{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:22:25Z","timestamp":1790749345403,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS067283"],"award-info":[{"award-number":["NS067283"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s00401-017-1732-8","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T07:57:43Z","timestamp":1496822263000},"page":"729-748","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington\u2019s disease"],"prefix":"10.1007","volume":"134","author":[{"given":"Junghee","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jin","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunha","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Jae","family":"Hyeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soojin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jae","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoenjoo","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Joon","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunah","family":"Choo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ae Nim","family":"Pae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Sang","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil W.","family":"Kowall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"1732_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0197-0186(96)00136-2","volume":"31","author":"AM Beckmann","year":"1997","unstructured":"Beckmann AM, Wilce PA (1997) Egr transcription factors in the nervous system. Neurochem Int 31:477\u2013510","journal-title":"Neurochem Int"},{"key":"1732_CR2","first-page":"984","volume":"30","author":"BK Bhuyan","year":"1970","unstructured":"Bhuyan BK, Reusser F (1970) Comparative biological activity of nogalamycin and its analogs. Cancer Res 30:984\u2013989","journal-title":"Cancer Res"},{"key":"1732_CR3","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.pneurobio.2007.03.004","volume":"83","author":"JH Cha","year":"2007","unstructured":"Cha JH (2007) Transcriptional signatures in Huntington\u2019s disease. Prog Neurobiol 83:228\u2013248","journal-title":"Prog Neurobiol"},{"key":"1732_CR4","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/ana.71","volume":"49","author":"S Chatterjee","year":"2001","unstructured":"Chatterjee S, Zaman K, Ryu H, Conforto A, Ratan RR (2001) Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons. Ann Neurol 49:345\u2013354","journal-title":"Ann Neurol"},{"key":"1732_CR5","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1126\/science.1072613","volume":"296","author":"AW Dunah","year":"2002","unstructured":"Dunah AW, Jeong H, Griffin A, Kim YM, Standaert DG, Hersch SM, Mouradian MM, Young AB, Tanese N, Krainc D (2002) Sp1 and TAFII130 transcriptional activity disrupted in early Huntington\u2019s disease. Science 296:2238\u20132243","journal-title":"Science"},{"key":"1732_CR6","doi-asserted-by":"crossref","first-page":"9418","DOI":"10.1523\/JNEUROSCI.23-28-09418.2003","volume":"23","author":"RJ Ferrante","year":"2003","unstructured":"Ferrante RJ, Kubilus JK, Lee J, Ryu H, Beesen A, Zucker B, Smith K, Kowall NW, Ratan RR, Luthi-Carter R, Hersch SM (2003) Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington\u2019s disease mice. J Neurosci 23:9418\u20139427","journal-title":"J Neurosci"},{"key":"1732_CR7","doi-asserted-by":"publisher","first-page":"10335","DOI":"10.1523\/JNEUROSCI.2599-04.2004","volume":"24","author":"RJ Ferrante","year":"2004","unstructured":"Ferrante RJ, Ryu H, Kubilus JK, D\u2019Mello S, Sugars KL, Lee JH, Lu P, Smith K, Browne SE, Beal MF et al (2004) Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington\u2019s disease. J Neurosci 24:10335\u201310342","journal-title":"J Neurosci"},{"key":"1732_CR8","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/0009-2797(83)90018-2","volume":"46","author":"R Ganguli","year":"1983","unstructured":"Ganguli R, Chowdhury K, Chakraborty B, Neogy RK (1983) Interaction of nogalamycin with chromatin. Chem Biol Interact 46:347\u2013352","journal-title":"Chem Biol Interact"},{"key":"1732_CR9","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1074\/jbc.M410210200","volume":"280","author":"G