{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:30:35Z","timestamp":1792510235346,"version":"4.5.0"},"reference-count":192,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1007\/s00401-011-0852-9","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T13:36:05Z","timestamp":1309440965000},"page":"187-204","source":"Crossref","is-referenced-by-count":394,"title":["Neuropathology underlying clinical variability in patients with synucleinopathies"],"prefix":"10.1007","volume":"122","author":[{"given":"Glenda M.","family":"Halliday","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L.","family":"Holton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Revesz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,7,1]]},"reference":[{"key":"852_CR1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/0891988704267470","volume":"17","author":"D Aarsland","year":"2004","unstructured":"Aarsland D, Ballard CG, Halliday G (2004) Are Parkinson\u2019s disease with dementia and dementia with Lewy bodies the same entity? J Geriatr Psychiatry Neurol 17:137\u2013145","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"852_CR2","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/mds.21560","volume":"22","author":"RD Abbott","year":"2007","unstructured":"Abbott RD, Ross GW, Petrovitch H et al (2007) Bowel movement frequency in late-life and incidental Lewy bodies. Mov Disord 22:1581\u20131586","journal-title":"Mov Disord"},{"key":"852_CR3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000131165","volume":"142","author":"R Adams","year":"1961","unstructured":"Adams R, Van Bogaert L, Van Der Eecken H (1961) [Nigro-striate and cerebello-nigro-striate degeneration. (Clinical uniqueness and pathological variability of presenile degeneration of the extrapyramidal rigidity type.)]. Psychiatr Neurol (Basel) 142:219\u2013259","journal-title":"Psychiatr Neurol (Basel)"},{"key":"852_CR4","doi-asserted-by":"crossref","first-page":"e7114","DOI":"10.1371\/journal.pone.0007114","volume":"4","author":"A Al-Chalabi","year":"2009","unstructured":"Al-Chalabi A, Durr A, Wood NW et al (2009) Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy. PLoS One 4:e7114","journal-title":"PLoS One"},{"key":"852_CR5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00401-009-0523-2","volume":"117","author":"I Alafuzoff","year":"2009","unstructured":"Alafuzoff I, Ince PG, Arzberger T et al (2009) Staging\/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium. Acta Neuropathol 117:635\u2013652","journal-title":"Acta Neuropathol"},{"key":"852_CR6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1001\/archneur.59.1.102","volume":"59","author":"H Apaydin","year":"2002","unstructured":"Apaydin H, Ahlskog JE, Parisi JE, Boeve BF, Dickson DW (2002) Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response. Arch Neurol 59:102\u2013112","journal-title":"Arch Neurol"},{"key":"852_CR7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF00310020","volume":"83","author":"K Arima","year":"1992","unstructured":"Arima K, Murayama S, Mukoyama M, Inose T (1992) Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy. 1. Neuronal cytoplasmic inclusions. Acta Neuropathol 83:453\u2013460","journal-title":"Acta Neuropathol"},{"key":"852_CR8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s004010050917","volume":"96","author":"K Arima","year":"1998","unstructured":"Arima K, Ueda K, Sunohara N et al (1998) NACP\/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy. Acta Neuropathol 96:439\u2013444","journal-title":"Acta Neuropathol"},{"key":"852_CR9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/brain\/95.3.457","volume":"95","author":"R Bannister","year":"1972","unstructured":"Bannister R, Oppenheimer DR (1972) Degenerative diseases of the nervous system associated with autonomic failure. Brain 95:457\u2013474","journal-title":"Brain"},{"key":"852_CR10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00401-009-0538-8","volume":"117","author":"TG Beach","year":"2009","unstructured":"Beach TG, Adler CH, Lue L et al (2009) Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol 117:613\u2013634","journal-title":"Acta Neuropathol"},{"key":"852_CR11","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00401-010-0664-3","volume":"119","author":"TG Beach","year":"2010","unstructured":"Beach TG, Adler CH, Sue LI et al (2010) Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol 119:689\u2013702","journal-title":"Acta Neuropathol"},{"key":"852_CR12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/ana.20021","volume":"55","author":"EE Benarroch","year":"2004","unstructured":"Benarroch EE, Schmeichel AM, Low PA, Parisi JE (2004) Involvement of medullary serotonergic groups in multiple system atrophy. Ann Neurol 55:418\u2013422","journal-title":"Ann Neurol"},{"key":"852_CR13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1212\/01.wnl.0000196638.98781.bb","volume":"66","author":"EE Benarroch","year":"2006","unstructured":"Benarroch EE, Schmeichel AM, Sandroni P, Low PA, Parisi JE (2006) Involvement of vagal autonomic nuclei in multiple system atrophy and Lewy body disease. Neurology 66:378\u2013383","journal-title":"Neurology"},{"key":"852_CR14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/ana.410430205","volume":"43","author":"EE Benarroch","year":"1998","unstructured":"Benarroch EE, Smithson IL, Low PA, Parisi JE (1998) Depletion of catecholaminergic neurons of the rostral ventrolateral medulla in multiple systems atrophy with autonomic failure. Ann Neurol 43:156\u2013163","journal-title":"Ann Neurol"},{"key":"852_CR15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1365-2990.2006.00727.x","volume":"32","author":"A Bloch","year":"2006","unstructured":"Bloch A, Probst A, Bissig H, Adams H, Tolnay M (2006) Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol Appl Neurobiol 32:284\u2013295","journal-title":"Neuropathol Appl Neurobiol"},{"key":"852_CR16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.sleep.2006.08.017","volume":"8","author":"BF Boeve","year":"2007","unstructured":"Boeve BF, Dickson DW, Olson EJ et al (2007) Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Sleep Med 8:60\u201364","journal-title":"Sleep Med"},{"key":"852_CR17","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1212\/01.wnl.0000312279.49272.9f","volume":"70","author":"H Braak","year":"2008","unstructured":"Braak H, Del Tredici K (2008) Invited Article: Nervous system pathology in sporadic Parkinson disease. Neurology 70:1916\u20131925","journal-title":"Neurology"},{"key":"852_CR18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici K, R\u00fcb U et al (2003) Staging of brain pathology related to sporadic Parkinson\u2019s disease. Neurobiol Aging 24:197\u2013211","journal-title":"Neurobiol Aging"},{"key":"852_CR19","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/brain\/awq158","volume":"133","author":"RG Brown","year":"2010","unstructured":"Brown RG, Lacomblez L, Landwehrmeyer BG et al (2010) Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy. Brain 133:2382\u20132393","journal-title":"Brain"},{"key":"852_CR20","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrn2477","volume":"9","author":"P Brundin","year":"2008","unstructured":"Brundin P, Li JY, Holton JL, Lindvall O, Revesz T (2008) Research in motion: the enigma of Parkinson\u2019s disease pathology spread. Nat Rev Neurosci 9:741\u2013745","journal-title":"Nat Rev Neurosci"},{"key":"852_CR21","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1750-3639.1999.tb00550.x","volume":"9","author":"L Buee","year":"1999","unstructured":"Buee L, Delacourte A (1999) Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick\u2019s disease. Brain Pathol 9:681\u2013693","journal-title":"Brain Pathol"},{"key":"852_CR22","first-page":"924","volume":"146","author":"V Buee-Scherrer","year":"1995","unstructured":"Buee-Scherrer V, Buee L, Hof PR et al (1995) Neurofibrillary degeneration in amyotrophic lateral sclerosis\/parkinsonism\u2013dementia complex of Guam. Immunochemical characterization of tau proteins. Am J Pathol 146:924\u2013932","journal-title":"Am J Pathol"},{"key":"852_CR23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/1097-0029(20000701)50:1<10::AID-JEMT3>3.0.CO;2-6","volume":"50","author":"O Bugiani","year":"2000","unstructured":"Bugiani O, Giaccone G, Piccardo P et al (2000) Neuropathology of Gerstmann\u2013Straussler\u2013Scheinker