{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:24:33Z","timestamp":1790717073407,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA096832"],"award-info":[{"award-number":["CA096832"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA188516"],"award-info":[{"award-number":["CA188516"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA021765"],"award-info":[{"award-number":["P30CA021765"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R50CA211481"],"award-info":[{"award-number":["R50CA211481"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R25CA23944"],"award-info":[{"award-number":["R25CA23944"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s00401-019-01975-4","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T11:45:21Z","timestamp":1550231121000},"page":"637-655","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo"],"prefix":"10.1007","volume":"137","author":[{"given":"Andr\u00e9 B.","family":"Silveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawryn H.","family":"Kasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjian","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy I.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon D.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Easton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald A.","family":"Yergeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Rosencrance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Boggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Rusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Finkelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Noyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent L.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beisi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Broniscer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Wetmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley B.","family":"Pounds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Ellison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne J.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"1975_CR1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM et al (2000) Gene ontology: tool for the unification of biology. The gene ontology consortium. Nat Genet 25:25\u201329. \n                    https:\/\/doi.org\/10.1038\/75556","journal-title":"Nat Genet"},{"key":"1975_CR2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature08460","volume":"462","author":"DA Barbie","year":"2009","unstructured":"Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF et al (2009) Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462:108\u2013112. \n                    https:\/\/doi.org\/10.1038\/nature08460","journal-title":"Nature"},{"key":"1975_CR3","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.ccr.2013.04.011","volume":"23","author":"W Beguelin","year":"2013","unstructured":"Beguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M et al (2013) EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell 23:677\u2013692. \n                    https:\/\/doi.org\/10.1016\/j.ccr.2013.04.011","journal-title":"Cancer Cell"},{"key":"1975_CR4","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/ng.127","volume":"40","author":"I Ben-Porath","year":"2008","unstructured":"Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A et al (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40:499\u2013507. \n                    https:\/\/doi.org\/10.1038\/ng.127","journal-title":"Nat Genet"},{"key":"1975_CR5","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.ccr.2013.10.006","volume":"24","author":"S Bender","year":"2013","unstructured":"Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M et al (2013) Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 24:660\u2013672. \n                    https:\/\/doi.org\/10.1016\/j.ccr.2013.10.006","journal-title":"Cancer Cell"},{"key":"1975_CR6","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/ng.2936","volume":"46","author":"P Buczkowicz","year":"2014","unstructured":"Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Letourneau L, Dzamba M et al (2014) Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nat Genet 46:451\u2013456. \n                    https:\/\/doi.org\/10.1038\/ng.2936","journal-title":"Nat Genet"},{"key":"1975_CR7","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nature26000","volume":"555","author":"D Capper","year":"2018","unstructured":"Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D et al (2018) DNA methylation-based classification of central nervous system tumours. Nature 555:469\u2013474. \n                    https:\/\/doi.org\/10.1038\/nature26000","journal-title":"Nature"},{"key":"1975_CR8","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1101\/gad.217778.113","volume":"27","author":"KM Chan","year":"2013","unstructured":"Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M et al (2013) The histone H3.3K27M mutation in pediatric glioma