{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:36:12Z","timestamp":1789187772229,"version":"build-2803163510"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:00:00Z","timestamp":1490140800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s00401-017-1702-1","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T17:29:41Z","timestamp":1490203781000},"page":"297-316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Identification of T cell target antigens in glioblastoma stem-like cells using an integrated proteomics-based approach in patient specimens"],"prefix":"10.1007","volume":"134","author":[{"given":"Carmen","family":"Rapp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Warta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slava","family":"Stamova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Nowrouzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Geisenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Gal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Roesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Dettling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Juenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Bucur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Jungk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"DaoTrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rezvan","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Sahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Reuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Fermi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Herpel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Eckstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Grabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus A.","family":"Weigand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Debus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Unterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Abdollahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Beckhove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Herold-Mende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,22]]},"reference":[{"key":"1702_CR1","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1158\/1078-0432.CCR-09-1322","volume":"16","author":"N Ahmed","year":"2010","unstructured":"Ahmed N, Salsman VS, Kew Y, Shaffer D, Powell S, Zhang YJ et al (2010) HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors. Clin Cancer Res 16:474\u2013485. doi:\n                        10.1158\/1078-0432.CCR-09-1322","journal-title":"Clin Cancer Res"},{"key":"1702_CR2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature12477","volume":"500","author":"LB Alexandrov","year":"2013","unstructured":"Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SAJR, Behjati S, Biankin AV et al (2013) Signatures of mutational processes in human cancer. Nature 500:415\u2013421. doi:\n                        10.1038\/nature12477","journal-title":"Nature"},{"key":"1702_CR3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1477-5956-11-22","volume":"11","author":"S Aretz","year":"2013","unstructured":"Aretz S, Krohne TU, Kammerer K, Warnken U, Hotz-Wagenblatt A, Bergmann M et al (2013) In-depth mass spectrometric mapping of the human vitreous proteome. Proteome Sci 11:22. doi:\n                        10.1186\/1477-5956-11-22","journal-title":"Proteome Sci"},{"key":"1702_CR4","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s11060-015-1836-8","volume":"123","author":"TD Azad","year":"2015","unstructured":"Azad TD, Razavi S-M, Jin B, Lee K, Li G (2015) Glioblastoma antigen discovery\u2013foundations for immunotherapy. J Neurooncol 123:347\u2013358. doi:\n                        10.1007\/s11060-015-1836-8","journal-title":"J Neurooncol"},{"key":"1702_CR5","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/nature05236","volume":"444","author":"S Bao","year":"2006","unstructured":"Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB et al (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756\u2013760. doi:\n                        10.1038\/nature05236","journal-title":"Nature"},{"key":"1702_CR6","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1172\/JCI37646","volume":"120","author":"P Beckhove","year":"2010","unstructured":"Beckhove P, Warta R, Lemke B, Stoycheva D, Momburg F, Schn\u00f6lzer M et al (2010) Rapid T cell\u2013based identification of human tumor tissue antigens by automated two-dimensional protein fractionation. J Clin Invest 120:2230\u20132242. doi:\n                        10.1172\/JCI37646","journal-title":"J Clin Invest"},{"key":"1702_CR7","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s10555-006-9003-5","volume":"25","author":"A Ben-Baruch","year":"2006","unstructured":"Ben-Baruch A (2006) The multifaceted roles of chemokines in malignancy. Cancer Metastasis Rev 25:357\u2013371. doi:\n                        10.1007\/s10555-006-9003-5","journal-title":"Cancer Metastasis Rev"},{"key":"1702_CR8","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1172\/JCI39608","volume":"119","author":"A