{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:59:52Z","timestamp":1793411992719,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["ZIA AI001086-08"],"award-info":[{"award-number":["ZIA AI001086-08"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Indiana Alzheimer Disease Center P30","award":["AG010133"],"award-info":[{"award-number":["AG010133"]}]},{"DOI":"10.13039\/501100001691","name":"Japanese Society for the Promotion of Science","doi-asserted-by":"crossref","award":["Fellowship for Japanese Biomedical and Behavioral Researchers at NIH"],"award-info":[{"award-number":["Fellowship for Japanese Biomedical and Behavioral Researchers at NIH"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s00401-017-1692-z","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T11:10:10Z","timestamp":1489489810000},"page":"751-765","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid"],"prefix":"10.1007","volume":"133","author":[{"given":"Eri","family":"Saijo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardino","family":"Ghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Zanusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Oblak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Furman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc I.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-6101","authenticated-orcid":false,"given":"Byron","family":"Caughey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"1692_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nm.2294","volume":"17","author":"R Atarashi","year":"2011","unstructured":"Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S et al (2011) Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat Med 17:175\u2013178. doi:\n                    10.1038\/nm.2294","journal-title":"Nat Med"},{"key":"1692_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1001\/jamaneurol.2016.4614","volume":"74","author":"M Bongianni","year":"2017","unstructured":"Bongianni M, Orr\u00f9 CD, Groveman BR, Sacchetto L, Fiorini M, Tonoli G, Triva G, Capaldi S, Testi S, Ferrari S et al (2017) Diagnosis of human prion disease using real-time quaking-induced conversion testing of olfactory mucosa and cerebrospinal fluid samples. JAMA Neurol 74:1\u20138","journal-title":"JAMA Neurol"},{"key":"1692_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0076-6879(06)12001-7","volume":"412","author":"J Castilla","year":"2006","unstructured":"Castilla J, Saa P, Morales R, Abid K, Maundrell K, Soto C (2006) Protein misfolding cyclic amplification for diagnosis and prion propagation studies. Methods Enzymol 412:3\u201321","journal-title":"Methods Enzymol"},{"key":"1692_CR4","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev.neuro.26.010302.081142","volume":"26","author":"B Caughey","year":"2003","unstructured":"Caughey B, Lansbury PT (2003) Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci 26:267\u2013298","journal-title":"Annu Rev Neurosci"},{"key":"1692_CR5","doi-asserted-by":"publisher","first-page":"20914","DOI":"10.1073\/pnas.0710152105","volume":"104","author":"DW Colby","year":"2007","unstructured":"Colby DW, Zhang Q, Wang S, Groth D, Legname G, Riesner D, Prusiner SB (2007) Prion detection by an amyloid seeding assay. Proc Natl Acad Sci USA 104:20914\u201320919","journal-title":"Proc Natl Acad Sci USA"},{"key":"1692_CR6","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1007\/s12035-015-9133-2","volume":"53","author":"M Cramm","year":"2015","unstructured":"Cramm M, Schmitz M, Karch A, Mitrova E, Kuhn F, Schroeder B, Raeber A, Varges D, Kim YS, Satoh K et al (2016) Stability and reproducibility underscore utility of RT-QuIC for diagnosis of Creutzfeldt-Jakob disease. Mol Neurobiol 53:1896\u20131904.\u00a0doi:\n                    10.1007\/s12035-015-9133-2","journal-title":"Mol Neurobiol"},{"key":"1692_CR7","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1007\/s12035-014-8709-6","volume":"51","author":"M Cramm","year":"2015","unstructured":"Cramm M, Schmitz M, Karch A, Zafar S, Varges D, Mitrova E, Schroeder B, Raeber A, Kuhn F, Zerr I (2015) Characteristic CSF prion seeding efficiency in humans with prion diseases. Mol Neurobiol 51:396\u2013405. doi:\n                    10.1007\/s12035-014-8709-6","journal-title":"Mol Neurobiol"},{"key":"1692_CR8","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1007\/s00259-015-3231-2","volume":"43","author":"M Dani","year":"2016","unstructured":"Dani M, Brooks DJ, Edison P (2016) Tau imaging in neurodegenerative diseases. Eur J Nucl Med Mol Imaging 43:1139\u20131150. doi:\n                    