Gardian","year":"2005","unstructured":"Gardian G, Browne SE, Choi DK, Klivenyi P, Ryu H, Gregorio J, Kubilus JK, Brett Langley B, Ratan RR, Ferrante RJ, Beal MF (2005) Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington\u2019s disease. J Biol Chem 280:556\u2013563","journal-title":"J Biol Chem"},{"key":"1732_CR10","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/sj.bjc.6601575","volume":"90","author":"SB Hake","year":"2004","unstructured":"Hake SB, Xiao A, Allis CD (2004) Linking the epigenetic \u201clanguage\u201d of covalent histone modifications to cancer. Br J Cancer 90:761\u2013769","journal-title":"Br J Cancer"},{"key":"1732_CR11","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0301-0082(96)00021-4","volume":"50","author":"DG Herrera","year":"1996","unstructured":"Herrera DG, Robertson HA (1996) Activation of c-fos in the brain. Progr Neurobiol 50:83\u2013107","journal-title":"Progr Neurobiol"},{"key":"1732_CR12","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1073\/pnas.0437870100","volume":"100","author":"E Hockly","year":"2003","unstructured":"Hockly E, Richon VM, Woodman B et al (2003) Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington\u2019s disease. Proc Natl Acad Sci USA 100:2041\u20132046","journal-title":"Proc Natl Acad Sci USA"},{"key":"1732_CR13","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"Huntington\u2019s Disease Collaborative Research Group","year":"1993","unstructured":"Huntington\u2019s Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. Cell 72:971\u2013983","journal-title":"Cell"},{"key":"1732_CR14","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1093\/nar\/gkt1041","volume":"42","author":"YJ Hwang","year":"2014","unstructured":"Hwang YJ, Han DH, Kim KY, Min S-J, Kowall NW, Yang L, Lee J, Kim YS, Ryu H (2014) ESET methylates UBF at K232\/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription. Nucleic Acids Res 42:1628\u20131643","journal-title":"Nucleic Acids Res"},{"key":"1732_CR15","doi-asserted-by":"publisher","first-page":"5280","DOI":"10.1093\/hmg\/dds379","volume":"21","author":"H Jia","year":"2012","unstructured":"Jia H, Kast RJ, Steffan JS, Thomas EA (2012) Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington\u2019s disease mice: implications for the ubiquitin-proteasomal and autophagy systems. Hum Mol Genet 21:5280\u20135293","journal-title":"Hum Mol Genet"},{"key":"1732_CR16","doi-asserted-by":"publisher","first-page":"E56","DOI":"10.1073\/pnas.1415195112","volume":"112","author":"H Jia","year":"2015","unstructured":"Jia H, Morris CD, Williams RM, Loring JF, Thomas EA (2015) HDAC inhibition imparts beneficial transgenerational effects in Huntington\u2019s disease mice via altered DNA and histone methylation. Proc Natl Acad Sci USA 112:E56\u2013E64","journal-title":"Proc Natl Acad Sci USA"},{"key":"1732_CR17","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.nbd.2012.01.016","volume":"46","author":"H Jia","year":"2012","unstructured":"Jia H, Pallos J, Jacques V et al (2012) Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine elicited phenotypes in model systems of Huntington\u2019s disease. Neurobiol Dis 46:351\u2013361","journal-title":"Neurobiol Dis"},{"key":"1732_CR18","doi-asserted-by":"publisher","first-page":"D623","DOI":"10.1093\/nar\/gkn698","volume":"37","author":"A Kamburov","year":"2009","unstructured":"Kamburov A, Wierling C, Lehrach H, Herwig R (2009) ConsensusPathDB\u2014a database for integrating human functional interaction networks. Nucleic Acids Res 37:D623\u2013D628","journal-title":"Nucleic Acids Res"},{"key":"1732_CR19","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/nrd2681","volume":"7","author":"AG Kazantsev","year":"2008","unstructured":"Kazantsev AG, Thompson LM (2008) Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat Rev Drug Discov 7:854\u2013868","journal-title":"Nat Rev Drug Discov"},{"key":"1732_CR20","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1126\/science.287.5459.1837","volume":"287","author":"P Kazemi-Esfarjani","year":"2000","unstructured":"Kazemi-Esfarjani P, Benzer S (2000) Genetic suppression of