reprograms H3K27Methylation and gene expression. Genes Dev 27:985\u2013990. \n                    https:\/\/doi.org\/10.1101\/gad.217778.113","journal-title":"Genes Dev"},{"key":"1975_CR9","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ceb.2015.10.003","volume":"37","author":"E Conway","year":"2015","unstructured":"Conway E, Healy E, Bracken AP (2015) PRC2 mediated H3K27Methylations in cellular identity and cancer. Curr Opin Cell Biol 37:42\u201348. \n                    https:\/\/doi.org\/10.1016\/j.ceb.2015.10.003","journal-title":"Curr Opin Cell Biol"},{"key":"1975_CR10","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1158\/1541-7786.MCR-16-0389","volume":"15","author":"FJ Cordero","year":"2017","unstructured":"Cordero FJ, Huang Z, Grenier C, He X, Hu G, McLendon RE, Murphy SK, Hashizume R, Becher OJ (2017) Histone H3.3K27M represses to accelerate gliomagenesis in a murine model of DIPG. Mol Cancer Res 15:1243\u20131254. \n                    https:\/\/doi.org\/10.1158\/1541-7786.MCR-16-0389","journal-title":"Mol Cancer Res"},{"key":"1975_CR11","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.cmet.2018.03.004","volume":"27","author":"ST Crooke","year":"2018","unstructured":"Crooke ST, Witztum JL, Bennett CF, Baker BF (2018) RNA-targeted therapeutics. Cell Metab 27:714\u2013739. \n                    https:\/\/doi.org\/10.1016\/j.cmet.2018.03.004","journal-title":"Cell Metab"},{"key":"1975_CR12","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1158\/0008-5472.CAN-10-3597","volume":"71","author":"R Endersby","year":"2011","unstructured":"Endersby R, Zhu X, Hay N, Ellison DW, Baker SJ (2011) Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. Cancer Res 71:4106\u20134116. \n                    https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-3597","journal-title":"Cancer Res"},{"key":"1975_CR13","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/ng.621","volume":"42","author":"T Ernst","year":"2010","unstructured":"Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV, Waghorn K et al (2010) Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 42:722\u2013726. \n                    https:\/\/doi.org\/10.1038\/ng.621","journal-title":"Nat Genet"},{"key":"1975_CR14","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nrg.2016.13","volume":"17","author":"AP Feinberg","year":"2016","unstructured":"Feinberg AP, Koldobskiy MA, Gondor A (2016) Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Nat Rev Genet 17:284\u2013299. \n                    https:\/\/doi.org\/10.1038\/nrg.2016.13","journal-title":"Nat Rev Genet"},{"key":"1975_CR15","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1016\/j.celrep.2013.11.020","volume":"5","author":"C Fellmann","year":"2013","unstructured":"Fellmann C, Hoffmann T, Sridhar V, Hopfgartner B, Muhar M, Roth M et al (2013) An optimized microRNA backbone for effective single-copy RNAi. Cell Rep 5:1704\u20131713. \n                    https:\/\/doi.org\/10.1016\/j.celrep.2013.11.020","journal-title":"Cell Rep"},{"key":"1975_CR16","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1126\/science.aao4750","volume":"360","author":"MG Filbin","year":"2018","unstructured":"Filbin MG, Tirosh I, Hovestadt V, Shaw ML, Escalante LE, Mathewson ND et al (2018) Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Science 360:331\u2013335. \n                    https:\/\/doi.org\/10.1126\/science.aao4750","journal-title":"Science"},{"key":"1975_CR17","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/ng.2950","volume":"46","author":"AM Fontebasso","year":"2014","unstructured":"Fontebasso AM, Papillon-Cavanagh S, Schwartzentruber J, Nikbakht H, Gerges N, Fiset PO et al (2014) Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma. Nat Genet 46:462\u2013466. \n                    https:\/\/doi.org\/10.1038\/ng.2950","journal-title":"Nat Genet"},{"key":"1975_CR18","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1126\/science.1253799","volume":"346","author":"K Funato","year":"2014","unstructured":"Funato K, Major T, Lewis PW, Allis CD, Tabar V (2014) Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation. Science 346:1529\u20131533. \n                    https:\/\/doi.org\/10.1126\/science.1253799","journal-title":"Science"},{"key":"1975_CR19","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/nm0715-827a","volume":"21","author":"CS Grasso","year":"2015","unstructured":"Grasso CS, Tang Y, Truffaux N, Berlow NE, Liu L, Debily MA et al (2015) Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med 21:827. \n                    https:\/\/doi.org\/10.1038\/nm0715-827a","journal-title":"Nat Med"},{"key":"1975_CR20","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1038\/nm.3716","volume":"20","author":"R Hashizume","year":"2014","unstructured":"Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X et al (2014) Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med 20:1394\u20131396. \n                    https:\/\/doi.org\/10.1038\/nm.3716","journal-title":"Nat