{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:43:06Z","timestamp":1790142186494,"version":"4.0.1"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft (DE)","award":["KO 947\/15-1"],"award-info":[{"award-number":["KO 947\/15-1"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KO 947\/13-1"],"award-info":[{"award-number":["KO 947\/13-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GU 335\/29-1"],"award-info":[{"award-number":["GU 335\/29-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MU 2789\/8-1"],"award-info":[{"award-number":["MU 2789\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Interdisciplinary Center for Clinical Research (IZKF)","award":["Project E13"],"award-info":[{"award-number":["Project E13"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s00401-016-1658-6","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T16:45:06Z","timestamp":1482252306000},"page":"463-483","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis"],"prefix":"10.1007","volume":"133","author":[{"given":"Christian P.","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubov S.","family":"Kalinichenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Tiesel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"St\u00f6ckl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sprenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Fuchser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Praetner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine E.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"M\u00fchle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"B\u00fcttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif B.","family":"Ekici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Smaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucyna","family":"Pomierny-Chamiolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Pomierny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Filip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Eulenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Gulbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anbarasu","family":"Lourdusamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reichel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"1658_CR1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders S, Pyl PT, Huber W (2015) HTSeq\u2014a Python framework to work with high-throughput sequencing data. Bioinformatics 31:166\u2013169","journal-title":"Bioinformatics"},{"key":"1658_CR2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/jnc.12834","volume":"131","author":"M Bae","year":"2014","unstructured":"Bae M, Bandaru VV, Patel N, Haughey NJ (2014) Ceramide metabolism analysis in a model of binge drinking reveals both neuroprotective and toxic effects of ethanol. J Neurochem 131:645\u2013654","journal-title":"J Neurochem"},{"key":"1658_CR3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pbb.2013.01.023","volume":"105","author":"A Bahi","year":"2013","unstructured":"Bahi A (2013) Individual differences in elevated plus-maze exploration predicted higher ethanol consumption and preference in outbred mice. Pharmacol Biochem Behav 105:83\u201388","journal-title":"Pharmacol Biochem Behav"},{"key":"1658_CR4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.alcohol.2014.07.022","volume":"49","author":"AM Barkley-Levenson","year":"2015","unstructured":"Barkley-Levenson AM, Crabbe JC (2015) Genotypic and sex differences in anxiety-like behavior and alcohol-induced anxiolysis in High Drinking in the Dark selected mice. Alcohol 49:29\u201336","journal-title":"Alcohol"},{"key":"1658_CR5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0376-8716(85)90008-0","volume":"15","author":"C Baum-Baicker","year":"1985","unstructured":"Baum-Baicker C (1985) The psychological benefits of moderate alcohol consumption: a review of the literature. Drug Alcohol Depend 15:305\u2013322","journal-title":"Drug Alcohol Depend"},{"key":"1658_CR6","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1360-0443.2010.03351.x","volume":"106","author":"JM Boden","year":"2011","unstructured":"Boden JM, Fergusson DM (2011) Alcohol and depression. Addiction 