{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:13:00Z","timestamp":1794485580353,"version":"4.9.1"},"reference-count":235,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T00:00:00Z","timestamp":1303603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1007\/s00401-011-0826-y","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T00:56:41Z","timestamp":1303606601000},"page":"571-587","source":"Crossref","is-referenced-by-count":298,"title":["Alzheimer\u2019s disease is not \u201cbrain aging\u201d: neuropathological, genetic, and epidemiological human studies"],"prefix":"10.1007","volume":"121","author":[{"given":"Peter T.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A.","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina R.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna H.","family":"Neltner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Jicha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"Abner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Van Eldik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Kryscio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Scheff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,24]]},"reference":[{"key":"826_CR1","unstructured":"(1997) Consensus recommendations for the postmortem diagnosis of Alzheimer\u2019s disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer\u2019s Disease. Neurobiol Aging 18:S1\u2013S2"},{"key":"826_CR2","doi-asserted-by":"crossref","unstructured":"(2001) Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet 357:169\u2013175","DOI":"10.1016\/S0140-6736(00)03589-3"},{"key":"826_CR3","unstructured":"(2007) Prevalence of stroke\u2013United States, 2005. MMWR Morb Mortal Wkly Rep 56:469\u2013474"},{"key":"826_CR4","unstructured":"(1994) Sundt\u2019s occlusive cerebrovascular disease. W.B. Saunders, Philadelphia"},{"key":"826_CR5","doi-asserted-by":"crossref","unstructured":"Abner EL, Kryscio RJ, Schmitt FA et al (2011) \u201cEnd-Stage\u201d neurofibrillary tangle pathology in preclinical Alzheimer\u2019s disease: fact or fiction? J Alzheimers Dis","DOI":"10.3233\/JAD-2011-101980"},{"key":"826_CR6","unstructured":"Abner EL, Schmitt FA, Mendiondo MS, Marcum JL, Kryscio RJ (2011) Vitamin E and all-cause mortality: a meta-analysis. Curr Aging Sci [Epub ahead of print]"},{"key":"826_CR7","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1161\/STROKEAHA.109.568402","volume":"41","author":"P Adib-Samii","year":"2010","unstructured":"Adib-Samii P, Brice G, Martin RJ, Markus HS (2010) Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype: study in 200 consecutively recruited individuals. Stroke 41:630\u2013634","journal-title":"Stroke"},{"key":"826_CR8","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1212\/WNL.0b013e3181f4d7f8","volume":"75","author":"S Ahtiluoto","year":"2010","unstructured":"Ahtiluoto S, Polvikoski T, Peltonen M et al (2010) Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study. Neurology 75:1195\u20131202","journal-title":"Neurology"},{"key":"826_CR9","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1212\/WNL.54.4.843","volume":"54","author":"TA Ala","year":"2000","unstructured":"Ala TA, Beh GO, Frey WH 2nd (2000) Pure hippocampal sclerosis: a rare cause of dementia mimicking Alzheimer\u2019s disease. Neurology 54:843\u2013848","journal-title":"Neurology"},{"key":"826_CR10","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1750-3639.2008.00147.x","volume":"18","author":"I Alafuzoff","year":"2008","unstructured":"Alafuzoff I, Arzberger T, Al-Sarraj S et al (2008) Staging of neurofibrillary pathology in Alzheimer\u2019s disease: a study of the BrainNet Europe Consortium. Brain Pathol 18:484\u2013496","journal-title":"Brain Pathol"},{"key":"826_CR11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3233\/JAD-2010-1215","volume":"19","author":"D Albani","year":"2010","unstructured":"Albani D, Polito L, Forloni G (2010) Sirtuins as novel targets for Alzheimer\u2019s disease and other neurodegenerative disorders: experimental and genetic evidence. J Alzheimers Dis 19:11\u201326","journal-title":"J Alzheimers Dis"},{"key":"826_CR12","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000128103","volume":"30","author":"NB Allen","year":"2008","unstructured":"Allen NB, Lichtman JH, Cohen HW et al (2008) Vascular disease among hospitalized multiple sclerosis patients. Neuroepidemiology 30:234\u2013238","journal-title":"Neuroepidemiology"},{"key":"826_CR13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/B978-0-444-53702-7.00011-7","volume":"185","author":"E Altena","year":"2010","unstructured":"Altena E, Ramautar JR, Van Der Werf YD, Van Someren EJ (2010) Do sleep complaints contribute to age-related cognitive decline? Prog Brain Res 185:181\u2013205","journal-title":"Prog Brain Res"},{"key":"826_CR14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/WNL.42.3.631","volume":"42","author":"PV Arriagada","year":"1992","unstructured":"Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer\u2019s disease. Neurology 42:631\u2013639","journal-title":"Neurology"},{"key":"826_CR15","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1212\/01.wnl.0000247053.45483.4e","volume":"67","author":"Z Arvanitakis","year":"2006","unstructured":"Arvanitakis Z, Schneider JA, Wilson RS et al (2006) Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology 67:1960\u20131965","journal-title":"Neurology"},{"key":"826_CR16","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.socscimed.2009.11.018","volume":"70","author":"S Asiskovitch","year":"2010","unstructured":"Asiskovitch S (2010) Gender and health outcomes: the impact of healthcare systems and their financing on life expectancies of women and men. Soc Sci Med 70:886\u2013895","journal-title":"Soc Sci Med"},{"key":"826_CR17","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1152\/physrev.00026.2007","volume":"88","author":"G Aubert","year":"2008","unstructured":"Aubert G, Lansdorp PM (2008) Telomeres and aging. Physiol Rev 88:557\u2013579","journal-title":"Physiol Rev"},{"key":"826_CR18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/archneurol.2010.225","volume":"68","author":"LD Baker","year":"2011","unstructured":"Baker LD, Cross DJ, Minoshima S et al (2011) Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch Neurol 68:51\u201357","journal-title":"Arch Neurol"},{"key":"826_CR19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00002093-200210000-00001","volume":"16","author":"WW Barker","year":"2002","unstructured":"Barker WW, Luis CA, Kashuba A et al (2002) Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer Dis Assoc Disord 16:203\u2013212","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"826_CR20","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.urolonc.2009.07.013","volume":"27","author":"P Bassi","year":"2009","unstructured":"Bassi P, Sacco E (2009) Cancer and aging: the molecular pathways. Urol Oncol 27:620\u2013627","journal-title":"Urol Oncol"},{"key":"826_CR21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10561-008-9067-2","volume":"9","author":"TG Beach","year":"2008","unstructured":"Beach TG, Sue LI, Walker DG et al (2008) The Sun Health Research Institute Brain Donation Program: description and experience, 1987\u20132007. Cell Tissue Bank 9:229\u2013245","journal-title":"Cell Tissue Bank"},{"key":"826_CR22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/WAD.0b013e318142774e","volume":"21","author":"DL Beekly","year":"2007","unstructured":"Beekly DL, Ramos EM, Lee WW et al (2007) The National Alzheimer\u2019s Coordinating Center (NACC) database: the Uniform Data Set. Alzheimer Dis Assoc Disord 21:249\u2013258","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"826_CR23","first-page":"270","volume":"18","author":"DL Beekly","year":"2004","unstructured":"Beekly DL, Ramos EM, van Belle G et al (2004) The National Alzheimer\u2019s Coordinating Center (NACC) Database: an Alzheimer disease database. Alzheimer Dis Assoc Disord 18:270\u2013277","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"826_CR24","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/gerona\/60.4.471","volume":"60","author":"MS Beeri","year":"2005","unstructured":"Beeri MS, Silverman JM, Davis KL et al (2005) Type 2 diabetes is negatively associated with Alzheimer\u2019s disease neuropathology. J Gerontol A Biol Sci Med Sci 60:471\u2013475","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"826_CR25","doi-asserted-by":"crossref","unstructured":"Belbin O, Carrasquillo MM, Crump M et al (2010) Investigation of 15 of the top candidate genes for late-onset Alzheimer\u2019s disease. Hum Genet","DOI":"10.1007\/s00439-010-0924-2"},{"key":"826_CR26","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1136\/jnnp.2004.054445","volume":"76","author":"DA Bennett","year":"2005","unstructured":"Bennett DA, Schneider JA, Wilson RS et al (2005) Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people. J Neurol Neurosurg Psychiatry 76:1194\u20131199","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"826_CR27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1212\/01.WNL.0000042478.08543.F7","volume":"60","author":"DA Bennett","year":"2003","unstructured":"Bennett DA, Wilson RS, Schneider JA et al (2003) Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer\u2019s disease. Neurology 60:246\u2013252","journal-title":"Neurology"},{"key":"826_CR28","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neuron.2010.10.013","volume":"68","author":"L Bertram","year":"2010","unstructured":"Bertram L, Lill CM, Tanzi RE (2010) The genetics of Alzheimer disease: back to the future. Neuron 68:270\u2013281","journal-title":"Neuron"},{"key":"826_CR29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1006\/nbdi.1995.0019","volume":"2","author":"AL Biere","year":"1995","unstructured":"Biere AL, Ostaszewski