Med"},{"key":"1975_CR21","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.neuron.2009.08.021","volume":"63","author":"Y Hirabayashi","year":"2009","unstructured":"Hirabayashi Y, Suzki N, Tsuboi M, Endo TA, Toyoda T, Shinga J et al (2009) Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. Neuron 63:600\u2013613. \n                    https:\/\/doi.org\/10.1016\/j.neuron.2009.08.021","journal-title":"Neuron"},{"key":"1975_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3811","author":"C Jones","year":"2014","unstructured":"Jones C, Baker SJ (2014) Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma. Nat Rev Cancer. \n                    https:\/\/doi.org\/10.1038\/nrc3811","journal-title":"Nat Rev Cancer"},{"issue":"566\u2013580","key":"1975_CR23","doi-asserted-by":"publisher","first-page":"e519","DOI":"10.1016\/j.cell.2016.09.027","volume":"167","author":"G La Manno","year":"2016","unstructured":"La Manno G, Gyllborg D, Codeluppi S, Nishimura K, Salto C, Zeisel A et al (2016) Molecular diversity of midbrain development in mouse, human, and stem cells. Cell 167(566\u2013580):e519. \n                    https:\/\/doi.org\/10.1016\/j.cell.2016.09.027","journal-title":"Cell"},{"key":"1975_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ccell.2018.11.015","volume":"35","author":"JD Larson","year":"2019","unstructured":"Larson JD, Kasper LH, Paugh BS, Jin H, Wu G, Kwon CH et al (2019) Histone H3.3 K27M accelerates spontaneous brainstem glioma and drives restricted changes in bivalent gene expression. Cancer Cell 35:1\u201316. \n                    https:\/\/doi.org\/10.1016\/j.ccell.2018.11.015","journal-title":"Cancer Cell"},{"key":"1975_CR25","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.stem.2014.05.006","volume":"14","author":"A Laugesen","year":"2014","unstructured":"Laugesen A, Helin K (2014) Chromatin repressive complexes in stem cells, development, and cancer. Cell Stem Cell 14:735\u2013751. \n                    https:\/\/doi.org\/10.1016\/j.stem.2014.05.006","journal-title":"Cell Stem Cell"},{"key":"1975_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v025.i01","volume":"25","author":"S Le","year":"2008","unstructured":"Le S, Josse J, Husson F (2008) FactoMineR: an R package for multivariate analysis. J Stat Softw 25:1\u201318","journal-title":"J Stat Softw"},{"key":"1975_CR27","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1126\/science.1232245","volume":"340","author":"PW Lewis","year":"2013","unstructured":"Lewis PW, Muller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA et al (2013) Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 340:857\u2013861. \n                    https:\/\/doi.org\/10.1126\/science.1232245","journal-title":"Science"},{"key":"1975_CR28","doi-asserted-by":"publisher","first-page":"11628","DOI":"10.1038\/ncomms11628","volume":"7","author":"RA Lindquist","year":"2016","unstructured":"Lindquist RA, Guinto CD, Rodas-Rodriguez JL, Fuentealba LC, Tate MC, Rowitch DH et al (2016) Identification of proliferative progenitors associated with prominent postnatal growth of the pons. Nat Commun 7:11628. \n                    https:\/\/doi.org\/10.1038\/ncomms11628","journal-title":"Nat Commun"},{"issue":"1294\u20131308","key":"1975_CR29","doi-asserted-by":"publisher","first-page":"e1297","DOI":"10.1016\/j.cmet.2018.04.013","volume":"27","author":"TT Lu","year":"2018","unstructured":"Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T et al (2018) The polycomb-dependent epigenome controls beta cell dysfunction, dedifferentiation, and diabetes. Cell Metab 27(1294\u20131308):e1297. \n                    https:\/\/doi.org\/10.1016\/j.cmet.2018.04.013","journal-title":"Cell Metab"},{"issue":"520\u2013537","key":"1975_CR30","doi-asserted-by":"publisher","first-page":"e525","DOI":"10.1016\/j.ccell.2017.08.017","volume":"32","author":"A Mackay","year":"2017","unstructured":"Mackay A, Burford A, Carvalho D, Izquierdo E, Fazal-Salom J, Taylor KR et al (2017) Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma. Cancer Cell 32(520\u2013537):e525. \n                    https:\/\/doi.org\/10.1016\/j.ccell.2017.08.017","journal-title":"Cancer Cell"},{"key":"1975_CR31","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/nprot.2013.092","volume":"8","author":"H Mi","year":"2013","unstructured":"Mi H, Muruganujan A, Casagrande JT, Thomas PD (2013) Large-scale gene function analysis with the PANTHER classification system. Nat Protoc 8:1551\u20131566. \n                    https:\/\/doi.org\/10.1038\/nprot.2013.092","journal-title":"Nat Protoc"},{"key":"1975_CR32","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/nm.4293","volume":"23","author":"F Mohammad","year":"2017","unstructured":"Mohammad F, Weissmann S, Leblanc B, Pandey DP, Hojfeldt JW, Comet I et al (2017) EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas. Nat Med 23:483\u2013492. \n                    https:\/\/doi.org\/10.1038\/nm.4293","journal-title":"Nat