{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:10:09Z","timestamp":1792782609919,"version":"4.5.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Financial Supporting Project of Long-term Overseas Dispatch of PNU's Tenure-track Faculty","award":["2015"],"award-info":[{"award-number":["2015"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG023501"],"award-info":[{"award-number":["AG023501"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG019724"],"award-info":[{"award-number":["AG019724"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tau Consortium","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"name":"Bluefield Project to Cure FTD","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00401-019-02075-z","type":"journal-article","created":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T08:02:28Z","timestamp":1569052948000},"page":"27-43","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Evidence of corticofugal tau spreading in patients with frontotemporal dementia"],"prefix":"10.1007","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8460-1377","authenticated-orcid":false,"given":"Eun-Joo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hye L.","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie E.","family":"Gaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa L.","family":"Nana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jersey","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Spina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Jun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana Marisa","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea T.","family":"Grinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel H.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Boxer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Gorno-Tempini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Seeley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,21]]},"reference":[{"key":"2075_CR1","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/459924a","volume":"459","author":"A Aguzzi","year":"2009","unstructured":"Aguzzi A (2009) Cell biology: beyond the prion principle. Nature 459:924\u2013925","journal-title":"Nature"},{"key":"2075_CR2","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/ana.21154","volume":"61","author":"C Amador-Ortiz","year":"2007","unstructured":"Amador-Ortiz C, Lin WL, Ahmed Z, Personett D, Davies P, Duara R et al (2007) TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Ann Neurol 61:435\u2013445","journal-title":"Ann Neurol"},{"key":"2075_CR3","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00401-014-1373-0","volume":"129","author":"S Boluda","year":"2015","unstructured":"Boluda S, Iba M, Zhang B, Raible KM, Lee VM, Trojanowski JQ (2015) Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. Acta Neuropathol 129:221\u2013237","journal-title":"Acta Neuropathol"},{"key":"2075_CR4","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239\u2013259","journal-title":"Acta Neuropathol"},{"key":"2075_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici K, R\u00fcb U, de Vos R, Jansen Steur E, Braak E (2003) Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24:197\u2013211","journal-title":"Neurobiol Aging"},{"key":"2075_CR6","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","volume":"70","author":"H Braak","year":"2011","unstructured":"Braak H, Thal DR, Ghebremedhin E, Del Tredici K (2011) Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol 70:960\u2013969","journal-title":"J Neuropathol Exp Neurol"},{"key":"2075_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nrn3887","volume":"16","author":"J Brettschneider","year":"2015","unstructured":"Brettschneider J, Del Tredici K, Lee VM, Trojanowski JQ (2015) Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nat Rev Neurosci 16:109\u2013120","journal-title":"Nat Rev Neurosci"},{"key":"2075_CR8","first-page":"251","volume":"101","author":"P Brodal","year":"1978","unstructured":"Brodal P (1978) The corticopontine projection in the rhesus monkey. Origin and principles of organization Brain 101:251\u2013283","journal-title":"Origin and principles of organization Brain"},{"key":"2075_CR9","volume-title":"Core text of neuroanatomy","author":"MB Carpenter","year":"1991","unstructured":"Carpenter MB (1991) Core text of neuroanatomy. Williams & Wilkins, Baltimore"},{"key":"2075_CR10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1155\/2013\/793530","volume":"26","author":"F Caso","year":"2013","unstructured":"Caso F, Gesierich B, Henry M, Sidhu M, LaMarre A, Babiak M et al (2013) Nonfluent\/agrammatic PPA with in-vivo cortical amyloidosis and Pick's disease pathology. Behav Neurol 26:95\u2013106","journal-title":"Behav Neurol"},{"key":"2075_CR11","doi-asserted-by":"publisher","first-page":"9928","DOI":"10.1523\/JNEUROSCI.2185-07.2007","volume":"27","author":"CN