B, Zhao H et al (1995) Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing. Neurobiol Dis 2:177\u2013187","journal-title":"Neurobiol Dis"},{"key":"826_CR30","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/archneurol.2010.108","volume":"67","author":"A Biffi","year":"2010","unstructured":"Biffi A, Anderson CD, Desikan RS et al (2010) Genetic variation and neuroimaging measures in Alzheimer disease. Arch Neurol 67:677\u2013685","journal-title":"Arch Neurol"},{"key":"826_CR31","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/WAD.0b013e3181c53b00","volume":"24","author":"RS Black","year":"2010","unstructured":"Black RS, Sperling RA, Safirstein B et al (2010) A single ascending dose study of bapineuzumab in patients with Alzheimer disease. Alzheimer Dis Assoc Disord 24:198\u2013203","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"826_CR32","doi-asserted-by":"crossref","first-page":"281","DOI":"10.18632\/aging.100034","volume":"1","author":"MV Blagosklonny","year":"2009","unstructured":"Blagosklonny MV (2009) Validation of anti-aging drugs by treating age-related diseases. Aging (Albany NY) 1:281\u2013288","journal-title":"Aging (Albany NY)"},{"key":"826_CR33","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/BF01273157","volume":"103","author":"K Blennow","year":"1996","unstructured":"Blennow K, Bogdanovic N, Alafuzoff I, Ekman R, Davidsson P (1996) Synaptic pathology in Alzheimer\u2019s disease: relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele. J Neural Transm 103:603\u2013618","journal-title":"J Neural Transm"},{"key":"826_CR34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00401-010-0719-5","volume":"120","author":"D Boche","year":"2010","unstructured":"Boche D, Denham N, Holmes C, Nicoll JA (2010) Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer\u2019s disease pathogenesis. Acta Neuropathol 120:369\u2013384","journal-title":"Acta Neuropathol"},{"key":"826_CR35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-010-0705-y","volume":"120","author":"D Boche","year":"2010","unstructured":"Boche D, Donald J, Love S et al (2010) Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer\u2019s disease. Acta Neuropathol 120:13\u201320","journal-title":"Acta Neuropathol"},{"key":"826_CR36","doi-asserted-by":"crossref","first-page":"M554","DOI":"10.1093\/gerona\/54.11.M554","volume":"54","author":"P Bordin","year":"1999","unstructured":"Bordin P, Da Col PG, Peruzzo P et al (1999) Causes of death and clinical diagnostic errors in extreme aged hospitalized people: a retrospective clinical\u2013necropsy survey. J Gerontol A Biol Sci Med Sci 54:M554\u2013M559","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"826_CR37","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1159\/000116984","volume":"33","author":"H Braak","year":"1993","unstructured":"Braak H, Braak E, Bohl J (1993) Staging of Alzheimer-related cortical destruction. Eur Neurol 33:403\u2013408","journal-title":"Eur Neurol"},{"key":"826_CR38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-010-0789-4","volume":"121","author":"H Braak","year":"2011","unstructured":"Braak H, Del Tredici K (2011) The pathological process underlying Alzheimer\u2019s disease in individuals under thirty. Acta Neuropathol 121:171\u2013181","journal-title":"Acta Neuropathol"},{"key":"826_CR39","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2214\/ajr.151.3.559","volume":"151","author":"BH Braffman","year":"1988","unstructured":"Braffman BH, Zimmerman RA, Trojanowski JQ et al (1988) Brain MR: pathologic correlation with gross and histopathology. 2. Hyperintense white-matter foci in the elderly. AJR Am J Roentgenol 151:559\u2013566","journal-title":"AJR Am J Roentgenol"},{"key":"826_CR40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-4684-7853-2_10","volume":"190","author":"WT Brown","year":"1985","unstructured":"Brown WT, Kieras FJ, Houck GE Jr, Dutkowski R, Jenkins EC (1985) A comparison of adult and childhood progerias: Werner syndrome and Hutchinson\u2013Gilford progeria syndrome. Adv Exp Med Biol 190:229\u2013244","journal-title":"Adv Exp Med Biol"},{"key":"826_CR41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrn2620","volume":"10","author":"G Bu","year":"2009","unstructured":"Bu G (2009) Apolipoprotein E and its receptors in Alzheimer\u2019s disease: pathways, pathogenesis and therapy. Nat Rev Neurosci 10:333\u2013344","journal-title":"Nat Rev Neurosci"},{"key":"826_CR42","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nrm2944","volume":"11","author":"CR Burtner","year":"2010","unstructured":"Burtner CR, Kennedy BK (2010) Progeria syndromes and ageing: what is the connection? Nat Rev Mol Cell Biol 11:567\u2013578","journal-title":"Nat Rev Mol Cell Biol"},{"key":"826_CR43","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.neurobiolaging.2003.12.027","volume":"25","author":"DA Butterfield","year":"2004","unstructured":"Butterfield DA, Bush AI (2004) Alzheimer\u2019s amyloid beta-peptide (1\u201342): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide. Neurobiol Aging 25:563\u2013568","journal-title":"Neurobiol Aging"},{"issue":"Suppl A","key":"826_CR44","first-page":"1","volume":"27","author":"R Cacabelos","year":"2005","unstructured":"Cacabelos R, Fernandez-Novoa L, Lombardi V, Kubota Y, Takeda M (2005) Molecular genetics of Alzheimer\u2019s disease and aging. Methods Find Exp Clin Pharmacol 27(Suppl A):1\u2013573","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"826_CR45","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1212\/WNL.53.1.201","volume":"53","author":"RJ Caselli","year":"1999","unstructured":"Caselli RJ, Graff-Radford NR, Reiman EM et al (1999) Preclinical memory decline in cognitively normal apolipoprotein E-epsilon4 homozygotes. Neurology 53:201\u2013207","journal-title":"Neurology"},{"key":"826_CR46","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1586\/14737175.7.5.473","volume":"7","author":"RJ Castellani","year":"2007","unstructured":"Castellani RJ, Zhu X, Lee HG et al (2007) Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees? Expert Rev Neurother 7:473\u2013485","journal-title":"Expert Rev Neurother"},{"key":"826_CR47","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cell.2006.06.010","volume":"125","author":"DC Chan","year":"2006","unstructured":"Chan DC (2006) Mitochondria: dynamic organelles in disease, aging, and development. Cell 125:1241\u20131252","journal-title":"Cell"},{"key":"826_CR48","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S1474-4422(05)70168-X","volume":"4","author":"MS Chong","year":"2005","unstructured":"Chong MS, Sahadevan S (2005) Preclinical Alzheimer\u2019s disease: diagnosis and prediction of progression. Lancet Neurol 4:576\u2013579","journal-title":"Lancet Neurol"},{"key":"826_CR49","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/ncb1901","volume":"11","author":"F Clavaguera","year":"2009","unstructured":"Clavaguera F, Bolmont T, Crowther RA et al (2009) Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 11:909\u2013913","journal-title":"Nat Cell Biol"},{"key":"826_CR50","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0022-3999(02)00523-8","volume":"54","author":"LH Coker","year":"2003","unstructured":"Coker LH, Shumaker SA (2003) Type 2 diabetes mellitus and cognition: an understudied issue in women\u2019s health. J Psychosom Res 54:129\u2013139","journal-title":"J Psychosom Res"},{"key":"826_CR51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0197-4580(97)00001-8","volume":"18","author":"A Convit","year":"1997","unstructured":"Convit A, De Leon MJ, Tarshish C et al (1997) Specific hippocampal volume reductions in individuals at risk for Alzheimer\u2019s disease. Neurobiol Aging 18:131\u2013138","journal-title":"Neurobiol Aging"},{"key":"826_CR52","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","volume":"261","author":"EH Corder","year":"1993","unstructured":"Corder EH, Saunders AM, Strittmatter WJ et al (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families. Science (New York, NY) 261:921\u2013923","journal-title":"Science (New York, NY)"},{"key":"826_CR53","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1212\/WNL.48.1.154","volume":"48","author":"J Corey-Bloom","year":"1997","unstructured":"Corey-Bloom J, Sabbagh MN, Bondi MW et al (1997) Hippocampal sclerosis contributes to dementia in the elderly. Neurology 48:154\u2013160","journal-title":"Neurology"},{"key":"826_CR54","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/ana.21915","volume":"67","author":"MM Corrada","year":"2010","unstructured":"Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas CH (2010) Dementia incidence continues to increase with age in the oldest old: the 90+ study. Ann Neurol 67:114\u2013121","journal-title":"Ann Neurol"},{"key":"826_CR55","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/archneurol.2009.27","volume":"66","author":"S Craft","year":"2009","unstructured":"Craft S (2009) The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged. Arch Neurol 66:300\u2013305","journal-title":"Arch Neurol"},{"key":"826_CR56","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1001\/archneur.57.5.713","volume":"57","author":"HA Crystal","year":"2000","unstructured":"Crystal HA, Dickson D, Davies P et al (2000) The relative frequency of \u201cdementia of unknown etiology\u201d increases with age and is nearly 50% in nonagenarians. Arch Neurol 57:713\u2013719","journal-title":"Arch Neurol"},{"key":"826_CR57","unstructured":"De Berardis G, D\u2019Ettorre A, Graziano G et al (2011) The burden of hospitalization related to diabetes mellitus: a population-based study. Nutr Metab Cardiovasc Dis [Epub ahead of print]"},{"key":"826_CR58","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/nature08890","volume":"464","author":"A Calignon de","year":"2010","unstructured":"de Calignon