Bonertz","year":"2009","unstructured":"Bonertz A, Weitz J, Pietsch D-HK, Rahbari NN, Schlude C, Ge Y et al (2009) Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. J Clin Invest 119:3311\u20133321. doi:\n                        10.1172\/JCI39608","journal-title":"J Clin Invest"},{"key":"1702_CR9","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1158\/1078-0432.CCR-11-1669","volume":"18","author":"CE Brown","year":"2012","unstructured":"Brown CE, Starr R, Aguilar B, Shami AF, Martinez C, D\u2019Apuzzo M et al (2012) Stem-like tumor-initiating cells isolated from IL13Ralpha2 expressing gliomas are targeted and killed by IL13-zetakine-redirected T Cells. Clin Cancer Res 18:2199\u20132209. doi:\n                        10.1158\/1078-0432.CCR-11-1669","journal-title":"Clin Cancer Res"},{"key":"1702_CR10","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1158\/0008-5472.CAN-10-2046","volume":"71","author":"MW Butler","year":"2011","unstructured":"Butler MW, Fukui T, Salit J, Shaykhiev R, Mezey JG, Hackett NR et al (2011) Modulation of cystatin A expression in human airway epithelium related to genotype, smoking, COPD, and lung cancer. Cancer Res 71:2572\u20132581. doi:\n                        10.1158\/0008-5472.CAN-10-2046","journal-title":"Cancer Res"},{"key":"1702_CR11","first-page":"1652","volume":"63","author":"MJ Campa","year":"2003","unstructured":"Campa MJ, Wang MZ, Howard B, Fitzgerald MC, Patz EF (2003) Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer. Cancer Res 63:1652\u20131656","journal-title":"Cancer Res"},{"key":"1702_CR12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/path.4366","volume":"234","author":"B Campos","year":"2014","unstructured":"Campos B, Gal Z, Baader A, Schneider T, Sliwinski C, Gassel K et al (2014) Aberrant self-renewal and quiescence contribute to the aggressiveness of glioblastoma. J Pathol 234:23\u201333. doi:\n                        10.1002\/path.4366","journal-title":"J Pathol"},{"key":"1702_CR13","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.4049\/jimmunol.0802845","volume":"182","author":"R Castriconi","year":"2009","unstructured":"Castriconi R, Daga A, Dondero A, Zona G, Poliani PL, Melotti A et al (2009) NK cells recognize and kill human glioblastoma cells with stem cell-like properties. J Immunol 182:3530\u20133539. doi:\n                        10.4049\/jimmunol.0802845","journal-title":"J Immunol"},{"key":"1702_CR14","unstructured":"Celldex Therapeutics Inc. (2016) Data safety and monitoring board recommends Celldex\u2019s Phase 3 Study of RINTEGA\u00ae (rindopepimut) in newly diagnosed glioblastoma be discontinued as it is unlikely to meet primary overall survival endpoint in patients with minimal residual disease. \n                        http:\/\/ir.celldex.com\/releasedetail.cfm?ReleaseID=959021\n                        \n                    . Accessed 26 Jan 2017"},{"key":"1702_CR15","doi-asserted-by":"publisher","first-page":"5323","DOI":"10.1158\/1078-0432.CCR-09-0737","volume":"15","author":"MA Cheever","year":"2009","unstructured":"Cheever MA, Allison JP, Ferris AS, Finn OJ, Hastings BM, Hecht TT et al (2009) The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res 15:5323\u20135337. doi:\n                        10.1158\/1078-0432.CCR-09-0737","journal-title":"Clin Cancer Res"},{"key":"1702_CR16","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.gene.2016.07.020","volume":"591","author":"S Cheng","year":"2016","unstructured":"Cheng S, Luo M, Ding C, Peng C, Lv Z, Tong R et al (2016) Downregulation of Peptidylprolyl isomerase A promotes cell death and enhances doxorubicin-induced apoptosis in hepatocellular carcinoma. Gene 591:236\u2013244. doi:\n                        10.1016\/j.gene.2016.07.020","journal-title":"Gene"},{"key":"1702_CR17","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cell.2012.03.009","volume":"149","author":"J Chen","year":"2012","unstructured":"Chen J, McKay RM, Parada LF (2012) Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell 149:36\u201347. doi:\n                        10.1016\/j.cell.2012.03.009","journal-title":"Cell"},{"key":"1702_CR18","first-page":"334","volume":"6","author":"RH Dahlrot","year":"2013","unstructured":"Dahlrot RH, Hermansen SK, Hansen S, Kristensen BW (2013) What is the clinical value of cancer stem cell markers in gliomas? Int J Clin Exp Pathol 6:334\u2013348","journal-title":"Int J Clin Exp Pathol"},{"key":"1702_CR19","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1158\/1078-0432.CCR-09-2730","volume":"16","author":"T Tomaso Di","year":"2010","unstructured":"Di Tomaso T, Mazzoleni S, Wang E, Sovena G, Clavenna D, Franzin A et al (2010) Immunobiological characterization of cancer stem cells isolated from glioblastoma patients. Clin Cancer Res 16:800\u2013813. doi:\n                        10.1158\/1078-0432.CCR-09-2730","journal-title":"Clin Cancer Res"},{"key":"1702_CR20","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.4049\/jimmunol.168.7.3195","volume":"168","author":"JH