10.1007\/s00259-015-3231-2","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1692_CR9","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1099\/jgv.0.000367","volume":"97","author":"RP Dassanayake","year":"2016","unstructured":"Dassanayake RP, Orru CD, Hughson AG, Caughey B, Graca T, Zhuang D, Madsen-Bouterse SA, Knowles DP, Schneider DA (2016) Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion. J Gen Virol 97:803\u2013812. doi:\n                    10.1099\/jgv.0.000367","journal-title":"J Gen Virol"},{"key":"1692_CR10","doi-asserted-by":"publisher","first-page":"4330","DOI":"10.1021\/bi2004685","volume":"50","author":"PD Dinkel","year":"2011","unstructured":"Dinkel PD, Siddiqua A, Huynh H, Shah M, Margittai M (2011) Variations in filament conformation dictate seeding barrier between three- and four-repeat tau. Biochemistry 50:4330\u20134336. doi:\n                    10.1021\/bi2004685","journal-title":"Biochemistry"},{"key":"1692_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00401-016-1644-z","volume":"133","author":"JL Furman","year":"2016","unstructured":"Furman JL, Vaquer-Alicea J, White CL 3rd, Cairns NJ, Nelson PT, Diamond MI (2017) Widespread tau seeding activity at early Braak stages. Acta Neuropathol 133:91\u2013100. doi:\n                    10.1007\/s00401-016-1644-z","journal-title":"Acta Neuropathol"},{"key":"1692_CR12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0896-6273(92)90117-V","volume":"8","author":"M Goedert","year":"1992","unstructured":"Goedert M, Spillantini MG, Cairns NJ, Crowther RA (1992) Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron 8:159\u2013168","journal-title":"Neuron"},{"key":"1692_CR13","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2147\/NDT.S12518","volume":"8","author":"M Gold","year":"2012","unstructured":"Gold M, Lorenzl S, Stewart AJ, Morimoto BH, Williams DR, Gozes I (2012) Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy. Neuropsychiatr Dis Treat 8:85\u201393. doi:\n                    10.2147\/NDT.S12518","journal-title":"Neuropsychiatr Dis Treat"},{"key":"1692_CR14","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00401-013-1191-9","volume":"127","author":"M Hasegawa","year":"2014","unstructured":"Hasegawa M, Watanabe S, Kondo H, Akiyama H, Mann DM, Saito Y, Murayama S (2014) 3R and 4R tau isoforms in paired helical filaments in Alzheimer\u2019s disease. Acta Neuropathol 127:303\u2013305. doi:\n                    10.1007\/s00401-013-1191-9","journal-title":"Acta Neuropathol"},{"key":"1692_CR15","doi-asserted-by":"publisher","first-page":"E4376","DOI":"10.1073\/pnas.1411649111","volume":"111","author":"BB Holmes","year":"2014","unstructured":"Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI (2014) Proteopathic tau seeding predicts tauopathy in vivo. Proc Natl Acad Sci USA 111:E4376\u2013E4385. doi:\n                    10.1073\/pnas.1411649111","journal-title":"Proc Natl Acad Sci USA"},{"key":"1692_CR16","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1212\/01.wnl.0000436625.63650.27","volume":"81","author":"WT Hu","year":"2013","unstructured":"Hu WT, Watts K, Grossman M, Glass J, Lah JJ, Hales C, Shelnutt M, Van Deerlin V, Trojanowski JQ, Levey AI (2013) Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP. Neurology 81:1945\u20131952. doi:\n                    10.1212\/01.wnl.0000436625.63650.27","journal-title":"Neurology"},{"key":"1692_CR17","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/ana.24559","volume":"79","author":"DJ Irwin","year":"2016","unstructured":"Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB et al (2016) Deep clinical and neuropathological phenotyping of Pick disease. Ann Neurol 79:272\u2013287. doi:\n                    10.1002\/ana.24559","journal-title":"Ann Neurol"},{"key":"1692_CR18","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1128\/JCM.02731-15","volume":"54","author":"K Masujin","year":"2016","unstructured":"Masujin K, Orru CD, Miyazawa K, Groveman BR, Raymond LD, Hughson AG, Caughey B (2016) Detection of atypical H-type bovine spongiform encephalopathy and discrimination of bovine prion strains by real-time quaking-induced conversion. J Clin Microbiol 54:676\u2013686. doi:\n                    10.1128\/JCM.02731-15","journal-title":"J Clin Microbiol"},{"key":"1692_CR19","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/ana.23589","volume":"72","author":"LI McGuire","year":"2012","unstructured":"McGuire LI, Peden AH, Orru CD, Wilham JM, Appleford NE, Mallinson G, Andrews M, Head MW, Caughey B, Will RG et al (2012) RT-QuIC analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease. Ann Neurol 72:278\u2013285","journal-title":"Ann Neurol"},{"key":"1692_CR20","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/ana.24679","volume":"80","author":"LI McGuire","year":"2016","unstructured":"McGuire LI, Poleggi A, Poggiolini I, Suardi S, Grznarova K, Shi S, de Vil B, Sarros S, Satoh K, Cheng K et al (2016) Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic Creutzfeldt-Jakob disease: an international study. Ann Neurol 80:160\u2013165. doi:\n                    10.1002\/ana.24679","journal-title":"Ann Neurol"},{"key":"1692_CR21","doi-asserted-by":"publisher","first-page":"5804","DOI":"10.1021\/bi501050g","volume":"53","author":"V Meyer","year":"2014","unstructured":"Meyer V, Dinkel PD, Rickman Hager E, Margittai M (2014) Amplification of Tau fibrils from minute quantities of seeds. Biochemistry 53:5804\u20135809. doi:\n                    10.1021\/bi501050g","journal-title":"Biochemistry"},{"key":"1692_CR22","doi-asserted-by":"publisher","first-page":"6960","DOI":"10.1021\/bi400866w","volume":"52","author":"OA Morozova","year":"2013","unstructured":"Morozova OA, March ZM, Robinson AS, Colby DW (2013) Conformational features of tau fibrils from Alzheimer\u2019s disease brain are faithfully propagated by unmodified recombinant protein. Biochemistry 52:6960\u20136967. doi:\n                    10.1021\/bi400866w","journal-title":"Biochemistry"},{"key":"1692_CR23","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s10048-006-0053-1","volume":"7","author":"J Murrell","year":"2006","unstructured":"Murrell J, Ghetti B, Cochran E, Macias-Islas MA, Medina L, Varpetian A, Cummings JL, Mendez MF, Kawas C, Chui H et al (2006) The A431E mutation in PSEN1 causing familial Alzheimer\u2019s disease originating in Jalisco State, Mexico: an additional fifteen families. Neurogenetics 7:277\u2013279. doi:\n                    10.1007\/s10048-006-0053-1","journal-title":"Neurogenetics"},{"key":"1692_CR24","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1056\/NEJMoa1315200","volume":"371","author":"CD Orru","year":"2014","unstructured":"Orru CD, Bongianni M, Tonoli G, Ferrari S, Hughson AG, Groveman BR, Fiorini M, Pocchiari M, Monaco S, Caughey B et al (2014) A test for Creutzfeldt-Jakob disease using nasal brushings. N Engl J Med 371:519\u2013529","journal-title":"N Engl J Med"},{"key":"1692_CR25","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1128\/JCM.02906-14","volume":"53","author":"CD Orru","year":"2015","unstructured":"Orru CD, Favole A, Corona C, Mazza M, Manca M, Groveman BR, Hughson AG, Acutis PL, Caramelli M, Zanusso G et al (2015) Detection and discrimination of classical and atypical L-type bovine spongiform encephalopathy by real-time quaking-induced conversion. J Clin Microbiol 53:1115\u20131120. doi:\n                    10.1128\/jcm.02906-14","journal-title":"J Clin Microbiol"},{"key":"1692_CR26","doi-asserted-by":"publisher","first-page":"e02451","DOI":"10.1128\/mBio.02451-14","volume":"6","author":"CD Orru","year":"2015","unstructured":"Orru CD, Groveman BR, Hughson AG, Zanusso G, Coulthart MB, Caughey B (2015) Rapid and sensitive RT-QuIC detection of human Creutzfeldt-Jakob disease using cerebrospinal fluid. MBio 6:e02451\u201314. doi:\n                    10.1128\/mBio.02451-14","journal-title":"MBio."},{"key":"1692_CR27","doi-asserted-by":"publisher","first-page":"e1004983","DOI":"10.1371\/journal.ppat.1004983","volume":"11","author":"CD Orru","year":"2015","unstructured":"Orru CD, Groveman BR, Raymond LD, Hughson AG, Nonno R, Zou W, Ghetti B, Gambetti P, Caughey B (2015) Bank vole prion protein as an apparently universal substrate for RT-QuIC-based detection and discrimination of prion strains. PLoS Path 11:e1004983. doi:\n                    10.1371\/journal.ppat.1004983","journal-title":"PLoS Path"},{"key":"1692_CR28","doi-asserted-by":"publisher","first-page":"147","DOI":"10.4161\/pri.19430","volume":"6","author":"CD Orru","year":"2012","unstructured":"Orru CD, Wilham JM, Vascellari S, Hughson AG, Caughey B (2012) New generation QuIC assays for prion seeding activity. Prion 6:147\u2013152. doi:\n                    10.4161\/pri.19430","journal-title":"Prion"},{"key":"1692_CR29","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1038\/nprot.2016.120","volume":"11","author":"M Schmitz","year":"2016","unstructured":"Schmitz M, Cramm M, Llorens F, Muller-Cramm D, Collins S, Atarashi R, Satoh K, Orru CD, Groveman BR, Zafar S et al (2016) The real-time quaking-induced conversion assay for detection of human prion disease and