A, Fox LM, Pitstick R et al (2010) Caspase activation precedes and leads to tangles. Nature 464:1201\u20131204","journal-title":"Nature"},{"key":"826_CR59","doi-asserted-by":"crossref","first-page":"c3666","DOI":"10.1136\/bmj.c3666","volume":"341","author":"S Debette","year":"2010","unstructured":"Debette S, Markus HS (2010) The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. Br Med J 341:c3666","journal-title":"Br Med J"},{"key":"826_CR60","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.neurobiolaging.2004.05.004","volume":"26","author":"C DeCarli","year":"2005","unstructured":"DeCarli C, Massaro J, Harvey D et al (2005) Measures of brain morphology and infarction in the Framingham heart study: establishing what is normal. Neurobiol Aging 26:491\u2013510","journal-title":"Neurobiol Aging"},{"key":"826_CR61","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.neurobiolaging.2008.04.016","volume":"29","author":"K Del Tredici","year":"2008","unstructured":"Del Tredici K, Braak H (2008) Neurofibrillary changes of the Alzheimer type in very elderly individuals: neither inevitable nor benign: Commentary on \u201cNo disease in the brain of a 115-year-old woman\u201d. Neurobiol Aging 29:1133\u20131136","journal-title":"Neurobiol Aging"},{"key":"826_CR62","doi-asserted-by":"crossref","unstructured":"Dickson DW, Crystal HA, Bevona C et al (1995) Correlations of synaptic and pathological markers with cognition of the elderly. Neurobiol Aging 16:285\u2013298 (discussion 298\u2013304)","DOI":"10.1016\/0197-4580(95)00013-5"},{"key":"826_CR63","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF00293396","volume":"88","author":"DW Dickson","year":"1994","unstructured":"Dickson DW, Davies P, Bevona C et al (1994) Hippocampal sclerosis: a common pathological feature of dementia in very old (> or =80\u00a0years of age) humans. Acta Neuropathol 88:212\u2013221","journal-title":"Acta Neuropathol"},{"key":"826_CR64","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1080\/10715760701416996","volume":"41","author":"Q Ding","year":"2007","unstructured":"Ding Q, Dimayuga E, Keller JN (2007) Oxidative stress alters neuronal RNA- and protein-synthesis: implications for neural viability. Free Radic Res 41:903\u2013910","journal-title":"Free Radic Res"},{"key":"826_CR65","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1093\/brain\/awq141","volume":"133","author":"D Dolan","year":"2010","unstructured":"Dolan D, Troncoso J, Resnick SM et al (2010) Age, Alzheimer\u2019s disease and dementia in the Baltimore Longitudinal Study of Ageing. Brain 133:2225\u20132231","journal-title":"Brain"},{"key":"826_CR66","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-1-4419-8997-0_14","volume":"543","author":"W Droge","year":"2003","unstructured":"Droge W (2003) Oxidative stress and aging. Adv Exp Med Biol 543:191\u2013200","journal-title":"Adv Exp Med Biol"},{"key":"826_CR67","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S1474-4422(10)70223-4","volume":"9","author":"B Dubois","year":"2010","unstructured":"Dubois B, Feldman HH, Jacova C et al (2010) Revising the definition of Alzheimer\u2019s disease: a new lexicon. Lancet Neurol 9:1118\u20131127","journal-title":"Lancet Neurol"},{"key":"826_CR68","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1161\/hs1001.096193","volume":"32","author":"J Fang","year":"2001","unstructured":"Fang J, Alderman MH (2001) Trend of stroke hospitalization, United States, 1988\u20131997. Stroke 32:2221\u20132226","journal-title":"Stroke"},{"key":"826_CR69","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1053\/j.gastro.2007.02.057","volume":"132","author":"P Ferenci","year":"2007","unstructured":"Ferenci P, Czlonkowska A, Merle U et al (2007) Late-onset Wilson\u2019s disease. Gastroenterology 132:1294\u20131298","journal-title":"Gastroenterology"},{"key":"826_CR70","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jns.2004.09.004","volume":"226","author":"MS Fernando","year":"2004","unstructured":"Fernando MS, Ince PG (2004) Vascular pathologies and cognition in a population-based cohort of elderly people. J Neurol Sci 226:13\u201317","journal-title":"J Neurol Sci"},{"issue":"Suppl 2","key":"826_CR71","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1097\/00002093-200304002-00002","volume":"17","author":"CE Finch","year":"2003","unstructured":"Finch CE (2003) The biology of aging in model organisms. Alzheimer Dis Assoc Disord 17(Suppl 2):S39\u2013S41","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"826_CR72","doi-asserted-by":"crossref","first-page":"12845","DOI":"10.1074\/jbc.M808759200","volume":"284","author":"B Frost","year":"2009","unstructured":"Frost B, Jacks RL, Diamond MI (2009) Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem 284:12845\u201312852","journal-title":"J Biol Chem"},{"key":"826_CR73","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/archpsyc.55.9.809","volume":"55","author":"S Gao","year":"1998","unstructured":"Gao S, Hendrie HC, Hall KS, Hui S (1998) The relationships between age, sex, and the incidence of dementia and Alzheimer disease: a meta-analysis. Arch Gen Psychiatry 55:809\u2013815","journal-title":"Arch Gen Psychiatry"},{"key":"826_CR74","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0140-6736(00)02604-0","volume":"356","author":"E Garde","year":"2000","unstructured":"Garde E, Mortensen EL, Krabbe K, Rostrup E, Larsson HB (2000) Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study. Lancet 356:628\u2013634","journal-title":"Lancet"},{"key":"826_CR75","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","volume":"63","author":"M Gatz","year":"2006","unstructured":"Gatz M, Reynolds CA, Fratiglioni L et al (2006) Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 63:168\u2013174","journal-title":"Arch Gen Psychiatry"},{"key":"826_CR76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-006-0144-y","volume":"113","author":"P Giannakopoulos","year":"2007","unstructured":"Giannakopoulos P, Gold G, Kovari E et al (2007) Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience. Acta Neuropathol 113:1\u201312","journal-title":"Acta Neuropathol"},{"key":"826_CR77","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0165-0173(97)00023-4","volume":"25","author":"P Giannakopoulos","year":"1997","unstructured":"Giannakopoulos P, Hof PR, Michel JP, Guimon J, Bouras C (1997) Cerebral cortex pathology in aging and Alzheimer\u2019s disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts. Brain Res Brain Res Rev 25:217\u2013245","journal-title":"Brain Res Brain Res Rev"},{"key":"826_CR78","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1159\/000119730","volume":"25","author":"C Giannattasio","year":"2008","unstructured":"Giannattasio C, Poleggi A, Puopolo M et al (2008) Survival in Alzheimer\u2019s disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele. Dement Geriatr Cogn Disord 25:354\u2013358","journal-title":"Dement Geriatr Cogn Disord"},{"key":"826_CR79","doi-asserted-by":"crossref","unstructured":"Gold G, Bouras C, Kovari E et al (2000) Clinical validity of Braak neuropathological staging in the oldest-old. Acta Neuropathol 99:579\u2013582 (discussion 583\u2013574)","DOI":"10.1007\/s004010051163"},{"key":"826_CR80","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1093\/brain\/awm228","volume":"130","author":"G Gold","year":"2007","unstructured":"Gold G, Giannakopoulos P, Herrmann FR, Bouras C, Kovari E (2007) Identification of Alzheimer and vascular lesion thresholds for mixed dementia. Brain 130:2830\u20132836","journal-title":"Brain"},{"key":"826_CR81","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/01.STR.0000166052.89772.b5","volume":"36","author":"G Gold","year":"2005","unstructured":"Gold G, Kovari E, Herrmann FR et al (2005) Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia. Stroke 36:1184\u20131188","journal-title":"Stroke"},{"key":"826_CR82","doi-asserted-by":"crossref","unstructured":"Guo JL, Lee VM (2011) Seeding of normal tau by pathological tau conformers drives pathogenesis of Alzheimer-like tangles. J Biol Chem","DOI":"10.1074\/jbc.M110.209296"},{"key":"826_CR83","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1212\/01.wnl.0000176053.98907.3f","volume":"65","author":"CB Hall","year":"2005","unstructured":"Hall CB, Verghese J, Sliwinski M et al (2005) Dementia incidence may increase more slowly after age 90: results from the Bronx Aging Study. Neurology 65:882\u2013886","journal-title":"Neurology"},{"key":"826_CR84","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1096-8628(19991203)87:4<311::AID-AJMG6>3.0.CO;2-5","volume":"87","author":"A Harder","year":"1999","unstructured":"Harder A, Jendroska K, Kreuz F et al (1999) Novel twelve-generation kindred of fatal familial insomnia from Germany representing the entire spectrum of disease expression. Am J Med Genet 87:311\u2013316","journal-title":"Am J Med Genet"},{"key":"826_CR85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2001.tb05631.x","volume":"928","author":"D Harman","year":"2001","unstructured":"Harman D (2001) Aging: overview. Ann N Y Acad Sci 928:1\u201321","journal-title":"Ann N Y Acad Sci"},{"key":"826_CR86","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1001\/archneur.65.9.1211","volume":"65","author":"V Haroutunian","year":"2008","unstructured":"Haroutunian V, Schnaider-Beeri M, Schmeidler J et al (2008) Role of the neuropathology of Alzheimer disease in dementia in the oldest-old. Arch Neurol 65:1211\u20131217","journal-title":"Arch Neurol"},{"key":"826_CR87","first-page":"184","volume":"3","author":"A Harras","year":"1995","unstructured":"Harras A (1995) Tapping the SEER database. Cancer Pract 3:184\u2013186","journal-title":"Cancer Pract"},{"key":"826_CR88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1395.001","volume":"1100","author":"L Hayflick","year":"2007","unstructured":"Hayflick