{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:02:37Z","timestamp":1793361757126,"version":"4.5.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,5,28]],"date-time":"2016-05-28T00:00:00Z","timestamp":1464393600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100001545","name":"Children's Tumor Foundation","doi-asserted-by":"publisher","award":["2015-05-010"],"award-info":[{"award-number":["2015-05-010"]}],"id":[{"id":"10.13039\/100001545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MO 1421\/2-1"],"award-info":[{"award-number":["MO 1421\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s00401-016-1583-8","type":"journal-article","created":{"date-parts":[[2016,5,28]],"date-time":"2016-05-28T12:49:57Z","timestamp":1464439797000},"page":"289-307","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["The importance of nerve microenvironment for schwannoma development"],"prefix":"10.1007","volume":"132","author":[{"given":"Alexander","family":"Schulz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"B\u00fcttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan L.","family":"Baader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Kluwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Salamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor-Felix","family":"Mautner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mindos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Parkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Gehlhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Wade","family":"Clapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,28]]},"reference":[{"key":"1583_CR1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1365-2249.2011.04515.x","volume":"167","author":"P Allavena","year":"2012","unstructured":"Allavena P, Mantovani A (2012) Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment. Clin Exp Immunol 167:195\u2013205. doi: 10.1111\/j.1365-2249.2011.04515.x","journal-title":"Clin Exp Immunol"},{"key":"1583_CR2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1212\/WNL.54.1.71","volume":"54","author":"J Antinheimo","year":"2000","unstructured":"Antinheimo J, Sankila R, Carpen O, Pukkala E, Sainio M, Jaaskelainen J (2000) Population-based analysis of sporadic and type 2 neurofibromatosis-associated meningiomas and schwannomas. Neurology 54:71\u201376","journal-title":"Neurology"},{"key":"1583_CR3","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1046\/j.1523-1747.1999.00609.x","volume":"112","author":"RP Atit","year":"1999","unstructured":"Atit RP, Crowe MJ, Greenhalgh DG, Wenstrup RJ, Ratner N (1999) The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts. J Invest Dermatol 112:835\u2013842. doi: 10.1046\/j.1523-1747.1999.00609.x","journal-title":"J Invest Dermatol"},{"key":"1583_CR4","doi-asserted-by":"publisher","DOI":"10.3791\/3606","author":"AR Bauder","year":"2012","unstructured":"Bauder AR, Ferguson TA (2012) Reproducible mouse sciatic nerve crush and subsequent assessment of regeneration by whole mount muscle analysis. J Vis Exp JoVE. doi: 10.3791\/3606","journal-title":"J Vis Exp JoVE"},{"key":"1583_CR5","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1093\/neuonc\/nou020","volume":"16","author":"A Boin","year":"2014","unstructured":"Boin A, Couvelard A, Couderc C, Brito I, Filipescu D, Kalamarides M, Bedossa P, De Koning L, Danelsky C, Dubois T et al (2014) Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas. Neuro-oncology 16:1196\u20131209. doi: 10.1093\/neuonc\/nou020","journal-title":"Neuro-oncology"},{"key":"1583_CR6","doi-asserted-by":"publisher","first-page":"714","DOI":"10.3171\/jns.1993.78.5.0714","volume":"78","author":"KJ Burchiel","year":"1993","unstructured":"Burchiel KJ, Johans TJ, Ochoa J (1993) The surgical treatment of painful traumatic neuromas. J Neurosurg 78:714\u2013719. doi: 10.3171\/jns.1993.78.5.0714","journal-title":"J Neurosurg"},{"key":"1583_CR7","doi-asserted-by":"publisher","first-page":"6493","DOI":"10.1158\/0008-5472.CAN-04-1303","volume":"65","author":"N Cabioglu","year":"2005","unstructured":"Cabioglu