disease. Microsc Res Tech 50:10\u201315","journal-title":"Microsc Res Tech"},{"issue":"Suppl 1","key":"852_CR24","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1002\/mds.22783","volume":"25","author":"RE Burke","year":"2010","unstructured":"Burke RE (2010) Evaluation of the Braak staging scheme for Parkinson\u2019s disease: introduction to a panel presentation. Mov Disord 25(Suppl 1):S76\u2013S77","journal-title":"Mov Disord"},{"key":"852_CR25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/ana.21541","volume":"64","author":"RE Burke","year":"2008","unstructured":"Burke RE, Dauer WT, Vonsattel JP (2008) A critical evaluation of the Braak staging scheme for Parkinson\u2019s disease. Ann Neurol 64:485\u2013491","journal-title":"Ann Neurol"},{"key":"852_CR26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1471-4159.2001.00021.x","volume":"76","author":"BC Campbell","year":"2001","unstructured":"Campbell BC, McLean CA, Culvenor JG et al (2001) The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson\u2019s disease. J Neurochem 76:87\u201396","journal-title":"J Neurochem"},{"key":"852_CR27","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1468-1331.2009.02661.x","volume":"16","author":"CC Chang","year":"2009","unstructured":"Chang CC, Chang YY, Chang WN et al (2009) Cognitive deficits in multiple system atrophy correlate with frontal atrophy and disease duration. Eur J Neurol 16:1144\u20131150","journal-title":"Eur J Neurol"},{"key":"852_CR28","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1001\/archneurol.2009.54","volume":"66","author":"LN Clark","year":"2009","unstructured":"Clark LN, Kartsaklis LA, Wolf Gilbert R et al (2009) Association of glucocerebrosidase mutations with dementia with Lewy bodies. Arch Neurol 66:578\u2013583","journal-title":"Arch Neurol"},{"key":"852_CR29","doi-asserted-by":"crossref","unstructured":"Compta Y, Parkkinen L, O\u2019Sullivan SS et al (2011) Lewy- and Alzheimer-type pathologies in Parkinson\u2019s disease dementia: which is more important? Brain 134:1493\u20131505","DOI":"10.1093\/brain\/awr031"},{"key":"852_CR30","doi-asserted-by":"crossref","unstructured":"Cullen V, Sardi SP, Ng J et al (2011) Acid beta-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter alpha-synuclein processing. Ann Neurol 69:940\u2013953","DOI":"10.1002\/ana.22400"},{"key":"852_CR31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1096\/fj.10-164624","volume":"25","author":"KM Danzer","year":"2011","unstructured":"Danzer KM, Ruf WP, Putcha P et al (2011) Heat-shock protein 70 modulates toxic extracellular alpha-synuclein oligomers and rescues trans-synaptic toxicity. FASEB J 25:326\u2013336","journal-title":"FASEB J"},{"key":"852_CR32","first-page":"330","volume":"13","author":"J Dejerine","year":"1900","unstructured":"Dejerine J, Thomas AA (1900) L\u2019atrophie olivo-ponto-c\u201ar\u201abelleuse. Nouv Iconogr Salp\u02c6tr 13:330\u2013370","journal-title":"Nouv Iconogr Salp\u02c6tr"},{"key":"852_CR33","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/01.jnen.0000205145.54457.ea","volume":"65","author":"V Deramecourt","year":"2006","unstructured":"Deramecourt V, Bombois S, Maurage CA et al (2006) Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies. J Neuropathol Exp Neurol 65:278\u2013288","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR34","doi-asserted-by":"crossref","first-page":"13010","DOI":"10.1073\/pnas.0903691106","volume":"106","author":"P Desplats","year":"2009","unstructured":"Desplats P, Lee HJ, Bae EJ et al (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci USA 106:13010\u201313015","journal-title":"Proc Natl Acad Sci USA"},{"key":"852_CR35","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S1474-4422(09)70238-8","volume":"8","author":"DW Dickson","year":"2009","unstructured":"Dickson DW, Braak H, Duda JE et al (2009) Neuropathological assessment of Parkinson\u2019s disease: refining the diagnostic criteria. Lancet Neurol 8:1150\u20131157","journal-title":"Lancet Neurol"},{"key":"852_CR36","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/BF00691284","volume":"78","author":"DW Dickson","year":"1989","unstructured":"Dickson DW, Crystal H, Mattiace LA et al (1989) Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques. Acta Neuropathol 78:572\u2013584","journal-title":"Acta Neuropathol"},{"key":"852_CR37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00401-008-0345-7","volume":"115","author":"DW Dickson","year":"2008","unstructured":"Dickson DW, Fujishiro H, DelleDonne A et al (2008) Evidence that incidental Lewy body disease is pre-symptomatic Parkinson\u2019s disease. Acta Neuropathol 115:437\u2013444","journal-title":"Acta Neuropathol"},{"key":"852_CR38","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0002-9440(10)65226-1","volume":"155","author":"DW Dickson","year":"1999","unstructured":"Dickson DW, Liu W, Hardy J et al (1999) Widespread alterations of alpha-synuclein in multiple system atrophy. Am J Pathol 155:1241\u20131251","journal-title":"Am J Pathol"},{"key":"852_CR39","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1212\/WNL.41.9.1402","volume":"41","author":"DW Dickson","year":"1991","unstructured":"Dickson DW, Ruan D, Crystal H et al (1991) Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer\u2019s disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology 41:1402\u20131409","journal-title":"Neurology"},{"key":"852_CR40","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1002\/mds.22637","volume":"25","author":"DW Dickson","year":"2010","unstructured":"Dickson DW, Uchikado H, Fujishiro H, Tsuboi Y (2010) Evidence in favor of Braak staging of Parkinson\u2019s disease. Mov Disord 25:S78\u2013S82","journal-title":"Mov Disord"},{"key":"852_CR41","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00401-003-0790-2","volume":"107","author":"MJ Doherty","year":"2004","unstructured":"Doherty MJ, Bird TD, Leverenz JB (2004) Alpha-synuclein in motor neuron disease: an immunohistologic study. Acta Neuropathol 107:169\u2013175","journal-title":"Acta Neuropathol"},{"key":"852_CR42","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0002-9440(10)64781-5","volume":"157","author":"JE Duda","year":"2000","unstructured":"Duda JE, Giasson BI, Chen Q et al (2000) Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies. Am J Pathol 157:1439\u20131445","journal-title":"Am J Pathol"},{"key":"852_CR43","doi-asserted-by":"crossref","unstructured":"Emre M, Aarsland D, Brown R et al (2007) Clinical diagnostic criteria for dementia associated with Parkinson\u2019s disease. Mov Disord 22:1689\u20131707 (quiz 837)","DOI":"10.1002\/mds.21507"},{"issue":"Pt 6","key":"852_CR44","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1093\/brain\/113.6.1823","volume":"113","author":"JM Fearnley","year":"1990","unstructured":"Fearnley JM, Lees AJ (1990) Striatonigral degeneration. A clinicopathological study. Brain 113(Pt 6):1823\u20131842","journal-title":"Brain"},{"key":"852_CR45","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/S0002-9440(10)61119-4","volume":"160","author":"MS Forman","year":"2002","unstructured":"Forman MS, Schmidt ML, Kasturi S et al (2002) Tau and alpha-synuclein pathology in amygdala of Parkinsonism\u2013dementia complex patients of Guam. Am J Pathol 160:1725\u20131731","journal-title":"Am J Pathol"},{"key":"852_CR46","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1532-5415.1969.tb01316.x","volume":"17","author":"LS Forno","year":"1969","unstructured":"Forno LS (1969) Concentric hyalin intraneuronal inclusions of Lewy type in the brains of elderly persons (50 incidental cases): relationship to parkinsonism. J Am Geriatr Soc 17:557\u2013575","journal-title":"J Am Geriatr Soc"},{"key":"852_CR47","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrneurol.2009.175","volume":"5","author":"M Fotuhi","year":"2009","unstructured":"Fotuhi M, Hachinski V, Whitehouse PJ (2009) Changing perspectives regarding late-life dementia. Nat Rev Neurol 5:649\u2013658","journal-title":"Nat Rev Neurol"},{"key":"852_CR48","doi-asserted-by":"crossref","unstructured":"Frigerio R, Fujishiro H, Ahn TB et al (2011) Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies? Neurobiol Aging 32:857\u2013863","DOI":"10.1016\/j.neurobiolaging.2009.05.019"},{"key":"852_CR49","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1001\/archneurol.2009.170","volume":"66","author":"R