L (2007) Biological aging is no longer an unsolved problem. Ann N Y Acad Sci 1100:1\u201313","journal-title":"Ann N Y Acad Sci"},{"key":"826_CR89","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1212\/WNL.49.5.1306","volume":"49","author":"J Heitner","year":"1997","unstructured":"Heitner J, Dickson D (1997) Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study. Neurology 49:1306\u20131311","journal-title":"Neurology"},{"key":"826_CR90","doi-asserted-by":"crossref","first-page":"16755","DOI":"10.1523\/JNEUROSCI.4521-10.2010","volume":"30","author":"K Herrup","year":"2010","unstructured":"Herrup K (2010) Reimagining Alzheimer\u2019s disease\u2014an age-based hypothesis. J Neurosci 30:16755\u201316762","journal-title":"J Neurosci"},{"key":"826_CR91","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/jnen\/62.1.55","volume":"62","author":"PR Hof","year":"2003","unstructured":"Hof PR, Bussiere T, Gold G et al (2003) Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease. J Neuropathol Exp Neurol 62:55\u201367","journal-title":"J Neuropathol Exp Neurol"},{"key":"826_CR92","first-page":"1075","volume":"11","author":"PR Hof","year":"1996","unstructured":"Hof PR, Glannakopoulos P, Bouras C (1996) The neuropathological changes associated with normal brain aging. Histol Histopathol 11:1075\u20131088","journal-title":"Histol Histopathol"},{"key":"826_CR93","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1098\/rstb.1997.0163","volume":"352","author":"R Holliday","year":"1997","unstructured":"Holliday R (1997) Understanding ageing. Philos Trans R Soc Lond B Biol Sci 352:1793\u20131797","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"826_CR94","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0140-6736(08)61075-2","volume":"372","author":"C Holmes","year":"2008","unstructured":"Holmes C, Boche D, Wilkinson D et al (2008) Long-term effects of Abeta42 immunisation in Alzheimer\u2019s disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372:216\u2013223","journal-title":"Lancet"},{"key":"826_CR95","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(79)90349-4","volume":"163","author":"PR Huttenlocher","year":"1979","unstructured":"Huttenlocher PR (1979) Synaptic density in human frontal cortex\u2014developmental changes and effects of aging. Brain Res 163:195\u2013205","journal-title":"Brain Res"},{"key":"826_CR96","doi-asserted-by":"crossref","unstructured":"Imhof A, Kovari E, von Gunten A et al (2007) Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm? J Neurol Sci","DOI":"10.1016\/j.jns.2007.01.025"},{"key":"826_CR97","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.0919-6544.2001.00425.x","volume":"22","author":"E Iseki","year":"2002","unstructured":"Iseki E, Tsunoda S, Suzuki K et al (2002) Regional quantitative analysis of NFT in brains of non-demented elderly persons: comparisons with findings in brains of late-onset Alzheimer\u2019s disease and limbic NFT dementia. Neuropathology 22:34\u201339","journal-title":"Neuropathology"},{"key":"826_CR98","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2337\/diabetes.53.2.474","volume":"53","author":"J Janson","year":"2004","unstructured":"Janson J, Laedtke T, Parisi JE et al (2004) Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 53:474\u2013481","journal-title":"Diabetes"},{"key":"826_CR99","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1212\/WNL.55.5.735-d","volume":"55","author":"K Jellinger","year":"2000","unstructured":"Jellinger K (2000) Pure hippocampal sclerosis: a rare cause of dementia mimicking Alzheimer\u2019s disease. Neurology 55:739\u2013740","journal-title":"Neurology"},{"key":"826_CR100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00401-008-0466-z","volume":"117","author":"KA Jellinger","year":"2009","unstructured":"Jellinger KA (2009) Criteria for the neuropathological diagnosis of dementing disorders: routes out of the swamp? Acta Neuropathol 117:101\u2013110","journal-title":"Acta Neuropathol"},{"key":"826_CR101","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/BF00296500","volume":"88","author":"KA Jellinger","year":"1994","unstructured":"Jellinger KA (1994) Hippocampal sclerosis: a common pathological feature of dementia in very old humans. Acta Neuropathol 88:599","journal-title":"Acta Neuropathol"},{"key":"826_CR102","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3233\/JAD-2008-14110","volume":"14","author":"KA Jellinger","year":"2008","unstructured":"Jellinger KA (2008) The pathology of \u201cvascular dementia\u201d: a critical update. J Alzheimers Dis 14:107\u2013123","journal-title":"J Alzheimers Dis"},{"key":"826_CR103","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jns.2010.08.038","volume":"299","author":"KA Jellinger","year":"2010","unstructured":"Jellinger KA, Attems J (2010) Is there pure vascular dementia in old age? J Neurol Sci 299:150\u2013154","journal-title":"J Neurol Sci"},{"key":"826_CR104","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jns.2007.01.045","volume":"257","author":"KA Jellinger","year":"2007","unstructured":"Jellinger KA, Attems J (2007) Neuropathological evaluation of mixed dementia. J Neurol Sci 257:80\u201387","journal-title":"J Neurol Sci"},{"key":"826_CR105","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.3233\/JAD-2010-100603","volume":"21","author":"KA Jellinger","year":"2010","unstructured":"Jellinger KA, Attems J (2010) Prevalence and pathology of vascular dementia in the oldest-old. J Alzheimers Dis 21:1283\u20131293","journal-title":"J Alzheimers Dis"},{"key":"826_CR106","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00401-010-0654-5","volume":"119","author":"KA Jellinger","year":"2010","unstructured":"Jellinger KA, Attems J (2010) Prevalence of dementia disorders in the oldest-old: an autopsy study. Acta Neuropathol 119:421\u2013433","journal-title":"Acta Neuropathol"},{"key":"826_CR107","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jns.2008.06.008","volume":"273","author":"GA Jicha","year":"2008","unstructured":"Jicha GA, Parisi JE, Dickson DW et al (2008) Age and apoE associations with complex pathologic features in Alzheimer\u2019s disease. J Neurol Sci 273:34\u201339","journal-title":"J Neurol Sci"},{"key":"826_CR108","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1212\/01.wnl.0000324924.91351.7d","volume":"71","author":"KA Josephs","year":"2008","unstructured":"Josephs KA, Whitwell JL, Knopman DS et al (2008) Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype. Neurology 71:743\u2013749","journal-title":"Neurology"},{"key":"826_CR109","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1001\/archneurol.2010.201","volume":"67","author":"G Jun","year":"2010","unstructured":"Jun G, Naj AC, Beecham GW et al (2010) Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol 67:1473\u20131484","journal-title":"Arch Neurol"},{"key":"826_CR110","doi-asserted-by":"crossref","unstructured":"Jyrkka J, Enlund H, Lavikainen P, Sulkava R, Hartikainen S (2011) Association of polypharmacy with nutritional status, functional ability and cognitive capacity over a three-year period in an elderly population. Pharmacoepidemiol Drug Saf [Epub ahead of print]","DOI":"10.1002\/pds.2116"},{"key":"826_CR111","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1172\/JCI11013","volume":"106","author":"DE Kang","year":"2000","unstructured":"Kang DE, Pietrzik CU, Baum L et al (2000) Modulation of amyloid beta-protein clearance and Alzheimer\u2019s disease susceptibility by the LDL receptor-related protein pathway. J Clin Invest 106:1159\u20131166","journal-title":"J Clin Invest"},{"key":"826_CR112","first-page":"105","volume-title":"Alzheimer disease","author":"R Katzman","year":"1994","unstructured":"Katzman R, Kawas C (1994) The epidemiology of dementia and Alzheimer disease. In: Terry RD (ed) Alzheimer disease. Raven Press, New York, pp 105\u2013122"},{"key":"826_CR113","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1098\/rstb.2010.0275","volume":"366","author":"TB Kirkwood","year":"2011","unstructured":"Kirkwood TB (2011) Systems biology of ageing and longevity. Philos Trans R Soc Lond B Biol Sci 366:64\u201370","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"826_CR114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2423(01)35014-X","volume":"35","author":"JA Knight","year":"2000","unstructured":"Knight JA (2000) The biochemistry of aging. Adv Clin Chem 35:1\u201362","journal-title":"Adv Clin Chem"},{"key":"826_CR115","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/jnen\/62.11.1087","volume":"62","author":"DS Knopman","year":"2003","unstructured":"Knopman DS, Parisi JE, Salviati A et al (2003) Neuropathology of cognitively normal elderly. J Neuropathol Exp Neurol 62:1087\u20131095","journal-title":"J Neuropathol Exp Neurol"},{"key":"826_CR116","unstructured":"Krach C, Velkoff VA (1999) Centenarians in the United States. Current Population Reports, vol. Series P23-199RV, US Dept of Health and Human Services\/NIH, US Dept of Commerce\/Census Bureau, Washington, DC"},{"key":"826_CR117","doi-asserted-by":"crossref","first-page":"R652","DOI":"10.1016\/j.cub.2006.07.029","volume":"16","author":"BA Kudlow","year":"2006","unstructured":"Kudlow BA, Kennedy BK (2006) Aging: progeria and the lamin connection. Curr Biol 16:R652\u2013R654","journal-title":"Curr Biol"},{"key":"826_CR118","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1001\/archneur.59.11.1737","volume":"59","author":"WA Kukull","year":"2002","unstructured":"Kukull WA, Higdon R, Bowen JD et al (2002) Dementia and Alzheimer disease incidence: a prospective cohort study. Arch Neurol 59:1737\u20131746","journal-title":"Arch Neurol"},{"key":"826_CR119","doi-asserted-by":"crossref","unstructured":"Kulminski AM, Culminskaya I, Ukraintseva SV et al (2011) Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan. Aging