{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:22:40Z","timestamp":1793740960689,"version":"4.6.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T00:00:00Z","timestamp":1479340800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s00401-016-1643-0","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T06:21:04Z","timestamp":1479363664000},"page":"5-12","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":323,"title":["The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants"],"prefix":"10.1007","volume":"133","author":[{"given":"Kristian W.","family":"Pajtler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Ramaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan R.","family":"Hansford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"von Hoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen D.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Frappaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonehiro","family":"Kanemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Massimino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Faure-Conter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piergiorgio","family":"Modena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Tabori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ichimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Giangaspero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Castel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Kool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Dirks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Grundy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas K.","family":"Foreman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Gajjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Korshunov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Finlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Gilbertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Ellison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Aldape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Merchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bouffet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan M.","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,17]]},"reference":[{"key":"1643_CR1","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.ccr.2011.08.013","volume":"20","author":"JM Atkinson","year":"2011","unstructured":"Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM et al (2011) An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. Cancer Cell 20:384\u2013399. doi: 10.1016\/j.ccr.2011.08.013","journal-title":"Cancer Cell"},{"key":"1643_CR2","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00401-014-1327-6","volume":"128","author":"M Barszczyk","year":"2014","unstructured":"Barszczyk M, Buczkowicz P, Castelo-Branco P, Mack SC, Ramaswamy V, Mangerel J, Agnihotri S, Remke M, Golbourn B, Pajovic S et al (2014) Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells. Acta Neuropathol 128:863\u2013877. doi: 10.1007\/s00401-014-1327-6","journal-title":"Acta Neuropathol"},{"key":"1643_CR3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s003810050544","volume":"15","author":"E Bouffet","year":"1999","unstructured":"Bouffet E, Foreman N (1999) Chemotherapy for intracranial ependymomas. Child\u2019s Nerv Syst ChNS 15:563\u2013570","journal-title":"Child\u2019s Nerv Syst ChNS"},{"key":"1643_CR4","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/j.ijrobp.2011.10.039","volume":"83","author":"E Bouffet","year":"2012","unstructured":"Bouffet E, Hawkins CE, Ballourah W, Taylor MD, Bartels UK, Schoenhoff N, Tsangaris E, Huang A, Kulkarni A, Mabbot DJ et al (2012) Survival benefit for pediatric patients with recurrent ependymoma treated with reirradiation. Int J Radiat Oncol Biol Phys 83:1541\u20131548. doi: 10.1016\/j.ijrobp.2011.10.039","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1643_CR5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/(SICI)1096-911X(199806)30:6<319::AID-MPO1>3.0.CO;2-H","volume":"30","author":"E