Frigerio","year":"2009","unstructured":"Frigerio R, Fujishiro H, Maraganore DM et al (2009) Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease. Arch Neurol 66:1114\u20131119","journal-title":"Arch Neurol"},{"issue":"Suppl 1","key":"852_CR50","first-page":"S30","volume":"23","author":"H Fujishiro","year":"2008","unstructured":"Fujishiro H, Ahn T-B, Frigerio R et al (2008) Incidental Lewy bodies in various neurodegenerative disorders. Mov Disord 23(Suppl 1):S30","journal-title":"Mov Disord"},{"key":"852_CR51","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/NEN.0b013e31817d7a1d","volume":"67","author":"H Fujishiro","year":"2008","unstructured":"Fujishiro H, Ferman TJ, Boeve BF et al (2008) Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases. J Neuropathol Exp Neurol 67:649\u2013656","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR52","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neulet.2010.09.036","volume":"486","author":"H Fujishiro","year":"2010","unstructured":"Fujishiro H, Iseki E, Higashi S et al (2010) Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia. Neurosci Lett 486:19\u201323","journal-title":"Neurosci Lett"},{"key":"852_CR53","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00401-008-0383-1","volume":"116","author":"H Fujishiro","year":"2008","unstructured":"Fujishiro H, Tsuboi Y, Lin WL, Uchikado H, Dickson DW (2008) Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer\u2019s disease with amygdala Lewy bodies. Acta Neuropathol 116:17\u201324","journal-title":"Acta Neuropathol"},{"key":"852_CR54","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb841","volume":"4","author":"H Fujiwara","year":"2002","unstructured":"Fujiwara H, Hasegawa M, Dohmae N et al (2002) alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4:160\u2013164","journal-title":"Nat Cell Biol"},{"key":"852_CR55","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0140-6736(05)79256-4","volume":"352","author":"WP Gai","year":"1998","unstructured":"Gai WP, Power JH, Blumbergs PC, Blessing WW (1998) Multiple-system atrophy: a new alpha-synuclein disease? Lancet 352:547\u2013548","journal-title":"Lancet"},{"key":"852_CR56","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0002-9440(10)64548-8","volume":"157","author":"JE Galvin","year":"2000","unstructured":"Galvin JE, Giasson B, Hurtig HI, Lee VM, Trojanowski JQ (2000) Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology. Am J Pathol 157:361\u2013368","journal-title":"Am J Pathol"},{"key":"852_CR57","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/mds.23637","volume":"26","author":"T Gasser","year":"2011","unstructured":"Gasser T, Hardy J, Mizuno Y (2011) Milestones in PD genetics. Mov Disord 26:1042\u20131048","journal-title":"Mov Disord"},{"key":"852_CR58","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archneur.56.1.33","volume":"56","author":"DJ Gelb","year":"1999","unstructured":"Gelb DJ, Oliver E, Gilman S (1999) Diagnostic criteria for Parkinson\u2019s disease. Arch Neurol 56:33\u201339","journal-title":"Arch Neurol"},{"key":"852_CR59","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/mds.20678","volume":"21","author":"F Geser","year":"2006","unstructured":"Geser F, Wenning GK, Seppi K et al (2006) Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG). Mov Disord 21:179\u2013186","journal-title":"Mov Disord"},{"key":"852_CR60","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1750-3639.1995.tb00578.x","volume":"5","author":"B Ghetti","year":"1995","unstructured":"Ghetti B, Dlouhy SR, Giaccone G et al (1995) Gerstmann\u2013Straussler\u2013Scheinker disease and the Indiana kindred. Brain Pathol 5:61\u201375","journal-title":"Brain Pathol"},{"key":"852_CR61","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","volume":"51","author":"WR Gibb","year":"1988","unstructured":"Gibb WR, Lees AJ (1988) The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 51:745\u2013752","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"852_CR62","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","volume":"71","author":"S Gilman","year":"2008","unstructured":"Gilman S, Wenning GK, Low PA et al (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71:670\u2013676","journal-title":"Neurology"},{"key":"852_CR63","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/jnnp.32.1.28","volume":"32","author":"JG Graham","year":"1969","unstructured":"Graham JG, Oppenheimer DR (1969) Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. J Neurol Neurosurg Psychiatry 32:28\u201334","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"852_CR64","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1750-1326-6-6","volume":"6","author":"E Greggio","year":"2011","unstructured":"Greggio E, Bisaglia M, Civiero L, Bubacco L (2011) Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson\u2019s disease? Mol Neurodegener 6:6","journal-title":"Mol Neurodegener"},{"key":"852_CR65","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00401-008-0344-8","volume":"115","author":"G Halliday","year":"2008","unstructured":"Halliday G, Hely M, Reid W, Morris J (2008) The progression of pathology in longitudinally followed patients with Parkinson\u2019s disease. Acta Neuropathol 115:409\u2013415","journal-title":"Acta Neuropathol"},{"key":"852_CR66","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1749-6632.2009.05118.x","volume":"1184","author":"GM Halliday","year":"2010","unstructured":"Halliday GM, McCann H (2010) The progression of pathology in Parkinson\u2019s disease. Ann N Y Acad Sci 1184:188\u2013195","journal-title":"Ann N Y Acad Sci"},{"key":"852_CR67","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00702-011-0641-6","volume":"118","author":"GM Halliday","year":"2011","unstructured":"Halliday GM, Song YJ, Harding AJ (2011) Striatal beta-amyloid in dementia with Lewy bodies but not Parkinson\u2019s disease. J Neural Transm 118:713\u2013719","journal-title":"J Neural Transm"},{"key":"852_CR68","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1750-3639.2000.tb00269.x","volume":"10","author":"RL Hamilton","year":"2000","unstructured":"Hamilton RL (2000) Lewy bodies in Alzheimer\u2019s disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol 10:378\u2013384","journal-title":"Brain Pathol"},{"key":"852_CR69","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/archneur.64.4.545","volume":"64","author":"K Hara","year":"2007","unstructured":"Hara K, Momose Y, Tokiguchi S et al (2007) Multiplex families with multiple system atrophy. Arch Neurol 64:545\u2013551","journal-title":"Arch Neurol"},{"key":"852_CR70","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s004010100390","volume":"102","author":"AJ Harding","year":"2001","unstructured":"Harding AJ, Halliday GM (2001) Cortical Lewy body pathology in the diagnosis of dementia. Acta Neuropathol (Berl) 102:355\u2013363","journal-title":"Acta Neuropathol (Berl)"},{"key":"852_CR71","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1749-6632.2009.04365.x","volume":"1170","author":"CH Hawkes","year":"2009","unstructured":"Hawkes CH, Del Tredici K, Braak H (2009) Parkinson\u2019s disease: the dual hit theory revisited. Ann N Y Acad Sci 1170:615\u2013622","journal-title":"Ann N Y Acad Sci"},{"key":"852_CR72","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/mds.20324","volume":"20","author":"MA Hely","year":"2005","unstructured":"Hely MA, Morris JG, Reid WG, Trafficante R (2005) Sydney Multicenter Study of Parkinson\u2019s disease: non-l-dopa-responsive problems dominate at 15\u00a0years. Mov Disord 20:190\u2013199","journal-title":"Mov Disord"},{"key":"852_CR73","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1365-2990.2003.00470.x","volume":"29","author":"N Hishikawa","year":"2003","unstructured":"Hishikawa N, Hashizume Y, Ujihira N et al (2003) Alpha-synuclein-positive structures in association with diffuse neurofibrillary tangles with calcification. Neuropathol Appl Neurobiol 29:280\u2013287","journal-title":"Neuropathol Appl Neurobiol"},{"key":"852_CR74","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/mds.20497","volume":"20","author":"Y Huang","year":"2005","unstructured":"Huang Y, Garrick R, Cook R et al (2005) Pallidal stimulation reduces treatment-induced dyskinesias in \u201cminimal-change\u201d multiple system atrophy. Mov Disord 20:1042\u20131047","journal-title":"Mov