N, Summy J, Miller C, Parikh NU, Sahin AA, Tuzlali S, Pumiglia K, Gallick GE, Price JE (2005) CXCL-12\/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation. Cancer Res 65:6493\u20136497. doi: 10.1158\/0008-5472.CAN-04-1303","journal-title":"Cancer Res"},{"key":"1583_CR8","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1016\/j.febslet.2014.04.001","volume":"588","author":"J Cooper","year":"2014","unstructured":"Cooper J, Giancotti FG (2014) Molecular insights into NF2\/Merlin tumor suppressor function. FEBS Lett 588:2743\u20132752. doi: 10.1016\/j.febslet.2014.04.001","journal-title":"FEBS Lett"},{"key":"1583_CR9","doi-asserted-by":"publisher","first-page":"9250","DOI":"10.1523\/JNEUROSCI.3649-04.2004","volume":"24","author":"G Corfas","year":"2004","unstructured":"Corfas G, Velardez MO, Ko CP, Ratner N, Peles E (2004) Mechanisms and roles of axon-Schwann cell interactions. J Neurosci Offi J Soc Neurosci 24:9250\u20139260. doi: 10.1523\/JNEUROSCI.3649-04.2004","journal-title":"J Neurosci Offi J Soc Neurosci"},{"key":"1583_CR10","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860\u2013867. doi: 10.1038\/nature01322","journal-title":"Nature"},{"key":"1583_CR11","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s00428-012-1236-9","volume":"460","author":"M Vries de","year":"2012","unstructured":"de Vries M, Hogendoorn PC, Briaire-de Bruyn I, Malessy MJ, van der Mey AG (2012) Intratumoral hemorrhage, vessel density, and the inflammatory reaction contribute to volume increase of sporadic vestibular schwannomas. Virchows Archiv Int J Pathol 460:629\u2013636. doi: 10.1007\/s00428-012-1236-9","journal-title":"Virchows Archiv Int J Pathol"},{"key":"1583_CR12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1749-6632.1999.tb08574.x","volume":"883","author":"ML Feltri","year":"1999","unstructured":"Feltri ML, D\u2019Antonio M, Previtali S, Fasolini M, Messing A, Wrabetz L (1999) P0-Cre transgenic mice for inactivation of adhesion molecules in Schwann cells. Ann N Y Acad Sci 883:116\u2013123","journal-title":"Ann N Y Acad Sci"},{"key":"1583_CR13","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu414","author":"JR Gehlhausen","year":"2014","unstructured":"Gehlhausen JR, Park SJ, Hickox AE, Shew M, Staser K, Rhodes SD, Menon K, Lajiness JD, Mwanthi M, Yang X et al (2014) A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation. Hum Mol Genet. doi: 10.1093\/hmg\/ddu414","journal-title":"Hum Mol Genet"},{"key":"1583_CR14","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1101\/gad.14.13.1617","volume":"14","author":"M Giovannini","year":"2000","unstructured":"Giovannini M, Robanus-Maandag E, van der Valk M, Niwa-Kawakita M, Abramowski V, Goutebroze L, Woodruff JM, Berns A, Thomas G (2000) Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev 14:1617\u20131630","journal-title":"Genes Dev"},{"key":"1583_CR15","doi-asserted-by":"publisher","first-page":"6216","DOI":"10.1038\/onc.2010.363","volume":"29","author":"KD Hadfield","year":"2010","unstructured":"Hadfield KD, Smith MJ, Urquhart JE, Wallace AJ, Bowers NL, King AT, Rutherford SA, Trump D, Newman WG, Evans DG (2010) Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas. Oncogene 29:6216\u20136221. doi: 10.1038\/onc.2010.363","journal-title":"Oncogene"},{"key":"1583_CR16","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00401-002-0535-7","volume":"104","author":"C Hagel","year":"2002","unstructured":"Hagel C, Lindenau M, Lamszus K, Kluwe L, Stavrou D, Mautner VF (2002) Polyneuropathy in neurofibromatosis 2: clinical findings, molecular genetics and neuropathological alterations in sural nerve biopsy specimens. Acta Neuropathol 104:179\u2013187. doi: 10.1007\/s00401-002-0535-7","journal-title":"Acta Neuropathol"},{"key":"1583_CR17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0168-0102(01)00216-4","volume":"40","author":"M Hirasawa","year":"2001","unstructured":"Hirasawa M, Cho A, Sreenath T, Sauer B, Julien JP, Kulkarni AB (2001) Neuron-specific expression of Cre recombinase during the late phase of brain development. Neurosci Res 