Cell [Epub ahead of print]","DOI":"10.1111\/j.1474-9726.2011.00689.x"},{"key":"826_CR120","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1258\/rsmmsl.46.4.310","volume":"46","author":"NE Langlois","year":"2006","unstructured":"Langlois NE (2006) The use of histology in 638 coronial post-mortem examinations of adults: an audit. Med Sci Law 46:310\u2013320","journal-title":"Med Sci Law"},{"key":"826_CR121","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1749-6632.1993.tb23028.x","volume":"695","author":"H Lassmann","year":"1993","unstructured":"Lassmann H, Fischer P, Jellinger K (1993) Synaptic pathology of Alzheimer\u2019s disease. Ann N Y Acad Sci 695:59\u201364","journal-title":"Ann N Y Acad Sci"},{"key":"826_CR122","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0006-8993(01)03228-0","volume":"924","author":"CM Lauderback","year":"2002","unstructured":"Lauderback CM, Kanski J, Hackett JM et al (2002) Apolipoprotein E modulates Alzheimer\u2019s Abeta(1\u201342)-induced oxidative damage to synaptosomes in an allele-specific manner. Brain Res 924:90\u201397","journal-title":"Brain Res"},{"key":"826_CR123","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jalz.2010.11.003","volume":"7","author":"LJ Launer","year":"2011","unstructured":"Launer LJ (2011) Counting dementia: there is no one \u201cbest\u201d way. Alzheimers Dement 7:10\u201314","journal-title":"Alzheimers Dement"},{"key":"826_CR124","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/nbdi.1996.0003","volume":"3","author":"CA Lemere","year":"1996","unstructured":"Lemere CA, Blusztajn JK, Yamaguchi H et al (1996) Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis 3:16\u201332","journal-title":"Neurobiol Dis"},{"key":"826_CR125","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1001\/archneur.59.7.1099","volume":"59","author":"JB Leverenz","year":"2002","unstructured":"Leverenz JB, Agustin CM, Tsuang D et al (2002) Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study. Arch Neurol 59:1099\u20131106","journal-title":"Arch Neurol"},{"key":"826_CR126","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s004010050914","volume":"96","author":"JB Leverenz","year":"1998","unstructured":"Leverenz JB, Yu CE, Schellenberg GD (1998) Aging-associated neuropathology in Werner syndrome. Acta Neuropathol 96:421\u2013424","journal-title":"Acta Neuropathol"},{"key":"826_CR127","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1002\/jnr.21346","volume":"85","author":"MA Lovell","year":"2007","unstructured":"Lovell MA, Markesbery WR (2007) Oxidative damage in mild cognitive impairment and early Alzheimer\u2019s disease. J Neurosci Res 85:3036\u20133040","journal-title":"J Neurosci Res"},{"key":"826_CR128","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.nbd.2007.07.030","volume":"29","author":"MA Lovell","year":"2008","unstructured":"Lovell MA, Markesbery WR (2008) Oxidatively modified RNA in mild cognitive impairment. Neurobiol Dis 29:169\u2013175","journal-title":"Neurobiol Dis"},{"key":"826_CR129","doi-asserted-by":"crossref","first-page":"878","DOI":"10.2967\/jnumed.108.058529","volume":"50","author":"VJ Lowe","year":"2009","unstructured":"Lowe VJ, Kemp BJ, Jack CR Jr et al (2009) Comparison of 18F-FDG and PiB PET in cognitive impairment. J Nucl Med 50:878\u2013886","journal-title":"J Nucl Med"},{"key":"826_CR130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jns.2010.08.063","volume":"299","author":"JA Luchsinger","year":"2010","unstructured":"Luchsinger JA (2010) Diabetes, related conditions, and dementia. J Neurol Sci 299:35\u201338","journal-title":"J Neurol Sci"},{"key":"826_CR131","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.2741\/2130","volume":"12","author":"C Mancuso","year":"2007","unstructured":"Mancuso C, Scapagini G, Curro D et al (2007) Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. Front Biosci 12:1107\u20131123","journal-title":"Front Biosci"},{"key":"826_CR132","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cell.2005.01.031","volume":"120","author":"GM Martin","year":"2005","unstructured":"Martin GM (2005) Genetic modulation of senescent phenotypes in Homo sapiens. Cell 120:523\u2013532","journal-title":"Cell"},{"key":"826_CR133","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1139\/g89-059","volume":"31","author":"GM Martin","year":"1989","unstructured":"Martin GM (1989) Genetic modulation of the senescent phenotype in Homo sapiens. Genome 31:390\u2013397","journal-title":"Genome"},{"key":"826_CR134","first-page":"509","volume":"10","author":"E Masliah","year":"1995","unstructured":"Masliah E (1995) Mechanisms of synaptic dysfunction in Alzheimer\u2019s disease. Histol Histopathol 10:509\u2013519","journal-title":"Histol Histopathol"},{"key":"826_CR135","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1212\/WNL.0b013e3181eee25f","volume":"75","author":"T Matsuzaki","year":"2010","unstructured":"Matsuzaki T, Sasaki K, Tanizaki Y et al (2010) Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study. Neurology 75:764\u2013770","journal-title":"Neurology"},{"key":"826_CR136","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jalz.2010.11.005","volume":"7","author":"R Mayeux","year":"2011","unstructured":"Mayeux R, Reitz C, Brickman AM et al (2011) Operationalizing diagnostic criteria for Alzheimer\u2019s disease and other age-related cognitive impairment\u2014Part 1. Alzheimers Dement 7:15\u201334","journal-title":"Alzheimers Dement"},{"key":"826_CR137","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","volume":"68","author":"AC McKee","year":"2009","unstructured":"McKee AC, Cantu RC, Nowinski CJ et al (2009) Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 68:709\u2013735","journal-title":"J Neuropathol Exp Neurol"},{"key":"826_CR138","unstructured":"McNaughton D, Knight W, Guerreiro R et al (2010) Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series. Neurobiol Aging [Epub ahead of print]"},{"key":"826_CR139","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","volume":"41","author":"SS Mirra","year":"1991","unstructured":"Mirra SS, Heyman A, McKeel D et al (1991) The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer\u2019s disease. Neurology 41:479\u2013486","journal-title":"Neurology"},{"key":"826_CR140","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0022-510X(92)90047-O","volume":"108","author":"T Mizutani","year":"1992","unstructured":"Mizutani T, Shimada H (1992) Neuropathological background of twenty-seven centenarian brains. J Neurol Sci 108:168\u2013177","journal-title":"J Neurol Sci"},{"key":"826_CR141","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/0192623310391481","volume":"39","author":"TJ Montine","year":"2011","unstructured":"Montine TJ (2011) Prevalence estimates for latent neurodegenerative disease. Toxicol Pathol 39:99\u2013102","journal-title":"Toxicol Pathol"},{"key":"826_CR142","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0074-7742(06)81004-4","volume":"81","author":"JH Morrison","year":"2007","unstructured":"Morrison JH, Hof PR (2007) Life and death of neurons in the aging cerebral cortex. Int Rev Neurobiol 81:41\u201357","journal-title":"Int Rev Neurobiol"},{"key":"826_CR143","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1001\/archneur.58.8.1243","volume":"58","author":"D Mungas","year":"2001","unstructured":"Mungas D, Reed BR, Ellis WG, Jagust WJ (2001) The effects of age on rate of progression of Alzheimer disease and dementia with associated cerebrovascular disease. Arch Neurol 58:1243\u20131247","journal-title":"Arch Neurol"},{"key":"826_CR144","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1212\/WNL.46.3.673","volume":"46","author":"RH Myers","year":"1996","unstructured":"Myers RH, Schaefer EJ, Wilson PW et al (1996) Apolipoprotein E epsilon4 association with dementia in a population-based study: the Framingham study. Neurology 46:673\u2013677","journal-title":"Neurology"},{"key":"826_CR145","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000017111","volume":"10","author":"Z Nagy","year":"1999","unstructured":"Nagy Z, Hindley NJ, Braak H et al (1999) The progression of Alzheimer\u2019s disease from limbic regions to the neocortex: clinical, radiological and pathological relationships. Dement Geriatr Cogn Disord 10:115\u2013120","journal-title":"Dement Geriatr Cogn Disord"},{"key":"826_CR146","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.neulet.2008.11.006","volume":"450","author":"PT Nelson","year":"2009","unstructured":"Nelson PT, Abner EL, Scheff SW et al (2009) Alzheimer\u2019s-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment. Neurosci Lett 450:336\u2013339","journal-title":"Neurosci Lett"},{"key":"826_CR147","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/NEN.0b013e3181aacbe9","volume":"68","author":"PT Nelson","year":"2009","unstructured":"Nelson PT, Abner EL, Schmitt FA et al (2009) Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease. J Neuropathol Exp Neurol 68:774\u2013784","journal-title":"J Neuropathol Exp Neurol"},{"key":"826_CR148","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1750-3639.2008.00244.x","volume":"20","author":"PT Nelson","year":"2010","unstructured":"Nelson PT, Abner EL, Schmitt FA et al (2010) Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol 20:66\u201379","journal-title":"Brain Pathol"},{"key":"826_CR149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/NEN.0b013e3181919a48","volume":"68","author":"PT Nelson","year":"2009","unstructured":"Nelson PT, Braak H, Markesbery WR (2009) Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J Neuropathol Exp Neurol 68:1\u201314","journal-title":"J Neuropathol Exp Neurol"},{"key":"826_CR150","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/nen.0b013e31815c5efb","volume":"66","author":"PT Nelson","year":"2007","unstructured":"Nelson