106:906\u2013914","journal-title":"Addiction"},{"key":"1658_CR7","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/nn.4102","volume":"18","author":"P Botta","year":"2015","unstructured":"Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP et al (2015) Regulating anxiety with extrasynaptic inhibition. Nat Neurosci 18:1493\u20131500","journal-title":"Nat Neurosci"},{"key":"1658_CR8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S1569-7339(10)70098-9","volume-title":"Handbook of the behavioral neurobiology of serotonin","author":"GV Carr","year":"2010","unstructured":"Carr GV, Lucki I (2010) The Role of Serotonin in Depression. In: M\u00fcller CP, Jacobs BL (eds) Handbook of the behavioral neurobiology of serotonin. Academic Press, London, pp 493\u2013506"},{"key":"1658_CR9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S et al (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29:15\u201321","journal-title":"Bioinformatics"},{"key":"1658_CR10","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.neuropharm.2011.08.036","volume":"61","author":"AC Easton","year":"2011","unstructured":"Easton AC, Lucchesi W, Schumann G, Peter GK, M\u00fcller CP, Fernandes C (2011) alphaCaMKII autophosphorylation controls exploratory activity to threatening novel stimuli. Neuropharmacology 61:1424\u20131431","journal-title":"Neuropharmacology"},{"key":"1658_CR11","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/npp.2013.60","volume":"38","author":"AC Easton","year":"2013","unstructured":"Easton AC, Lucchesi W, Lourdusamy A, Lenz B, Solati J, Golub Y et al (2013) \u03b1CaMKII autophosphorylation controls the establishment of alcohol drinking behavior. Neuropsychopharmacology 38:1636\u20131647","journal-title":"Neuropsychopharmacology"},{"key":"1658_CR12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbr.2013.05.045","volume":"252","author":"AC Easton","year":"2013","unstructured":"Easton AC, Lucchesi W, Mizuno K, Fernandes C, Schumann G, Giese KP et al (2013) alphaCaMKII autophosphorylation controls the establishment of alcohol-induced conditioned place preference in mice. Behav Brain Res 252:72\u201376","journal-title":"Behav Brain Res"},{"key":"1658_CR13","unstructured":"EMCDDA (2012) European Monitoring Center for Addictive Drugs, State of the drug problem 2012. http:\/\/www.emcdda.europa.eu\/publications\/annual-report\/2012 . Accessed 20 June 2013"},{"key":"1658_CR14","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1016\/j.bbamem.2009.08.016","volume":"1788","author":"J Fantini","year":"2009","unstructured":"Fantini J, Barrantes FJ (2009) Sphingolipid\/cholesterol regulation of neurotransmitter receptor conformation and function. Biochim Biophys Acta 1788:2345\u20132361","journal-title":"Biochim Biophys Acta"},{"key":"1658_CR15","volume-title":"The mouse brain in stereotaxic coordinates","author":"KBJ Franklin","year":"1997","unstructured":"Franklin KBJ, Paxionos G (1997) The mouse brain in stereotaxic coordinates. Academic Press, San Diego"},{"key":"1658_CR16","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/alcalc\/agm065","volume":"42","author":"E Garcia-Valdecasas-Campelo","year":"2007","unstructured":"Garcia-Valdecasas-Campelo E, Gonzalez-Reimers E, Santolaria-Fernandez F, De La Vega-Prieto MJ, Milena-Abril A, Sanchez-Perez MJ et al (2007) Brain atrophy in alcoholics: relationship with alcohol intake; liver disease; nutritional status, and inflammation. Alcohol Alcohol 42:533\u2013538","journal-title":"Alcohol Alcohol"},{"key":"1658_CR17","first-page":"185","volume":"31","author":"NW Gilpin","year":"2008","unstructured":"Gilpin NW, Koob GF (2008) Neurobiology of alcohol dependence: focus on motivational mechanisms. Alcohol Res Health 31:185\u2013195","journal-title":"Alcohol Res Health"},{"key":"1658_CR18","doi-asserted-by":"crossref","first-page":"e0139012","DOI":"10.1371\/journal.pone.0139012","volume":"10","author":"J Godfrey","year":"2015","unstructured":"Godfrey J, Jeanguenin L, Castro N, Olney JJ, Dudley J, Pipkin J et al (2015) Chronic voluntary ethanol consumption induces favorable ceramide profiles in selectively bred alcohol-preferring (P) rats. PLoS One 10:e0139012","journal-title":"PLoS