polyglutamine toxicity in Drosophila. Science 287:1837\u20131840","journal-title":"Science"},{"key":"1732_CR21","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1093\/hmg\/ddn067","volume":"17","author":"J Lee","year":"2008","unstructured":"Lee J, Hagerty S, Cormier KA, Kung AL, Ferrante RJ, Ryu H (2008) Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation. Hum Mol Genet 17:1774\u20131782","journal-title":"Hum Mol Genet"},{"key":"1732_CR22","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/cdd.2011.196","volume":"19","author":"J Lee","year":"2012","unstructured":"Lee J, Hong YK, Jeon GS, Hwang YJ, Kim KY, Seon KH, Jung M-K, Picketts DJ, Kowall NW, Cho KS, Ryu H (2012) ATRX induction by mutant huntingtin via Cdx-2 modulates heterochromatin condensation and pathology in Huntington\u2019s disease. Cell Death Differ 19:1109\u20131116","journal-title":"Cell Death Differ"},{"key":"1732_CR23","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1007\/s13311-013-0206-5","volume":"10","author":"J Lee","year":"2013","unstructured":"Lee J, Hwang YJ, Kim KY, Kowall NW, Ryu H (2013) Epigenetic mechanisms of neurodegeneration in Huntington\u2019s disease. Neurotherapeutics 10:664\u2013676","journal-title":"Neurotherapeutics"},{"key":"1732_CR24","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s00401-013-1103-z","volume":"125","author":"J Lee","year":"2013","unstructured":"Lee J, Hwang YJ, Shin J-Y, Lee W-C, Wie J, Kim KY, Lee MY, Hwang D, Ratan RR, Kowall NW, So I, Kim J-I, Ryu H (2013) Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca2+ signaling in Huntington\u2019s disease. Acta Neuropathol 125:727\u2013739","journal-title":"Acta Neuropathol"},{"key":"1732_CR25","doi-asserted-by":"publisher","first-page":"40398","DOI":"10.1074\/jbc.C500140200","volume":"280","author":"J Lee","year":"2005","unstructured":"Lee J, Kim CH, Simon D, Aminova L, Andreyev A, Kushnareva Y, Murphy A, Lonze BE, Kim KS, Ginty DD, Ferrante RJ, Ryu H, Ratan RR (2005) Mitochondrial CREB regulates mitochondrial gene expression and neuronal survival. J Biol Chem 280:40398\u201340401","journal-title":"J Biol Chem"},{"key":"1732_CR26","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00401-010-0788-5","volume":"121","author":"J Lee","year":"2011","unstructured":"Lee J, Kosaras B, Del Signore SJ, Cormier K, McKee A, Ratan RR, Kowall NW, Ryu H (2011) Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington\u2019s disease mice. Acta Neuropathol 121:487\u2013498","journal-title":"Acta Neuropathol"},{"key":"1732_CR27","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0163-7258(91)90080-6","volume":"51","author":"LH Li","year":"1991","unstructured":"Li LH, Krueger WC (1991) The biochemical pharmacology of nogalamycin and its derivatives. Pharmacol Ther 51:239\u2013255","journal-title":"Pharmacol Ther"},{"key":"1732_CR28","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1093\/hmg\/9.9.1259","volume":"9","author":"R Luthi-Carter","year":"2000","unstructured":"Luthi-Carter R, Strand A, Peters NL, Solano SM, Hollingsworth ZR, Menon AS, Frey AS, Spektor BS, Penney EB, Schilling G, Ross CA, Borchelt DR, Tapscott SJ, Young AB, Cha JH, Olson JM (2000) Decreased expression of striatal signaling genes in a mouse model of Huntington\u2019s disease. Hum Mol Genet 9:1259\u20131271","journal-title":"Hum Mol Genet"},{"key":"1732_CR29","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"L Mangiarini","year":"1996","unstructured":"Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, Bates GP (1996) Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87:493\u2013506","journal-title":"Cell"},{"key":"1732_CR30","doi-asserted-by":"publisher","first-page":"15179","DOI":"10.1073\/pnas.261400698","volume":"98","author":"A McCampbell","year":"2001","unstructured":"McCampbell A, Taye AA, Whitty L, Penney E, Steffan JS, Fischbeck KH (2001) Histone deacetylase inhibitors reduce polyglutamine toxicity. Proc Natl Acad Sci USA 98:15179\u201315184","journal-title":"Proc Natl Acad Sci USA"},{"key":"1732_CR31","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/1040-8428(91)90017-7","volume":"11","author":"FM