Cearley","year":"2007","unstructured":"Cearley CN, Wolfe JH (2007) A single injection of an adeno-associated virus vector into nuclei with divergent connections results in widespread vector distribution in the brain and global correction of a neurogenetic disease. J Neurosci 27:9928\u20139940","journal-title":"J Neurosci"},{"key":"2075_CR12","doi-asserted-by":"publisher","first-page":"9535","DOI":"10.1073\/pnas.1301175110","volume":"110","author":"F Clavaguera","year":"2013","unstructured":"Clavaguera F, Akatsu H, Fraser G, Crowther RA, Frank S, Hench J et al (2013) Brain homogenates from human tauopathies induce tau inclusions in mouse brain. Proc Natl Acad Sci USA 110:9535\u20139540","journal-title":"Proc Natl Acad Sci USA"},{"key":"2075_CR13","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/ncb1901","volume":"11","author":"F Clavaguera","year":"2009","unstructured":"Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A et al (2009) Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 11:909\u2013913","journal-title":"Nat Cell Biol"},{"key":"2075_CR14","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.neuron.2011.11.033","volume":"73","author":"A de Calignon","year":"2012","unstructured":"de Calignon A, Polydoro M, Suarez-Calvet M, William C, Adamowicz DH, Kopeikina KJ et al (2012) Propagation of tau pathology in a model of early Alzheimer's disease. Neuron 73:685\u2013697","journal-title":"Neuron"},{"key":"2075_CR15","volume-title":"Structure of the human brain, a photographic atlas","author":"SJ DeArmond","year":"1989","unstructured":"DeArmond SJ, Fusco MM, Dewey MM (1989) Structure of the human brain, a photographic atlas. Oxford University Press, Oxford"},{"key":"2075_CR16","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1097\/WCO.0b013e32833be924","volume":"23","author":"DW Dickson","year":"2010","unstructured":"Dickson DW, Ahmed Z, Algom AA, Tsuboi Y, Josephs KA (2010) Neuropathology of variants of progressive supranuclear palsy. Curr Opin Neurol 23:394\u2013400","journal-title":"Curr Opin Neurol"},{"key":"2075_CR17","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s12031-011-9589-0","volume":"45","author":"DW Dickson","year":"2011","unstructured":"Dickson DW, Kouri N, Murray ME, Josephs KA (2011) Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau). J Mol Neurosci 45:384\u2013389","journal-title":"J Mol Neurosci"},{"key":"2075_CR18","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1126\/science.1194516","volume":"330","author":"YS Eisele","year":"2010","unstructured":"Eisele YS, Oberm\u00fcller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H et al (2010) Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science 330:980\u2013982","journal-title":"Science"},{"key":"2075_CR19","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41586-018-0454-y","volume":"561","author":"B Falcon","year":"2018","unstructured":"Falcon B, Zhang W, Murzin AG, Murshudov G, Garringer HJ, Vidal R et al (2018) Structures of filaments from Pick's disease reveal a novel tau protein fold. Nature 561:137\u2013140","journal-title":"Nature"},{"key":"2075_CR20","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.1093\/cercor\/bhw157","volume":"26","author":"L Fan","year":"2016","unstructured":"Fan L, Li H, Zhuo J, Zhang Y, Wang J, Chen L et al (2016) The human brainnetome atlas: a new brain atlas based on connectional architecture. Cereb Cortex 26:3508\u20133526","journal-title":"Cereb Cortex"},{"key":"2075_CR21","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/ana.23844","volume":"73","author":"RC Gardner","year":"2013","unstructured":"Gardner RC, Boxer AL, Trujillo A, Mirsky JB, Guo CC, Gennatas ED et al (2013) Intrinsic connectivity network disruption in progressive supranuclear palsy. Ann Neurol 73:603\u2013616","journal-title":"Ann Neurol"},{"issue":"6248","key":"2075_CR22","doi-asserted-by":"publisher","first-page":"1255555","DOI":"10.1126\/science.1255555","volume":"349","author":"M. Goedert","year":"2015","unstructured":"Goedert M (2015) Neurodegeneration. Alzheimer's and Parkinson's diseases: the prion concept in relation to assembled A\u03b2, tau, and \u03b1-synuclein. Science 349:1255555","journal-title":"Science"},{"key":"2075_CR23","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","volume":"76","author":"ML Gorno-Tempini","year":"2011","unstructured":"Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF et al (2011) Classification of primary progressive aphasia and its variants. Neurology 76:1006\u20131014","journal-title":"Neurology"},{"key":"2075_CR24","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.febslet.2013.01.051","volume":"587","author":"JL Guo","year":"2013","unstructured":"Guo JL, Lee VM (2013) Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau. FEBS Lett 