One"},{"key":"1658_CR19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0376-8716(95)01160-4","volume":"39","author":"BF Grant","year":"1995","unstructured":"Grant BF, Harford TC (1995) Comorbidity between DSM-IV alcohol use disorders and major depression: results of a national survey. Drug Alcohol Depend 39:197\u2013206","journal-title":"Drug Alcohol Depend"},{"key":"1658_CR20","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1038\/sj.onc.1207146","volume":"22","author":"E Gulbins","year":"2003","unstructured":"Gulbins E, Kolesnick R (2003) Raft ceramide in molecular medicine. Oncogene 22:7070\u20137077","journal-title":"Oncogene"},{"key":"1658_CR21","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nm.3214","volume":"19","author":"E Gulbins","year":"2013","unstructured":"Gulbins E, Palmada M, Reichel M, L\u00fcth A, B\u00f6hmer C, Amato D et al (2013) Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nature Med 19:934\u2013938","journal-title":"Nature Med"},{"key":"1658_CR22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","volume":"9","author":"YA Hannun","year":"2008","unstructured":"Hannun YA, Obeid LM (2008) Principles of bioactive lipid signalling: lessons from sphingolipids. Nature Rev Mol Cell Biol 9:139\u2013150","journal-title":"Nature Rev Mol Cell Biol"},{"key":"1658_CR23","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1530-0277.2011.01668.x","volume":"36","author":"SJ Hayton","year":"2012","unstructured":"Hayton SJ, Mahoney MK, Olmstead MC (2012) Behavioral traits predicting alcohol drinking in outbred rats: an investigation of anxiety, novelty seeking, and cognitive flexibility. Alcohol Clin Exp Res 36:594\u2013603","journal-title":"Alcohol Clin Exp Res"},{"key":"1658_CR24","volume-title":"Drinking occasions: comparative perspectives on alcohol and culture","author":"DB Heath","year":"2000","unstructured":"Heath DB (2000) Drinking occasions: comparative perspectives on alcohol and culture. Brunner\/Mazel, Levittown"},{"key":"1658_CR25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.tins.2007.06.006","volume":"30","author":"M Heilig","year":"2007","unstructured":"Heilig M, Koob GF (2007) A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci 30:399\u2013406","journal-title":"Trends Neurosci"},{"issue":"10","key":"1658_CR26","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1038\/npp.2014.92","volume":"39","author":"LM Hodges","year":"2014","unstructured":"Hodges LM, Fyer AJ, Weissman MM, Logue MW, Haghighi F, Evgrafov O et al (2014) Evidence for linkage and association of GABRB3 and GABRA5 to panic disorder. Neuropsychopharmacology 39(10):2423\u20132431","journal-title":"Neuropsychopharmacology"},{"key":"1658_CR27","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ng0795-288","volume":"10","author":"K Horinouchi","year":"1995","unstructured":"Horinouchi K, Erlich S, Perl DP, Ferlinz K, Bisgaier CL, Sandhoff K et al (1995) Acid sphingomyelinase deficient mice: a model of types A and B Niemann\u2013Pick disease. Nature Genet 10:288\u2013293","journal-title":"Nature Genet"},{"key":"1658_CR28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.tips.2013.01.004","volume":"34","author":"JP Huston","year":"2013","unstructured":"Huston JP, Silva MA, Topic B, M\u00fcller CP (2013) What\u2019s conditioned in conditioned place preference? Trends Pharmacol Sci 34:162\u2013166","journal-title":"Trends Pharmacol Sci"},{"key":"1658_CR29","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/jnc.13537","volume":"137","author":"JP Huston","year":"2016","unstructured":"Huston JP, Kornhuber J, M\u00fchle C, Japtok L, Komorowski M, Mattern C et al (2016) A sphingolipid mechanism for behavioral extinction. J Neurochem 137:589\u2013603","journal-title":"J Neurochem"},{"key":"1658_CR30","doi-asserted-by":"crossref","first-page":"E854","DOI":"10.1152\/ajpendo.00371.2013","volume":"306","author":"M Jain","year":"2014","unstructured":"Jain M, Ngoy S, Sheth SA, Swanson RA, Rhee EP, Liao R et al (2014) Systematic survey of lipids across mouse tissues. Am J Physiol Endocrinol Metab 306:E854\u2013E868","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1658_CR31","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.cellsig.2009.01.026","volume":"21","author":"RW