","year":"2000","unstructured":"Breteler MM (2000) Vascular risk factors for Alzheimer\u2019s disease: an epidemiologic perspective. Neurobiol Aging 21:153\u2013160","journal-title":"Neurobiol Aging"},{"key":"718_CR11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jns.2007.01.015","volume":"257","author":"WR Brown","year":"2007","unstructured":"Brown WR, Moody DM, Thore CR, Challa VR, Anstrom JA (2007) Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well. J Neurol Sci 257:62\u201366","journal-title":"J Neurol Sci"},{"key":"718_CR12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1073\/pnas.0608251104","volume":"104","author":"N Chow","year":"2007","unstructured":"Chow N, Bell RD, Deane R et al (2007) Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer\u2019s phenotype. Proc Natl Acad Sci USA 104:823\u2013828","journal-title":"Proc Natl Acad Sci USA"},{"key":"718_CR13","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1212\/WNL.42.3.473","volume":"42","author":"HC Chui","year":"1992","unstructured":"Chui HC, Victoroff JI, Margolin D et al (1992) Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer\u2019s Disease Diagnostic and Treatment Centers. Neurology 42:473\u2013480","journal-title":"Neurology"},{"key":"718_CR14","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1172\/JCI25247","volume":"115","author":"JR Cirrito","year":"2005","unstructured":"Cirrito JR, Deane R, Fagan AM et al (2005) P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest 115:3285\u20133290","journal-title":"J Clin Invest"},{"key":"718_CR15","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.neuron.2005.10.028","volume":"48","author":"JR Cirrito","year":"2005","unstructured":"Cirrito JR, Yamada KA, Finn MB et al (2005) Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 48:913\u2013922","journal-title":"Neuron"},{"key":"718_CR16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2007.06.011","volume":"30","author":"CW Cotman","year":"2007","unstructured":"Cotman CW, Berchtold NC, Christie L-A (2007) Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci 30:464\u2013472","journal-title":"Trends Neurosci"},{"key":"718_CR17","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/01616412.1993.11740127","volume":"15","author":"JC la Torre de","year":"1993","unstructured":"de la Torre JC, Mussivand T (1993) Can disturbed brain microcirculation cause Alzheimer\u2019s disease? Neurol Res 15:146\u2013153","journal-title":"Neurol Res"},{"key":"718_CR18","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nm890","volume":"9","author":"R Deane","year":"2003","unstructured":"Deane R, Du Yan S, Submamaryan RK et al (2003) RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 9:907\u2013913","journal-title":"Nat Med"},{"key":"718_CR19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuron.2004.07.017","volume":"43","author":"R Deane","year":"2004","unstructured":"Deane R, Wu Z, Sagare A et al (2004) LRP\/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 43:333\u2013344","journal-title":"Neuron"},{"key":"718_CR20","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1111\/j.1532-5415.2007.01378.x","volume":"55","author":"DS Dede","year":"2007","unstructured":"Dede DS, Yavuz B, Yavuz BB et al (2007) Assessment of endothelial function in Alzheimer\u2019s disease: is Alzheimer\u2019s disease a vascular disease? J Am Geriatr Soc 55:1613\u20131617","journal-title":"J Am Geriatr Soc"},{"key":"718_CR21","doi-asserted-by":"crossref","first-page":"10621","DOI":"10.1523\/JNEUROSCI.22-24-10621.2002","volume":"22","author":"MH Deininger","year":"2002","unstructured":"Deininger MH, Fimmen BA, Thal DR, Schluesener HJ, Meyermann R (2002) Aberrant neuronal and paracellular deposition of endostatin in brains of patients with Alzheimer\u2019s disease. J Neurosci 22:10621\u201310626","journal-title":"J Neurosci"},{"key":"718_CR22","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1212\/WNL.0b013e3181b59bf3","volume":"73","author":"Y Deschaintre","year":"2009","unstructured":"Deschaintre Y, Richard F, Leys D, Pasquier F (2009) Treatment of vascular risk factors is associated with slower decline in Alzheimer disease. Neurology 73:674\u2013680","journal-title":"Neurology"},{"key":"718_CR23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000197886","volume":"24","author":"T Erkinjuntti","year":"2009","unstructured":"Erkinjuntti T, Gauthier S (2009) The concept of vascular cognitive impairment. Front Neurol Neurosci 24:79\u201385","journal-title":"Front Neurol Neurosci"},{"key":"718_CR24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(99)02355-7","volume":"354","author":"MM Esiri","year":"1999","unstructured":"Esiri MM, Nagy Z, Smith MZ, Barnetson L, Smith AD (1999) Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer\u2019s disease. Lancet 354:919\u2013920","journal-title":"Lancet"},{"key":"718_CR25","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/japplphysiol.01044.2005","volume":"100","author":"FM Faraci","year":"2006","unstructured":"Faraci FM (2006) Reactive oxygen species: influence on cerebral vascular tone. J Appl Physiol 100:739\u2013743","journal-title":"J Appl Physiol"},{"key":"718_CR26","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neurobiolaging.2007.07.015","volume":"30","author":"AJ Farrall","year":"2009","unstructured":"Farrall AJ, Wardlaw JM (2009) Blood-brain barrier: ageing and microvascular disease\u2013systematic review and meta-analysis. Neurobiol Aging 30:337\u2013352","journal-title":"Neurobiol Aging"},{"key":"718_CR27","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1161\/01.STR.0000221308.94473.14","volume":"37","author":"MS Fernando","year":"2006","unstructured":"Fernando MS, Simpson JE, Matthews F et al (2006) White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke 37:1391\u20131398","journal-title":"Stroke"},{"key":"718_CR28","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrneurol.2009.175","volume":"5","author":"M Fotuhi","year":"2009","unstructured":"Fotuhi M, Hachinski V, Whitehouse PJ (2009) Changing perspectives regarding late-life dementia. Nat Rev Neurol 5:649\u2013658","journal-title":"Nat Rev Neurol"},{"key":"718_CR29","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1056\/NEJMra0801082","volume":"359","author":"B Furie","year":"2008","unstructured":"Furie B, Furie BC (2008) Mechanisms of thrombus formation. N Engl J Med 359:938\u2013949","journal-title":"N Engl J Med"},{"key":"718_CR30","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.freeradbiomed.2010.01.006","volume":"48","author":"R Gill","year":"2010","unstructured":"Gill R, Tsung A, Billiar T (2010) Linking oxidative stress to inflammation: Toll-like receptors. Free Radic Biol Med 48:1121\u20131132","journal-title":"Free Radic Biol Med"},{"key":"718_CR31","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1161\/STROKEAHA.109.559641","volume":"40","author":"M Gomis","year":"2009","unstructured":"Gomis M, Sobrino T, Ois A et al (2009) Plasma beta-amyloid 1\u201340 is associated with the diffuse small vessel disease subtype. Stroke 40:3197\u20133201","journal-title":"Stroke"},{"key":"718_CR32","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1136\/jnnp.67.5.654","volume":"67","author":"JM Goulding","year":"1999","unstructured":"Goulding JM, Signorini DF, Chatterjee S et al (1999) Inverse relation between Braak stage and cerebrovascular pathology in Alzheimer predominant dementia. J Neurol Neurosurg Psychiatry 67:654\u2013657","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"718_CR33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1212\/01.wnl.0000191403.95453.6a","volume":"66","author":"ME Gurol","year":"2006","unstructured":"Gurol ME, Irizarry MC, Smith EE et al (2006) Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy. Neurology 66:23\u201329","journal-title":"Neurology"},{"key":"718_CR34","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1161\/01.STR.0000237236.88823.47","volume":"37","author":"V Hachinski","year":"2006","unstructured":"Hachinski V, Iadecola C, Petersen RC et al (2006) National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke 37:2220\u20132241","journal-title":"Stroke"},{"key":"718_CR35","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1212\/WNL.43.10.2159-a","volume":"43","author":"VC Hachinski","year":"1993","unstructured":"Hachinski VC, Bowler JV (1993) Vascular dementia. Neurology 43:2159\u20132160 author reply 2160\u20132161","journal-title":"Neurology"},{"key":"718_CR36","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0140-6736(74)91496-2","volume":"2","author":"VC Hachinski","year":"1974","unstructured":"Hachinski VC, Lassen NA, Marshall J (1974) Multi-infarct dementia. A cause of mental deterioration in the elderly. Lancet 2:207\u2013210","journal-title":"Lancet"},{"key":"718_CR37","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1161\/ATVBAHA.109.188516","volume":"29","author":"S Hayashi","year":"2009","unstructured":"Hayashi S, Sato N, Yamamoto A et al (2009) Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy. Arterioscler Thromb Vasc Biol 29:1909\u20131915","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"718_CR38","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1001\/archneur.66.3.343","volume":"66","author":"EP Helzner","year":"2009","unstructured":"Helzner EP, Luchsinger JA, Scarmeas N et al (2009) Contribution of vascular risk factors to the progression in Alzheimer disease. Arch Neurol 66:343\u2013348","journal-title":"Arch Neurol"},{"key":"718_CR39","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1212\/WNL.51.1.159","volume":"51","author":"A Heyman","year":"1998","unstructured":"Heyman A, Fillenbaum GG, Welsh-Bohmer KA et al (1998) Cerebral infarcts in patients with autopsy-proven Alzheimer\u2019s disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer\u2019s Disease. Neurology 51:159\u2013162","journal-title":"Neurology"},{"key":"718_CR40","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1212\/01.WNL.0000150886.50187.30","volume":"64","author":"LS Honig","year":"2005","unstructured":"Honig LS, Kukull W, Mayeux R (2005) Atherosclerosis and AD: analysis of data from the US National Alzheimer\u2019s Coordinating Center. Neurology 64:494\u2013500","journal-title":"Neurology"},{"key":"718_CR41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrn1387","volume":"5","author":"C Iadecola","year":"2004","unstructured":"Iadecola C (2004) Neurovascular regulation in the normal