study of other protein misfolding diseases. Nat Protoc 11:2233\u20132242. doi:\n                    10.1038\/nprot.2016.120","journal-title":"Nat Protoc"},{"key":"1692_CR30","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/S1474-4422(13)70090-5","volume":"12","author":"MG Spillantini","year":"2013","unstructured":"Spillantini MG, Goedert M (2013) Tau pathology and neurodegeneration. Lancet Neurol 12:609\u2013622. doi:\n                    10.1016\/S1474-4422(13)70090-5","journal-title":"Lancet Neurol"},{"key":"1692_CR31","doi-asserted-by":"publisher","first-page":"4113","DOI":"10.1073\/pnas.94.8.4113","volume":"94","author":"MG Spillantini","year":"1997","unstructured":"Spillantini MG, Goedert M, Crowther RA, Murrell JR, Farlow MR, Ghetti B (1997) Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments. Proc Natl Acad Sci USA 94:4113\u20134118","journal-title":"Proc Natl Acad Sci USA"},{"key":"1692_CR32","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.pep.2005.01.016","volume":"41","author":"FW Studier","year":"2005","unstructured":"Studier FW (2005) Protein production by auto-induction in high density shaking cultures. Protein Expr Purif 41:207\u2013234","journal-title":"Protein Expr Purif"},{"key":"1692_CR33","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/ana.24716","volume":"80","author":"S Takeda","year":"2016","unstructured":"Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE et al (2016) Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer\u2019s disease mouse model and human patients. Ann Neurol 80:355\u2013367. doi:\n                    10.1002\/ana.24716","journal-title":"Ann Neurol"},{"key":"1692_CR34","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00401-015-1503-3","volume":"131","author":"S Taniguchi-Watanabe","year":"2016","unstructured":"Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M et al (2016) Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau. Acta Neuropathol 131:267\u2013280. doi:\n                    10.1007\/s00401-015-1503-3","journal-title":"Acta Neuropathol"},{"key":"1692_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/82868","volume":"4","author":"KL Tucker","year":"2001","unstructured":"Tucker KL, Meyer M, Barde YA (2001) Neurotrophins are required for nerve growth during development. Nat Neurosci 4:29\u201337. doi:\n                    10.1038\/82868","journal-title":"Nat Neurosci"},{"key":"1692_CR36","doi-asserted-by":"publisher","first-page":"e1001217","DOI":"10.1371\/journal.ppat.1001217","volume":"6","author":"JM Wilham","year":"2010","unstructured":"Wilham JM, Orr\u00fa CD, Bessen RA, Atarashi R, Sano K, Race B, Meade-White KD, Taubner LM, Timmes A, Caughey B (2010) Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. PLoS Path 6:e1001217. doi:\n                    10.1371\/journal.ppat.1001217","journal-title":"PLoS Path"},{"key":"1692_CR37","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/j.1445-5994.2006.01153.x","volume":"36","author":"DR Williams","year":"2006","unstructured":"Williams DR (2006) Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau. Intern Med J 36:652\u2013660. doi:\n                    10.1111\/j.1445-5994.2006.01153.x","journal-title":"Intern Med J"},{"key":"1692_CR38","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1056\/NEJMc1410732","volume":"371","author":"G Zanusso","year":"2014","unstructured":"Zanusso G, Bongianni M, Caughey B (2014) A test for Creutzfeldt-Jakob disease using nasal brushings. N Engl J Med 371:1842\u20131843. doi:\n                    10.1056\/NEJMc1410732","journal-title":"N Engl J Med"},{"key":"1692_CR39","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrneurol.2016.65","volume":"12","author":"G Zanusso","year":"2016","unstructured":"Zanusso G, Monaco S, Pocchiari M, Caughey B (2016) Advanced tests for early and accurate diagnosis of Creutzfeldt-Jakob disease. Nat Rev Neurol 12:325\u2013333. doi:\n                    10.1038\/nrneurol.2016.65","journal-title":"Nat Rev Neurol"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-017-1692-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-017-1692-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-017-1692-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T12:47:01Z","timestamp":1589633221000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-017-1692-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["1692"],"URL":"https:\/\/doi.org\/10.1007\/s00401-017-1692-z","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]},"assertion":[{"value":"27 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}