Dufour","year":"2002","unstructured":"Dufour JH, Dziejman M, Liu MT, Leung JH, Lane TE, Luster AD (2002) IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol 168:3195\u20133204","journal-title":"J Immunol"},{"key":"1702_CR21","first-page":"12","volume":"7","author":"GP Dunn","year":"2007","unstructured":"Dunn GP, Dunn IF, Curry WT (2007) Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in human glioma. Cancer Immun 7:12","journal-title":"Cancer Immun"},{"key":"1702_CR22","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1093\/brain\/aws042","volume":"135","author":"V Dutoit","year":"2012","unstructured":"Dutoit V, Herold-Mende C, Hilf N, Schoor O, Beckhove P, Bucher J et al (2012) Exploiting the glioblastoma peptidome to discover novel tumour-associated antigens for immunotherapy. Brain 135:1042\u20131054. doi:\n                        10.1093\/brain\/aws042","journal-title":"Brain"},{"key":"1702_CR23","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1200\/JCO.2007.15.1829","volume":"26","author":"CE Eyler","year":"2008","unstructured":"Eyler CE, Rich JN (2008) Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol 26:2839\u20132845. doi:\n                        10.1200\/JCO.2007.15.1829","journal-title":"J Clin Oncol"},{"key":"1702_CR24","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1083\/jcb.153.5.999","volume":"153","author":"L Foghsgaard","year":"2001","unstructured":"Foghsgaard L, Wissing D, Mauch D, Lademann U, Bastholm L, Boes M et al (2001) Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol 153:999\u20131010","journal-title":"J Cell Biol"},{"key":"1702_CR25","doi-asserted-by":"publisher","first-page":"7011","DOI":"10.1158\/0008-5472.CAN-04-1364","volume":"64","author":"R Galli","year":"2004","unstructured":"Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, de Vitis S et al (2004) Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64:7011\u20137021. doi:\n                        10.1158\/0008-5472.CAN-04-1364","journal-title":"Cancer Res"},{"key":"1702_CR26","doi-asserted-by":"publisher","first-page":"12472","DOI":"10.18632\/oncotarget.2998","volume":"5","author":"L Galluzzi","year":"2014","unstructured":"Galluzzi L, Vacchelli E, Bravo-San Pedro J-M, Buque A, Senovilla L, Baracco EE et al (2014) Classification of current anticancer immunotherapies. Oncotarget 5:12472\u201312508. doi:\n                        10.18632\/oncotarget.2998","journal-title":"Oncotarget"},{"key":"1702_CR27","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1056\/NEJMoa1501824","volume":"372","author":"EB Garon","year":"2015","unstructured":"Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP et al (2015) Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 372:2018\u20132028. doi:\n                        10.1056\/NEJMoa1501824","journal-title":"N Engl J Med"},{"key":"1702_CR28","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00262-011-1106-3","volume":"61","author":"Y Ge","year":"2012","unstructured":"Ge Y, Domschke C, Stoiber N, Schott S, Heil J, Rom J et al (2012) Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome. Cancer Immunol Immunother 61:353\u2013362. doi:\n                        10.1007\/s00262-011-1106-3","journal-title":"Cancer Immunol Immunother"},{"key":"1702_CR29","doi-asserted-by":"publisher","first-page":"8988","DOI":"10.1158\/0008-5472.CAN-10-2225","volume":"70","author":"JC Ghosh","year":"2010","unstructured":"Ghosh JC, Siegelin MD, Dohi T, Altieri DC (2010) Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells. Cancer Res 70:8988\u20138993. doi:\n                        10.1158\/0008-5472.CAN-10-2225","journal-title":"Cancer Res"},{"key":"1702_CR30","doi-asserted-by":"publisher","first-page":"5188","DOI":"10.1074\/jbc.M705904200","volume":"283","author":"JC Ghosh","year":"2008","unstructured":"Ghosh JC, Dohi T, Kang BH, Altieri DC (2008) Hsp60 regulation of tumor cell apoptosis. J Biol Chem 283:5188\u20135194. doi:\n                        10.1074\/jbc.M705904200","journal-title":"J Biol Chem"},{"key":"1702_CR31","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/jcb.22350","volume":"108","author":"CA Gilbert","year":"2009","unstructured":"Gilbert CA, Ross AH (2009) Cancer stem cells: cell culture, markers, and targets for new therapies. J Cell Biochem 108:1031\u20131038. doi:\n                        10.1002\/jcb.22350","journal-title":"J Cell Biochem"},{"key":"1702_CR32","doi-asserted-by":"publisher","first-page":"D784","DOI":"10.1093\/nar\/gku1166","volume":"43","author":"FF Gonzalez-Galarza","year":"2015","unstructured":"Gonzalez-Galarza FF, Takeshita LYC, Santos EJM, Kempson F, Maia MHT, da Silva Andrea, Soares Luciana et al (2015) Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations. Nucleic Acids Res 43:D784\u2013D788. doi:\n                        10.1093\/nar\/gku1166","journal-title":"Nucleic Acids Res"},{"key":"1702_CR33","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646\u2013674. doi:\n                        