brain and in Alzheimer\u2019s disease. Nat Rev Neurosci 5:347\u2013360","journal-title":"Nat Rev Neurosci"},{"key":"718_CR42","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cmet.2008.03.010","volume":"7","author":"C Iadecola","year":"2008","unstructured":"Iadecola C, Davisson RL (2008) Hypertension and cerebrovascular dysfunction. Cell Metab 7:476\u2013484","journal-title":"Cell Metab"},{"key":"718_CR43","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/01.STR.0000054050.51530.76","volume":"34","author":"C Iadecola","year":"2003","unstructured":"Iadecola C, Gorelick PB (2003) Converging pathogenic mechanisms in vascular and neurodegenerative dementia. Stroke 34:335\u2013337","journal-title":"Stroke"},{"key":"718_CR44","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nn2003","volume":"10","author":"C Iadecola","year":"2007","unstructured":"Iadecola C, Nedergaard M (2007) Glial regulation of the cerebral microvasculature. Nat Neurosci 10:1369\u20131376","journal-title":"Nat Neurosci"},{"key":"718_CR45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/5715","volume":"2","author":"C Iadecola","year":"1999","unstructured":"Iadecola C, Zhang F, Niwa K et al (1999) SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci 2:157\u2013161","journal-title":"Nat Neurosci"},{"key":"718_CR46","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00401-009-0635-8","volume":"119","author":"M Ihara","year":"2010","unstructured":"Ihara M, Polvikoski TM, Hall R et al (2010) Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer\u2019s disease, and dementia with Lewy bodies. Acta Neuropathol 119:579\u2013589","journal-title":"Acta Neuropathol"},{"key":"718_CR47","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1212\/WNL.51.4.1009","volume":"51","author":"WJ Jagust","year":"1998","unstructured":"Jagust WJ, Haan MN, Reed BR, Eberling JL (1998) Brain perfusion imaging predicts survival in Alzheimer\u2019s disease. Neurology 51:1009\u20131013","journal-title":"Neurology"},{"key":"718_CR48","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jalz.2006.09.002","volume":"3","author":"KA Jellinger","year":"2007","unstructured":"Jellinger KA (2007) The enigma of mixed dementia. Alzheimers Dement 3:40\u201353","journal-title":"Alzheimers Dement"},{"key":"718_CR49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2008.03.006","volume":"270","author":"KA Jellinger","year":"2008","unstructured":"Jellinger KA (2008) Morphologic diagnosis of \u201cvascular dementia\u201d\u2014a critical update. J Neurol Sci 270:1\u201312","journal-title":"J Neurol Sci"},{"key":"718_CR50","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00401-010-0654-5","volume":"119","author":"KA Jellinger","year":"2010","unstructured":"Jellinger KA, Attems J (2010) Prevalence of dementia disorders in the oldest-old: an autopsy study. Acta Neuropathol 119:421\u2013433","journal-title":"Acta Neuropathol"},{"key":"718_CR51","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1007\/s00415-003-0142-0","volume":"250","author":"KA Jellinger","year":"2003","unstructured":"Jellinger KA, Mitter-Ferstl E (2003) The impact of cerebrovascular lesions in Alzheimer disease\u2014a comparative autopsy study. J Neurol 250:1050\u20131055","journal-title":"J Neurol"},{"key":"718_CR52","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF00294806","volume":"90","author":"K Jendroska","year":"1995","unstructured":"Jendroska K, Poewe W, Daniel SE et al (1995) Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain. Acta Neuropathol 90:461\u2013466","journal-title":"Acta Neuropathol"},{"key":"718_CR53","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1212\/01.WNL.0000158283.28251.3C","volume":"64","author":"JR Jennings","year":"2005","unstructured":"Jennings JR, Muldoon MF, Ryan C et al (2005) Reduced cerebral blood flow response and compensation among patients with untreated hypertension. Neurology 64:1358\u20131365","journal-title":"Neurology"},{"key":"718_CR54","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0197-4580(00)00137-8","volume":"21","author":"KA Johnson","year":"2000","unstructured":"Johnson KA, Albert MS (2000) Perfusion abnormalities in prodromal AD. Neurobiol Aging 21:289\u2013292","journal-title":"Neurobiol Aging"},{"key":"718_CR55","first-page":"226","volume":"4","author":"RN Kalaria","year":"1992","unstructured":"Kalaria RN (1992) The blood-brain barrier and cerebral microcirculation in Alzheimer disease. Cerebrovasc Brain Metab Rev 4:226\u2013260","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"718_CR56","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0197-4580(00)00125-1","volume":"21","author":"RN Kalaria","year":"2000","unstructured":"Kalaria RN (2000) The role of cerebral ischemia in Alzheimer\u2019s disease. Neurobiol Aging 21:321\u2013330","journal-title":"Neurobiol Aging"},{"key":"718_CR57","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.neurobiolaging.2007.10.020","volume":"30","author":"RN Kalaria","year":"2009","unstructured":"Kalaria RN (2009) Linking cerebrovascular defense mechanisms in brain ageing and Alzheimer\u2019s disease. Neurobiol Aging 30:1512\u20131514","journal-title":"Neurobiol