Muggia","year":"1991","unstructured":"Muggia FM, Green MD (1991) New anthracycline antitumor antibiotics. Crit Rev Oncol Hematol 11:43\u201364","journal-title":"Crit Rev Oncol Hematol"},{"key":"1732_CR32","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1126\/science.1056784","volume":"291","author":"FC Nucifora Jr","year":"2001","unstructured":"Nucifora FC Jr, Sasaki M, Peters MF, Huang H, Cooper JK, Yamada M, Takahashi H, Tsuji S, Troncoso J, Dawson VL, Dawson TM, Ross CA (2001) Interference by huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity. Science 291:2423\u20132428","journal-title":"Science"},{"key":"1732_CR33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0009-2797(86)90049-9","volume":"57","author":"CK Panda","year":"1986","unstructured":"Panda CK, Choudhury K, Neogy RK (1986) Preferential binding of adriamycin and nogalamycin to DNase-I hypersensitive sites of Sarcoma-180 chromatin. Chem Biol Interact 57:65\u201372","journal-title":"Chem Biol Interact"},{"key":"1732_CR34","doi-asserted-by":"publisher","first-page":"8735","DOI":"10.1093\/nar\/14.22.8735","volume":"14","author":"J Portugal","year":"1986","unstructured":"Portugal J, Waring MJ (1986) Antibiotics which can alter the rotational orientation of nucleosome core DNA. Nucleic Acids Res 14:8735\u20138754","journal-title":"Nucleic Acids Res"},{"key":"1732_CR35","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0092-8674(02)00644-X","volume":"108","author":"EJ Richards","year":"2002","unstructured":"Richards EJ, Elgin SC (2002) Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. Cell 108:489\u2013500","journal-title":"Cell"},{"key":"1732_CR36","first-page":"2235","volume":"41","author":"CL Richardson","year":"1981","unstructured":"Richardson CL, Grant AD, Schpok SL, Krueger WC, Li LH (1981) Template specificity of DNA binding by nogalamycin and its analogs utilizing competitive fluorescence polarization. Cancer Res 41:2235\u20132240","journal-title":"Cancer Res"},{"key":"1732_CR37","doi-asserted-by":"publisher","first-page":"19176","DOI":"10.1073\/pnas.0606373103","volume":"103","author":"H Ryu","year":"2006","unstructured":"Ryu H, Lee J, Hagerty SW, Soh BY, McAlpin SE, Cormier KA, Smith KM, Ferrante RJ (2006) ESET\/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington\u2019s disease. Proc Natl Acad Sci USA 103:19176\u201319181","journal-title":"Proc Natl Acad Sci USA"},{"key":"1732_CR38","doi-asserted-by":"publisher","first-page":"13915","DOI":"10.1073\/pnas.0502878102","volume":"102","author":"H Ryu","year":"2005","unstructured":"Ryu H, Lee J, Impey S, Ratan RR, Ferrante RJ (2005) Antioxidants modulate mitochondrial protein kinase A and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons. Proc Natl Acad Sci USA 102:13915\u201313920","journal-title":"Proc Natl Acad Sci USA"},{"key":"1732_CR39","doi-asserted-by":"publisher","first-page":"4281","DOI":"10.1073\/pnas.0737363100","volume":"100","author":"H Ryu","year":"2003","unstructured":"Ryu H, Lee JH, Olofsson BA, Mwidau A, Deodoglu A, Escudero M, Flemington E, Azizkhan-Clifford J, Ferrante RJ, Ratan RR (2003) Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proc Natl Acad Sci USA 100:4281\u20134286","journal-title":"Proc Natl Acad Sci USA"},{"key":"1732_CR40","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1093\/hmg\/ddm078","volume":"11","author":"G Sadri-Vakili","year":"2007","unstructured":"Sadri-Vakili G, Bouzou B, Benn CL, Kim MO, Chawla P, Overland RP, Glajch KE, Xia E, Qiu Z, Hersch SM, Clark TW, Yohrling GJ, Cha JH (2007) Histones associated with downregulated genes are hypo-acetylated in Huntington\u2019s disease models. Hum Mol Genet 11:1293\u20131306","journal-title":"Hum Mol Genet"},{"key":"1732_CR41","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/ncpneuro0199","volume":"2","author":"G Sadri-Vakili","year":"2006","unstructured":"Sadri-Vakili G, Cha JH (2006) Mechanisms of disease: histone modifications in Huntington\u2019s disease. Nat Clin Pract Neurol 2:330\u2013338","journal-title":"Nat Clin Pract Neurol"},{"key":"1732_CR42","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1101\/gad.973302","volume":"16","author":"DC