{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:27:41Z","timestamp":1792618061598,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["MDA382033"],"award-info":[{"award-number":["MDA382033"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["602894"],"award-info":[{"award-number":["602894"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA034196"],"award-info":[{"award-number":["CA034196"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 OD020351"],"award-info":[{"award-number":["U54 OD020351"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS062055"],"award-info":[{"award-number":["R01NS062055"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s00401-019-01989-y","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T20:15:08Z","timestamp":1552680908000},"page":"103-121","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["ALS\/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response"],"prefix":"10.1007","volume":"138","author":[{"given":"Corey J.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Bredvik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne R.","family":"Burstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M.","family":"Meadows","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalia","family":"Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Case","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa A.","family":"Milner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hibiki","family":"Kawamata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamir","family":"Zuberi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Piersigilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathleen","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3893-1348","authenticated-orcid":false,"given":"Giovanni","family":"Manfredi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"1989_CR1","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1093\/brain\/awu138","volume":"137","author":"S Bannwarth","year":"2014","unstructured":"Bannwarth S, Ait-El-Mkadem S, Chaussenot A, Genin EC, Lacas-Gervais S, Fragaki K et al (2014) A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement. Brain 137:2329\u20132345. \n                    https:\/\/doi.org\/10.1093\/brain\/awu138","journal-title":"Brain"},{"issue":"935\u2013944","key":"1989_CR2","doi-asserted-by":"publisher","first-page":"e934","DOI":"10.1016\/j.cmet.2017.03.005","volume":"25","author":"LD BonDurant","year":"2017","unstructured":"BonDurant LD, Ameka M, Naber MC, Markan KR, Idiga SO, Acevedo MR et al (2017) FGF21 regulates metabolism through adipose-dependent and -independent mechanisms. Cell Metab 25(935\u2013944):e934. \n                    https:\/\/doi.org\/10.1016\/j.cmet.2017.03.005","journal-title":"Cell Metab"},{"key":"1989_CR3","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1093\/hmg\/ddx436","volume":"27","author":"SJ Brockmann","year":"2018","unstructured":"Brockmann SJ, Freischmidt A, Oeckl P, Muller K, Ponna SK, Helferich AM et al (2018) CHCHD10 mutations p. R15L and p.G66\u00a0V cause motoneuron disease by haploinsufficiency. Hum Mol Genet 27:706\u2013715. \n                    https:\/\/doi.org\/10.1093\/hmg\/ddx436","journal-title":"Hum Mol Genet"},{"key":"1989_CR4","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1093\/hmg\/ddx397","volume":"27","author":"SR Burstein","year":"2018","unstructured":"Burstein SR, Valsecchi F, Kawamata H, Bourens M, Zeng R, Zuberi A et al (2018) In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions. Hum Mol Genet 27:160\u2013177. \n                    https:\/\/doi.org\/10.1093\/hmg\/ddx397","journal-title":"Hum Mol Genet"},{"key":"1989_CR5","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1039\/c0mb00058b","volume":"6","author":"G Cavallaro","year":"2010","unstructured":"Cavallaro G (2010) Genome-wide analysis of eukaryotic twin CX9C proteins. Mol BioSyst 6:2459\u20132470. \n                    https:\/\/doi.org\/10.1039\/c0mb00058b","journal-title":"Mol BioSyst"},{"key":"1989_CR6","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S0006-8993(98)01258-X","volume":"835","author":"JN Crawley","year":"1999","unstructured":"Crawley JN (1999) Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Res 835:18\u201326","journal-title":"Brain Res"},{"key":"1989_CR7","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1093\/hmg\/ddq050","volume":"19","author":"SK Custer","year":"2010","unstructured":"Custer SK, Neumann M, Lu H, Wright AC, Taylor JP (2010) Transgenic mice