Aging"},{"key":"718_CR58","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nrneurol.2009.72","volume":"5","author":"RN Kalaria","year":"2009","unstructured":"Kalaria RN (2009) Neurodegenerative disease: diabetes, microvascular pathology and Alzheimer disease. Nat Rev Neurol 5:305\u2013306","journal-title":"Nat Rev Neurol"},{"key":"718_CR59","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1161\/01.RES.0000148637.85595.c5","volume":"95","author":"K Kazama","year":"2004","unstructured":"Kazama K, Anrather J, Zhou P et al (2004) Angiotensin II impairs neurovascular coupling in neocortex through NADPH-oxidase-derived radicals. Circ Res 95:1019\u20131026","journal-title":"Circ Res"},{"key":"718_CR60","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/CS20070458","volume":"115","author":"YS Kim","year":"2008","unstructured":"Kim YS, Immink RV, Stok WJ et al (2008) Dynamic cerebral autoregulatory capacity is affected early in Type 2 diabetes. Clin Sci 115:255\u2013262","journal-title":"Clin Sci"},{"key":"718_CR61","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1161\/STROKEAHA.107.481879","volume":"38","author":"J Kitayama","year":"2007","unstructured":"Kitayama J, Faraci FM, Lentz SR, Heistad DD (2007) Cerebral vascular dysfunction during hypercholesterolemia. Stroke 38:2136\u20132141","journal-title":"Stroke"},{"key":"718_CR62","doi-asserted-by":"crossref","unstructured":"Koike MA, Green KN, Blurton-Jones M, LaFerla FM (2010) Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. doi: 10.2353\/ajpath.2010.090750","DOI":"10.2353\/ajpath.2010.090750"},{"key":"718_CR63","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1073\/pnas.032670899","volume":"99","author":"M Koistinaho","year":"2002","unstructured":"Koistinaho M, Kettunen MI, Goldsteins G et al (2002) Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation. Proc Natl Acad Sci USA 99:1610\u20131615","journal-title":"Proc Natl Acad Sci USA"},{"key":"718_CR64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20060043","volume":"112","author":"JP Konsman","year":"2007","unstructured":"Konsman JP, Drukarch B, Van Dam A-M (2007) (Peri)vascular production and action of pro-inflammatory cytokines in brain pathology. Clin Sci 112:1\u201325","journal-title":"Clin Sci"},{"key":"718_CR65","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nature09001","volume":"465","author":"CK Lam","year":"2010","unstructured":"Lam CK, Yoo T, Hiner B, Liu Z, Grutzendler J (2010) Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization. Nature 465:478\u2013482","journal-title":"Nature"},{"key":"718_CR66","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2337\/dc06-2052","volume":"30","author":"D Last","year":"2007","unstructured":"Last D, Alsop DC, Abduljalil AM et al (2007) Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity. Diabetes Care 30:1193\u20131199","journal-title":"Diabetes Care"},{"key":"718_CR67","first-page":"1474","volume":"57","author":"JH Lee","year":"2000","unstructured":"Lee JH, Olichney JM, Hansen LA, Hofstetter CR, Thal LJ (2000) Small concomitant vascular lesions do not influence rates of cognitive decline in patients with Alzheimer disease. Arch Neurol 57:1474\u20131479","journal-title":"Arch Neurol"},{"key":"718_CR68","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2990.2006.00696.x","volume":"32","author":"H Lewis","year":"2006","unstructured":"Lewis H, Beher D, Cookson N et al (2006) Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia. Neuropathol Appl Neurobiol 32:103\u2013118","journal-title":"Neuropathol Appl Neurobiol"},{"key":"718_CR69","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.neurobiolaging.2007.10.011","volume":"30","author":"L Li","year":"2009","unstructured":"Li L, Zhang X, Yang D et al (2009) Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP. Neurobiol Aging 30:1091\u20131098","journal-title":"Neurobiol Aging"},{"key":"718_CR70","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/01.wnn.0000209870.69522.a3","volume":"19","author":"DJ Libon","year":"2006","unstructured":"Libon DJ, Price CC, Heilman KM, Grossman M (2006) Alzheimer\u2019s \u201cother dementia\u201d. Cogn Behav Neurol 19:112\u2013116","journal-title":"Cogn Behav Neurol"},{"key":"718_CR71","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.tips.2008.05.003","volume":"29","author":"C Marchesi","year":"2008","unstructured":"Marchesi C, Paradis P, Schiffrin EL (2008) Role of the renin-angiotensin system in vascular inflammation. Trends Pharmacol Sci 29:367\u2013374","journal-title":"Trends Pharmacol Sci"},{"key":"718_CR72","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1176\/ajp.155.6.785","volume":"155","author":"MJ Mentis","year":"1998","unstructured":"Mentis MJ, Alexander GE, Krasuski J et al (1998) Increasing required neural response to expose abnormal brain function in mild versus moderate or severe Alzheimer\u2019s disease: PET study using parametric visual stimulation. Am J Psychiatry 155:785\u2013794","journal-title":"Am J Psychiatry"},{"key":"718_CR73","doi-asserted-by":"crossref","first-page":"H1914","DOI":"10.1152\/ajpheart.00300.2009","volume":"296","author":"ML Modrick","year":"2009","unstructured":"Modrick ML, Didion SP, Sigmund CD, Faraci FM (2009) Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging. Am