Disord"},{"key":"852_CR75","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s004010050655","volume":"93","author":"M Inoue","year":"1997","unstructured":"Inoue M, Yagishita S, Ryo M et al (1997) The distribution and dynamic density of oligodendroglial cytoplasmic inclusions (GCIs) in multiple system atrophy: a correlation between the density of GCIs and the degree of involvement of striatonigral and olivopontocerebellar systems. Acta Neuropathol 93:585\u2013591","journal-title":"Acta Neuropathol"},{"key":"852_CR76","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","volume":"79","author":"J Jankovic","year":"2008","unstructured":"Jankovic J (2008) Parkinson\u2019s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79:368\u2013376","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"852_CR77","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/mds.10557","volume":"18","author":"KA Jellinger","year":"2003","unstructured":"Jellinger KA (2003) Neuropathological spectrum of synucleinopathies. Mov Disord 18:2\u201312","journal-title":"Mov Disord"},{"key":"852_CR78","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.bbadis.2008.07.006","volume":"1792","author":"KA Jellinger","year":"2009","unstructured":"Jellinger KA (2009) A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders. Biochim Biophys Acta 1792:730\u2013740","journal-title":"Biochim Biophys Acta"},{"key":"852_CR79","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000327360","volume":"31","author":"KA Jellinger","year":"2011","unstructured":"Jellinger KA, Attems J (2011) Prevalence and pathology of dementia with Lewy bodies in the oldest old: a comparison with other dementing disorders. Dement Geriatr Cogn Disord 31:309\u2013316","journal-title":"Dement Geriatr Cogn Disord"},{"key":"852_CR80","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1046\/j.1460-9568.1999.00754.x","volume":"11","author":"PH Jensen","year":"1999","unstructured":"Jensen PH, Li JY, Dahlstrom A, Dotti CG (1999) Axonal transport of synucleins is mediated by all rate components. Eur J Neurosci 11:3369\u20133376","journal-title":"Eur J Neurosci"},{"key":"852_CR81","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1365-2990.2007.00923.x","volume":"34","author":"ME Kalaitzakis","year":"2008","unstructured":"Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RK (2008) The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson\u2019s disease: a critical analysis of alpha-synuclein staging. Neuropathol Appl Neurobiol 34:284\u2013295","journal-title":"Neuropathol Appl Neurobiol"},{"key":"852_CR82","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/BF00294235","volume":"79","author":"S Kato","year":"1990","unstructured":"Kato S, Nakamura H (1990) Cytoplasmic argyrophilic inclusions in neurons of pontine nuclei in patients with olivopontocerebellar atrophy: immunohistochemical and ultrastructural studies. Acta Neuropathol 79:584\u2013594","journal-title":"Acta Neuropathol"},{"key":"852_CR83","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1212\/01.wnl.0000310413.04462.6a","volume":"70","author":"Y Kawai","year":"2008","unstructured":"Kawai Y, Suenaga M, Takeda A et al (2008) Cognitive impairments in multiple system atrophy: MSA-C vs MSA-P. Neurology 70:1390\u20131396","journal-title":"Neurology"},{"key":"852_CR84","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neurobiolaging.2007.08.022","volume":"30","author":"BJ Kelley","year":"2009","unstructured":"Kelley BJ, Haidar W, Boeve BF et al (2009) Prominent phenotypic variability associated with mutations in progranulin. Neurobiol Aging 30:739\u2013751","journal-title":"Neurobiol Aging"},{"key":"852_CR85","doi-asserted-by":"crossref","unstructured":"Kingsbury AE, Bandopadhyay R, Silveira-Moriyama L et al (2010) Brain stem pathology in Parkinson\u2019s disease: an evaluation of the Braak staging model. Mov Disord 25:2508\u20132515","DOI":"10.1002\/mds.23305"},{"key":"852_CR86","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/ana.410370215","volume":"37","author":"WC Koller","year":"1995","unstructured":"Koller WC, Glatt SL, Hubble JP et al (1995) Apolipoprotein E genotypes in Parkinson\u2019s disease with and without dementia. Ann Neurol 37:242\u2013245","journal-title":"Ann Neurol"},{"key":"852_CR87","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0022-510X(86)90130-9","volume":"73","author":"H Konno","year":"1986","unstructured":"Konno H, Yamamoto T, Iwasaki Y, Iizuka H (1986) Shy-Drager syndrome and amyotrophic lateral sclerosis. Cytoarchitectonic and morphometric studies of sacral autonomic neurons. J Neurol Sci 73:193\u2013204","journal-title":"J Neurol Sci"},{"key":"852_CR88","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nm1747","volume":"14","author":"JH Kordower","year":"2008","unstructured":"Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW (2008) Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson\u2019s disease. Nat Med 14:504\u2013506","journal-title":"Nat Med"},{"key":"852_CR89","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/jnnp.57.5.594","volume":"57","author":"K Kosaka","year":"1994","unstructured":"Kosaka K (1994) Diffuse neurofibrillary tangles with calcification: a new presenile dementia. J Neurol Neurosurg Psychiatry 57:594\u2013596","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"852_CR90","first-page":"299","volume":"7","author":"K Kosaka","year":"1988","unstructured":"Kosaka K, Tsuchiya K, Yoshimura M (1988) Lewy body disease with and without dementia: a clinicopathological study of 35 cases. Clin Neuropathol 7:299\u2013305","journal-title":"Clin Neuropathol"},{"key":"852_CR91","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1212\/01.WNL.0000165987.89198.65","volume":"64","author":"ML Kraybill","year":"2005","unstructured":"Kraybill ML, Larson EB, Tsuang DW et al (2005) Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both. Neurology 64:2069\u20132073","journal-title":"Neurology"},{"key":"852_CR92","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00002093-200304000-00009","volume":"17","author":"TA Krefft","year":"2003","unstructured":"Krefft TA, Graff-Radford NR, Dickson DW, Baker M, Castellani RJ (2003) Familial primary progressive aphasia. Alzheimer Dis Assoc Disord 17:106\u2013112","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"852_CR93","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00401-007-0336-0","volume":"115","author":"T Lashley","year":"2008","unstructured":"Lashley T, Holton JL, Gray E et al (2008) Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson\u2019s disease patients. Acta Neuropathol 115:417\u2013425","journal-title":"Acta Neuropathol"},{"key":"852_CR94","doi-asserted-by":"crossref","first-page":"9262","DOI":"10.1074\/jbc.M109.081125","volume":"285","author":"HJ Lee","year":"2010","unstructured":"Lee HJ, Suk JE, Patrick C et al (2010) Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem 285:9262\u20139272","journal-title":"J Biol Chem"},{"key":"852_CR95","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/S0140-6736(09)60492-X","volume":"373","author":"AJ Lees","year":"2009","unstructured":"Lees AJ, Hardy J, Revesz T (2009) Parkinson\u2019s disease. Lancet 373:2055\u20132066","journal-title":"Lancet"},{"key":"852_CR96","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1750-3639.2007.00117.x","volume":"18","author":"JB Leverenz","year":"2008","unstructured":"Leverenz JB, Hamilton R, Tsuang DW et al (2008) Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient. Brain Pathol 18:220\u2013224","journal-title":"Brain Pathol"},{"key":"852_CR97","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nm1746","volume":"14","author":"JY Li","year":"2008","unstructured":"Li JY, Englund E, Holton JL et al (2008) Lewy bodies in grafted neurons in subjects with Parkinson\u2019s disease suggest host-to-graft disease propagation. Nat Med 14:501\u2013503","journal-title":"Nat Med"},{"key":"852_CR98","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/mds.23012","volume":"25","author":"JY Li","year":"2010","unstructured":"Li JY, Englund E, Widner H et al (2010) Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson\u2019s disease. Mov Disord 25:1091\u20131096","journal-title":"Mov Disord"},{"key":"852_CR99","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1046\/j.1471-4159.2003.02166.x","volume":"88","author":"W Li","year":"2004","unstructured":"Li W, Hoffman