Bouffet","year":"1998","unstructured":"Bouffet E, Perilongo G, Canete A, Massimino M (1998) Intracranial ependymomas in children: a critical review of prognostic factors and a plea for cooperation. Med Pediatr Oncol 30:319\u2013329 (discussion 329\u2013331)","journal-title":"Med Pediatr Oncol"},{"key":"1643_CR6","doi-asserted-by":"publisher","first-page":"673","DOI":"10.3171\/2013.2.peds12345","volume":"11","author":"TA Cage","year":"2013","unstructured":"Cage TA, Clark AJ, Aranda D, Gupta N, Sun PP, Parsa AT, Auguste KI (2013) A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas. J Neurosurg Pediatr 11:673\u2013681. doi: 10.3171\/2013.2.peds12345","journal-title":"J Neurosurg Pediatr"},{"key":"1643_CR7","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/sj.bjc.6600180","volume":"86","author":"M Carter","year":"2002","unstructured":"Carter M, Nicholson J, Ross F, Crolla J, Allibone R, Balaji V, Perry R, Walker D, Gilbertson R, Ellison DW (2002) Genetic abnormalities detected in ependymomas by comparative genomic hybridisation. Br J Cancer 86:929\u2013939. doi: 10.1038\/sj.bjc.6600180","journal-title":"Br J Cancer"},{"key":"1643_CR8","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1016\/s0002-9440(10)64491-4","volume":"161","author":"S Dyer","year":"2002","unstructured":"Dyer S, Prebble E, Davison V, Davies P, Ramani P, Ellison D, Grundy R (2002) Genomic imbalances in pediatric intracranial ependymomas define clinically relevant groups. Am J Pathol 161:2133\u20132141. doi: 10.1016\/s0002-9440(10)64491-4","journal-title":"Am J Pathol"},{"key":"1643_CR9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1477-5751-10-7","volume":"10","author":"DW Ellison","year":"2011","unstructured":"Ellison DW, Kocak M, Figarella-Branger D, Felice G, Catherine G, Pietsch T, Frappaz D, Massimino M, Grill J, Boyett JM et al (2011) Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts. J Negat Results Biomed 10:7. doi: 10.1186\/1477-5751-10-7","journal-title":"J Negat Results Biomed"},{"key":"1643_CR10","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1002\/pbc.24274","volume":"59","author":"JH Garvin Jr","year":"2012","unstructured":"Garvin JH Jr, Selch MT, Holmes E, Berger MS, Finlay JL, Flannery A, Goldwein JW, Packer RJ, Rorke-Adams LB, Shiminski-Maher T et al (2012) Phase II study of pre-irradiation chemotherapy for childhood intracranial ependymoma. Children\u2019s Cancer Group protocol 9942: a report from the Children\u2019s Oncology Group. Pediatr Blood Cancer 59:1183\u20131189. doi: 10.1002\/pbc.24274","journal-title":"Pediatr Blood Cancer"},{"key":"1643_CR11","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s11060-013-1254-8","volume":"115","author":"AJ Ghia","year":"2013","unstructured":"Ghia AJ, Mahajan A, Allen PK, Armstrong TS, Lang FF Jr, Gilbert MR, Brown PD (2013) Supratentorial gross-totally resected non-anaplastic ependymoma: population based patterns of care and outcomes analysis. J Neurooncol 115:513\u2013520. doi: 10.1007\/s11060-013-1254-8","journal-title":"J Neurooncol"},{"key":"1643_CR12","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s00401-012-0981-9","volume":"124","author":"C Godfraind","year":"2012","unstructured":"Godfraind C, Kaczmarska JM, Kocak M, Dalton J, Wright KD, Sanford RA, Boop FA, Gajjar A, Merchant TE, Ellison DW (2012) Distinct disease-risk groups in pediatric supratentorial and posterior fossa ependymomas. Acta Neuropathol 124:247\u2013257. doi: 10.1007\/s00401-012-0981-9","journal-title":"Acta Neuropathol"},{"key":"1643_CR13","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s12885-016-2323-0","volume":"16","author":"D Gramatzki","year":"2016","unstructured":"Gramatzki D, Roth P, Felsberg J, Hofer S, Rushing EJ, Hentschel B, Westphal M, Krex D, Simon M, Schnell O et al (2016) Chemotherapy for intracranial ependymoma in adults. BMC Cancer 16:287. doi: 