10.1016\/j.cell.2011.02.013","journal-title":"Cell"},{"key":"1702_CR34","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s00262-015-1674-8","volume":"64","author":"N Hashimoto","year":"2015","unstructured":"Hashimoto N, Tsuboi A, Kagawa N, Chiba Y, Izumoto S, Kinoshita M et al (2015) Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response. Cancer Immunol Immunother 64:707\u2013716. doi:\n                        10.1007\/s00262-015-1674-8","journal-title":"Cancer Immunol Immunother"},{"key":"1702_CR35","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/path.2894","volume":"224","author":"Y Hashimoto","year":"2011","unstructured":"Hashimoto Y, Kim DJ, Adams JC (2011) The roles of fascins in health and disease. J Pathol 224:289\u2013300. doi:\n                        10.1002\/path.2894","journal-title":"J Pathol"},{"key":"1702_CR36","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.2174\/0929867311209066050","volume":"19","author":"J He","year":"2012","unstructured":"He J, Liu Y, Lubman DM (2012) Targeting glioblastoma stem cells: cell surface markers. Curr Med Chem 19:6050\u20136055","journal-title":"Curr Med Chem"},{"key":"1702_CR37","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/ijc.10233","volume":"98","author":"C Herold-Mende","year":"2002","unstructured":"Herold-Mende C, Mueller MM, Bonsanto MM, Schmitt HP, Kunze S, Steiner HH (2002) Clinical impact and functional aspects of tenascin-C expression during glioma progression. Int J Cancer 98:362\u2013369","journal-title":"Int J Cancer"},{"key":"1702_CR38","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nrd3220","volume":"9","author":"CS Higano","year":"2010","unstructured":"Higano CS, Small EJ, Schellhammer P, Yasothan U, Gubernick S, Kirkpatrick P et al (2010) Sipuleucel-T. Nat Rev Drug Discov 9:513\u2013514. doi:\n                        10.1038\/nrd3220","journal-title":"Nat Rev Drug Discov"},{"key":"1702_CR39","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1002\/ijc.28233","volume":"133","author":"T Horn","year":"2013","unstructured":"Horn T, Grab J, Schusdziarra J, Schmid S, Maurer T, Nawroth R et al (2013) Antitumor T cell responses in bladder cancer are directed against a limited set of antigens and are modulated by regulatory T cells and routine treatment approaches. Int J Cancer 133:2145\u20132156. doi:\n                        10.1002\/ijc.28233","journal-title":"Int J Cancer"},{"key":"1702_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkn923","volume":"37","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki RA (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37:1\u201313. doi:\n                        10.1093\/nar\/gkn923","journal-title":"Nucleic Acids Res"},{"key":"1702_CR41","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44\u201357. doi:\n                        10.1038\/nprot.2008.211","journal-title":"Nat Protoc"},{"key":"1702_CR42","unstructured":"ImmunoCellular Therapeutics Ltd. (2013) ImmunoCellular Therapeutics Phase II Study Demonstrates That Glioblastoma Patients Live Longer Without Disease Progression When Treated With ICT-107. \n                        http:\/\/investors.imuc.com\/releasedetail.cfm?ReleaseID=813442\n                        \n                    . Accessed 26 Jan 2017"},{"key":"1702_CR43","doi-asserted-by":"publisher","first-page":"7983","DOI":"10.1158\/0008-5472.CAN-07-1493","volume":"67","author":"JS Jarboe","year":"2007","unstructured":"Jarboe JS, Johnson KR, Choi Y, Lonser RR, Park JK (2007) Expression of interleukin-13 receptor alpha2 in glioblastoma multiforme: implications for targeted therapies. Cancer Res 67:7983\u20137986. doi:\n                        10.1158\/0008-5472.CAN-07-1493","journal-title":"Cancer Res"},{"key":"1702_CR44","doi-asserted-by":"publisher","first-page":"356","DOI":"10.5966\/sctm.2013-0135","volume":"3","author":"J Ji","year":"2014","unstructured":"Ji J, Judkowski VA, Liu G, Wang H, Bunying A, Li Z et al (2014) Identification of novel human leukocyte antigen-A*0201-restricted, cytotoxic T lymphocyte epitopes on CD133 for cancer stem cell immunotherapy. Stem Cells Transl Med 3:356\u2013364. doi:\n                        10.5966\/sctm.2013-0135","journal-title":"Stem Cells Transl Med"},{"key":"1702_CR45","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1056\/NEJMoa1001294","volume":"363","author":"PW Kantoff","year":"2010","unstructured":"Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF et al (2010) Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 363:411\u2013422. doi:\n                        10.1056\/NEJMoa1001294","journal-title":"N Engl J Med"},{"key":"1702_CR46","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.aca.2008.04.043","volume":"627","author":"BO Keller","year":"2008","unstructured":"Keller BO, Sui J, Young AB, Whittal RM (2008) Interferences and contaminants encountered in modern mass spectrometry. Anal Chim Acta 627:71\u201381. doi:\n                        10.1016\/j.aca.2008.04.043","journal-title":"Anal Chim Acta"},{"key":"1702_CR47","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/00002371-200411000-00005","volume":"27","author":"T