PN, Stirling W, Price DL, Lee MK (2004) Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson\u2019s disease-linked mutations. J Neurochem 88:401\u2013410","journal-title":"J Neurochem"},{"key":"852_CR100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neulet.2003.09.075","volume":"354","author":"WL Lin","year":"2004","unstructured":"Lin WL, DeLucia MW, Dickson DW (2004) Alpha-synuclein immunoreactivity in neuronal nuclear inclusions and neurites in multiple system atrophy. Neurosci Lett 354:99\u2013102","journal-title":"Neurosci Lett"},{"key":"852_CR101","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1212\/01.wnl.0000230161.28299.3c","volume":"67","author":"OL Lopez","year":"2006","unstructured":"Lopez OL, Becker JT, Sweet RA, Martin-Sanchez FJ, Hamilton RL (2006) Lewy bodies in the amygdala increase risk for major depression in subjects with Alzheimer disease. Neurology 67:660\u2013665","journal-title":"Neurology"},{"key":"852_CR102","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1212\/WNL.54.9.1780","volume":"54","author":"OL Lopez","year":"2000","unstructured":"Lopez OL, Hamilton RL, Becker JT et al (2000) Severity of cognitive impairment and the clinical diagnosis of AD with Lewy bodies. Neurology 54:1780\u20131787","journal-title":"Neurology"},{"key":"852_CR103","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S1474-4422(10)70090-9","volume":"9","author":"ED Louis","year":"2010","unstructured":"Louis ED (2010) Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry. Lancet Neurol 9:613\u2013622","journal-title":"Lancet Neurol"},{"key":"852_CR104","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/brain\/awm266","volume":"130","author":"ED Louis","year":"2007","unstructured":"Louis ED, Faust PL, Vonsattel JP et al (2007) Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain 130:3297\u20133307","journal-title":"Brain"},{"key":"852_CR105","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/NEN.0b013e3181ac10a7","volume":"68","author":"WR Markesbery","year":"2009","unstructured":"Markesbery WR, Jicha GA, Liu H, Schmitt FA (2009) Lewy body pathology in normal elderly subjects. J Neuropathol Exp Neurol 68:816\u2013822","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR106","doi-asserted-by":"crossref","first-page":"e1000180","DOI":"10.1371\/journal.pmed.1000180","volume":"6","author":"FE Matthews","year":"2009","unstructured":"Matthews FE, Brayne C, Lowe J et al (2009) Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study. PLoS Med 6:e1000180","journal-title":"PLoS Med"},{"key":"852_CR107","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","volume":"68","author":"AC McKee","year":"2009","unstructured":"McKee AC, Cantu RC, Nowinski CJ et al (2009) Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 68:709\u2013735","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR108","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","volume":"65","author":"IG McKeith","year":"2005","unstructured":"McKeith IG, Dickson DW, Lowe J et al (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65:1863\u20131872","journal-title":"Neurology"},{"key":"852_CR109","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nm0798-755","volume":"4","author":"E Mezey","year":"1998","unstructured":"Mezey E, Dehejia A, Harta G et al (1998) Alpha synuclein in neurodegenerative disorders: murderer or accomplice? Nat Med 4:755\u2013757","journal-title":"Nat Med"},{"key":"852_CR110","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","volume":"41","author":"SS Mirra","year":"1991","unstructured":"Mirra SS, Heyman A, McKeel D et al (1991) The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer\u2019s disease. Neurology 41:479\u2013486","journal-title":"Neurology"},{"key":"852_CR111","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1093\/jnen\/62.8.812","volume":"62","author":"F Mori","year":"2003","unstructured":"Mori F, Piao YS, Hayashi S et al (2003) Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy. J Neuropathol Exp Neurol 62:812\u2013819","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR112","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ana.410160407","volume":"16","author":"JC Morris","year":"1984","unstructured":"Morris JC, Cole M, Banker BQ, Wright D (1984) Hereditary dysphasic dementia and the Pick\u2013Alzheimer spectrum. Ann Neurol 16:455\u2013466","journal-title":"Ann Neurol"},{"key":"852_CR113","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1212\/WNL.46.6.1693","volume":"46","author":"S Nakamura","year":"1996","unstructured":"Nakamura S, Ohnishi K, Nishimura M et al (1996) Large neurons in the tuberomammillary nucleus in patients with Parkinson\u2019s disease and multiple system atrophy. Neurology 46:1693\u20131696","journal-title":"Neurology"},{"key":"852_CR114","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0140-6736(10)62345-8","volume":"377","author":"MA Nalls","year":"2011","unstructured":"Nalls MA, Plagnol V, Hernandez DG et al (2011) Imputation of sequence variants for identification of genetic risks for Parkinson\u2019s disease: a meta-analysis of genome-wide association studies. Lancet 377:641\u2013649","journal-title":"Lancet"},{"key":"852_CR115","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00415-009-5324-y","volume":"257","author":"PT Nelson","year":"2010","unstructured":"Nelson PT, Jicha GA, Kryscio RJ et al (2010) Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol 257:359\u2013366","journal-title":"J Neurol"},{"key":"852_CR116","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1212\/WNL.0b013e3181bacf9e","volume":"73","author":"PT Nelson","year":"2009","unstructured":"Nelson PT, Kryscio RJ, Jicha GA et al (2009) Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies. Neurology 73:1127\u20131133","journal-title":"Neurology"},{"key":"852_CR117","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s00415-010-5630-4","volume":"257","author":"PT Nelson","year":"2010","unstructured":"Nelson PT, Schmitt FA, Jicha GA et al (2010) Association between male gender and cortical Lewy body pathology in large autopsy series. J Neurol 257:1875\u20131881","journal-title":"J Neurol"},{"key":"852_CR118","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/brain\/awp044","volume":"132","author":"J Neumann","year":"2009","unstructured":"Neumann J, Bras J, Deas E et al (2009) Glucocerebrosidase mutations in clinical and pathologically proven Parkinson\u2019s disease. Brain 132:1783\u20131794","journal-title":"Brain"},{"key":"852_CR119","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s004010000224","volume":"100","author":"M Neumann","year":"2000","unstructured":"Neumann M, Adler S, Schluter O et al (2000) Alpha-synuclein accumulation in a case of neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden\u2013Spatz syndrome) with widespread cortical and brainstem-type Lewy bodies. Acta Neuropathol 100:568\u2013574","journal-title":"Acta Neuropathol"},{"key":"852_CR120","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1097\/00005072-199912000-00007","volume":"58","author":"KL Newell","year":"1999","unstructured":"Newell KL, Boyer P, Gomez-Tortosa E et al (1999) Alpha-synuclein immunoreactivity is present in axonal swellings in neuroaxonal dystrophy and acute traumatic brain injury. J Neuropathol Exp Neurol 58:1263\u20131268","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR121","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2990.2004.00564.x","volume":"30","author":"M Nishie","year":"2004","unstructured":"Nishie M, Mori F, Yoshimoto M, Takahashi H, Wakabayashi K (2004) A quantitative investigation of neuronal cytoplasmic and intranuclear inclusions in the pontine and inferior olivary nuclei in multiple system atrophy. Neuropathol Appl Neurobiol 30:546\u2013554","journal-title":"Neuropathol Appl Neurobiol"},{"key":"852_CR122","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.parkreldis.2010.09.009","volume":"17","author":"K Nishioka","year":"2011","unstructured":"Nishioka K, Ross OA, Vilarino-Guell C et al (2011) Glucocerebrosidase mutations in diffuse Lewy body disease. Parkinsonism Relat Disord 17:55\u201357","journal-title":"Parkinsonism Relat Disord"},{"key":"852_CR123","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1093\/brain\/awn065","volume":"131","author":"SS O\u2019Sullivan","year":"2008","unstructured":"O\u2019Sullivan SS, Massey LA, Williams DR