10.1186\/s12885-016-2323-0","journal-title":"BMC Cancer"},{"key":"1643_CR14","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1200\/JCO.2001.19.5.1288","volume":"19","author":"J Grill","year":"2001","unstructured":"Grill J, Le Deley MC, Gambarelli D, Raquin MA, Couanet D, Pierre-Kahn A, Habrand JL, Doz F, Frappaz D, Gentet JC et al (2001) Postoperative chemotherapy without irradiation for ependymoma in children under 5\u00a0years of age: a multicenter trial of the French Society of Pediatric Oncology. J Clin Oncol 19:1288\u20131296","journal-title":"J Clin Oncol"},{"key":"1643_CR15","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/s1470-2045(07)70208-5","volume":"8","author":"RG Grundy","year":"2007","unstructured":"Grundy RG, Wilne SA, Weston CL, Robinson K, Lashford LS, Ironside J, Cox T, Chong WK, Campbell RH, Bailey CC et al (2007) Primary postoperative chemotherapy without radiotherapy for intracranial ependymoma in children: the UKCCSG\/SIOP prospective study. Lancet Oncol 8:696\u2013705. doi: 10.1016\/s1470-2045(07)70208-5","journal-title":"Lancet Oncol"},{"key":"1643_CR16","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/nature09173","volume":"466","author":"RA Johnson","year":"2010","unstructured":"Johnson RA, Wright KD, Poppleton H, Mohankumar KM, Finkelstein D, Pounds SB, Rand V, Leary SE, White E, Eden C et al (2010) Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature 466:632\u2013636. doi: 10.1038\/nature09173","journal-title":"Nature"},{"key":"1643_CR17","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1158\/1078-0432.ccr-11-2489","volume":"18","author":"JP Kilday","year":"2012","unstructured":"Kilday JP, Mitra B, Domerg C, Ward J, Andreiuolo F, Osteso-Ibanez T, Mauguen A, Varlet P, Le Deley MC, Lowe J et al (2012) Copy number gain of 1q25 predicts poor progression-free survival for pediatric intracranial ependymomas and enables patient risk stratification: a prospective European clinical trial cohort analysis on behalf of the Children\u2019s Cancer Leukaemia Group (CCLG), Societe Francaise d\u2019Oncologie Pediatrique (SFOP), and International Society for Pediatric Oncology (SIOP). Clin Cancer Res 18:2001\u20132011. doi: 10.1158\/1078-0432.ccr-11-2489","journal-title":"Clin Cancer Res"},{"key":"1643_CR18","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.1200\/jco.2009.27.3359","volume":"28","author":"A Korshunov","year":"2010","unstructured":"Korshunov A, Witt H, Hielscher T, Benner A, Remke M, Ryzhova M, Milde T, Bender S, Wittmann A, Schottler A et al (2010) Molecular staging of intracranial ependymoma in children and adults. J Clin Oncol 28:3182\u20133190. doi: 10.1200\/jco.2009.27.3359","journal-title":"J Clin Oncol"},{"key":"1643_CR19","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97\u2013109. doi: 10.1007\/s00401-007-0243-4","journal-title":"Acta Neuropathol"},{"key":"1643_CR20","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803\u2013820. doi: 10.1007\/s00401-016-1545-1","journal-title":"Acta Neuropathol"},{"key":"1643_CR21","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1093\/neuonc\/not121","volume":"15","author":"SM Macdonald","year":"2013","unstructured":"Macdonald SM, Sethi R, Lavally B, Yeap BY, Marcus KJ, Caruso P, Pulsifer M, Huang M, Ebb D, Tarbell NJ et al (2013) Proton radiotherapy for pediatric central nervous system ependymoma: clinical outcomes for 70 patients. Neuro-oncology 15:1552\u20131559. doi: 10.1093\/neuonc\/not121","journal-title":"Neuro-oncology"},{"key":"1643_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/nature13108","author":"SC Mack","year":"2014","unstructured":"Mack SC, Witt H, Piro RM, Gu L, Zuyderduyn S, Stutz AM, Wang X, Gallo M, Garzia L, Zayne K et al (2014) Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature. doi: 10.1038\/nature13108","journal-title":"Nature"},{"key":"1643_CR23","doi-asserted-by":"publisher","unstructured":"Mack SC, Witt H, Wang X, Milde T, Yao Y, Bertrand KC, Korshunov A, Pfister SM, Taylor