Kikuchi","year":"2004","unstructured":"Kikuchi T, Akasaki Y, Abe T, Fukuda T, Saotome H, Ryan JL et al (2004) Vaccination of glioma patients with fusions of dendritic and glioma cells and recombinant human interleukin 12. J Immunother 27:452\u2013459","journal-title":"J Immunother"},{"key":"1702_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11060-013-1265-5","volume":"116","author":"J Kmiecik","year":"2014","unstructured":"Kmiecik J, Zimmer J, Chekenya M (2014) Natural killer cells in intracranial neoplasms: presence and therapeutic efficacy against brain tumours. J Neurooncol 116:1\u20139. doi:\n                        10.1007\/s11060-013-1265-5","journal-title":"J Neurooncol"},{"key":"1702_CR49","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s00401-013-1195-5","volume":"126","author":"C Koelsche","year":"2013","unstructured":"Koelsche C, Sahm F, Capper D, Reuss D, Sturm D, Jones DTW et al (2013) Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system. Acta Neuropathol 126:907\u2013915. doi:\n                        10.1007\/s00401-013-1195-5","journal-title":"Acta Neuropathol"},{"key":"1702_CR50","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1056\/NEJMoa1500596","volume":"372","author":"DT Le","year":"2015","unstructured":"Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD et al (2015) PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 372:2509\u20132520. doi:\n                        10.1056\/NEJMoa1500596","journal-title":"N Engl J Med"},{"key":"1702_CR51","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.autrev.2008.12.002","volume":"8","author":"EY Lee","year":"2009","unstructured":"Lee EY, Lee Z-H, Song YW (2009) CXCL10 and autoimmune diseases. Autoimmun Rev 8:379\u2013383. doi:\n                        10.1016\/j.autrev.2008.12.002","journal-title":"Autoimmun Rev"},{"key":"1702_CR52","doi-asserted-by":"publisher","first-page":"5515","DOI":"10.1158\/1078-0432.CCR-05-0464","volume":"11","author":"LM Liau","year":"2005","unstructured":"Liau LM, Prins RM, Kiertscher SM, Odesa SK, Kremen TJ, Giovannone AJ et al (2005) Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment. Clin Cancer Res 11:5515\u20135525. doi:\n                        10.1158\/1078-0432.CCR-05-0464","journal-title":"Clin Cancer Res"},{"key":"1702_CR53","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1002\/cncr.21862","volume":"106","author":"M Li","year":"2006","unstructured":"Li M, Zhai Q, Bharadwaj U, Wang H, Li F, Fisher WE et al (2006) Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147. Cancer 106:2284\u20132294. doi:\n                        10.1002\/cncr.21862","journal-title":"Cancer"},{"key":"1702_CR54","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1476-4598-5-67","volume":"5","author":"G Liu","year":"2006","unstructured":"Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR et al (2006) Analysis of gene expression and chemoresistance of CD133\u00a0+\u00a0cancer stem cells in glioblastoma. Mol Cancer 5:67. doi:\n                        10.1186\/1476-4598-5-67","journal-title":"Mol Cancer"},{"key":"1702_CR55","doi-asserted-by":"publisher","first-page":"4296","DOI":"10.1158\/1078-0432.CCR-10-2557","volume":"17","author":"J Lohr","year":"2011","unstructured":"Lohr J, Ratliff T, Huppertz A, Ge Y, Dictus C, Ahmadi R et al (2011) Effector T-cell infiltration positively impacts survival of glioblastoma patients and is impaired by tumor-derived TGF-beta. Clin Cancer Res 17:4296\u20134308. doi:\n                        10.1158\/1078-0432.CCR-10-2557","journal-title":"Clin Cancer Res"},{"key":"1702_CR56","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97\u2013109. doi:\n                        10.1007\/s00401-007-0243-4","journal-title":"Acta Neuropathol"},{"key":"1702_CR57","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1440-1711.2005.01403.x","volume":"84","author":"GW Lynch","year":"2006","unstructured":"Lynch GW, Turville S, Carter B, Sloane AJ, Chan A, Muljadi N et al (2006) Marked differences in the structures and protein associations of lymphocyte and monocyte CD4: resolution of a novel CD4 isoform. Immunol Cell Biol 84:154\u2013165. doi:\n                        10.1111\/j.1440-1711.2005.01403.x","journal-title":"Immunol Cell Biol"},{"key":"1702_CR58","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2174\/138161282001140113124343","volume":"20","author":"A Mock","year":"2014","unstructured":"Mock A, Chiblak S, Herold-Mende C (2014) Lessons we learned from high-throughput and top-down systems biology analyses about glioma stem cells. Curr Pharm Des 20:66\u201372","journal-title":"Curr Pharm Des"},{"key":"1702_CR59","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/path.2400","volume":"216","author":"S Mussunoor","year":"2008","unstructured":"Mussunoor S, Murray GI (2008) The role of annexins in tumour development and progression. J Pathol 216:131\u2013140. doi:\n                        10.1002\/path.2400","journal-title":"J Pathol"},{"key":"1702_CR60","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1200\/JCO.2010.30.7744","volume":"29","author":"H