et al (2008) Clinical outcomes of progressive supranuclear palsy and multiple system atrophy. Brain 131:1362\u20131372","journal-title":"Brain"},{"key":"852_CR124","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1600-0463.2007.apm_521.x","volume":"115","author":"M Oinas","year":"2007","unstructured":"Oinas M, Sulkava R, Polvikoski T, Kalimo H, Paetau A (2007) Reappraisal of a consecutive autopsy series of patients with primary degenerative dementia: Lewy-related pathology. APMIS 115:820\u2013827","journal-title":"APMIS"},{"key":"852_CR125","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0022-510X(92)90137-A","volume":"112","author":"JE Olsson","year":"1992","unstructured":"Olsson JE, Brunk U, Lindvall B, Eeg-Olofsson O (1992) Dopa-responsive dystonia with depigmentation of the substantia nigra and formation of Lewy bodies. J Neurol Sci 112:90\u201395","journal-title":"J Neurol Sci"},{"key":"852_CR126","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1750-3639.2006.00032.x","volume":"17","author":"S Orimo","year":"2007","unstructured":"Orimo S, Takahashi A, Uchihara T et al (2007) Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson\u2019s disease. Brain Pathol 17:24\u201330","journal-title":"Brain Pathol"},{"key":"852_CR127","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00401-007-0254-1","volume":"114","author":"T Ozawa","year":"2007","unstructured":"Ozawa T (2007) Morphological substrate of autonomic failure and neurohormonal dysfunction in multiple system atrophy: impact on determining phenotype spectrum. Acta Neuropathol 114:201\u2013211","journal-title":"Acta Neuropathol"},{"key":"852_CR128","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/jnnp.2005.073528","volume":"77","author":"T Ozawa","year":"2006","unstructured":"Ozawa T, Healy DG, Abou-Sleiman PM et al (2006) The alpha-synuclein gene in multiple system atrophy. J Neurol Neurosurg Psychiatry 77:464\u2013467","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"852_CR129","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1093\/brain\/awh303","volume":"127","author":"T Ozawa","year":"2004","unstructured":"Ozawa T, Paviour D, Quinn NP et al (2004) The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. Brain 127:2657\u20132671","journal-title":"Brain"},{"key":"852_CR130","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1136\/jnnp.2009.182576","volume":"81","author":"T Ozawa","year":"2010","unstructured":"Ozawa T, Tada M, Kakita A et al (2010) The phenotype spectrum of Japanese multiple system atrophy. J Neurol Neurosurg Psychiatry 81:1253\u20131255","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"852_CR131","doi-asserted-by":"crossref","unstructured":"Paisan-Ruiz C, Li A, Schneider SA et al (2010) Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations. Neurobiol Aging. doi: 10.1016\/j.neurobiolaging.2010.05.009","DOI":"10.1016\/j.neurobiolaging.2010.05.009"},{"key":"852_CR132","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0022-510X(89)90219-0","volume":"94","author":"MI Papp","year":"1989","unstructured":"Papp MI, Kahn JE, Lantos PL (1989) Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy\u2013Drager syndrome). J Neurol Sci 94:79\u2013100","journal-title":"J Neurol Sci"},{"key":"852_CR133","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0022-510X(92)90286-T","volume":"107","author":"MI Papp","year":"1992","unstructured":"Papp MI, Lantos PL (1992) Accumulation of tubular structures in oligodendroglial and neuronal cells as the basic alteration in multiple system atrophy. J Neurol Sci 107:172\u2013182","journal-title":"J Neurol Sci"},{"issue":"Pt 2","key":"852_CR134","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/brain\/117.2.235","volume":"117","author":"MI Papp","year":"1994","unstructured":"Papp MI, Lantos PL (1994) The distribution of oligodendroglial inclusions in multiple system atrophy and its relevance to clinical symptomatology. Brain 117(Pt 2):235\u2013243","journal-title":"Brain"},{"key":"852_CR135","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00401-008-0346-6","volume":"115","author":"L Parkkinen","year":"2008","unstructured":"Parkkinen L, Pirttila T, Alafuzoff I (2008) Applicability of current staging\/categorization of alpha-synuclein pathology and their clinical relevance. Acta Neuropathol 115:399\u2013407","journal-title":"Acta Neuropathol"},{"key":"852_CR136","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/msj.20157","volume":"77","author":"DP Perl","year":"2010","unstructured":"Perl DP (2010) Neuropathology of Alzheimer\u2019s disease. Mt Sinai J Med 77:32\u201342","journal-title":"Mt Sinai J Med"},{"key":"852_CR137","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1017\/S1041610209009454","volume":"21","author":"O Piguet","year":"2009","unstructured":"Piguet O, Halliday GM, Creasey H, Broe GA, Kril JJ (2009) Frontotemporal dementia and dementia with Lewy bodies in a case\u2013control study of Alzheimer\u2019s disease. Int Psychogeriatr 21:688\u2013695","journal-title":"Int Psychogeriatr"},{"key":"852_CR138","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1001\/archneur.61.12.1915","volume":"61","author":"A Popescu","year":"2004","unstructured":"Popescu A, Lippa CF, Lee VM, Trojanowski JQ (2004) Lewy bodies in the amygdala: increase of alpha-synuclein aggregates in neurodegenerative diseases with tau-based inclusions. Arch Neurol 61:1915\u20131919","journal-title":"Arch Neurol"},{"key":"852_CR139","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1002\/mds.21076","volume":"21","author":"GW Ross","year":"2006","unstructured":"Ross GW, Abbott RD, Petrovitch H et al (2006) Association of olfactory dysfunction with incidental Lewy bodies. Mov Disord 21:2062\u20132067","journal-title":"Mov Disord"},{"key":"852_CR140","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/ana.21786","volume":"67","author":"OA Ross","year":"2010","unstructured":"Ross OA, Vilarino-Guell C, Wszolek ZK, Farrer MJ, Dickson DW (2010) Reply to: SNCA variants are associated with increased risk of multiple system atrophy. Ann Neurol 67:414\u2013415","journal-title":"Ann Neurol"},{"key":"852_CR141","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/jnen\/63.7.742","volume":"63","author":"Y Saito","year":"2004","unstructured":"Saito Y, Ruberu NN, Sawabe M et al (2004) Lewy body-related alpha-synucleinopathy in aging. J Neuropathol Exp Neurol 63:742\u2013749","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR142","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/jnen\/63.4.323","volume":"63","author":"Y Saito","year":"2004","unstructured":"Saito Y, Suzuki K, Hulette CM, Murayama S (2004) Aberrant phosphorylation of alpha-synuclein in human Niemann\u2013Pick type C1 disease. J Neuropathol Exp Neurol 63:323\u2013328","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR143","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s004010000330","volume":"101","author":"ML Schmidt","year":"2001","unstructured":"Schmidt ML, Zhukareva V, Newell KL, Lee VM, Trojanowski JQ (2001) Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer\u2019s disease. Acta Neuropathol 101:518\u2013524","journal-title":"Acta Neuropathol"},{"key":"852_CR144","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/ana.21685","volume":"65","author":"SW Scholz","year":"2009","unstructured":"Scholz SW, Houlden H, Schulte C et al (2009) SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol 65:610\u2013614","journal-title":"Ann Neurol"},{"key":"852_CR145","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/S0140-6736(99)04137-9","volume":"354","author":"A Schrag","year":"1999","unstructured":"Schrag A, Ben-Shlomo Y, Quinn NP (1999) Prevalence of progressive supranuclear palsy and multiple system atrophy: a cross-sectional study. Lancet 354:1771\u20131775","journal-title":"Lancet"},{"key":"852_CR146","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/mds.21839","volume":"23","author":"A Schrag","year":"2008","unstructured":"Schrag A, Wenning GK, Quinn N, Ben-Shlomo Y (2008) Survival in multiple system atrophy. Mov Disord 23:294\u2013296","journal-title":"Mov Disord"},{"key":"852_CR147","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00401-004-0840-4","volume":"107","author":"J Sebeo","year":"2004","unstructured":"Sebeo J, Hof PR, Perl DP (2004) Occurrence of alpha-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism\u2013dementia