MD (2013) Emerging insights into the ependymoma epigenome. Brain Pathol (Zurich, Switzerland) 23:206\u2013209. doi: 10.1111\/bpa.12020","DOI":"10.1111\/bpa.12020"},{"key":"1643_CR24","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1158\/1078-0432.CCR-05-2363","volume":"12","author":"F Mendrzyk","year":"2006","unstructured":"Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B, Lichter P (2006) Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma. Clin Cancer Res 12:2070\u20132079. doi: 10.1158\/1078-0432.CCR-05-2363","journal-title":"Clin Cancer Res"},{"key":"1643_CR25","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S1470-2045(08)70342-5","volume":"10","author":"TE Merchant","year":"2009","unstructured":"Merchant TE, Li C, Xiong X, Kun LE, Boop FA, Sanford RA (2009) Conformal radiotherapy after surgery for paediatric ependymoma: a prospective study. Lancet Oncol 10:258\u2013266","journal-title":"Lancet Oncol"},{"key":"1643_CR26","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s00401-011-0866-3","volume":"122","author":"T Milde","year":"2011","unstructured":"Milde T, Kleber S, Korshunov A, Witt H, Hielscher T, Koch P, Kopp HG, Jugold M, Deubzer HE, Oehme I et al (2011) A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat. Acta Neuropathol 122:637\u2013650. doi: 10.1007\/s00401-011-0866-3","journal-title":"Acta Neuropathol"},{"key":"1643_CR27","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/ng.3323","volume":"47","author":"KM Mohankumar","year":"2015","unstructured":"Mohankumar KM, Currle DS, White E, Boulos N, Dapper J, Eden C, Nimmervoll B, Thiruvenkatam R, Connelly M, Kranenburg TA (2015) An in vivo screen identifies ependymoma oncogenes and tumor-suppressor gene. Nat Genet 47:878\u2013887. doi: 10.1038\/ng.3323","journal-title":"Nat Genet"},{"key":"1643_CR28","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jocn.2015.11.014","volume":"28","author":"M Nuno","year":"2016","unstructured":"Nuno M, Yu JJ, Varshneya K, Alexander J, Mukherjee D, Black KL, Patil CG (2016) Treatment and survival of supratentorial and posterior fossa ependymomas in adults. J Clin Neurosci 28:24\u201330. doi: 10.1016\/j.jocn.2015.11.014","journal-title":"J Clin Neurosci"},{"key":"1643_CR29","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.ccell.2015.04.002","volume":"27","author":"KW Pajtler","year":"2015","unstructured":"Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P et al (2015) Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups. Cancer Cell 27:728\u2013743. doi: 10.1016\/j.ccell.2015.04.002","journal-title":"Cancer Cell"},{"key":"1643_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/nature13109","author":"M Parker","year":"2014","unstructured":"Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y, Lee R, Tatevossian RG, Phoenix TN, Thiruvenkatam R et al (2014) C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in ependymoma. Nature. doi: 10.1038\/nature13109","journal-title":"Nature"},{"key":"1643_CR31","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.65.7825","author":"V Ramaswamy","year":"2016","unstructured":"Ramaswamy V, Hielscher T, Mack SC, Lassaletta A, Lin T, Pajtler KW, Jones DT, Luu B, Cavalli FM, Aldape K et al (2016) Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: a retrospective multicohort analysis. J Clin Oncol. doi: 10.1200\/jco.2015.65.7825","journal-title":"J Clin Oncol"},{"key":"1643_CR32","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1038\/sj.bjc.6604651","volume":"99","author":"V Rand","year":"2008","unstructured":"Rand V, Prebble E, Ridley L, Howard M, Wei W, Brundler MA, Fee BE, Riggins GJ, Coyle B, Grundy RG (2008) Investigation of chromosome 1q reveals differential expression of members of the S100 family in clinical subgroups of intracranial paediatric ependymoma. Br J Cancer 99:1136\u20131143. doi: 10.1038\/sj.bjc.6604651","journal-title":"Br J Cancer"},{"key":"1643_CR33","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.ccr.2005.09.001","volume":"8","author":"MD