expressing mutant forms VCP\/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone. Hum Mol Genet 19:1741\u20131755. \n                    https:\/\/doi.org\/10.1093\/hmg\/ddq050ddq050","journal-title":"Hum Mol Genet"},{"key":"1989_CR8","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1056\/NEJMra022567","volume":"348","author":"S DiMauro","year":"2003","unstructured":"DiMauro S, Schon EA (2003) Mitochondrial respiratory-chain diseases. N Engl J Med 348:2656\u20132668","journal-title":"N Engl J Med"},{"key":"1989_CR9","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","volume":"185","author":"LR Fischer","year":"2004","unstructured":"Fischer LR, Culver DG, Tennant P, Davis AA, Wang M, Castellano-Sanchez A et al (2004) Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp Neurol 185:232\u2013240","journal-title":"Exp Neurol"},{"key":"1989_CR10","doi-asserted-by":"publisher","first-page":"9434","DOI":"10.1523\/JNEUROSCI.3080-04.2004","volume":"24","author":"SM Fleming","year":"2004","unstructured":"Fleming SM, Salcedo J, Fernagut PO, Rockenstein E, Masliah E, Levine MS et al (2004) Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein. J Neurosci 24:9434\u20139440. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.3080-04.2004","journal-title":"J Neurosci"},{"key":"1989_CR11","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1016\/S0960-8966(17)30279-1","volume":"27S1","author":"CDE Fratter","year":"2017","unstructured":"Fratter CDE, Carver J, Sergeant K, Barbosa IA, Hofer M, Esiri M et al (2017) Mitochondrial disease and lipid storage myopathy due to mutation in CHCHD10 or DNM1L and disordered mitochondrial dynamics. Neuromusc Disord 27S1:S21","journal-title":"Neuromusc Disord"},{"key":"1989_CR12","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1093\/nar\/gkg563","volume":"31","author":"E Gasteiger","year":"2003","unstructured":"Gasteiger E, Gattiker A, Hoogland C, Ivanyi I, Appel RD, Bairoch A (2003) ExPASy: the proteomics server for in-depth protein knowledge and analysis. Nucleic Acids Res 31:3784\u20133788","journal-title":"Nucleic Acids Res"},{"key":"1989_CR13","doi-asserted-by":"publisher","first-page":"58","DOI":"10.15252\/emmm.201505496","volume":"8","author":"EC Genin","year":"2016","unstructured":"Genin EC, Plutino M, Bannwarth S, Villa E, Cisneros-Barroso E, Roy M et al (2016) CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis. EMBO Mol Med 8:58\u201372. \n                    https:\/\/doi.org\/10.15252\/emmm.201505496","journal-title":"EMBO Mol Med"},{"key":"1989_CR14","doi-asserted-by":"publisher","DOI":"10.3791\/2202","author":"I Gostimskaya","year":"2010","unstructured":"Gostimskaya I, Galkin A (2010) Preparation of highly coupled rat heart mitochondria. J Vis Exp. \n                    https:\/\/doi.org\/10.3791\/2202","journal-title":"J Vis Exp"},{"key":"1989_CR15","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy270","author":"X Huang","year":"2018","unstructured":"Huang X, Wu BP, Nguyen D, Liu YT, Marani M, Hench J et al (2018) CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10. Hum Mol Genet. \n                    https:\/\/doi.org\/10.1093\/hmg\/ddy270","journal-title":"Hum Mol Genet"},{"key":"1989_CR16","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1126\/science.1244360","volume":"342","author":"SC Johnson","year":"2013","unstructured":"Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A et al (2013) mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science 342:1524\u20131528. \n                    https:\/\/doi.org\/10.1126\/science.1244360","journal-title":"Science"},{"key":"1989_CR17","doi-asserted-by":"publisher","first-page":"3917","DOI":"10.1083\/jcb.201709172","volume":"216","author":"H Kawamata","year":"2017","unstructured":"Kawamata H, Manfredi G (2017) Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases. J Cell Biol 216:3917\u20133929. \n                    https:\/\/doi.org\/10.1083\/jcb.201709172","journal-title":"J Cell Biol"},{"issue":"419\u2013428","key":"1989_CR18","doi-asserted-by":"publisher","first-page":"e415","DOI":"10.1016\/j.cmet.2017.07.007","volume":"26","author":"NA Khan","year":"2017","unstructured":"Khan NA, Nikkanen J, Yatsuga S, Jackson C, Wang L, Pradhan S et al (2017) mTORC1 regulates mitochondrial integrated stress response and mitochondrial myopathy progression. Cell Metab 26(419\u2013428):e415. \n                    https:\/\/doi.org\/10.1016\/j.cmet.2017.07.007","journal-title":"Cell