PT, Jicha GA, Schmitt FA et al (2007) Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles \u201cdo count\u201d when staging disease severity. J Neuropathol Exp Neurol 66:1136\u20131146","journal-title":"J Neuropathol Exp Neurol"},{"key":"826_CR151","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/NEN.0b013e3181d8db07","volume":"69","author":"PT Nelson","year":"2010","unstructured":"Nelson PT, Kukull WA, Frosch MP (2010) Thinking outside the box: Alzheimer-type neuropathology that does not map directly onto current consensus recommendations. J Neuropathol Exp Neurol 69:449\u2013454","journal-title":"J Neuropathol Exp Neurol"},{"key":"826_CR152","unstructured":"Nelson PT, Schmitt FA, Lin Y et al (2010) Hippocampal sclerosis in advanced age: clinical and pathological features in 106 cases. Brain"},{"key":"826_CR153","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.bbadis.2008.08.005","volume":"1792","author":"PT Nelson","year":"2009","unstructured":"Nelson PT, Smith CD, Abner EA et al (2009) Human cerebral neuropathology of type 2 diabetes mellitus. Biochim Biophys Acta 1792:454\u2013469","journal-title":"Biochim Biophys Acta"},{"key":"826_CR154","doi-asserted-by":"crossref","unstructured":"Newman AB, Glynn NW, Taylor CA et al (2011) Health and function of participants in the Long Life Family Study: a comparison with other cohorts. Aging (Albany NY)","DOI":"10.18632\/aging.100242"},{"key":"826_CR155","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/01.jnen.0000240466.10758.ce","volume":"65","author":"JA Nicoll","year":"2006","unstructured":"Nicoll JA, Barton E, Boche D et al (2006) Abeta species removal after abeta42 immunization. J Neuropathol Exp Neurol 65:1040\u20131048","journal-title":"J Neuropathol Exp Neurol"},{"key":"826_CR156","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1440-1789.2006.00722.x","volume":"26","author":"K Noda","year":"2006","unstructured":"Noda K, Sasaki K, Fujimi K et al (2006) Quantitative analysis of neurofibrillary pathology in a general population to reappraise neuropathological criteria for senile dementia of the neurofibrillary tangle type (tangle-only dementia): the Hisayama Study. Neuropathology 26:508\u2013518","journal-title":"Neuropathology"},{"key":"826_CR157","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/01.jnen.0000228136.58062.bf","volume":"65","author":"A Nunomura","year":"2006","unstructured":"Nunomura A, Castellani RJ, Zhu X et al (2006) Involvement of oxidative stress in Alzheimer disease. J Neuropathol Exp Neurol 65:631\u2013641","journal-title":"J Neuropathol Exp Neurol"},{"key":"826_CR158","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3233\/JAD-2009-1179","volume":"18","author":"RJ O\u2019Brien","year":"2009","unstructured":"O\u2019Brien RJ, Resnick SM, Zonderman AB et al (2009) Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA). J Alzheimers Dis 18:665\u2013675","journal-title":"J Alzheimers Dis"},{"key":"826_CR159","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1532-5415.2008.01686.x","volume":"56","author":"OI Okereke","year":"2008","unstructured":"Okereke OI, Kang JH, Cook NR et al (2008) Type 2 diabetes mellitus and cognitive decline in two large cohorts of community-dwelling older adults. J Am Geriatr Soc 56:1028\u20131036","journal-title":"J Am Geriatr Soc"},{"key":"826_CR160","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3233\/JAD-2007-11211","volume":"11","author":"AM Olovnikov","year":"2007","unstructured":"Olovnikov AM (2007) Hypothesis: lifespan is regulated by chronomere DNA of the hypothalamus. J Alzheimers Dis 11:241\u2013252","journal-title":"J Alzheimers Dis"},{"key":"826_CR161","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/(SICI)1096-9861(19970728)384:2<312::AID-CNE10>3.0.CO;2-K","volume":"384","author":"B Pakkenberg","year":"1997","unstructured":"Pakkenberg B, Gundersen HJ (1997) Neocortical neuron number in humans: effect of sex and age. J Comp Neurol 384:312\u2013320","journal-title":"J Comp Neurol"},{"key":"826_CR162","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0531-5565(02)00151-1","volume":"38","author":"B Pakkenberg","year":"2003","unstructured":"Pakkenberg B, Pelvig D, Marner L et al (2003) Aging and the human neocortex. Exp Gerontol 38:95\u201399","journal-title":"Exp Gerontol"},{"key":"826_CR163","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2174\/156720209787466019","volume":"6","author":"M Pallas","year":"2009","unstructured":"Pallas M, Casadesus G, Smith MA et al (2009) Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection. Curr Neurovasc Res 6:70\u201381","journal-title":"Curr Neurovasc Res"},{"key":"826_CR164","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/157488908783421492","volume":"3","author":"M Pallas","year":"2008","unstructured":"Pallas M, Verdaguer E, Tajes M, Gutierrez-Cuesta J, Camins A (2008) Modulation of sirtuins: new targets for antiageing. Recent Pat CNS Drug Discov 3:61\u201369","journal-title":"Recent Pat CNS Drug Discov"},{"key":"826_CR165","doi-asserted-by":"crossref","unstructured":"Pao WC, Dickson DW, Crook JE et al (2011) Hippocampal sclerosis in the elderly: genetic and pathologic findings, some mimicking Alzheimer disease clinically. Alzheimer Dis Assoc Disord [Epub ahead of print]","DOI":"10.1097\/WAD.0b013e31820f8f50"},{"key":"826_CR166","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.2337\/diabetes.51.4.1256","volume":"51","author":"R Peila","year":"2002","unstructured":"Peila R, Rodriguez BL, Launer LJ (2002) Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu-Asia Aging Study. Diabetes 51:1256\u20131262","journal-title":"Diabetes"},{"key":"826_CR167","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0891-5849(02)01113-9","volume":"33","author":"G Perry","year":"2002","unstructured":"Perry G, Nunomura A, Hirai K et al (2002) Is oxidative damage the fundamental pathogenic mechanism of Alzheimer\u2019s and other neurodegenerative diseases? Free Radic Biol Med 33:1475\u20131479","journal-title":"Free Radic Biol Med"},{"key":"826_CR168","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.neuroscience.2006.10.045","volume":"145","author":"JJ Perry","year":"2007","unstructured":"Perry JJ, Fan L, Tainer JA (2007) Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair. Neuroscience 145:1280\u20131299","journal-title":"Neuroscience"},{"key":"826_CR169","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1093\/rheumatology\/keh383","volume":"43","author":"M Pertovaara","year":"2004","unstructured":"Pertovaara M, Lehtimaki T, Rontu R et al (2004) Presence of apolipoprotein E epsilon4 allele predisposes to early onset of primary Sjogren\u2019s syndrome. Rheumatology (Oxford) 43:1484\u20131487","journal-title":"Rheumatology (Oxford)"},{"key":"826_CR170","doi-asserted-by":"crossref","unstructured":"Petrovitch H, Ross GW, He Q et al (2007) Characterization of Japanese\u2013American men with a single neocortical AD lesion type. Neurobiol Aging [Epub ahead of print]","DOI":"10.1016\/j.neurobiolaging.2007.03.026"},{"key":"826_CR171","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/ana.20318","volume":"57","author":"H Petrovitch","year":"2005","unstructured":"Petrovitch H, Ross GW, Steinhorn SC et al (2005) AD lesions and infarcts in demented and non-demented Japanese\u2013American men. Ann Neurol 57:98\u2013103","journal-title":"Ann Neurol"},{"key":"826_CR172","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1212\/WNL.0b013e318200d6f9","volume":"75","author":"TM Polvikoski","year":"2010","unstructured":"Polvikoski TM, van Straaten EC, Barkhof F et al (2010) Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old. Neurology 75:2071\u20132078","journal-title":"Neurology"},{"key":"826_CR173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2190\/8M7H-CJL7-6K5T-UMFV","volume":"34","author":"LW Poon","year":"1992","unstructured":"Poon LW, Clayton GM, Martin P et al (1992) The Georgia Centenarian Study. Int J Aging Hum Dev 34:1\u201317","journal-title":"Int J Aging Hum Dev"},{"key":"826_CR174","unstructured":"D.o.E.a.S.A (2002) Population Division, United Nations Secretariat, World Population Ageing 1950\u20132050. United Nations, New York"},{"key":"826_CR175","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.neurobiolaging.2009.04.002","volume":"30","author":"JL Price","year":"2009","unstructured":"Price JL, McKeel DW Jr, Buckles VD et al (2009) Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging 30:1026\u20131036","journal-title":"Neurobiol Aging"},{"key":"826_CR176","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1212\/01.wnl.0000191298.68045.50","volume":"66","author":"I Prohovnik","year":"2006","unstructured":"Prohovnik I, Perl DP, Davis KL et al (2006) Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease. Neurology 66:49\u201355","journal-title":"Neurology"},{"key":"826_CR177","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.mad.2004.10.003","volume":"126","author":"TA Prolla","year":"2005","unstructured":"Prolla TA (2005) Multiple roads to the aging phenotype: insights from the molecular dissection of progerias through DNA microarray analysis. Mech Ageing Dev 126:461\u2013465","journal-title":"Mech Ageing Dev"},{"key":"826_CR178","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.biocel.2004.10.011","volume":"37","author":"M Puzianowska-Kuznicka","year":"2005","unstructured":"Puzianowska-Kuznicka M, Kuznicki J (2005) Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing? Int J Biochem Cell Biol 37:947\u2013960","journal-title":"Int J Biochem Cell Biol"},{"key":"826_CR179","doi-asserted-by":"crossref","unstructured":"Rauramaa T, Pikkarainen M, Englund E et al (2011) TAR-DNA binding protein-43 and alterations in the hippocampus. J Neural Transm [Epub ahead of print]","DOI":"10.1007\/s00702-010-0574-5"},{"issue":"Suppl 1","key":"826_CR180","first-page":"43","volume":"8","author":"GW