40:125\u2013132","journal-title":"Neurosci Res"},{"key":"1583_CR18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/01.MP.0000062654.83617.B7","volume":"16","author":"T Hirose","year":"2003","unstructured":"Hirose T, Tani T, Shimada T, Ishizawa K, Shimada S, Sano T (2003) Immunohistochemical demonstration of EMA\/Glut1-positive perineurial cells and CD34-positive fibroblastic cells in peripheral nerve sheath tumors. Mod Pathol Off J U St Can Acad Pathol Inc 16:293\u2013298. doi: 10.1097\/01.MP.0000062654.83617.B7","journal-title":"Mod Pathol Off J U St Can Acad Pathol Inc"},{"key":"1583_CR19","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nrn1746","volume":"6","author":"KR Jessen","year":"2005","unstructured":"Jessen KR, Mirsky R (2005) The origin and development of glial cells in peripheral nerves. Nat Rev Neurosci 6:671\u2013682. doi: 10.1038\/nrn1746","journal-title":"Nat Rev Neurosci"},{"key":"1583_CR20","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/MAO.0000000000000189","volume":"35","author":"CK Kandathil","year":"2014","unstructured":"Kandathil CK, Dilwali S, Wu CC, Ibrahimov M, McKenna MJ, Lee H, Stankovic KM (2014) Aspirin intake correlates with halted growth of sporadic vestibular schwannoma in vivo. Otol Neurotol Off Publ Am Otol Soc Am Neurotol Soc Eur Acad Otol Neurotol 35:353\u2013357. doi: 10.1097\/MAO.0000000000000189","journal-title":"Otol Neurotol Off Publ Am Otol Soc Am Neurotol Soc Eur Acad Otol Neurotol"},{"key":"1583_CR21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1097\/PAI.0b013e318244ff4b","volume":"20","author":"JR Karamchandani","year":"2012","unstructured":"Karamchandani JR, Nielsen TO, van de Rijn M, West RB (2012) Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol AIMM Off Publ Soc Appl Immunohistochem 20:445\u2013450. doi: 10.1097\/PAI.0b013e318244ff4b","journal-title":"Appl Immunohistochem Mol Morphol AIMM Off Publ Soc Appl Immunohistochem"},{"key":"1583_CR22","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1073\/pnas.68.4.820","volume":"68","author":"AG Knudson Jr","year":"1971","unstructured":"Knudson AG Jr (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820\u2013823","journal-title":"Proc Natl Acad Sci USA"},{"key":"1583_CR23","doi-asserted-by":"publisher","first-page":"149185","DOI":"10.1155\/2014\/149185","volume":"2014","author":"G Landskron","year":"2014","unstructured":"Landskron G, De la Fuente M, Thuwajit P, Thuwajit C, Hermoso MA (2014) Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res 2014:149185. doi: 10.1155\/2014\/149185","journal-title":"J Immunol Res"},{"key":"1583_CR24","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1097\/MAO.0b013e318298ac79","volume":"34","author":"L Lassaletta","year":"2013","unstructured":"Lassaletta L, Torres-Martin M, Pena-Granero C, Roda JM, Santa-Cruz-Ruiz S, Castresana JS, Gavilan J, Rey JA (2013) NF2 genetic alterations in sporadic vestibular schwannomas: clinical implications. Otol Neurotol Off Publ Am Otol Soc Am Neurotol Soc Eur Acad Otol Neurotol 34:1355\u20131361. doi: 10.1097\/MAO.0b013e318298ac79","journal-title":"Otol Neurotol Off Publ Am Otol Soc Am Neurotol Soc Eur Acad Otol Neurotol"},{"key":"1583_CR25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1158\/1541-7786.MCR-05-0261","volume":"4","author":"H Lu","year":"2006","unstructured":"Lu H, Ouyang W, Huang C (2006) Inflammation, a key event in cancer development. Mol Cancer Res MCR 4:221\u2013233. doi: 10.1158\/1541-7786.MCR-05-0261","journal-title":"Mol Cancer Res MCR"},{"key":"1583_CR26","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1172\/JCI27648","volume":"116","author":"Y Luo","year":"2006","unstructured":"Luo Y, Zhou H, Krueger J, Kaplan C, Lee SH, Dolman C, Markowitz D, Wu W, Liu C, Reisfeld RA et al (2006) Targeting tumor-associated macrophages as a novel strategy against breast cancer. J Clin Investig 116:2132\u20132141. doi: 10.1172\/JCI27648","journal-title":"J Clin Investig"},{"key":"1583_CR27","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","volume":"23","author":"A Mantovani","year":"2002","unstructured":"Mantovani