Metab"},{"key":"1989_CR19","doi-asserted-by":"publisher","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","volume":"14","author":"D Kim","year":"2013","unstructured":"Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL (2013) TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol 14:R36. \n                    https:\/\/doi.org\/10.1186\/gb-2013-14-4-r36","journal-title":"Genome Biol"},{"key":"1989_CR20","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1038\/nprot.2013.155","volume":"8","author":"M Leger","year":"2013","unstructured":"Leger M, Quiedeville A, Bouet V, Haelewyn B, Boulouard M, Schumann-Bard P et al (2013) Object recognition test in mice. Nat Protoc 8:2531\u20132537. \n                    https:\/\/doi.org\/10.1038\/nprot.2013.155","journal-title":"Nat Protoc"},{"key":"1989_CR21","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708558","author":"C Lehmer","year":"2018","unstructured":"Lehmer C, Schludi MH, Ransom L, Greiling J, Junghanel M, Exner N et al (2018) A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS. EMBO Mol Med. \n                    https:\/\/doi.org\/10.15252\/emmm.201708558","journal-title":"EMBO Mol Med"},{"key":"1989_CR22","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1083\/jcb.201302044","volume":"201","author":"YR Li","year":"2013","unstructured":"Li YR, King OD, Shorter J, Gitler AD (2013) Stress granules as crucibles of ALS pathogenesis. J Cell Biol 201:361\u2013372. \n                    https:\/\/doi.org\/10.1083\/jcb.201302044","journal-title":"J Cell Biol"},{"key":"1989_CR23","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.neuron.2013.07.033","volume":"79","author":"SC Ling","year":"2013","unstructured":"Ling SC, Polymenidou M, Cleveland DW (2013) Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron 79:416\u2013438. \n                    https:\/\/doi.org\/10.1016\/j.neuron.2013.07.033","journal-title":"Neuron"},{"key":"1989_CR24","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550. \n                    https:\/\/doi.org\/10.1186\/s13059-014-0550-8","journal-title":"Genome Biol"},{"key":"1989_CR25","doi-asserted-by":"publisher","DOI":"10.7554\/elife.41973","author":"E Martineau","year":"2018","unstructured":"Martineau E, Di Polo A, Vande Velde C, Robitaille R (2018) Dynamic neuromuscular remodeling precedes motor-unit loss in a mouse model of ALS. Elife. \n                    https:\/\/doi.org\/10.7554\/elife.41973","journal-title":"Elife"},{"key":"1989_CR26","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/cr.2018.16","volume":"28","author":"A Melber","year":"2018","unstructured":"Melber A, Haynes CM (2018) UPR(mt) regulation and output: a stress response mediated by mitochondrial\u2013nuclear communication. Cell Res 28:281\u2013295. \n                    https:\/\/doi.org\/10.1038\/cr.2018.16","journal-title":"Cell Res"},{"key":"1989_CR27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-1-61779-328-8_3","volume":"793","author":"TA Milner","year":"2011","unstructured":"Milner TA, Waters EM, Robinson DC, Pierce JP (2011) Degenerating processes identified by electron microscopic immunocytochemical methods. Methods Mol Biol 793:23\u201359. \n                    https:\/\/doi.org\/10.1007\/978-1-61779-328-8_3","journal-title":"Methods Mol Biol"},{"key":"1989_CR28","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201808888","author":"GM Palomo","year":"2018","unstructured":"Palomo GM, Granatiero V, Kawamata H, Konrad C, Kim M, Arreguin AJ et al (2018) Parkin is a disease modifier in the mutant SOD1 mouse model of ALS. EMBO Mol Med. \n                    https:\/\/doi.org\/10.15252\/emmm.201808888","journal-title":"EMBO Mol Med"},{"key":"1989_CR29","doi-asserted-by":"publisher","first-page":"177.e16","DOI":"10.1016\/j.neurobiolaging.2016.12.008","volume":"51","author":"F Perrone","year":"2017","unstructured":"Perrone F, Nguyen HP, Van Mossevelde S, Moisse M, Sieben A, Santens P et al (2017) Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients. Neurobiol Aging 51:177.e9\u2013177.e16. \n                    https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.12.008","journal-title":"Neurobiol Aging"},{"key":"1989_CR30","doi-asserted-by":"publisher","first-page":"6517","DOI":"10.1074\/jbc.RA117.001073","volume":"293","author":"N Purandare","year":"2018","unstructured":"Purandare N, Somayajulu M, Huttemann M, Grossman LI, Aras S (2018) The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): partners in mitochondrial and nuclear function and dysfunction. J Biol Chem 