Rebeck","year":"2001","unstructured":"Rebeck GW, Cho HS, Grabowski TJ, Greenberg SM (2001) The effects of AbetaPP mutations and APOE polymorphisms on cerebral amyloid angiopathy. Amyloid 8(Suppl 1):43\u201347","journal-title":"Amyloid"},{"key":"826_CR181","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1212\/01.wnl.0000240129.46080.53","volume":"67","author":"C Regan","year":"2006","unstructured":"Regan C, Katona C, Walker Z et al (2006) Relationship of vascular risk to the progression of Alzheimer disease. Neurology 67:1357\u20131362","journal-title":"Neurology"},{"key":"826_CR182","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1056\/NEJM199603213341202","volume":"334","author":"EM Reiman","year":"1996","unstructured":"Reiman EM, Caselli RJ, Yun LS et al (1996) Preclinical evidence of Alzheimer\u2019s disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 334:752\u2013758","journal-title":"N Engl J Med"},{"key":"826_CR183","doi-asserted-by":"crossref","unstructured":"Reitz C, Brayne C, Mayeux R (2011) Epidemiology of Alzheimer disease. Nat Rev Neurol","DOI":"10.1038\/nrneurol.2011.2"},{"key":"826_CR184","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/ana.10161","volume":"51","author":"KP Riley","year":"2002","unstructured":"Riley KP, Snowdon DA, Markesbery WR (2002) Alzheimer\u2019s neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Ann Neurol 51:567\u2013577","journal-title":"Ann Neurol"},{"key":"826_CR185","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/oxfordjournals.aje.a009560","volume":"148","author":"WA Rocca","year":"1998","unstructured":"Rocca WA, Cha RH, Waring SC, Kokmen E (1998) Incidence of dementia and Alzheimer\u2019s disease: a reanalysis of data from Rochester, Minnesota, 1975\u20131984. Am J Epidemiol 148:51\u201362","journal-title":"Am J Epidemiol"},{"key":"826_CR186","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jalz.2010.11.002","volume":"7","author":"WA Rocca","year":"2011","unstructured":"Rocca WA, Petersen RC, Knopman DS et al (2011) Trends in the incidence and prevalence of Alzheimer\u2019s disease, dementia, and cognitive impairment in the United States. Alzheimers Dement 7:80\u201393","journal-title":"Alzheimers Dement"},{"key":"826_CR187","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.neurobiolaging.2007.12.003","volume":"30","author":"L Rosvall","year":"2009","unstructured":"Rosvall L, Rizzuto D, Wang HX et al (2009) APOE-related mortality: effect of dementia, cardiovascular disease and gender. Neurobiol Aging 30:1545\u20131551","journal-title":"Neurobiol Aging"},{"key":"826_CR188","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/209109a0","volume":"209","author":"M Roth","year":"1966","unstructured":"Roth M, Tomlinson BE, Blessed G (1966) Correlation between scores for dementia and counts of \u2018senile plaques\u2019 in cerebral grey matter of elderly subjects. Nature 209:109\u2013110","journal-title":"Nature"},{"key":"826_CR189","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1365-2559.2005.02243.x","volume":"47","author":"J Roulson","year":"2005","unstructured":"Roulson J, Benbow EW, Hasleton PS (2005) Discrepancies between clinical and autopsy diagnosis and the value of post mortem histology; a meta-analysis and review. Histopathology 47:551\u2013559","journal-title":"Histopathology"},{"key":"826_CR190","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1176\/ajp.148.9.1164","volume":"148","author":"EH Rubin","year":"1991","unstructured":"Rubin EH, Kinscherf DA, Grant EA, Storandt M (1991) The influence of major depression on clinical and psychometric assessment of senile dementia of the Alzheimer type. Am J Psychiatry 148:1164\u20131171","journal-title":"Am J Psychiatry"},{"key":"826_CR191","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1212\/WNL.0b013e3181c67808","volume":"73","author":"S Salloway","year":"2009","unstructured":"Salloway S, Sperling R, Gilman S et al (2009) A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 73:2061\u20132070","journal-title":"Neurology"},{"key":"826_CR192","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.canlet.2005.04.009","volume":"236","author":"D Sarkar","year":"2006","unstructured":"Sarkar D, Fisher PB (2006) Molecular mechanisms of aging-associated inflammation. Cancer Lett 236:13\u201323","journal-title":"Cancer Lett"},{"key":"826_CR193","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1056\/NEJMoa0806142","volume":"360","author":"GM Savva","year":"2009","unstructured":"Savva GM, Wharton SB, Ince PG et al (2009) Age, neuropathology, and dementia. N Engl J Med 360:2302\u20132309","journal-title":"N Engl J Med"},{"key":"826_CR194","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1136\/jnnp.2004.053645","volume":"76","author":"N Scarmeas","year":"2005","unstructured":"Scarmeas N, Habeck CG, Hilton J et al (2005) APOE related alterations in cerebral activation even at college age. J Neurol Neurosurg Psychiatry 76:1440\u20131444","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"826_CR195","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/JAD-2006-9S312","volume":"9","author":"SW Scheff","year":"2006","unstructured":"Scheff SW, Price DA (2006) Alzheimer\u2019s disease-related alterations in synaptic density: neocortex and hippocampus. J Alzheimers Dis 9:101\u2013115","journal-title":"J Alzheimers Dis"},{"key":"826_CR196","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0197-4580(01)00222-6","volume":"22","author":"SW Scheff","year":"2001","unstructured":"Scheff SW, Price DA, Sparks DL (2001) Quantitative assessment of possible age-related change in synaptic numbers in the human frontal cortex. Neurobiol Aging 22:355\u2013365","journal-title":"Neurobiol Aging"},{"key":"826_CR197","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1212\/WNL.55.3.370","volume":"55","author":"FA Schmitt","year":"2000","unstructured":"Schmitt FA, Davis DG, Wekstein DR et al (2000) \u201cPreclinical\u201d AD revisited: neuropathology of cognitively normal older adults. Neurology 55:370\u2013376","journal-title":"Neurology"},{"key":"826_CR198","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3233\/JAD-2009-1227","volume":"18","author":"JA Schneider","year":"2009","unstructured":"Schneider JA, Aggarwal NT, Barnes L, Boyle P, Bennett DA (2009) The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis 18:691\u2013701","journal-title":"J Alzheimers Dis"},{"key":"826_CR199","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/ana.21142","volume":"62","author":"JA Schneider","year":"2007","unstructured":"Schneider JA, Boyle PA, Arvanitakis Z, Bienias JL, Bennett DA (2007) Subcortical infarcts, Alzheimer\u2019s disease pathology, and memory function in older persons. Ann Neurol 62:59\u201366","journal-title":"Ann Neurol"},{"key":"826_CR200","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1212\/01.WNL.0000118211.78503.F5","volume":"62","author":"JA Schneider","year":"2004","unstructured":"Schneider JA, Wilson RS, Bienias JL, Evans DA, Bennett DA (2004) Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology 62:1148\u20131155","journal-title":"Neurology"},{"key":"826_CR201","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10545-008-0778-0","volume":"31","author":"F Sedel","year":"2008","unstructured":"Sedel F, Tourbah A, Fontaine B et al (2008) Leukoencephalopathies associated with inborn errors of metabolism in adults. J Inherit Metab Dis 31:295\u2013307","journal-title":"J Inherit Metab Dis"},{"key":"826_CR202","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/brain\/awq056","volume":"133","author":"A Serrano-Pozo","year":"2010","unstructured":"Serrano-Pozo A, William CM, Ferrer I et al (2010) Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain 133:1312\u20131327","journal-title":"Brain"},{"key":"826_CR203","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jalz.2010.12.002","volume":"7","author":"S Seshadri","year":"2011","unstructured":"Seshadri S, Beiser A, Au R et al (2011) Operationalizing diagnostic criteria for Alzheimer\u2019s disease and other age-related cognitive impairment\u2014part 2. Alzheimers Dement 7:35\u201352","journal-title":"Alzheimers Dement"},{"key":"826_CR204","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","volume":"303","author":"S Seshadri","year":"2010","unstructured":"Seshadri S, Fitzpatrick AL, Ikram MA et al (2010) Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 303:1832\u20131840","journal-title":"JAMA"},{"key":"826_CR205","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3109\/00313025.2010.508791","volume":"42","author":"S Sharma","year":"2010","unstructured":"Sharma S, Shin JS, Grimshaw M, Clarke RA, Lee CS (2010) The senescence pathway in prostatic carcinogenesis. Pathology 42:507\u2013511","journal-title":"Pathology"},{"key":"826_CR206","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/qshc.2004.011973","volume":"14","author":"KG Shojania","year":"2005","unstructured":"Shojania KG, Burton EC, McDonald KM, Goldman L (2005) Overestimation of clinical diagnostic performance caused by low necropsy rates. Qual Saf Health Care 14:408\u2013413","journal-title":"Qual Saf Health Care"},{"key":"826_CR207","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1093\/brain\/awl203","volume":"129","author":"K Sleegers","year":"2006","unstructured":"Sleegers K, Brouwers N, Gijselinck I et al (2006) APP duplication is sufficient to cause early onset Alzheimer\u2019s dementia with cerebral amyloid angiopathy. Brain 129:2977\u20132983","journal-title":"Brain"},{"key":"826_CR208","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1034\/j.1600-0404.107.s179.6.x","volume":"179","author":"BJ Small","year":"2003","unstructured":"Small BJ, Mobly JL, Laukka EJ, Jones S, Backman L (2003) Cognitive deficits in preclinical Alzheimer\u2019s disease. Acta Neurol