Jenkins","year":"2009","unstructured":"Jenkins RW, Canals D, Hannun YA (2009) Roles and regulation of secretory and lysosomal acid sphingomyelinase. Cell Signal 21:836\u2013846","journal-title":"Cell Signal"},{"key":"1658_CR32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bbr.2016.07.054","volume":"314","author":"ME Jung","year":"2016","unstructured":"Jung ME, Metzger DB (2016) A sex difference in oxidative stress and behavioral suppression induced by ethanol withdrawal in rats. Behav Brain Res 314:199\u2013214","journal-title":"Behav Brain Res"},{"key":"1658_CR33","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuropharm.2016.07.022","volume":"110","author":"AN Karkhanis","year":"2016","unstructured":"Karkhanis AN, Huggins KN, Rose JH, Jones SR (2016) Switch from excitatory to inhibitory actions of ethanol on dopamine levels after chronic exposure: role of kappa opioid receptors. Neuropharmacology 110:190\u2013197","journal-title":"Neuropharmacology"},{"key":"1658_CR34","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1017\/S0140525X11000859","volume":"34","author":"TE Kippin","year":"2011","unstructured":"Kippin TE (2011) Does drug mis-instrumentalization lead to drug abuse? Behav Brain Sci 34:316\u2013317","journal-title":"Behav Brain Sci"},{"key":"1658_CR35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.psych.59.103006.093548","volume":"59","author":"GF Koob","year":"2008","unstructured":"Koob GF, Le Moal M (2008) Addiction and the brain antireward system. Annu Rev Psychol 59:29\u201353","journal-title":"Annu Rev Psychol"},{"key":"1658_CR36","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s00702-005-0374-5","volume":"112","author":"J Kornhuber","year":"2005","unstructured":"Kornhuber J, Medlin A, Bleich S, Jendrossek V, Henkel AW, Wiltfang J et al (2005) High activity of acid sphingomyelinase in major depression. J Neural Transm 112:1583\u20131590","journal-title":"J Neural Transm"},{"key":"1658_CR37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000315101","volume":"26","author":"J Kornhuber","year":"2010","unstructured":"Kornhuber J, Tripal P, Reichel M, M\u00fchle C, Rhein C, Muehlbacher M et al (2010) Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cell Physiol Biochem 26:9\u201320","journal-title":"Cell Physiol Biochem"},{"key":"1658_CR38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tips.2014.04.003","volume":"35","author":"J Kornhuber","year":"2014","unstructured":"Kornhuber J, M\u00fcller CP, Becker KA, Reichel M, Gulbins E (2014) The ceramide system as a novel antidepressant target. Trends Pharmacol Sci 35:293\u2013304","journal-title":"Trends Pharmacol Sci"},{"key":"1658_CR39","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","volume":"455","author":"V Krishnan","year":"2008","unstructured":"Krishnan V, Nestler EJ (2008) The molecular neurobiology of depression. Nature 455:894\u2013902","journal-title":"Nature"},{"key":"1658_CR40","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1471-4159.2010.07034.x","volume":"116","author":"MD Ledesma","year":"2011","unstructured":"Ledesma MD, Prinetti A, Sonnino S, Schuchman EH (2011) Brain pathology in Niemann Pick disease type A: insights from the acid sphingomyelinase knockout mice. J Neurochem 116:779\u2013788","journal-title":"J Neurochem"},{"key":"1658_CR41","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbr.2015.05.055","volume":"291","author":"KM Lee","year":"2015","unstructured":"Lee KM, Coehlo M, McGregor HA, Waltermire RS, Szumlinski KK (2015) Binge alcohol drinking elicits persistent negative affect in mice. Behav Brain Res 291:385\u2013398","journal-title":"Behav Brain Res"},{"key":"1658_CR42","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.pneurobio.2011.11.001","volume":"96","author":"B Lenz","year":"2012","unstructured":"Lenz B, M\u00fcller CP, Stoessel C, Sperling W, Biermann T, Hillemacher T et al (2012) Sex hormone activity in alcohol addiction: integrating organizational and activational effects. Prog Neurobiol 96:136\u2013163","journal-title":"Prog Neurobiol"},{"key":"1658_CR43","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550","journal-title":"Genome