Schultz","year":"2002","unstructured":"Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd (2002) SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev 16:919\u2013932","journal-title":"Genes Dev"},{"key":"1732_CR43","doi-asserted-by":"publisher","first-page":"4340","DOI":"10.1021\/bi00412a022","volume":"27","author":"MS Searle","year":"1998","unstructured":"Searle MS, Hall JG, Denny WA, Wakelin LP (1998) NMR studies of the interaction of the antibiotic nogalamycin with the hexadeoxyribonucleotide duplex d(5\u2032-GCATGC)2. Biochemistry 27:4340\u20134349","journal-title":"Biochemistry"},{"key":"1732_CR44","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1006\/jmbi.1996.0572","volume":"263","author":"CK Smith","year":"1996","unstructured":"Smith CK, Brannigan JA, Moore MH (1996) Factors affecting DNA sequence selectivity of nogalamycin intercalation: the crystal structure of d(TGTACA)2-nogalamycin2. J Mol Biol 263:237\u2013258","journal-title":"J Mol Biol"},{"key":"1732_CR45","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/S0169-328X(02)00216-4","volume":"102","author":"BS Spektor","year":"2002","unstructured":"Spektor BS, Miller DW, Hollingsworth ZR, Kaneko YA, Solano SM, Johnson JM, Penney JB Jr, Young AB, Luthi-Carter R (2002) Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington\u2019s disease. Brain Res Mol Brain Res 102:118\u2013128","journal-title":"Brain Res Mol Brain Res"},{"key":"1732_CR46","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1093\/hmg\/ddm064","volume":"16","author":"EC Stack","year":"2007","unstructured":"Stack EC, Del Signore SJ, Matson S, Goodrich SC, Markey AL, Cormier K, Hagerty SW, Soh BY, Smith K, Ryu H, Ferrante RJ (2007) Modulation of nucleosome dynamics in Huntington\u2019s disease. Hum Mol Genet 16:1164\u20131175","journal-title":"Hum Mol Genet"},{"key":"1732_CR47","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1002\/cne.20680","volume":"490","author":"EC Stack","year":"2005","unstructured":"Stack EC, Kubilus JK, Smith K, Cormier K, Del Signore SJ, Guelin E, Ryu H, Hersch SM, Ferrante RJ (2005) Chronology of behavioral symptoms and neuropathological sequela in R6\/2 Huntington\u2019s disease transgenic mice. J Comp Neurol 490:354\u2013370","journal-title":"J Comp Neurol"},{"key":"1732_CR48","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/35099568","volume":"413","author":"JS Steffan","year":"2001","unstructured":"Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM (2001) Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413:739\u2013743","journal-title":"Nature"},{"key":"1732_CR49","doi-asserted-by":"publisher","first-page":"6763","DOI":"10.1073\/pnas.100110097","volume":"97","author":"JS Steffan","year":"2000","unstructured":"Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, Gohler H, Wanker EE, Bates GP, Housman DE, Thompson LM (2000) The Huntington\u2019s disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci USA 97:6763\u20136768","journal-title":"Proc Natl Acad Sci USA"},{"key":"1732_CR50","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0168-9525(03)00074-X","volume":"19","author":"KL Sugars","year":"2003","unstructured":"Sugars KL, Rubinsztein DC (2003) Transcriptional abnormalities in Huntington disease. Trends Genet 19:233\u2013238","journal-title":"Trends Genet"},{"key":"1732_CR51","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1101\/gad.1087503","volume":"17","author":"JP Taylor","year":"2003","unstructured":"Taylor JP, Taye AA, Campbell C, Kazemi-Esfarjani P, Fischbeck KH, Min KT (2003) Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes Dev 17:1463\u20131468","journal-title":"Genes Dev"},{"key":"1732_CR52","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","volume":"9","author":"F Trettel","year":"2000","unstructured":"Trettel F, Rigamonti D, Hilditch-Maguire P, Wheeler VC, Sharp AH, Persichetti F, Cattaneo E, MacDonald ME (2000) Dominant phenotypes produced by the HD mutation in STHdh (Q111) striatal cell. Hum Mol Genet 9:2799\u20132809","journal-title":"Hum Mol Genet"},{"key":"1732_CR53","doi-asserted-by":"publisher","first-page":"12691","DOI":"10.1073\/pnas.0705534104","volume":"105","author":"TY