J Physiol Heart Circ Physiol 296:H1914\u2013H1919","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"718_CR74","doi-asserted-by":"crossref","unstructured":"Moskowitz MA, Lo EH, Iadecola C (2010) The science of stroke: mechanisms in search of treatments. Neuron. doi: 10.1016\/j.neuron.2010.07.002","DOI":"10.1016\/j.neuron.2010.07.002"},{"key":"718_CR75","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00005072-199702000-00007","volume":"56","author":"Z Nagy","year":"1997","unstructured":"Nagy Z, Esiri MM, Jobst KA et al (1997) The effects of additional pathology on the cognitive deficit in Alzheimer disease. J Neuropathol Exp Neurol 56:165\u2013170","journal-title":"J Neuropathol Exp Neurol"},{"key":"718_CR76","doi-asserted-by":"crossref","first-page":"H315","DOI":"10.1152\/ajpheart.00022.2002","volume":"283","author":"K Niwa","year":"2002","unstructured":"Niwa K, Kazama K, Younkin L et al (2002) Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein. Am J Physiol Heart Circ Physiol 283:H315\u2013H323","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"718_CR77","doi-asserted-by":"crossref","first-page":"9735","DOI":"10.1073\/pnas.97.17.9735","volume":"97","author":"K Niwa","year":"2000","unstructured":"Niwa K, Younkin L, Ebeling C et al (2000) Abeta 1\u201340-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc Natl Acad Sci USA 97:9735\u20139740","journal-title":"Proc Natl Acad Sci USA"},{"key":"718_CR78","doi-asserted-by":"crossref","first-page":"13007","DOI":"10.1523\/JNEUROSCI.4323-06.2006","volume":"26","author":"J Ohab","year":"2006","unstructured":"Ohab J, Fleming S, Blesch A, Carmichael S (2006) A neurovascular niche for neurogenesis after stroke. J Neurosci 26:13007\u201313016","journal-title":"J Neurosci"},{"key":"718_CR79","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.neuroscience.2009.12.040","volume":"166","author":"Y Pang","year":"2010","unstructured":"Pang Y, Campbell L, Zheng B et al (2010) Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development. Neuroscience 166:464\u2013475","journal-title":"Neuroscience"},{"key":"718_CR80","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/sj.jcbfm.9600491","volume":"27","author":"L Park","year":"2007","unstructured":"Park L, Anrather J, Girouard H, Zhou P, Iadecola C (2007) Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. J Cereb Blood Flow Metab 27:1908\u20131918","journal-title":"J Cereb Blood Flow Metab"},{"key":"718_CR81","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1073\/pnas.0711568105","volume":"105","author":"L Park","year":"2008","unstructured":"Park L, Zhou P, Pitstick R et al (2008) Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc Natl Acad Sci USA 105:1347\u20131352","journal-title":"Proc Natl Acad Sci USA"},{"key":"718_CR82","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1471-4159.2009.06426.x","volume":"112","author":"NS Patel","year":"2010","unstructured":"Patel NS, Mathura VS, Bachmeier C et al (2010) Alzheimer\u2019s beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2. J Neurochem 112:66\u201376","journal-title":"J Neurochem"},{"key":"718_CR83","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/jcbfm.2009.188","volume":"30","author":"OB Paulson","year":"2010","unstructured":"Paulson OB, Hasselbalch SG, Rostrup E, Knudsen GM, Pelligrino D (2010) Cerebral blood flow response to functional activation. J Cereb Blood Flow Metab 30:2\u201314","journal-title":"J Cereb Blood Flow Metab"},{"key":"718_CR84","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1212\/WNL.38.6.931","volume":"38","author":"I Prohovnik","year":"1988","unstructured":"Prohovnik I, Mayeux R, Sackeim HA et al (1988) Cerebral perfusion as a diagnostic marker of early Alzheimer\u2019s disease. Neurology 38:931\u2013937","journal-title":"Neurology"},{"key":"718_CR85","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","volume":"362","author":"HW Querfurth","year":"2010","unstructured":"Querfurth HW, LaFerla FM (2010) Alzheimer\u2019s disease. N Engl J Med 362:329\u2013344","journal-title":"N Engl J Med"},{"key":"718_CR86","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","volume":"43","author":"GC Roman","year":"1993","unstructured":"Roman GC, Takemici TK, Erkinjuntti T et al (1993) Vascular dementia: diagnostic criteria for research studies: report of the NINDS-AIREN international workshop. Neurology 43:250\u2013260","journal-title":"Neurology"},{"key":"718_CR87","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/ana.20493","volume":"57","author":"A Ruitenberg","year":"2005","unstructured":"Ruitenberg A, den Heijer T, Bakker SL et al (2005) Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study. Ann Neurol 57:789\u2013794","journal-title":"Ann Neurol"},{"key":"718_CR88","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1056\/NEJMoa0806142","volume":"360","author":"GM Savva","year":"2009","unstructured":"Savva GM, Wharton SB, Ince PG et al (2009) Age, neuropathology, and dementia. N Engl J Med 360:2302\u20132309","journal-title":"N Engl J Med"},{"key":"718_CR89","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ana.21706","volume":"66","author":"JA Schneider","year":"2009","unstructured":"Schneider JA, Arvanitakis