Biol"},{"key":"1658_CR44","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/nn1581","volume":"8","author":"DM Lovinger","year":"2005","unstructured":"Lovinger DM, Crabbe JC (2005) Laboratory models of alcoholism: treatment target identification and insight into mechanisms. Nat Neurosci 8:1471\u20131480","journal-title":"Nat Neurosci"},{"key":"1658_CR45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.psychres.2006.04.013","volume":"151","author":"TM Michel","year":"2007","unstructured":"Michel TM, Frangou S, Thiemeyer D, Camara S, Jecel J, Nara K et al (2007) Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder\u2014a postmortem study. Psychiatry Res 151:145\u2013150","journal-title":"Psychiatry Res"},{"key":"1658_CR46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2015.11.005","volume":"60","author":"M Miquel","year":"2016","unstructured":"Miquel M, Vazquez-Sanroman D, Carbo-Gas M, Gil-Miravet I, Sanchis-Segura C, Carulli D et al (2016) Have we been ignoring the elephant in the room? Seven arguments for considering the cerebellum as part of addiction circuitry. Neurosci Biobehav Rev 60:1\u201311","journal-title":"Neurosci Biobehav Rev"},{"key":"1658_CR47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1017\/S0140525X11000057","volume":"34","author":"CP M\u00fcller","year":"2011","unstructured":"M\u00fcller CP, Schumann G (2011) Drugs as instruments: a new framework for non-addictive psychoactive drug use. Behav Brain Sci 34:293\u2013310","journal-title":"Behav Brain Sci"},{"key":"1658_CR48","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1017\/S0140525X1100135X","volume":"34","author":"CP M\u00fcller","year":"2011","unstructured":"M\u00fcller CP, Schumann G (2011) To use or not to use: expanding the view on non-addictive psychoactive drug consumption and its implications. Behav Brain Sci 34:328\u2013347","journal-title":"Behav Brain Sci"},{"key":"1658_CR49","first-page":"34","volume":"7","author":"CP M\u00fcller","year":"2013","unstructured":"M\u00fcller CP (2013) Episodic memories and their relevance for psychoactive drug use and addiction. Front Behav Neurosci 7:34","journal-title":"Front Behav Neurosci"},{"key":"1658_CR50","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbr.2014.04.007","volume":"277","author":"CP M\u00fcller","year":"2015","unstructured":"M\u00fcller CP, Homberg JR (2015) The role of serotonin in drug use and addiction. Behav Brain Res 277:146\u2013192","journal-title":"Behav Brain Res"},{"key":"1658_CR51","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.bbalip.2014.12.014","volume":"1851","author":"CP M\u00fcller","year":"2015","unstructured":"M\u00fcller CP, Reichel M, M\u00fchle C, Rhein C, Gulbins E, Kornhuber J (2015) Brain membrane lipids in major depression and anxiety disorders. Biochim Biophys Acta 1851:1052\u20131065","journal-title":"Biochim Biophys Acta"},{"key":"1658_CR52","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/brain\/aws358","volume":"136","author":"S Nuber","year":"2013","unstructured":"Nuber S, Harmuth F, Kohl Z, Adame A, Trejo M, Sch\u00f6nig K et al (2013) A progressive dopaminergic phenotype associated with neurotoxic conversion of \u03b1-synuclein in BAC-transgenic rats. Brain 136:412\u2013432","journal-title":"Brain"},{"key":"1658_CR53","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/mp.2015.14","volume":"21","author":"TG Oliveira","year":"2016","unstructured":"Oliveira TG, Chan RB, Bravo FV, Miranda A, Silva RR, Zhou B et al (2016) The impact of chronic stress on the rat brain lipidome. Mol Psychiatry 21:80\u201388","journal-title":"Mol Psychiatry"},{"key":"1658_CR54","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0376-8716(00)00112-5","volume":"60","author":"S Peele","year":"2000","unstructured":"Peele S, Brodsky A (2000) Exploring psychological benefits associated with moderate alcohol use: a necessary corrective to assessments of drinking outcomes? Drug Alcohol Depend 60:221\u2013247","journal-title":"Drug Alcohol Depend"},{"key":"1658_CR55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1176\/appi.ajp.2012.12010112","volume":"170","author":"HM Pettinati","year":"2013","unstructured":"Pettinati HM, O\u2019Brien CP, Dundon