Tzeng","year":"2007","unstructured":"Tzeng TY, Lee CH, Chan LW, Shen CK (2007) Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1. Proc Natl Acad Sci USA 105:12691\u201312696","journal-title":"Proc Natl Acad Sci USA"},{"key":"1732_CR54","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.molcel.2005.06.011","volume":"19","author":"CR Vakoc","year":"2005","unstructured":"Vakoc CR, Mandat SA, Olenchock BA, Blobel GA (2005) Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Mol Cell 19:381\u2013391","journal-title":"Mol Cell"},{"key":"1732_CR55","doi-asserted-by":"publisher","first-page":"9185","DOI":"10.1128\/MCB.01529-06","volume":"26","author":"CR Vakoc","year":"2006","unstructured":"Vakoc CR, Sachdeva MM, Wang H, Blobel GA (2006) Profile of histone lysine methylation across transcribed mammalian chromatin. Mol Cell Biol 26:9185\u20139195","journal-title":"Mol Cell Biol"},{"key":"1732_CR56","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.molcel.2003.08.007","volume":"12","author":"H Wang","year":"2003","unstructured":"Wang H, An W, Cao R, Xia L, Erdjument-Bromage H, Chatton B, Tempst P, Roeder RG, Zhang Y (2003) mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell 12:475\u2013487","journal-title":"Mol Cell"},{"key":"1732_CR57","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1038\/sj.onc.1210895","volume":"27","author":"JK Wiencke","year":"2008","unstructured":"Wiencke JK, Zheng S, Morrison Z, Yeh R-F (2008) Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells. Oncogene 27:2412\u20132421","journal-title":"Oncogene"},{"key":"1732_CR58","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1091\/mbc.E04-11-0997","volume":"16","author":"R Wu","year":"2005","unstructured":"Wu R, Terry AV, Singh PB, Gilbert DM (2005) Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states. Mol Biol Cell 16:2872\u20132881","journal-title":"Mol Biol Cell"},{"key":"1732_CR59","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/sj.onc.1204998","volume":"21","author":"L Yang","year":"2002","unstructured":"Yang L, Xia L, Wu DY, Wang H, Chansky HA, Schubach WH, Hickstein DD, Zhang Y (2002) Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene 21:148\u2013152","journal-title":"Oncogene"},{"issue":"5","key":"1732_CR60","doi-asserted-by":"publisher","first-page":"e2234","DOI":"10.1371\/journal.pone.0002234","volume":"3","author":"J Yoon","year":"2008","unstructured":"Yoon J, Lee K-S, Park JS, Yu K, Paik S-G et al (2008) dSETDB1 and SU(VAR)3\u20139 sequentially function during germline-stem cell differentiation in Drosophila melanogaster. PLoS ONE 3(5):e2234","journal-title":"PLoS ONE"},{"key":"1732_CR61","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1152\/physrev.00041.2009","volume":"90","author":"C Zuccato","year":"2010","unstructured":"Zuccato C, Valenza M, Cattaneo E (2010) Molecular mechanisms and potential therapeutical targets in Huntington\u2019s disease. Physiol Rev 90:905\u2013981","journal-title":"Physiol Rev"},{"key":"1732_CR62","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/hmg\/ddi014","volume":"14","author":"B Zucker","year":"2005","unstructured":"Zucker B, Luthi-Carter R, Kama JA, Dunah AW, Stern EA, Fox JH, Standaert DG, Young AB, Augood SJ (2005) Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington\u2019s disease: neuronal selectivity and potential neuroprotective role of HAP1. Hum Mol Genet 14:179\u2013189","journal-title":"Hum Mol Genet"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-017-1732-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-017-1732-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-017-1732-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T12:48:00Z","timestamp":1589633280000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-017-1732-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,7]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["1732"],"URL":"https:\/\/doi.org\/10.1007\/s00401-017-1732-8","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,7]]},"assertion":[{"value":"8 December 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}