complex. Acta Neuropathol 107:497\u2013503","journal-title":"Acta Neuropathol"},{"key":"852_CR148","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/brain\/awp234","volume":"132","author":"M Selikhova","year":"2009","unstructured":"Selikhova M, Williams DR, Kempster PA et al (2009) A clinico-pathological study of subtypes in Parkinson\u2019s disease. Brain 132:2947\u20132957","journal-title":"Brain"},{"key":"852_CR149","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1001\/archneur.1960.03840110025004","volume":"2","author":"GM Shy","year":"1960","unstructured":"Shy GM, Drager GA (1960) A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study. Arch Neurol 2:511\u2013527","journal-title":"Arch Neurol"},{"key":"852_CR150","doi-asserted-by":"crossref","first-page":"37920","DOI":"10.1074\/jbc.M110.185728","volume":"285","author":"A Siddiqua","year":"2010","unstructured":"Siddiqua A, Margittai M (2010) Three- and four-repeat Tau coassemble into heterogeneous filaments: an implication for Alzheimer disease. J Biol Chem 285:37920\u201337926","journal-title":"J Biol Chem"},{"key":"852_CR151","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","volume":"361","author":"E Sidransky","year":"2009","unstructured":"Sidransky E, Nalls MA, Aasly JO et al (2009) Multicenter analysis of glucocerebrosidase mutations in Parkinson\u2019s disease. N Engl J Med 361:1651\u20131661","journal-title":"N Engl J Med"},{"key":"852_CR152","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1212\/WNL.37.3.529","volume":"37","author":"G Sobue","year":"1987","unstructured":"Sobue G, Hashizume Y, Mitsuma T, Takahashi A (1987) Size-dependent myelinated fiber loss in the corticospinal tract in Shy\u2013Drager syndrome and amyotrophic lateral sclerosis. Neurology 37:529\u2013532","journal-title":"Neurology"},{"key":"852_CR153","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jns.2005.09.003","volume":"240","author":"H Soma","year":"2006","unstructured":"Soma H, Yabe I, Takei A et al (2006) Heredity in multiple system atrophy. J Neurol Sci 240:107\u2013110","journal-title":"J Neurol Sci"},{"key":"852_CR154","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0304-3940(98)00504-7","volume":"251","author":"MG Spillantini","year":"1998","unstructured":"Spillantini MG, Crowther RA, Jakes R et al (1998) Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson\u2019s disease and dementia with Lewy bodies. Neurosci Lett 251:205\u2013208","journal-title":"Neurosci Lett"},{"key":"852_CR155","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1749-6632.2000.tb06900.x","volume":"920","author":"MG Spillantini","year":"2000","unstructured":"Spillantini MG, Goedert M (2000) The alpha-synucleinopathies: Parkinson\u2019s disease, dementia with Lewy bodies, and multiple system atrophy. Ann N Y Acad Sci 920:16\u201327","journal-title":"Ann N Y Acad Sci"},{"key":"852_CR156","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","volume":"388","author":"MG Spillantini","year":"1997","unstructured":"Spillantini MG, Schmidt ML, Lee VM-Y et al (1997) \u03b1-Synuclein in Lewy bodies. Nature 388:839\u2013840","journal-title":"Nature"},{"key":"852_CR157","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00005072-197907000-00001","volume":"38","author":"JH Sung","year":"1979","unstructured":"Sung JH, Mastri AR, Segal E (1979) Pathology of Shy\u2013Drager syndrome. J Neuropathol Exp Neurol 38:353\u2013368","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR158","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00309338","volume":"89","author":"K Suzuki","year":"1995","unstructured":"Suzuki K, Parker CC, Pentchev PG et al (1995) Neurofibrillary tangles in Niemann\u2013Pick disease type C. Acta Neuropathol 89:227\u2013238","journal-title":"Acta Neuropathol"},{"key":"852_CR159","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1001\/archneur.64.2.280","volume":"64","author":"GK Tofaris","year":"2007","unstructured":"Tofaris GK, Revesz T, Jacques TS, Papacostas S, Chataway J (2007) Adult-onset neurodegeneration with brain iron accumulation and cortical alpha-synuclein and tau pathology: a distinct clinicopathological entity. Arch Neurol 64:280\u2013282","journal-title":"Arch Neurol"},{"key":"852_CR160","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1001\/archneur.60.5.764","volume":"60","author":"JR Trivedi","year":"2003","unstructured":"Trivedi JR, Wolfe GI, Nations SP et al (2003) Adult polyglucosan body disease associated with Lewy bodies and tremor. Arch Neurol 60:764\u2013766","journal-title":"Arch Neurol"},{"key":"852_CR161","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1365-2990.2007.00907.x","volume":"33","author":"JQ Trojanowski","year":"2007","unstructured":"Trojanowski JQ, Revesz T (2007) Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy. Neuropathol Appl Neurobiol 33:615\u2013620","journal-title":"Neuropathol Appl Neurobiol"},{"key":"852_CR162","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1212\/01.WNL.0000150892.81839.D1","volume":"64","author":"DW Tsuang","year":"2005","unstructured":"Tsuang DW, Wilson RK, Lopez OL et al (2005) Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease. Neurology 64:509\u2013513","journal-title":"Neurology"},{"issue":"Suppl 3","key":"852_CR163","doi-asserted-by":"crossref","first-page":"S221","DOI":"10.1016\/S1353-8020(08)70005-1","volume":"13","author":"Y Tsuboi","year":"2007","unstructured":"Tsuboi Y, Uchikado H, Dickson DW (2007) Neuropathology of Parkinson\u2019s disease dementia and dementia with Lewy bodies with reference to striatal pathology. Parkinsonism Relat Disord 13(Suppl 3):S221\u2013S224","journal-title":"Parkinsonism Relat Disord"},{"key":"852_CR164","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1046\/j.1365-2990.2003.00453.x","volume":"29","author":"Y Tsuboi","year":"2003","unstructured":"Tsuboi Y, Wszolek ZK, Graff-Radford NR, Cookson N, Dickson DW (2003) Tau pathology in the olfactory bulb correlates with Braak stage, Lewy body pathology and apolipoprotein epsilon4. Neuropathol Appl Neurobiol 29:503\u2013510","journal-title":"Neuropathol Appl Neurobiol"},{"key":"852_CR165","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s004010051173","volume":"99","author":"K Tsuchiya","year":"2000","unstructured":"Tsuchiya K, Ozawa E, Haga C et al (2000) Constant involvement of the Betz cells and pyramidal tract in multiple system atrophy: a clinicopathological study of seven autopsy cases. Acta Neuropathol (Berl) 99:628\u2013636","journal-title":"Acta Neuropathol (Berl)"},{"key":"852_CR166","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/01.jnen.0000218449.17073.43","volume":"65","author":"H Uchikado","year":"2006","unstructured":"Uchikado H, DelleDonne A, Ahmed Z, Dickson DW (2006) Lewy bodies in progressive supranuclear palsy represent an independent disease process. J Neuropathol Exp Neurol 65:387\u2013395","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR167","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/01.jnen.0000225908.90052.07","volume":"65","author":"H Uchikado","year":"2006","unstructured":"Uchikado H, Lin WL, DeLucia MW, Dickson DW (2006) Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy. J Neuropathol Exp Neurol 65:685\u2013697","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR168","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1212\/WNL.45.4.709","volume":"45","author":"M Uchiyama","year":"1995","unstructured":"Uchiyama M, Isse K, Tanaka K et al (1995) Incidental Lewy body disease in a patient with REM sleep behavior disorder. Neurology 45:709\u2013712","journal-title":"Neurology"},{"key":"852_CR169","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1242\/jcs.02558","volume":"118","author":"MA Utton","year":"2005","unstructured":"Utton MA, Noble WJ, Hill JE, Anderton BH, Hanger DP (2005) Molecular motors implicated in the axonal transport of tau and alpha-synuclein. J Cell Sci 118:4645\u20134654","journal-title":"J Cell Sci"},{"key":"852_CR170","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/mds.23116","volume":"25","author":"SM Rooden van","year":"2010","unstructured":"van Rooden SM, Heiser WJ, Kok JN et al (2010) The identification of Parkinson\u2019s disease subtypes using cluster analysis: a systematic review. Mov Disord 25:969\u2013978","journal-title":"Mov Disord"},{"key":"852_CR171","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1600-0404.2010.01362.x","volume":"122","author":"H