Okada","year":"2011","unstructured":"Okada H, Kalinski P, Ueda R, Hoji A, Kohanbash G, Donegan TE et al (2011) Induction of CD8\u00a0+\u00a0T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in patients with recurrent malignant glioma. J Clin Oncol 29:330\u2013336. doi:\n                        10.1200\/JCO.2010.30.7744","journal-title":"J Clin Oncol"},{"key":"1702_CR61","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1479-5876-5-67","volume":"5","author":"H Okada","year":"2007","unstructured":"Okada H, Lieberman FS, Walter KA, Lunsford LD, Kondziolka DS, Bejjani GK et al (2007) Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas. J Transl Med 5:67. doi:\n                        10.1186\/1479-5876-5-67","journal-title":"J Transl Med"},{"key":"1702_CR62","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/cncr.25581","volume":"117","author":"R Pallini","year":"2011","unstructured":"Pallini R, Ricci-Vitiani L, Montano N, Mollinari C, Biffoni M, Cenci T et al (2011) Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis. Cancer 117:162\u2013174. doi:\n                        10.1002\/cncr.25581","journal-title":"Cancer"},{"key":"1702_CR63","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF02483447","volume":"20","author":"A Peraud","year":"2003","unstructured":"Peraud A, Mondal S, Hawkins C, Mastronardi M, Bailey K, Rutka JT (2003) Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades. Brain Tumor Pathol 20:53\u201358","journal-title":"Brain Tumor Pathol"},{"key":"1702_CR64","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18<3551:AID-ELPS3551>3.0.CO;2-2","volume":"20","author":"DN Perkins","year":"1999","unstructured":"Perkins DN, Pappin DJ, Creasy DM, Cottrell JS (1999) Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 20:3551\u20133567. doi:\n                        10.1002\/(SICI)1522-2683(19991201)20:18<3551:AID-ELPS3551>3.0.CO;2-2","journal-title":"Electrophoresis"},{"key":"1702_CR65","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nri2470","volume":"9","author":"M Perretti","year":"2009","unstructured":"Perretti M, D\u2019Acquisto F (2009) Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol 9:62\u201370. doi:\n                        10.1038\/nri2470","journal-title":"Nat Rev Immunol"},{"key":"1702_CR66","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00262-012-1319-0","volume":"62","author":"S Phuphanich","year":"2013","unstructured":"Phuphanich S, Wheeler CJ, Rudnick JD, Mazer M, Wang H, Nuno MA et al (2013) Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma. Cancer Immunol Immunother 62:125\u2013135. doi:\n                        10.1007\/s00262-012-1319-0","journal-title":"Cancer Immunol Immunother"},{"key":"1702_CR67","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/nature13904","volume":"515","author":"T Powles","year":"2014","unstructured":"Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C et al (2014) MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 515:558\u2013562. doi:\n                        10.1038\/nature13904","journal-title":"Nature"},{"key":"1702_CR68","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1158\/0008-5472.CAN-14-2415","volume":"75","author":"S Prasad","year":"2015","unstructured":"Prasad S, Gaedicke S, Machein M, Mittler G, Braun F, Hettich M et al (2015) Effective eradication of glioblastoma stem cells by local application of an AC133\/CD133-specific T-cell-engaging antibody and CD8 T cells. Cancer Res 75:2166\u20132176. doi:\n                        10.1158\/0008-5472.CAN-14-2415","journal-title":"Cancer Res"},{"key":"1702_CR69","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0168-9525(97)01103-7","volume":"13","author":"M Rebhan","year":"1997","unstructured":"Rebhan M, Chalifa-Caspi V, Prilusky J, Lancet D (1997) GeneCards: integrating information about genes, proteins and diseases. Trends Genet 13:163","journal-title":"Trends Genet"},{"key":"1702_CR70","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/35102167","volume":"414","author":"T Reya","year":"2001","unstructured":"Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414:105\u2013111. doi:\n                        10.1038\/35102167","journal-title":"Nature"},{"key":"1702_CR71","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1056\/NEJMra050541","volume":"353","author":"T Rhen","year":"2005","unstructured":"Rhen T, Cidlowski JA (2005) Antiinflammatory action of glucocorticoids\u2013new mechanisms for old drugs. N Engl J Med 353:1711\u20131723. doi:\n                        10.1056\/NEJMra050541","journal-title":"N Engl J Med"},{"key":"1702_CR72","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.anndiagpath.2005.07.005","volume":"9","author":"AA Roma","year":"2005","unstructured":"Roma AA, Prayson RA (2005) Fascin expression in 90 patients with glioblastoma multiforme. Ann Diagn Pathol 9:307\u2013311. doi:\n                        10.1016\/j.anndiagpath.2005.07.005","journal-title":"Ann Diagn