Med"},{"key":"1975_CR33","doi-asserted-by":"publisher","first-page":"7068","DOI":"10.1158\/0008-5472.CAN-13-0927","volume":"73","author":"BL Murphy","year":"2013","unstructured":"Murphy BL, Obad S, Bihannic L, Ayrault O, Zindy F, Kauppinen S et al (2013) Silencing of the miR-17\u2009~\u200992 cluster family inhibits medulloblastoma progression. Cancer Res 73:7068\u20137078. \n                    https:\/\/doi.org\/10.1158\/0008-5472.CAN-13-0927","journal-title":"Cancer Res"},{"issue":"635\u2013652","key":"1975_CR34","doi-asserted-by":"publisher","first-page":"e636","DOI":"10.1016\/j.ccell.2017.03.011","volume":"31","author":"S Nagaraja","year":"2017","unstructured":"Nagaraja S, Vitanza NA, Woo PJ, Taylor KR, Liu F, Zhang L et al (2017) Transcriptional dependencies in diffuse intrinsic pontine glioma. Cancer Cell 31(635\u2013652):e636. \n                    https:\/\/doi.org\/10.1016\/j.ccell.2017.03.011","journal-title":"Cancer Cell"},{"key":"1975_CR35","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/ng.620","volume":"42","author":"G Nikoloski","year":"2010","unstructured":"Nikoloski G, Langemeijer SM, Kuiper RP, Knops R, Massop M et al (2010) Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet 42:665\u2013667. \n                    https:\/\/doi.org\/10.1038\/ng.620","journal-title":"Nat Genet"},{"key":"1975_CR36","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nm.2651","volume":"18","author":"P Ntziachristos","year":"2012","unstructured":"Ntziachristos P, Tsirigos A, Van Vlierberghe P, Nedjic J, Trimarchi T, Flaherty MS et al (2012) Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat Med 18:298\u2013301. \n                    https:\/\/doi.org\/10.1038\/nm.2651","journal-title":"Nat Med"},{"key":"1975_CR37","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.celrep.2014.10.018","volume":"9","author":"DA Orlando","year":"2014","unstructured":"Orlando DA, Chen MW, Brown VE, Solanki S, Choi YJ, Olson ER et al (2014) Quantitative ChIP-Seq normalization reveals global modulation of the epigenome. Cell Rep 9:1163\u20131170. \n                    https:\/\/doi.org\/10.1016\/j.celrep.2014.10.018","journal-title":"Cell Rep"},{"key":"1975_CR38","doi-asserted-by":"publisher","first-page":"3999","DOI":"10.1200\/JCO.2011.35.5677","volume":"29","author":"BS Paugh","year":"2011","unstructured":"Paugh BS, Broniscer A, Qu C, Miller CP, Zhang J, Tatevossian RG et al (2011) Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J Clin Oncol 29:3999\u20134006. \n                    https:\/\/doi.org\/10.1200\/JCO.2011.35.5677","journal-title":"J Clin Oncol"},{"key":"1975_CR39","doi-asserted-by":"publisher","first-page":"15957","DOI":"10.1073\/pnas.1002530107","volume":"107","author":"JD Pereira","year":"2010","unstructured":"Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ (2010) Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc Natl Acad Sci USA 107:15957\u201315962. \n                    https:\/\/doi.org\/10.1073\/pnas.1002530107","journal-title":"Proc Natl Acad Sci USA"},{"key":"1975_CR40","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nm.4296","volume":"23","author":"A Piunti","year":"2017","unstructured":"Piunti A, Hashizume R, Morgan MA, Bartom ET, Horbinski CM, Marshall SA, Rendleman EJ, Ma Q et al (2017) Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas. Nat Med 23:493\u2013500. \n                    https:\/\/doi.org\/10.1038\/nm.4296","journal-title":"Nat Med"},{"key":"1975_CR41","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature10833","volume":"482","author":"J Schwartzentruber","year":"2012","unstructured":"Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K et al (2012) Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 482:226\u2013231. \n                    https:\/\/doi.org\/10.1038\/nature10833","journal-title":"Nature"},{"key":"1975_CR42","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1126\/science.1208130","volume":"333","author":"N Stransky","year":"2011","unstructured":"Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A et al (2011) The mutational landscape of head and neck squamous cell carcinoma. Science 333:1157\u20131160. \n                    https:\/\/doi.org\/10.1126\/science.1208130","journal-title":"Science"},{"key":"1975_CR43","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nrc3655","volume":"14","author":"D Sturm","year":"2014","unstructured":"Sturm D, Bender S, Jones DT, Lichter P, Grill J, Becher O, Hawkins C et al (2014) Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat Rev Cancer 14:92\u2013107. \n                    https:\/\/doi.org\/10.1038\/nrc3655","journal-title":"Nat Rev Cancer"},{"key":"1975_CR44","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102:15545\u201315550. \n                    https:\/\/doi.org\/10.1073\/pnas.0506580102","journal-title":"Proc Natl Acad Sci USA"},{"key":"1975_CR45","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/ng.2925","volume":"46","author":"KR Taylor","year":"2014","unstructured":"Taylor