WD (2013) Current status of co-occurring mood and substance use disorders: a new therapeutic target. Am J Psychiatry 170:23\u201330","journal-title":"Am J Psychiatry"},{"key":"1658_CR56","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1093\/clinchem\/28.10.2125","volume":"28","author":"A Poklis","year":"1982","unstructured":"Poklis A, Mackell MA (1982) Evaluation of a modified alcohol dehydrogenase assay for the determination of ethanol in blood. Clin Chem 28:2125\u20132127","journal-title":"Clin Chem"},{"key":"1658_CR57","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00213-008-1296-3","volume":"201","author":"ME Pum","year":"2008","unstructured":"Pum ME, Carey RJ, Huston JP, M\u00fcller CP (2008) Role of medial prefrontal, entorhinal, and occipital 5-HT in cocaine-induced place preference and hyperlocomotion: evidence for multiple dissociations. Psychopharmacology 201:391\u2013403","journal-title":"Psychopharmacology"},{"key":"1658_CR58","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1530-0277.2009.01064.x","volume":"34","author":"M Reichel","year":"2010","unstructured":"Reichel M, Greiner E, Richter-Schmidinger T, Yedibela O, Tripal P, Jacobi A et al (2010) Increased acid sphingomyelinase activity in peripheral blood cells of acutely intoxicated patients with alcohol dependence. Alcohol Clin Exp Res 34:46\u201350","journal-title":"Alcohol Clin Exp Res"},{"key":"1658_CR59","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1111\/j.1530-0277.2011.01529.x","volume":"35","author":"M Reichel","year":"2011","unstructured":"Reichel M, Beck J, M\u00fchle C, Rotter A, Bleich S, Gulbins E et al (2011) Activity of secretory sphingomyelinase is increased in plasma of alcohol-dependent patients. Alcohol Clin Exp Res 35:1852\u20131859","journal-title":"Alcohol Clin Exp Res"},{"key":"1658_CR60","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.bbalip.2015.08.005","volume":"1851","author":"M Reichel","year":"2015","unstructured":"Reichel M, Honig S, Liebisch G, Luth A, Kleuser B, Gulbins E et al (2015) Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients. Biochim Biophys Acta 1851:1501\u20131510","journal-title":"Biochim Biophys Acta"},{"key":"1658_CR61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1441.020","volume":"1141","author":"TW Robbins","year":"2008","unstructured":"Robbins TW, Ersche KD, Everitt BJ (2008) Drug addiction and the memory systems of the brain. Ann N Y Acad Sci 1141:1\u201321","journal-title":"Ann N Y Acad Sci"},{"key":"1658_CR62","doi-asserted-by":"crossref","first-page":"459","DOI":"10.55782\/ane-2009-1757","volume":"69","author":"M Sacharczuk","year":"2009","unstructured":"Sacharczuk M, Juszczak G, Swiergiel AH, Jaszczak K, Lipkowski AW, Sadowski B (2009) Alcohol reverses depressive and pronociceptive effects of chronic stress in mice with enhanced activity of the opioid system. Acta Neurobiol Exp (Wars) 69:459\u2013468","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"1658_CR63","unstructured":"SAMHSA (2011) National survey on drug use and health, Substance Abuse and Mental Health Services Administration, 2011. Rockville http:\/\/www.samhsa.gov\/data\/NSDUH\/ 011SummNatFindDetTables\/Index.aspx). Accessed 20 June 2013"},{"key":"1658_CR64","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1176\/ajp.154.7.948","volume":"154","author":"MA Schuckit","year":"1997","unstructured":"Schuckit MA, Tipp JE, Bergman M, Reich W, Hesselbrock VM, Smith TL (1997) Comparison of induced and independent major depressive disorders in 2,945 alcoholics. Am J Psychiatry 154:948\u2013957","journal-title":"Am J Psychiatry"},{"key":"1658_CR65","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1021\/pr800188y","volume":"7","author":"E Schwarz","year":"2008","unstructured":"Schwarz E, Prabakaran S, Whitfield P, Major H, Leweke FM, Koethe D et al (2008) High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides. J Proteome Res 7:4266\u20134277","journal-title":"J Proteome Res"},{"key":"1658_CR66","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2014.10.011","volume":"84","author":"M Shariatgorji","year":"2014","unstructured":"Shariatgorji M, Nilsson A, Goodwin RJ, Kallback P, Schintu N, Zhang