293:6517\u20136529. \n                    https:\/\/doi.org\/10.1074\/jbc.RA117.001073","journal-title":"J Biol Chem"},{"key":"1989_CR31","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3389\/fnins.2018.00326","volume":"12","author":"MD Purice","year":"2018","unstructured":"Purice MD, Taylor JP (2018) Linking hnRNP function to ALS and FTD pathology. Front Neurosci 12:326. \n                    https:\/\/doi.org\/10.3389\/fnins.2018.00326","journal-title":"Front Neurosci"},{"key":"1989_CR32","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1083\/jcb.201702058","volume":"216","author":"PM Quiros","year":"2017","unstructured":"Quiros PM, Prado MA, Zamboni N, D\u2019Amico D, Williams RW, Finley D et al (2017) Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals. J Cell Biol 216:2027\u20132045. \n                    https:\/\/doi.org\/10.1083\/jcb.201702058","journal-title":"J Cell Biol"},{"key":"1989_CR33","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1038\/s41418-018-0076-9","volume":"25","author":"AP Sfakianos","year":"2018","unstructured":"Sfakianos AP, Mellor LE, Pang YF, Kritsiligkou P, Needs H, Abou-Hamdan H et al (2018) The mTOR-S6 kinase pathway promotes stress granule assembly. Cell Death Differ 25:1766\u20131780. \n                    https:\/\/doi.org\/10.1038\/s41418-018-0076-9","journal-title":"Cell Death Differ"},{"key":"1989_CR34","doi-asserted-by":"publisher","first-page":"4588","DOI":"10.1093\/hmg\/ddx341","volume":"26","author":"SE Siegmund","year":"2017","unstructured":"Siegmund SE, Yang H, Sharma R, Javors M, Skinner O, Mootha V et al (2017) Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome. Hum Mol Genet 26:4588\u20134605. \n                    https:\/\/doi.org\/10.1093\/hmg\/ddx341","journal-title":"Hum Mol Genet"},{"key":"1989_CR35","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/hmg\/ddx393","volume":"27","author":"IR Straub","year":"2018","unstructured":"Straub IR, Janer A, Weraarpachai W, Zinman L, Robertson J, Rogaeva E et al (2018) Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS. Hum Mol Genet 27:178\u2013189. \n                    https:\/\/doi.org\/10.1093\/hmg\/ddx393","journal-title":"Hum Mol Genet"},{"key":"1989_CR36","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/S1474-4422(11)70155-7","volume":"10","author":"A Suomalainen","year":"2011","unstructured":"Suomalainen A, Elo JM, Pietilainen KH, Hakonen AH, Sevastianova K, Korpela M et al (2011) FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study. Lancet Neurol 10:806\u2013818. \n                    https:\/\/doi.org\/10.1016\/S1474-4422(11)70155-7","journal-title":"Lancet Neurol"},{"key":"1989_CR37","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nbt.2450","volume":"31","author":"C Trapnell","year":"2013","unstructured":"Trapnell C, Hendrickson DG, Sauvageau M, Goff L, Rinn JL, Pachter L (2013) Differential analysis of gene regulation at transcript resolution with RNA-seq. Nat Biotechnol 31:46\u201353. \n                    https:\/\/doi.org\/10.1038\/nbt.2450","journal-title":"Nat Biotechnol"},{"key":"1989_CR38","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nbt.1621","volume":"28","author":"C Trapnell","year":"2010","unstructured":"Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, van Baren MJ et al (2010) Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 28:511\u2013515. \n                    https:\/\/doi.org\/10.1038\/nbt.1621","journal-title":"Nat Biotechnol"},{"key":"1989_CR39","doi-asserted-by":"publisher","first-page":"15558","DOI":"10.1038\/ncomms15558","volume":"8","author":"JA Woo","year":"2017","unstructured":"Woo JA, Liu T, Trotter C, Fang CC, De Narvaez E, LePochat P et al (2017) Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity. Nat Commun 8:15558. \n                    https:\/\/doi.org\/10.1038\/ncomms15558","journal-title":"Nat Commun"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-019-01989-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-019-01989-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-019-01989-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T12:55:24Z","timestamp":1589633724000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-019-01989-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,14]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["1989"],"URL":"https:\/\/doi.org\/10.1007\/s00401-019-01989-y","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,14]]},"assertion":[{"value":"14 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}