Taylor","year":"2005","unstructured":"Taylor MD, Poppleton H, Fuller C, Su X, Liu Y, Jensen P, Magdaleno S, Dalton J, Calabrese C, Board J et al (2005) Radial glia cells are candidate stem cells of ependymoma. Cancer Cell 8:323\u2013335. doi: 10.1016\/j.ccr.2005.09.001","journal-title":"Cancer Cell"},{"key":"1643_CR34","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/modpathol.3800999","volume":"21","author":"T Tihan","year":"2008","unstructured":"Tihan T, Zhou T, Holmes E, Burger PC, Ozuysal S, Rushing EJ (2008) The prognostic value of histological grading of posterior fossa ependymomas in children: a Children\u2019s Oncology Group study and a review of prognostic factors. Modern Pathol 21:165\u2013177. doi: 10.1038\/modpathol.3800999","journal-title":"Modern Pathol"},{"key":"1643_CR35","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/pbc.23086","volume":"58","author":"R Venkatramani","year":"2012","unstructured":"Venkatramani R, Dhall G, Patel M, Grimm J, Hawkins C, McComb G, Krieger M, Wong K, O\u2019Neil S, Finlay JL (2012) Supratentorial ependymoma in children: to observe or to treat following gross total resection? Pediatr Blood Cancer 58:380\u2013383. doi: 10.1002\/pbc.23086","journal-title":"Pediatr Blood Cancer"},{"key":"1643_CR36","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s00401-012-0941-4","volume":"123","author":"K Wani","year":"2012","unstructured":"Wani K, Armstrong TS, Vera-Bolanos E, Raghunathan A, Ellison D, Gilbertson R, Vaillant B, Goldman S, Packer RJ, Fouladi M et al (2012) A prognostic gene expression signature in infratentorial ependymoma. Acta Neuropathol 123:727\u2013738. doi: 10.1007\/s00401-012-0941-4","journal-title":"Acta Neuropathol"},{"key":"1643_CR37","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ccr.2011.07.007","volume":"20","author":"H Witt","year":"2011","unstructured":"Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, Benner A, Hielscher T, Milde T, Remke M et al (2011) Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell 20:143\u2013157. doi: 10.1016\/j.ccr.2011.07.007","journal-title":"Cancer Cell"},{"key":"1643_CR38","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1093\/neuonc\/nov181","volume":"17","author":"KD Wright","year":"2015","unstructured":"Wright KD, Daryani VM, Turner DC, Onar-Thomas A, Boulos N, Orr BA, Gilbertson RJ, Stewart CF, Gajjar A (2015) Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma. Neuro-oncology 17:1620\u20131627. doi: 10.1093\/neuonc\/nov181","journal-title":"Neuro-oncology"},{"key":"1643_CR39","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1093\/neuonc\/nop056","volume":"12","author":"L Yu","year":"2010","unstructured":"Yu L, Baxter PA, Voicu H, Gurusiddappa S, Zhao Y, Adesina A, Man TK, Shu Q, Zhang YJ, Zhao XM et al (2010) A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo. Neuro Oncol 12:580\u2013594. doi: 10.1093\/neuonc\/nop056","journal-title":"Neuro Oncol"},{"key":"1643_CR40","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/pbc.20935","volume":"49","author":"S Zacharoulis","year":"2007","unstructured":"Zacharoulis S, Levy A, Chi SN, Gardner S, Rosenblum M, Miller DC, Dunkel I, Diez B, Sposto R, Ji L et al (2007) Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue. Pediatr Blood Cancer 49:34\u201340. doi: 10.1002\/pbc.20935","journal-title":"Pediatr Blood Cancer"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-016-1643-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-016-1643-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-016-1643-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T23:49:55Z","timestamp":1498348195000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-016-1643-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,17]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["1643"],"URL":"https:\/\/doi.org\/10.1007\/s00401-016-1643-0","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,17]]}}}