X et al (2014) Direct targeted quantitative molecular imaging of neurotransmitters in brain tissue sections. Neuron 84:697\u2013707","journal-title":"Neuron"},{"key":"1658_CR67","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.pnpbp.2012.06.018","volume":"39","author":"I Smaga","year":"2012","unstructured":"Smaga I, Pomierny B, Krzyzanowska W, Pomierny-Chamiolo L, Miszkiel J, Niedzielska E et al (2012) N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: behavioral and biochemical analyses in rats. Prog Neuropsychopharmacol Biol Psychiatry 39:280\u2013287","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1658_CR68","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physrev.00013.2008","volume":"89","author":"R Spanagel","year":"2009","unstructured":"Spanagel R (2009) Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev 89:649\u2013705","journal-title":"Physiol Rev"},{"key":"1658_CR69","doi-asserted-by":"crossref","first-page":"21128","DOI":"10.1073\/pnas.1211844110","volume":"109","author":"D Stacey","year":"2012","unstructured":"Stacey D, Bilbao A, Maroteaux M, Jia T, Easton AC, Longueville S et al (2012) RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proc Natl Acad Sci USA 109:21128\u201321133","journal-title":"Proc Natl Acad Sci USA"},{"key":"1658_CR70","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbi.2015.05.011","volume":"49","author":"P S\u00fc\u00df","year":"2015","unstructured":"S\u00fc\u00df P, Kalinichenko L, Baum W, Reichel M, Kornhuber J, Loskarn S et al (2015) Hippocampal structure and function are maintained despite severe innate peripheral inflammation. Brain Behav Immun 49:156\u2013170","journal-title":"Brain Behav Immun"},{"key":"1658_CR71","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1523\/JNEUROSCI.0430-10.2010","volume":"30","author":"RO Tasan","year":"2010","unstructured":"Tasan RO, Nguyen NK, Weger S, Sartori SB, Singewald N, Heilbronn R et al (2010) The central and basolateral amygdala are critical sites of neuropeptide Y\/Y2 receptor-mediated regulation of anxiety and depression. J Neurosci 30:6282\u20136290","journal-title":"J Neurosci"},{"key":"1658_CR72","first-page":"9876","volume":"39","author":"MP Veiga","year":"2000","unstructured":"Veiga MP, Go\u00f1i FM, Alonso A, Marsh D (2000) Mixed membranes of sphingolipids and glycerolipids as studied by spin-label ESR spectroscopy. A search for domain formation. Biochemistry 39:9876\u20139883","journal-title":"A search for domain formation. Biochemistry"},{"key":"1658_CR73","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/bjp.2008.30","volume":"154","author":"V Vengeliene","year":"2008","unstructured":"Vengeliene V, Bilbao A, Molander A, Spanagel R (2008) Neuropharmacology of alcohol addiction. Br J Pharmacol 154:299\u2013315","journal-title":"Br J Pharmacol"},{"key":"1658_CR74","doi-asserted-by":"crossref","first-page":"12867","DOI":"10.1038\/ncomms12867","volume":"7","author":"SA Wolfe","year":"2016","unstructured":"Wolfe SA, Workman ER, Heaney CF, Niere F, Namjoshi S, Cacheaux LP et al (2016) FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties. Nat Commun 7:12867","journal-title":"Nat Commun"},{"key":"1658_CR75","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1038\/npp.2015.372","volume":"41","author":"F Zheng","year":"2016","unstructured":"Zheng F, Puppel A, Huber SE, Link AS, Eulenburg V, van Brederode JF et al (2016) Activin controls ethanol potentiation of Inhibitory syn aptic transmission through GABA receptors and concomitant behavioral sedation. Neuropsychopharmacology 41:2024\u20132033","journal-title":"Neuropsychopharmacology"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-016-1658-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-016-1658-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-016-1658-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T09:41:36Z","timestamp":1718962896000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-016-1658-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":75,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["1658"],"URL":"https:\/\/doi.org\/10.1007\/s00401-016-1658-6","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,20]]}}}