Vefring","year":"2010","unstructured":"Vefring H, Haugarvoll K, Tysnes OB, Larsen JP, Kurz MW (2010) The role of APOE alleles in incident Parkinson\u2019s disease. The Norwegian ParkWest Study. Acta Neurol Scand 122:438\u2013441","journal-title":"Acta Neurol Scand"},{"key":"852_CR172","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s004010050049","volume":"99","author":"K Wakabayashi","year":"2000","unstructured":"Wakabayashi K, Fukushima T, Koide R et al (2000) Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden\u2013Spatz disease) with diffuse neurofibrillary and Lewy body pathology. Acta Neuropathol 99:331\u2013336","journal-title":"Acta Neuropathol"},{"key":"852_CR173","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0022-510X(98)00018-5","volume":"156","author":"K Wakabayashi","year":"1998","unstructured":"Wakabayashi K, Ikeuchi T, Ishikawa A, Takahashi H (1998) Multiple system atrophy with severe involvement of the motor cortical areas and cerebral white matter. J Neurol Sci 156:114\u2013117","journal-title":"J Neurol Sci"},{"key":"852_CR174","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00401-005-1029-1","volume":"110","author":"K Wakabayashi","year":"2005","unstructured":"Wakabayashi K, Mori F, Nishie M et al (2005) An autopsy case of early (\u201cminimal change\u201d) olivopontocerebellar atrophy (multiple system atrophy-cerebellar). Acta Neuropathol 110:185\u2013190","journal-title":"Acta Neuropathol"},{"key":"852_CR175","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0304-3940(98)00407-8","volume":"249","author":"K Wakabayashi","year":"1998","unstructured":"Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H (1998) Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 249:180\u2013182","journal-title":"Neurosci Lett"},{"key":"852_CR176","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/brain\/awf117","volume":"125","author":"H Watanabe","year":"2002","unstructured":"Watanabe H, Saito Y, Terao S et al (2002) Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients. Brain 125:1070\u20131083","journal-title":"Brain"},{"key":"852_CR177","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1212\/01.wnl.0000266626.64913.0f","volume":"69","author":"D Weisman","year":"2007","unstructured":"Weisman D, Cho M, Taylor C et al (2007) In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution. Neurology 69:356\u2013359","journal-title":"Neurology"},{"key":"852_CR178","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1468-1331.2009.02548.x","volume":"16","author":"GK Wenning","year":"2009","unstructured":"Wenning GK, Brown R (2009) Dementia in multiple system atrophy: does it exist? Eur J Neurol 16:551\u2013552","journal-title":"Eur J Neurol"},{"key":"852_CR179","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/mds.870090206","volume":"9","author":"GK Wenning","year":"1994","unstructured":"Wenning GK, Quinn N, Magalhaes M, Mathias C, Daniel SE (1994) \u201cMinimal change\u201d multiple system atrophy. Mov Disord 9:161\u2013166","journal-title":"Mov Disord"},{"key":"852_CR180","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1007\/s00415-009-5173-8","volume":"256","author":"GK Wenning","year":"2009","unstructured":"Wenning GK, Stefanova N (2009) Recent developments in multiple system atrophy. J Neurol 256:1791\u20131808","journal-title":"J Neurol"},{"key":"852_CR181","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/mds.870120203","volume":"12","author":"GK Wenning","year":"1997","unstructured":"Wenning GK, Tison F, Ben Shlomo Y, Daniel SE, Quinn NP (1997) Multiple system atrophy: a review of 203 pathologically proven cases. Mov Disord 12:133\u2013147","journal-title":"Mov Disord"},{"key":"852_CR182","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1212\/WNL.0b013e3181a826c0","volume":"72","author":"C Wider","year":"2009","unstructured":"Wider C, Van Gerpen JA, DeArmond S et al (2009) Leukoencephalopathy with spheroids (HDLS) and pigmentary leukodystrophy (POLD): a single entity? Neurology 72:1953\u20131959","journal-title":"Neurology"},{"key":"852_CR183","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1212\/01.wnl.0000247041.63081.98","volume":"67","author":"MM Williams","year":"2006","unstructured":"Williams MM, Xiong C, Morris JC, Galvin JE (2006) Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease. Neurology 67:1935\u20131941","journal-title":"Neurology"},{"key":"852_CR184","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/jnnp.2008.158949","volume":"80","author":"U Wullner","year":"2009","unstructured":"Wullner U, Schmitt I, Kammal M, Kretzschmar HA, Neumann M (2009) Definite multiple system atrophy in a German family. J Neurol Neurosurg Psychiatry 80:449\u2013450","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"852_CR185","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00702-007-0746-0","volume":"114","author":"U Wullner","year":"2007","unstructured":"Wullner U, Schmitz-Hubsch T, Abele M et al (2007) Features of probable multiple system atrophy patients identified among 4770 patients with parkinsonism enrolled in the multicentre registry of the German Competence Network on Parkinson\u2019s disease. J Neural Transm 114:1161\u20131165","journal-title":"J Neural Transm"},{"key":"852_CR186","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jns.2006.05.064","volume":"249","author":"I Yabe","year":"2006","unstructured":"Yabe I, Soma H, Takei A et al (2006) MSA-C is the predominant clinical phenotype of MSA in Japan: analysis of 142 patients with probable MSA. J Neurol Sci 249:115\u2013121","journal-title":"J Neurol Sci"},{"key":"852_CR187","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/jnen\/59.7.585","volume":"59","author":"M Yamazaki","year":"2000","unstructured":"Yamazaki M, Arai Y, Baba M et al (2000) Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism\u2013dementia complex of Guam. J Neuropathol Exp Neurol 59:585\u2013591","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR188","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/jnen\/64.3.245","volume":"64","author":"D Yancopoulou","year":"2005","unstructured":"Yancopoulou D, Xuereb JH, Crowther RA, Hodges JR, Spillantini MG (2005) Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia. J Neuropathol Exp Neurol 64:245\u2013253","journal-title":"J Neuropathol Exp Neurol"},{"key":"852_CR189","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1440-1789.2001.00390.x","volume":"21","author":"T Yokoyama","year":"2001","unstructured":"Yokoyama T, Kusunoki JI, Hasegawa K, Sakai H, Yagishita S (2001) Distribution and dynamic process of neuronal cytoplasmic inclusion (NCI) in MSA: correlation of the density of NCI and the degree of involvement of the pontine nuclei. Neuropathology 21:145\u2013154","journal-title":"Neuropathology"},{"key":"852_CR190","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1440-1789.2007.00841.x","volume":"27","author":"M Yoshida","year":"2007","unstructured":"Yoshida M (2007) Multiple system atrophy: alpha-synuclein and neuronal degeneration. Neuropathology 27:484\u2013493","journal-title":"Neuropathology"},{"key":"852_CR191","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/ana.21889","volume":"67","author":"JY Yun","year":"2010","unstructured":"Yun JY, Lee WW, Lee JY et al (2010) SNCA variants and multiple system atrophy. Ann Neurol 67:554\u2013555","journal-title":"Ann Neurol"},{"key":"852_CR192","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1212\/01.wnl.0000306697.48738.b6","volume":"70","author":"J Zaccai","year":"2008","unstructured":"Zaccai J, Brayne C, McKeith I, Matthews F, Ince PG (2008) Patterns and stages of alpha-synucleinopathy: relevance in a population-based cohort. Neurology 70:1042\u20131048","journal-title":"Neurology"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-011-0852-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-011-0852-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-011-0852-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:44:06Z","timestamp":1592700246000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-011-0852-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,1]]},"references-count":192,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["852"],"URL":"https:\/\/doi.org\/10.1007\/s00401-011-0852-9","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,1]]}}}