Scand Suppl 179:29\u201333","journal-title":"Acta Neurol Scand Suppl"},{"key":"826_CR209","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.277.10.813","volume":"277","author":"DA Snowdon","year":"1997","unstructured":"Snowdon DA, Greiner LH, Mortimer JA et al (1997) Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 277:813\u2013817","journal-title":"JAMA"},{"key":"826_CR210","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/archneurol.2008.579","volume":"66","author":"JA Sonnen","year":"2009","unstructured":"Sonnen JA, Larson EB, Brickell K et al (2009) Different patterns of cerebral injury in dementia with or without diabetes. Arch Neurol 66:315\u2013322","journal-title":"Arch Neurol"},{"key":"826_CR211","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/ana.21208","volume":"62","author":"JA Sonnen","year":"2007","unstructured":"Sonnen JA, Larson EB, Crane PK et al (2007) Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol 62:406\u2013413","journal-title":"Ann Neurol"},{"key":"826_CR212","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0749-0690(18)30182-4","volume":"13","author":"G Stanta","year":"1997","unstructured":"Stanta G, Campagner L, Cavallieri F, Giarelli L (1997) Cancer of the oldest old. What we have learned from autopsy studies. Clin Geriatr Med 13:55\u201368","journal-title":"Clin Geriatr Med"},{"key":"826_CR213","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","volume":"90","author":"WJ Strittmatter","year":"1993","unstructured":"Strittmatter WJ, Saunders AM, Schmechel D et al (1993) Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90:1977\u20131981","journal-title":"Proc Natl Acad Sci USA"},{"key":"826_CR214","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3233\/JAD-2010-100846","volume":"22","author":"RG Struble","year":"2010","unstructured":"Struble RG, Ala T, Patrylo PR, Brewer GJ, Yan XX (2010) Is brain amyloid production a cause or a result of dementia of the Alzheimer\u2019s type? J Alzheimers Dis 22:393\u2013399","journal-title":"J Alzheimers Dis"},{"key":"826_CR215","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.neurobiolaging.2005.09.021","volume":"27","author":"R Sultana","year":"2006","unstructured":"Sultana R, Boyd-Kimball D, Poon HF et al (2006) Redox proteomics identification of oxidized proteins in Alzheimer\u2019s disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD. Neurobiol Aging 27:1564\u20131576","journal-title":"Neurobiol Aging"},{"key":"826_CR216","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3233\/JAD-2010-1222","volume":"19","author":"R Sultana","year":"2010","unstructured":"Sultana R, Butterfield DA (2010) Role of oxidative stress in the progression of Alzheimer\u2019s disease. J Alzheimers Dis 19:341\u2013353","journal-title":"J Alzheimers Dis"},{"key":"826_CR217","doi-asserted-by":"crossref","unstructured":"Thal DR, Del Tredici K, Braak H (2004) Neurodegeneration in normal brain aging and disease. Sci Aging Knowledge Environ pe26","DOI":"10.1126\/sageke.2004.23.pe26"},{"key":"826_CR218","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1086\/504044","volume":"78","author":"J Theuns","year":"2006","unstructured":"Theuns J, Brouwers N, Engelborghs S et al (2006) Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease. Am J Hum Genet 78:936\u2013946","journal-title":"Am J Hum Genet"},{"key":"826_CR219","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0022-510X(70)90063-8","volume":"11","author":"BE Tomlinson","year":"1970","unstructured":"Tomlinson BE, Blessed G, Roth M (1970) Observations on the brains of demented old people. J Neurol Sci 11:205\u2013242","journal-title":"J Neurol Sci"},{"key":"826_CR220","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2869.2006.00499.x","volume":"15","author":"RE Tractenberg","year":"2006","unstructured":"Tractenberg RE, Singer CM, Kaye JA (2006) Characterizing sleep problems in persons with Alzheimer\u2019s disease and normal elderly. J Sleep Res 15:97\u2013103","journal-title":"J Sleep Res"},{"key":"826_CR221","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0197-4580(02)00052-0","volume":"23","author":"DE Vaillancourt","year":"2002","unstructured":"Vaillancourt DE, Newell KM (2002) Changing complexity in human behavior and physiology through aging and disease. Neurobiol Aging 23:1\u201311","journal-title":"Neurobiol Aging"},{"key":"826_CR222","doi-asserted-by":"crossref","unstructured":"von Gunten A, Ebbing K, Imhof A, Giannakopoulos P, Kovari E (2010) Brain aging in the oldest-old. Curr Gerontol Geriatr Res","DOI":"10.1155\/2010\/358531"},{"key":"826_CR223","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jns.2005.08.017","volume":"245","author":"GS Watson","year":"2006","unstructured":"Watson GS, Craft S (2006) Insulin resistance, inflammation, and cognition in Alzheimer\u2019s disease: lessons for multiple sclerosis. J Neurol Sci 245:21\u201333","journal-title":"J Neurol Sci"},{"key":"826_CR224","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1749-6632.2002.tb04794.x","volume":"977","author":"L White","year":"2002","unstructured":"White L, Petrovitch H, Hardman J et al (2002) Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann N Y Acad Sci 977:9\u201323","journal-title":"Ann N Y Acad Sci"},{"key":"826_CR225","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1177\/0891988705281872","volume":"18","author":"L White","year":"2005","unstructured":"White L, Small BJ, Petrovitch H et al (2005) Recent clinical\u2013pathologic research on the causes of dementia in late life: update from the Honolulu-Asia Aging Study. J Geriatr Psychiatry Neurol 18:224\u2013227","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"826_CR226","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.archger.2009.02.012","volume":"50","author":"LR Williams","year":"2010","unstructured":"Williams LR, Hutchinson CE, Jackson A et al (2010) Clinical correlates of cerebral white matter hyperintensities in cognitively normal older adults. Arch Gerontol Geriatr 50:127\u2013131","journal-title":"Arch Gerontol Geriatr"},{"key":"826_CR227","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1212\/WNL.59.3.364","volume":"59","author":"RS Wilson","year":"2002","unstructured":"Wilson RS, Barnes LL, Mendes de Leon CF et al (2002) Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology 59:364\u2013370","journal-title":"Neurology"},{"key":"826_CR228","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1212\/WNL.0b013e3181f39adc","volume":"75","author":"RS Wilson","year":"2010","unstructured":"Wilson RS, Leurgans SE, Boyle PA, Schneider JA, Bennett DA (2010) Neurodegenerative basis of age-related cognitive decline. Neurology 75:1070\u20131078","journal-title":"Neurology"},{"key":"826_CR229","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jalz.2010.11.006","volume":"7","author":"RS Wilson","year":"2011","unstructured":"Wilson RS, Weir DR, Leurgans SE et al (2011) Sources of variability in estimates of the prevalence of Alzheimer\u2019s disease in the United States. Alzheimers Dement 7:74\u201379","journal-title":"Alzheimers Dement"},{"key":"826_CR230","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ymgme.2004.04.011","volume":"82","author":"K Wong","year":"2004","unstructured":"Wong K, Sidransky E, Verma A et al (2004) Neuropathology provides clues to the pathophysiology of Gaucher disease. Mol Genet Metab 82:192\u2013207","journal-title":"Mol Genet Metab"},{"key":"826_CR231","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1749-6632.2000.tb06404.x","volume":"903","author":"JH Xuereb","year":"2000","unstructured":"Xuereb JH, Brayne C, Dufouil C et al (2000) Neuropathological findings in the very old. Results from the first 101 brains of a population-based longitudinal study of dementing disorders. Ann N Y Acad Sci 903:490\u2013496","journal-title":"Ann N Y Acad Sci"},{"key":"826_CR232","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev.pathmechdis.2.010506.092044","volume":"3","author":"BA Yankner","year":"2008","unstructured":"Yankner BA, Lu T, Loerch P (2008) The aging brain. Annu Rev Pathol 3:41\u201366","journal-title":"Annu Rev Pathol"},{"key":"826_CR233","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2377-6-2","volume":"6","author":"J Zaccai","year":"2006","unstructured":"Zaccai J, Ince P, Brayne C (2006) Population-based neuropathological studies of dementia: design, methods and areas of investigation\u2014a systematic review. BMC Neurol 6:2","journal-title":"BMC Neurol"},{"key":"826_CR234","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00401-001-0493-5","volume":"103","author":"D Zekry","year":"2002","unstructured":"Zekry D, Duyckaerts C, Moulias R et al (2002) Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly. Acta Neuropathol 103:481\u2013487","journal-title":"Acta Neuropathol"},{"key":"826_CR235","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.bbadis.2008.09.006","volume":"1792","author":"L Zhang","year":"2009","unstructured":"Zhang L, Bruce-Keller AJ, Dasuri K et al (2009) Diet-induced metabolic disturbances as modulators of brain homeostasis. Biochim Biophys Acta 1792:417\u2013422","journal-title":"Biochim Biophys Acta"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-011-0826-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-011-0826-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-011-0826-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T05:59:09Z","timestamp":1712383149000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-011-0826-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,24]]},"references-count":235,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["826"],"URL":"https:\/\/doi.org\/10.1007\/s00401-011-0826-y","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13284979.14644079","asserted-by":"object"}]},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,24]]}}}