Pathol"},{"key":"1702_CR73","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1007\/s00401-015-1519-8","volume":"131","author":"F Sahm","year":"2016","unstructured":"Sahm F, Schrimpf D, Jones DTW, Meyer J, Kratz A, Reuss D et al (2016) Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets. Acta Neuropathol 131:903\u2013910. doi:\n                        10.1007\/s00401-015-1519-8","journal-title":"Acta Neuropathol"},{"key":"1702_CR74","doi-asserted-by":"publisher","first-page":"4722","DOI":"10.1200\/JCO.2010.28.6963","volume":"28","author":"JH Sampson","year":"2010","unstructured":"Sampson JH, Heimberger AB, Archer GE, Aldape KD, Friedman AH, Friedman HS et al (2010) Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol 28:4722\u20134729. doi:\n                        10.1200\/JCO.2010.28.6963","journal-title":"J Clin Oncol"},{"key":"1702_CR75","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1093\/neuonc\/nou348","volume":"17","author":"J Schuster","year":"2015","unstructured":"Schuster J, Lai RK, Recht LD, Reardon DA, Paleologos NA, Groves MD et al (2015) A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study. Neuro Oncol 17:854\u2013861. doi:\n                        10.1093\/neuonc\/nou348","journal-title":"Neuro Oncol"},{"key":"1702_CR76","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/nri2274","volume":"8","author":"RA Seder","year":"2008","unstructured":"Seder RA, Darrah PA, Roederer M (2008) T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 8:247\u2013258. doi:\n                        10.1038\/nri2274","journal-title":"Nat Rev Immunol"},{"key":"1702_CR77","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nature03128","volume":"432","author":"SK Singh","year":"2004","unstructured":"Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T et al (2004) Identification of human brain tumour initiating cells. Nature 432:396\u2013401. doi:\n                        10.1038\/nature03128","journal-title":"Nature"},{"key":"1702_CR78","first-page":"5821","volume":"63","author":"SK Singh","year":"2003","unstructured":"Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J et al (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res 63:5821\u20135828","journal-title":"Cancer Res"},{"key":"1702_CR79","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1056\/NEJMoa1406498","volume":"371","author":"A Snyder","year":"2014","unstructured":"Snyder A, Makarov V, Merghoub T, Yuan J, Zaretsky JM, Desrichard A et al (2014) Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 371:2189\u20132199. doi:\n                        10.1056\/NEJMoa1406498","journal-title":"N Engl J Med"},{"key":"1702_CR80","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/j.drudis.2014.05.002","volume":"19","author":"PA Sotiropoulou","year":"2014","unstructured":"Sotiropoulou PA, Christodoulou MS, Silvani A, Herold-Mende C, Passarella D (2014) Chemical approaches to targeting drug resistance in cancer stem cells. Drug Discov Today 19:1547\u20131562. doi:\n                        10.1016\/j.drudis.2014.05.002","journal-title":"Drug Discov Today"},{"key":"1702_CR81","doi-asserted-by":"publisher","first-page":"4272","DOI":"10.1200\/JCO.2004.09.038","volume":"22","author":"HH Steiner","year":"2004","unstructured":"Steiner HH, Bonsanto MM, Beckhove P, Brysch M, Geletneky K, Ahmadi R et al (2004) Antitumor vaccination of patients with glioblastoma multiforme: a pilot study to assess feasibility, safety, and clinical benefit. J Clin Oncol 22:4272\u20134281. doi:\n                        10.1200\/JCO.2004.09.038","journal-title":"J Clin Oncol"},{"key":"1702_CR82","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa043330","volume":"352","author":"R Stupp","year":"2005","unstructured":"Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987\u2013996. doi:\n                        10.1056\/NEJMoa043330","journal-title":"N Engl J Med"},{"key":"1702_CR83","doi-asserted-by":"publisher","first-page":"D204","DOI":"10.1093\/nar\/gku989","volume":"43","author":"The UniProt Consortium","year":"2015","unstructured":"The UniProt Consortium (2015) UniProt: a hub for protein information. Nucleic Acids Res 43:D204\u2013D212. doi:\n                        10.1093\/nar\/gku989","journal-title":"Nucleic Acids Res"},{"key":"1702_CR84","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1074\/mcp.M500279-MCP200","volume":"4","author":"M Uhlen","year":"2005","unstructured":"Uhlen M, Bjorling E, Agaton C, Szigyarto CA-K, Amini B, Andersen E et al (2005) A human protein atlas for normal and cancer tissues based on antibody proteomics. Mol Cell Proteomics 4:1920\u20131932. doi:\n                        10.1074\/mcp.M500279-MCP200","journal-title":"Mol Cell Proteomics"},{"key":"1702_CR85","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ccr.2009.12.020","volume":"17","author":"RGW Verhaak","year":"2010","unstructured":"Verhaak RGW, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD et al (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17:98\u2013110. doi:\n                        10.1016\/j.ccr.2009.12.020","journal-title":"Cancer