Z, Leurgans SE, Bennett DA (2009) The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol 66:200\u2013208","journal-title":"Ann Neurol"},{"key":"718_CR90","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1212\/01.WNL.0000118211.78503.F5","volume":"62","author":"JA Schneider","year":"2004","unstructured":"Schneider JA, Wilson RS, Bienias JL, Evans DA, Bennett DA (2004) Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology 62:1148\u20131155","journal-title":"Neurology"},{"key":"718_CR91","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuroimage.2006.09.001","volume":"34","author":"ML Schroeter","year":"2007","unstructured":"Schroeter ML, Cutini S, Wahl MM, Scheid R, Yves von Cramon D (2007) Neurovascular coupling is impaired in cerebral microangiopathy\u2014an event-related Stroop study. Neuroimage 34:26\u201334","journal-title":"Neuroimage"},{"key":"718_CR92","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/ncpneuro0294","volume":"2","author":"OA Selnes","year":"2006","unstructured":"Selnes OA, Vinters HV (2006) Vascular cognitive impairment. Nat Clin Pract Neurol 2:538\u2013547","journal-title":"Nat Clin Pract Neurol"},{"key":"718_CR93","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI10498","volume":"106","author":"M Shibata","year":"2000","unstructured":"Shibata M, Yamada S, Kumar SR et al (2000) Clearance of Alzheimer\u2019s amyloid-beta (1\u201340) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 106:1489\u20131499","journal-title":"J Clin Invest"},{"key":"718_CR94","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0165-0173(00)00030-8","volume":"33","author":"GJ Siegel","year":"2000","unstructured":"Siegel GJ, Chauhan NB (2000) Neurotrophic factors in Alzheimer\u2019s and Parkinson\u2019s disease brain. Brain Res Brain Res Rev 33:199\u2013227","journal-title":"Brain Res Brain Res Rev"},{"key":"718_CR95","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1161\/01.STR.0000206439.62025.97","volume":"37","author":"M Silvestrini","year":"2006","unstructured":"Silvestrini M, Pasqualetti P, Baruffaldi R et al (2006) Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease. Stroke 37:1010\u20131015","journal-title":"Stroke"},{"key":"718_CR96","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1523\/JNEUROSCI.22-07-02451.2002","volume":"22","author":"FJ Sim","year":"2002","unstructured":"Sim FJ, Zhao C, Penderis J, Franklin RJ (2002) The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation. J Neurosci 22:2451\u20132459","journal-title":"J Neurosci"},{"key":"718_CR97","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-2990.2007.00828.x","volume":"33","author":"JE Simpson","year":"2007","unstructured":"Simpson JE, Fernando MS, Clark L et al (2007) White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses. Neuropathol Appl Neurobiol 33:410\u2013419","journal-title":"Neuropathol Appl Neurobiol"},{"key":"718_CR98","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2990.2009.01030.x","volume":"36","author":"JE Simpson","year":"2010","unstructured":"Simpson JE, Ince PG, Haynes LJ et al (2010) Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol 36:25\u201340","journal-title":"Neuropathol Appl Neurobiol"},{"key":"718_CR99","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1365-2990.2007.00890.x","volume":"33","author":"JE Simpson","year":"2007","unstructured":"Simpson JE, Ince PG, Higham CE et al (2007) Microglial activation in white matter lesions and nonlesional white matter of ageing brains. Neuropathol Appl Neurobiol 33:670\u2013683","journal-title":"Neuropathol Appl Neurobiol"},{"key":"718_CR100","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1161\/HYPERTENSIONAHA.109.146795","volume":"55","author":"PJ Smith","year":"2010","unstructured":"Smith PJ, Blumenthal JA, Babyak MA et al (2010) Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension 55:1331\u20131338","journal-title":"Hypertension"},{"key":"718_CR101","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1523\/JNEUROSCI.4956-08.2009","volume":"29","author":"M Snapyan","year":"2009","unstructured":"Snapyan M, Lemasson M, Brill MS et al (2009) Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling. J Neurosci 29:4172\u20134188","journal-title":"J Neurosci"},{"key":"718_CR102","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.1997.03540340047031","volume":"277","author":"DA Snowdon","year":"1997","unstructured":"Snowdon DA, Greiner LH, Mortimer JA et al (1997) Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 277:813\u2013817","journal-title":"JAMA"},{"key":"718_CR103","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/WNN.0b013e31805d859e","volume":"20","author":"IU Song","year":"2007","unstructured":"Song IU, Kim JS, Kim YI, Eah KY, Lee KS (2007) Clinical significance of silent cerebral infarctions in patients with Alzheimer disease. Cogn Behav Neurol 20:93\u201398","journal-title":"Cogn Behav Neurol"},{"key":"718_CR104","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/archneurol.2008.579","volume":"66","author":"JA Sonnen","year":"2009","unstructured":"Sonnen JA, Larson EB, Brickell K et al (2009) Different patterns of cerebral injury in dementia with or without diabetes. Arch Neurol 66:315\u2013322","journal-title":"Arch