KR, Mackay A, Truffaux N, Butterfield Y, Morozova O, Philippe C et al (2014) Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma. Nat Genet 46:457\u2013461. \n                    https:\/\/doi.org\/10.1038\/ng.2925","journal-title":"Nat Genet"},{"key":"1975_CR46","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1111\/bpa.12042","volume":"23","author":"S Venneti","year":"2013","unstructured":"Venneti S, Garimella MT, Sullivan LM, Martinez D, Huse JT, Heguy A et al (2013) Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas. Brain Pathol 23:558\u2013564. \n                    https:\/\/doi.org\/10.1111\/bpa.12042","journal-title":"Brain Pathol"},{"key":"1975_CR47","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1101\/gad.219626.113","volume":"27","author":"P Voigt","year":"2013","unstructured":"Voigt P, Tee WW, Reinberg D (2013) A double take on bivalent promoters. Genes Dev 27:1318\u20131338. \n                    https:\/\/doi.org\/10.1101\/gad.219626.113","journal-title":"Genes Dev"},{"key":"1975_CR48","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3389\/fonc.2012.00205","volume":"2","author":"KE Warren","year":"2012","unstructured":"Warren KE (2012) Diffuse intrinsic pontine glioma: poised for progress. Front Oncol 2:205. \n                    https:\/\/doi.org\/10.3389\/fonc.2012.00205","journal-title":"Front Oncol"},{"key":"1975_CR49","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/modpathol.2016.37","volume":"29","author":"G Wu","year":"2016","unstructured":"Wu G, Barnhill RL, Lee S, Li Y, Shao Y, Easton J et al (2016) The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing. Mod Pathol 29:359\u2013369. \n                    https:\/\/doi.org\/10.1038\/modpathol.2016.37","journal-title":"Mod Pathol"},{"key":"1975_CR50","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/ng.1102","volume":"44","author":"G Wu","year":"2012","unstructured":"Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J et al (2012) Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet 44:251\u2013253. \n                    https:\/\/doi.org\/10.1038\/ng.1102","journal-title":"Nat Genet"},{"key":"1975_CR51","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/ng.2938","volume":"46","author":"G Wu","year":"2014","unstructured":"Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y et al (2014) The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet 46:444\u2013450. \n                    https:\/\/doi.org\/10.1038\/ng.2938","journal-title":"Nat Genet"},{"key":"1975_CR52","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1126\/science.aaa1934","volume":"347","author":"A Zeisel","year":"2015","unstructured":"Zeisel A, Munoz-Manchado AB, Codeluppi S, Lonnerberg P, La Manno G, Jureus A et al (2015) Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq. Science 347:1138\u20131142. \n                    https:\/\/doi.org\/10.1126\/science.aaa1934","journal-title":"Science"},{"key":"1975_CR53","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/nature10725","volume":"481","author":"J Zhang","year":"2012","unstructured":"Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D et al (2012) The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481:157\u2013163. \n                    https:\/\/doi.org\/10.1038\/nature10725","journal-title":"Nature"},{"key":"1975_CR54","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","volume":"34","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O\u2019Keeffe S et al (2014) An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34:11929\u201311947. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.1860-14.2014","journal-title":"J Neurosci"},{"key":"1975_CR55","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.neuron.2015.11.013","volume":"89","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Sloan SA, Clarke LE, Caneda C, Plaza CA, Blumenthal PD et al (2016) Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse. Neuron 89:37\u201353. \n                    https:\/\/doi.org\/10.1016\/j.neuron.2015.11.013","journal-title":"Neuron"}],"updated-by":[{"DOI":"10.1007\/s00401-019-02006-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000}}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-019-01975-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-019-01975-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-019-01975-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T08:54:53Z","timestamp":1589619293000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-019-01975-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,15]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["1975"],"URL":"https:\/\/doi.org\/10.1007\/s00401-019-01975-4","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,15]]},"assertion":[{"value":"29 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2019","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original article can be found online.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}