Cell"},{"key":"1702_CR86","doi-asserted-by":"publisher","first-page":"D405","DOI":"10.1093\/nar\/gku938","volume":"43","author":"R Vita","year":"2015","unstructured":"Vita R, Overton JA, Greenbaum JA, Ponomarenko J, Clark JD, Cantrell JR et al (2015) The immune epitope database (IEDB) 3.0. Nucleic Acids Res 43:D405\u2013D412. doi:\n                        10.1093\/nar\/gku938","journal-title":"Nucleic Acids Res"},{"key":"1702_CR87","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1158\/1078-0432.CCR-07-4875","volume":"14","author":"S Vleeschouwer de","year":"2008","unstructured":"de Vleeschouwer S, Fieuws S, Rutkowski S, van Calenbergh F, van Loon J, Goffin J et al (2008) Postoperative adjuvant dendritic cell-based immunotherapy in patients with relapsed glioblastoma multiforme. Clin Cancer Res 14:3098\u20133104. doi:\n                        10.1158\/1078-0432.CCR-07-4875","journal-title":"Clin Cancer Res"},{"key":"1702_CR88","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1038\/nm.2883","volume":"18","author":"S Walter","year":"2012","unstructured":"Walter S, Weinschenk T, Stenzl A, Zdrojowy R, Pluzanska A, Szczylik C et al (2012) Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat Med 18:1254\u20131261. doi:\n                        10.1038\/nm.2883","journal-title":"Nat Med"},{"key":"1702_CR89","doi-asserted-by":"publisher","first-page":"5955","DOI":"10.1158\/0008-5472.CAN-07-5973","volume":"68","author":"CJ Wheeler","year":"2008","unstructured":"Wheeler CJ, Black KL, Liu G, Mazer M, X-x Zhang, Pepkowitz S et al (2008) Vaccination elicits correlated immune and clinical responses in glioblastoma multiforme patients. Cancer Res 68:5955\u20135964. doi:\n                        10.1158\/0008-5472.CAN-07-5973","journal-title":"Cancer Res"},{"key":"1702_CR90","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1093\/neuonc\/noq082","volume":"12","author":"A Wu","year":"2010","unstructured":"Wu A, Wei J, Kong L-Y, Wang Y, Priebe W, Qiao W et al (2010) Glioma cancer stem cells induce immunosuppressive macrophages\/microglia. Neuro Oncol 12:1113\u20131125. doi:\n                        10.1093\/neuonc\/noq082","journal-title":"Neuro Oncol"},{"key":"1702_CR91","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/ng.2938","volume":"46","author":"G Wu","year":"2014","unstructured":"Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y et al (2014) The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet 46:444\u2013450. doi:\n                        10.1038\/ng.2938","journal-title":"Nat Genet"},{"key":"1702_CR92","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1002\/stem.102","volume":"27","author":"Q Xu","year":"2009","unstructured":"Xu Q, Liu G, Yuan X, Xu M, Wang H, Ji J et al (2009) Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens. Stem Cells 27:1734\u20131740. doi:\n                        10.1002\/stem.102","journal-title":"Stem Cells"},{"key":"1702_CR93","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1158\/1078-0432.CCR-05-0120","volume":"11","author":"R Yamanaka","year":"2005","unstructured":"Yamanaka R, Homma J, Yajima N, Tsuchiya N, Sano M, Kobayashi T et al (2005) Clinical evaluation of dendritic cell vaccination for patients with recurrent glioma: results of a clinical phase I\/II trial. Clin Cancer Res 11:4160\u20134167. doi:\n                        10.1158\/1078-0432.CCR-05-0120","journal-title":"Clin Cancer Res"},{"key":"1702_CR94","first-page":"842","volume":"61","author":"JS Yu","year":"2001","unstructured":"Yu JS, Wheeler CJ, Zeltzer PM, Ying H, Finger DN, Lee PK et al (2001) Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration. Cancer Res 61:842\u2013847","journal-title":"Cancer Res"},{"key":"1702_CR95","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/nrd2137","volume":"8","author":"B-BS Zhou","year":"2009","unstructured":"Zhou B-BS, Zhang H, Damelin M, Geles KG, Grindley JC, Dirks PB (2009) Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov 8:806\u2013823. doi:\n                        10.1038\/nrd2137","journal-title":"Nat Rev Drug Discov"},{"key":"1702_CR96","doi-asserted-by":"publisher","first-page":"171","DOI":"10.18632\/oncotarget.2767","volume":"6","author":"X Zhu","year":"2015","unstructured":"Zhu X, Prasad S, Gaedicke S, Hettich M, Firat E, Niedermann G (2015) Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57. Oncotarget 6:171\u2013184. doi:\n                        10.18632\/oncotarget.2767","journal-title":"Oncotarget"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-017-1702-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-017-1702-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-017-1702-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T07:00:54Z","timestamp":1499842854000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-017-1702-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,22]]},"references-count":96,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["1702"],"URL":"https:\/\/doi.org\/10.1007\/s00401-017-1702-1","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,22]]}}}