Neurol"},{"key":"718_CR105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0022-510X(95)00105-B","volume":"131","author":"DL Sparks","year":"1995","unstructured":"Sparks DL, Scheff SW, Liu H et al (1995) Increased incidence of neurofibrillary tangles (NFT) in non-demented individuals with hypertension. J Neurol Sci 131:162\u2013169","journal-title":"J Neurol Sci"},{"key":"718_CR106","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/STROKEAHA.108.531343","volume":"40","author":"SS Staekenborg","year":"2009","unstructured":"Staekenborg SS, Koedam ELGE, Henneman WJP et al (2009) Progression of mild cognitive impairment to dementia: contribution of cerebrovascular disease compared with medial temporal lobe atrophy. Stroke 40:1269\u20131274","journal-title":"Stroke"},{"key":"718_CR107","doi-asserted-by":"crossref","first-page":"18727","DOI":"10.1073\/pnas.0606298103","volume":"103","author":"X Sun","year":"2006","unstructured":"Sun X, He G, Qing H et al (2006) Hypoxia facilitates Alzheimer\u2019s disease pathogenesis by up-regulating BACE1 gene expression. Proc Natl Acad Sci USA 103:18727\u201318732","journal-title":"Proc Natl Acad Sci USA"},{"key":"718_CR108","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1552-6569.2002.tb00106.x","volume":"12","author":"M Tanaka","year":"2002","unstructured":"Tanaka M, Fukuyama H, Yamauchi H et al (2002) Regional cerebral blood flow abnormalities in nondemented patients with memory impairment. J Neuroimaging 12:112\u2013118","journal-title":"J Neuroimaging"},{"key":"718_CR109","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0197-4580(01)00285-8","volume":"23","author":"E Tarkowski","year":"2002","unstructured":"Tarkowski E, Issa R, Sj\u00f6gren M et al (2002) Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer\u2019s disease and vascular dementia. Neurobiol Aging 23:237\u2013243","journal-title":"Neurobiol Aging"},{"key":"718_CR110","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.neuron.2007.05.012","volume":"54","author":"G Tesco","year":"2007","unstructured":"Tesco G, Koh YH, Kang EL et al (2007) Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron 54:721\u2013737","journal-title":"Neuron"},{"key":"718_CR111","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/380168a0","volume":"380","author":"T Thomas","year":"1996","unstructured":"Thomas T, Thomas G, McLendon C, Sutton T, Mullan M (1996) \u03b2-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380:168\u2013171","journal-title":"Nature"},{"key":"718_CR112","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.neurobiolaging.2007.02.027","volume":"29","author":"L Tong","year":"2008","unstructured":"Tong L, Balazs R, Soiampornkul R, Thangnipon W, Cotman CW (2008) Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging 29:1380\u20131393","journal-title":"Neurobiol Aging"},{"key":"718_CR113","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S1474-4422(09)70043-2","volume":"8","author":"BD Trapp","year":"2009","unstructured":"Trapp BD, Stys PK (2009) Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis. Lancet Neurol 8:280\u2013291","journal-title":"Lancet Neurol"},{"key":"718_CR114","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/jcbfm.2008.13","volume":"28","author":"AH Beek van","year":"2008","unstructured":"van Beek AH, Claassen JA, Rikkert MG, Jansen RW (2008) Cerebral autoregulation: an overview of current concepts and methodology with special focus on the elderly. J Cereb Blood Flow Metab 28:1071\u20131085","journal-title":"J Cereb Blood Flow Metab"},{"key":"718_CR115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0166-2236(99)01533-7","volume":"23","author":"HD Venters","year":"2000","unstructured":"Venters HD, Dantzer R, Kelley KW (2000) A new concept in neurodegeneration: TNFalpha is a silencer of survival signals. Trends Neurosci 23:175\u2013180","journal-title":"Trends Neurosci"},{"key":"718_CR116","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa022066","volume":"348","author":"SE Vermeer","year":"2003","unstructured":"Vermeer SE, Prins ND, den Heijer T et al (2003) Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 348:1215\u20131222","journal-title":"N Engl J Med"},{"key":"718_CR117","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000106614","volume":"8","author":"S Warkentin","year":"1997","unstructured":"Warkentin S, Passant U (1997) Functional imaging of the frontal lobes in organic dementia. Regional cerebral blood flow findings in normals, in patients with frontotemporal dementia and in patients with Alzheimer\u2019s disease, performing a word fluency test. Dement Geriatr Cogn Disord 8:105\u2013109","journal-title":"Dement Geriatr Cogn Disord"},{"key":"718_CR118","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nri2096","volume":"7","author":"C Weber","year":"2007","unstructured":"Weber C, Fraemohs L, Dejana E (2007) The role of junctional adhesion molecules in vascular inflammation. Nat Rev Immunol 7:467\u2013477","journal-title":"Nat Rev Immunol"},{"key":"718_CR119","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2005.01.010","volume":"120","author":"BM Weinstein","year":"2005","unstructured":"Weinstein BM (2005) Vessels and nerves: marching to the same