A, Sozzani S, Locati M, Allavena P, Sica A (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23:549\u2013555","journal-title":"Trends Immunol"},{"key":"1583_CR28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.6026\/97320630003282","volume":"3","author":"WS Martins","year":"2009","unstructured":"Martins WS, Lucas DC, Neves KF, Bertioli DJ (2009) WebSat\u2014a web software for microsatellite marker development. Bioinformation 3:282\u2013283","journal-title":"Bioinformation"},{"key":"1583_CR29","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/neuonc\/nop010","volume":"12","author":"VF Mautner","year":"2010","unstructured":"Mautner VF, Nguyen R, Kutta H, Fuensterer C, Bokemeyer C, Hagel C, Friedrich RE, Panse J (2010) Bevacizumab induces regression of vestibular schwannomas in patients with neurofibromatosis type 2. Neuro-oncology 12:14\u201318. doi: 10.1093\/neuonc\/nop010","journal-title":"Neuro-oncology"},{"key":"1583_CR30","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1101\/gad.12.8.1121","volume":"12","author":"AI McClatchey","year":"1998","unstructured":"McClatchey AI, Saotome I, Mercer K, Crowley D, Gusella JF, Bronson RT, Jacks T (1998) Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev 12:1121\u20131133","journal-title":"Genes Dev"},{"key":"1583_CR31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1615\/CritRevImmunol.v32.i6.10","volume":"32","author":"CD Mills","year":"2012","unstructured":"Mills CD (2012) M1 and M2 macrophages: oracles of health and disease. Crit Rev Immunol 32:463\u2013488","journal-title":"Crit Rev Immunol"},{"key":"1583_CR32","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1101\/gad.189601","volume":"15","author":"H Morrison","year":"2001","unstructured":"Morrison H, Sherman LS, Legg J, Banine F, Isacke C, Haipek CA, Gutmann DH, Ponta H, Herrlich P (2001) The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev 15:968\u2013980. doi: 10.1101\/gad.189601","journal-title":"Genes Dev"},{"key":"1583_CR33","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1158\/0008-5472.CAN-06-1608","volume":"67","author":"H Morrison","year":"2007","unstructured":"Morrison H, Sperka T, Manent J, Giovannini M, Ponta H, Herrlich P (2007) Merlin\/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac. Cancer Res 67:520\u2013527. doi: 10.1158\/0008-5472.CAN-06-1608","journal-title":"Cancer Res"},{"key":"1583_CR34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/01.LAB.0000056993.28149.BF","volume":"83","author":"M Mueller","year":"2003","unstructured":"Mueller M, Leonhard C, Wacker K, Ringelstein EB, Okabe M, Hickey WF, Kiefer R (2003) Macrophage response to peripheral nerve injury: the quantitative contribution of resident and hematogenous macrophages. Lab Investig J Tech Methods Pathol 83:175\u2013185","journal-title":"Lab Investig J Tech Methods Pathol"},{"key":"1583_CR35","doi-asserted-by":"publisher","first-page":"3390","DOI":"10.1523\/JNEUROSCI.4865-05.2006","volume":"26","author":"Y Nakai","year":"2006","unstructured":"Nakai Y, Zheng Y, MacCollin M, Ratner N (2006) Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. J Neurosci Off J Soc Neurosci 26:3390\u20133395. doi: 10.1523\/JNEUROSCI.4865-05.2006","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"1583_CR36","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.conb.2006.08.008","volume":"16","author":"KA Nave","year":"2006","unstructured":"Nave KA, Salzer JL (2006) Axonal regulation of myelination by neuregulin 1. Curr Opin Neurobiol 16:492\u2013500. doi: 10.1016\/j.conb.2006.08.008","journal-title":"Curr Opin Neurobiol"},{"key":"1583_CR37","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1007\/s00018-003-3027-6","volume":"60","author":"AJ Paige","year":"2003","unstructured":"Paige AJ (2003) Redefining tumour suppressor genes: exceptions to the two-hit hypothesis. Cell Mol Life Sci CMLS 60:2147\u20132163. doi: 10.1007\/s00018-003-3027-6","journal-title":"Cell Mol Life Sci CMLS"},{"key":"1583_CR38","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1083\/jcb.200307132","volume":"164","author":"DB