tune. Cell 120:299\u2013302","journal-title":"Cell"},{"key":"718_CR120","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-009-0498-z","volume":"118","author":"RO Weller","year":"2009","unstructured":"Weller RO, Boche D, Nicoll JA (2009) Microvasculature changes and cerebral amyloid angiopathy in Alzheimer\u2019s disease and their potential impact on therapy. Acta Neuropathol 118:87\u2013102","journal-title":"Acta Neuropathol"},{"key":"718_CR121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2003.09.086","volume":"1009","author":"Y Wen","year":"2004","unstructured":"Wen Y, Onyewuchi O, Yang S, Liu R, Simpkins JW (2004) Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain Res 1009:1\u20138","journal-title":"Brain Res"},{"key":"718_CR122","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bbadis.2006.10.011","volume":"1772","author":"Y Wen","year":"2007","unstructured":"Wen Y, Yang S-H, Liu R et al (2007) Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. Biochim Biophys Acta 1772:473\u2013483","journal-title":"Biochim Biophys Acta"},{"key":"718_CR123","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3233\/JAD-2009-1178","volume":"18","author":"L White","year":"2009","unstructured":"White L (2009) Brain lesions at autopsy in older Japanese-American men as related to cognitive impairment and dementia in the final years of life: a summary report from the Honolulu-Asia aging study. J Alzheimers Dis 18:713\u2013725","journal-title":"J Alzheimers Dis"},{"key":"718_CR124","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00441-008-0658-9","volume":"335","author":"H Wolburg","year":"2009","unstructured":"Wolburg H, Noell S, Mack A, Wolburg-Buchholz K, Fallier-Becker P (2009) Brain endothelial cells and the glio-vascular complex. Cell Tissue Res 335:75\u201396","journal-title":"Cell Tissue Res"},{"key":"718_CR125","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nm1287","volume":"11","author":"Z Wu","year":"2005","unstructured":"Wu Z, Guo H, Chow N et al (2005) Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med 11:959\u2013965","journal-title":"Nat Med"},{"key":"718_CR126","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0197-4580(03)00111-8","volume":"25","author":"S-P Yang","year":"2004","unstructured":"Yang S-P, Bae D-G, Kang HJ et al (2004) Co-accumulation of vascular endothelial growth factor with beta-amyloid in the brain of patients with Alzheimer\u2019s disease. Neurobiol Aging 25:283\u2013290","journal-title":"Neurobiol Aging"},{"key":"718_CR127","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.3174\/ajnr.A1562","volume":"30","author":"T Yoshiura","year":"2009","unstructured":"Yoshiura T, Hiwatashi A, Yamashita K et al (2009) Simultaneous measurement of arterial transit time, arterial blood volume, and cerebral blood flow using arterial spin-labeling in patients with Alzheimer disease. Am J Neuroradiol 30:1388\u20131393","journal-title":"Am J Neuroradiol"},{"key":"718_CR128","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrn2336","volume":"9","author":"S Zacchigna","year":"2008","unstructured":"Zacchigna S, Lambrechts D, Carmeliet P (2008) Neurovascular signalling defects in neurodegeneration. Nat Rev Neurosci 9:169\u2013181","journal-title":"Nat Rev Neurosci"},{"key":"718_CR129","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00401-001-0493-5","volume":"103","author":"D Zekry","year":"2002","unstructured":"Zekry D, Duyckaerts C, Moulias R et al (2002) Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly. Acta Neuropathol 103:481\u2013487","journal-title":"Acta Neuropathol"},{"key":"718_CR130","doi-asserted-by":"crossref","first-page":"7655","DOI":"10.1523\/JNEUROSCI.17-20-07655.1997","volume":"17","author":"F Zhang","year":"1997","unstructured":"Zhang F, Eckman C, Younkin S, Hsiao KK, Iadecola C (1997) Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein. J Neurosci 17:7655\u20137661","journal-title":"J Neurosci"},{"key":"718_CR131","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1007\/s11064-008-9899-y","volume":"34","author":"C Zhiyou","year":"2009","unstructured":"Zhiyou C, Yong Y, Shanquan S et al (2009) Upregulation of BACE1 and beta-amyloid protein mediated by chronic cerebral hypoperfusion contributes to cognitive impairment and pathogenesis of Alzheimer\u2019s disease. Neurochem Res 34:1226\u20131235","journal-title":"Neurochem Res"},{"key":"718_CR132","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","volume":"57","author":"BV Zlokovic","year":"2008","unstructured":"Zlokovic BV (2008) The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57:178\u2013201","journal-title":"Neuron"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-010-0718-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-010-0718-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-010-0718-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T20:32:45Z","timestamp":1740256365000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-010-0718-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,11]]},"references-count":132,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["718"],"URL":"https:\/\/doi.org\/10.1007\/s00401-010-0718-6","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,11]]}}}