Parkinson","year":"2004","unstructured":"Parkinson DB, Bhaskaran A, Droggiti A, Dickinson S, D\u2019Antonio M, Mirsky R, Jessen KR (2004) Krox-20 inhibits Jun-NH2-terminal kinase\/c-Jun to control Schwann cell proliferation and death. J Cell Biol 164:385\u2013394. doi: 10.1083\/jcb.200307132","journal-title":"J Cell Biol"},{"key":"1583_CR39","doi-asserted-by":"publisher","first-page":"3335","DOI":"10.1101\/gad.490608","volume":"22","author":"S Parrinello","year":"2008","unstructured":"Parrinello S, Noon LA, Harrisingh MC, Wingfield Digby P, Rosenberg LH, Cremona CA, Echave P, Flanagan AM, Parada LF, Lloyd AC (2008) NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F. Genes Dev 22:3335\u20133348. doi: 10.1101\/gad.490608","journal-title":"Genes Dev"},{"key":"1583_CR40","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1056\/NEJMoa0902579","volume":"361","author":"SR Plotkin","year":"2009","unstructured":"Plotkin SR, Stemmer-Rachamimov AO, Barker FG 2nd, Halpin C, Padera TP, Tyrrell A, Sorensen AG, Jain RK, di Tomaso E (2009) Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. N Engl J Med 361:358\u2013367. doi: 10.1056\/NEJMoa0902579","journal-title":"N Engl J Med"},{"key":"1583_CR41","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/30012","volume":"393","author":"Y Qiu","year":"1998","unstructured":"Qiu Y, Ravi L, Kung HJ (1998) Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells. Nature 393:83\u201385. doi: 10.1038\/30012","journal-title":"Nature"},{"key":"1583_CR42","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/nm.3394","volume":"19","author":"DF Quail","year":"2013","unstructured":"Quail DF, Joyce JA (2013) Microenvironmental regulation of tumor progression and metastasis. Nat Med 19:1423\u20131437. doi: 10.1038\/nm.3394","journal-title":"Nat Med"},{"key":"1583_CR43","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.celrep.2013.08.033","volume":"5","author":"S Ribeiro","year":"2013","unstructured":"Ribeiro S, Napoli I, White IJ, Parrinello S, Flanagan AM, Suter U, Parada LF, Lloyd AC (2013) Injury signals cooperate with nf1 loss to relieve the tumor-suppressive environment of adult peripheral nerve. Cell Rep 5:126\u2013136. doi: 10.1016\/j.celrep.2013.08.033","journal-title":"Cell Rep"},{"key":"1583_CR44","first-page":"305","volume":"127","author":"J Schneider","year":"1983","unstructured":"Schneider J, Warzok R, Schreiber D, Guthert H (1983) Tumors of the central nervous system in biopsy and autopsy material. 7th communication: neurinomas and neurofibromatoses with CNS involvement. Zentralblatt fur allgemeine Pathologie u pathologische Anatomie 127:305\u2013314","journal-title":"Zentralblatt fur allgemeine Pathologie u pathologische Anatomie"},{"key":"1583_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3348","author":"A Schulz","year":"2013","unstructured":"Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C, Mautner VF et al (2013) Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nat Neurosci. doi: 10.1038\/nn.3348","journal-title":"Nat Neurosci"},{"key":"1583_CR46","doi-asserted-by":"publisher","first-page":"10177","DOI":"10.1523\/JNEUROSCI.0840-10.2010","volume":"30","author":"A Schulz","year":"2010","unstructured":"Schulz A, Geissler KJ, Kumar S, Leichsenring G, Morrison H, Baader SL (2010) Merlin inhibits neurite outgrowth in the CNS. J Neurosci Off J Soc Neurosci 30:10177\u201310186. doi: 10.1523\/JNEUROSCI.0840-10.2010","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"1583_CR47","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1093\/brain\/awt327","volume":"137","author":"A Schulz","year":"2014","unstructured":"Schulz A, Kyselyova A, Baader SL, Jung MJ, Zoch A, Mautner VF, Hagel C, Morrison H (2014) Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling. Brain J Neurol 137:420\u2013432. doi: 10.1093\/brain\/awt327","journal-title":"Brain J Neurol"},{"key":"1583_CR48","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s40478-014-0082-1","volume":"2","author":"A Schulz","year":"2014","unstructured":"Schulz A, Zoch A, Morrison H (2014) A neuronal function of the tumor suppressor protein merlin. Acta Neuropathol Commun 2:82. doi: 10.1186\/s40478-014-0082-1","journal-title":"Acta Neuropathol Commun"},{"key":"1583_CR49","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1097\/00005072-199812000-00008","volume":"57","author":"AO Stemmer-Rachamimov","year":"1998","unstructured":"Stemmer-Rachamimov AO, Ino Y, Lim ZY, Jacoby LB, MacCollin M, Gusella JF, Ramesh V, Louis DN (1998) Loss of the NF2 gene and merlin occur by the tumorlet stage of schwannoma development in neurofibromatosis 2. J Neuropathol Exp Neurol 57:1164\u20131167","journal-title":"J Neuropathol Exp Neurol"},{"key":"1583_CR50","doi-asserted-by":"publisher","first-page":"3718","DOI":"10.1158\/0008-5472.CAN-03-4079","volume":"64","author":"AO Stemmer-Rachamimov","year":"2004","unstructured":"Stemmer-Rachamimov AO, Louis DN, Nielsen GP, Antonescu CR, Borowsky AD, Bronson RT, Burns DK, Cervera P, McLaughlin ME, Reifenberger G et al (2004) Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer Res 64:3718\u20133724. doi: 10.1158\/0008-5472.CAN-03-4079","journal-title":"Cancer Res"},{"key":"1583_CR51","first-page":"1649","volume":"151","author":"AO Stemmer-Rachamimov","year":"1997","unstructured":"Stemmer-Rachamimov AO, Xu L, Gonzalez-Agosti C, Burwick JA, Pinney D, Beauchamp R, Jacoby LB, Gusella JF, Ramesh V, Louis DN (1997) Universal absence of merlin, but not other ERM family members, in schwannomas. Am J Pathol 151:1649\u20131654","journal-title":"Am J Pathol"},{"key":"1583_CR52","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103050","author":"SM Stivaros","year":"2015","unstructured":"Stivaros SM, Stemmer-Rachamimov AO, Alston R, Plotkin SR, Nadol JB, Quesnel A, O\u2019Malley J, Whitfield GA, McCabe MG, Freeman SR et al (2015) Multiple synchronous sites of origin of vestibular schwannomas in neurofibromatosis Type 2. J Med Genet. doi: 10.1136\/jmedgenet-2015-103050","journal-title":"J Med Genet"},{"key":"1583_CR53","doi-asserted-by":"publisher","first-page":"597","DOI":"10.7150\/thno.11546","volume":"5","author":"X Sun","year":"2015","unstructured":"Sun X, Gao D, Gao L, Zhang C, Yu X, Jia B, Wang F, Liu Z (2015) Molecular imaging of tumor-infiltrating macrophages in a preclinical mouse model of breast cancer. Theranostics 5:597\u2013608. doi: 10.7150\/thno.11546","journal-title":"Theranostics"},{"key":"1583_CR54","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1523\/JNEUROSCI.22-15-06696.2002","volume":"22","author":"GK Tofaris","year":"2002","unstructured":"Tofaris GK, Patterson PH, Jessen KR, Mirsky R (2002) Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF. J Neurosci Off J Soc Neurosci 22:6696\u20136703","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"1583_CR55","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/0092-8674(93)90501-G","volume":"75","author":"JA Trofatter","year":"1993","unstructured":"Trofatter JA, MacCollin MM, Rutter JL, Murrell JR, Duyao MP, Parry DM, Eldridge R, Kley N, Menon AG, Pulaski K et al (1993) A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 75:826","journal-title":"Cell"},{"key":"1583_CR56","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/glia.21255","volume":"60","author":"V Velanac","year":"2012","unstructured":"Velanac V, Unterbarnscheidt T, Hinrichs W, Gummert MN, Fischer TM, Rossner MJ, Trimarco A, Brivio V, Taveggia C, Willem M et al (2012) Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination. Glia 60:203\u2013217. doi: 10.1002\/glia.21255","journal-title":"Glia"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-016-1583-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-016-1583-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-016-1583-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T20:23:24Z","timestamp":1656620604000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-016-1583-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,28]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["1583"],"URL":"https:\/\/doi.org\/10.1007\/s00401-016-1583-8","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,28]]}}}