587:717\u2013723","journal-title":"FEBS Lett"},{"key":"2075_CR25","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s00234-007-0267-4","volume":"49","author":"C Habas","year":"2007","unstructured":"Habas C, Cabanis EA (2007) Anatomical parcellation of the brainstem and cerebellar white matter: a preliminary probabilistic tractography study at 3 T. Neuroradiology 49:849\u2013863","journal-title":"Neuroradiology"},{"key":"2075_CR26","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/BF00296179","volume":"87","author":"PR Hof","year":"1994","unstructured":"Hof PR, Bouras C, Perl DP, Morrison JH (1994) Quantitative neuropathologic analysis of Pick's disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer's disease. Acta Neuropathol 87:115\u2013124","journal-title":"Acta Neuropathol"},{"key":"2075_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","volume":"8","author":"BT Hyman","year":"2012","unstructured":"Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC et al (2012) National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement 8:1\u201313","journal-title":"Alzheimers Dement"},{"key":"2075_CR28","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1523\/JNEUROSCI.2642-12.2013","volume":"33","author":"M Iba","year":"2013","unstructured":"Iba M, Guo JL, McBride JD, Zhang B, Trojanowski JQ, Lee VM (2013) Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. J Neurosci 33:1024\u20131037","journal-title":"J Neurosci"},{"key":"2075_CR29","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1523\/JNEUROSCI.3542-15.2016","volume":"36","author":"SJ Jackson","year":"2016","unstructured":"Jackson SJ, Kerridge C, Cooper J, Cavallini A, Falcon B, Cella CV et al (2016) Short fibrils constitute the major species of seed-competent tau in the brains of mice transgenic for human P301S tau. J Neurosci 36:762\u2013772","journal-title":"J Neurosci"},{"key":"2075_CR30","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.neuron.2016.09.055","volume":"92","author":"SK Kaufman","year":"2016","unstructured":"Kaufman SK, Sanders DW, Thomas TL, Ruchinskas AJ, Vaquer-Alicea J, Sharma AM et al (2016) Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo. Neuron 92:796\u2013812","journal-title":"Neuron"},{"key":"2075_CR31","doi-asserted-by":"crossref","unstructured":"Kim E-J, Vatsavayai S, Seeley WW (2017) Neuropathology of dementia. Cambridge university press, Cambridge","DOI":"10.1017\/9781139924771.008"},{"key":"2075_CR32","doi-asserted-by":"publisher","first-page":"2960","DOI":"10.1007\/s00415-018-9086-2","volume":"265","author":"EJ Kim","year":"2018","unstructured":"Kim EJ, Brown JA, Deng J, Hwang JL, Spina S, Miller ZA et al (2018) Mixed TDP-43 proteinopathy and tauopathy in frontotemporal lobar degeneration: nine case series. J Neurol 265:2960\u20132971","journal-title":"J Neurol"},{"key":"2075_CR33","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/ana.22424","volume":"70","author":"SE Lee","year":"2011","unstructured":"Lee SE, Rabinovici GD, Mayo MC, Wilson SM, Seeley WW, DeArmond SJ et al (2011) Clinicopathological correlations in corticobasal degeneration. Ann Neurol 70:327\u2013340","journal-title":"Ann Neurol"},{"key":"2075_CR34","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1093\/brain\/aww256","volume":"139","author":"H Ling","year":"2016","unstructured":"Ling H, Kovacs GG, Vonsattel JP, Davey K, Mok KY, Hardy J et al (2016) Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology. Brain 139:3237\u20133252","journal-title":"Brain"},{"key":"2075_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1212\/WNL.47.1.1","volume":"47","author":"I Litvan","year":"1996","unstructured":"Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC et al (1996) Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 47:1\u20139","journal-title":"Neurology"},{"key":"2075_CR36","doi-asserted-by":"publisher","first-page":"e31302","DOI":"10.1371\/journal.pone.0031302","volume":"7","author":"L Liu","year":"2012","unstructured":"Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C et al (2012) Trans-synaptic spread of tau pathology in vivo. PLoS ONE 7:e31302","journal-title":"PLoS ONE"},{"key":"2075_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-009-0612-2","volume":"119","author":"I Mackenzie","year":"2010","unstructured":"Mackenzie I, Neumann M, Bigio E, Cairns N, Alafuzoff I, Kril J et al (2010) Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol 119:1\u20134","journal-title":"Acta Neuropathol"},{"key":"2075_CR38","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","volume":"65","author":"IG McKeith","year":"2005","unstructured":"McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H et al (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65:1863\u20131872","journal-title":"Neurology"},{"key":"2075_CR39","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan E (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939\u2013944","journal-title":"Neurology"},{"key":"2075_CR40","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH et al (2011) The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7:263\u2013269","journal-title":"Alzheimers Dement"},{"key":"2075_CR41","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1126\/science.1131864","volume":"313","author":"M Meyer-Luehmann","year":"2006","unstructured":"Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E et al (2006) Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science 313:1781\u20131784","journal-title":"Science"},{"key":"2075_CR42","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/neup.12080","volume":"34","author":"Y Miki","year":"2014","unstructured":"Miki Y, Mori F, Tanji K, Kurotaki H, Kakita A, Takahashi H et al (2014) An autopsy case of incipient Pick's disease: immunohistochemical profile of early-stage Pick body formation. Neuropathology 34:386\u2013391","journal-title":"Neuropathology"},{"issue":"1","key":"2075_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","volume":"123","author":"Thomas J. Montine","year":"2011","unstructured":"Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW et al (2012) National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol 123:1\u201311","journal-title":"Acta Neuropathologica"},{"key":"2075_CR44","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-73971-6","volume-title":"Duvernoy's Atlas of the human brain stem and cerebellum","author":"TP Naidich","year":"2009","unstructured":"Naidich TP, Duvernoy HM, Delman BN, Sorensen AG, Kollias SS, Haacke EM (2009) Duvernoy's Atlas of the human brain stem and cerebellum. Springer, Vienna, NewYork"},{"key":"2075_CR45","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/bs.mcb.2017.06.009","volume":"141","author":"S Narasimhan","year":"2017","unstructured":"Narasimhan S, Lee VMY (2017) The use of mouse models to study cell-to-cell transmission of pathological tau. Methods Cell Biol 141:287\u2013305","journal-title":"Methods Cell Biol"},{"key":"2075_CR46","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","volume":"51","author":"D Neary","year":"1998","unstructured":"Neary D, Snowden J, Gustafson L, Passant U, Stuss D, Black S et al (1998) Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51:1546\u20131554","journal-title":"Neurology"},{"key":"2075_CR47","doi-asserted-by":"publisher","first-page":"4220","DOI":"10.1038\/s41467-018-06548-9","volume":"9","author":"S Porta","year":"2018","unstructured":"Porta S, Xu Y, Restrepo CR, Kwong LK, Zhang B, Brown HJ et al (2018) Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo. Nat Commun 9:4220","journal-title":"Nat Commun"},{"key":"2075_CR48","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1126\/science.6801762","volume":"216","author":"SB Prusiner","year":"1982","unstructured":"Prusiner SB (1982) Novel proteinaceous infectious particles cause scrapie. Science 216:136\u2013144","journal-title":"Science"},{"key":"2075_CR49","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3233\/JPD-140485","volume":"5","author":"J Rahimi","year":"2015","unstructured":"Rahimi J, Milenkovic I, Kovacs GG (2015) Patterns of tau and \u03b1-synuclein pathology in the visual system. J Parkinsons Dis 5:333\u2013340","journal-title":"J Parkinsons Dis"},{"key":"2075_CR50","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.neuron.2011.12.040","volume":"73","author":"A Raj","year":"2012","unstructured":"Raj A, Kuceyeski A, Weiner M (2012) A network diffusion model of disease progression in dementia. Neuron 73:1204\u20131215","journal-title":"Neuron"},{"key":"2075_CR51","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.dadm.2016.12.006","volume":"5","author":"MR Raman","year":"2016","unstructured":"Raman MR, Kantarci K, Murray ME, Jack CR, Vemuri P (2016) Imaging markers of cerebrovascular pathologies: pathophysiology, clinical presentation, and risk factors. Alzheimers Dement (Amst) 5:5\u201314","journal-title":"Alzheimers Dement (Amst)"},{"key":"2075_CR52","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1093\/brain\/awr179","volume":"134","author":"K Rascovsky","year":"2011","unstructured":"Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J et al (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134:2456\u20132477","journal-title":"Brain"},{"key":"2075_CR53","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1001\/archneur.1968.00470310034003","volume":"18","author":"JJ Rebeiz","year":"1968","unstructured":"Rebeiz JJ, Kolodny EH, Richardson EP Jr (1968) Corticodentatonigral degeneration with neuronal achromasia. Arch Neurol 18:20\u201333","journal-title":"Arch Neurol"},{"key":"2075_CR54","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1155\/2000\/421719","volume":"12","author":"C Rorden","year":"2000","unstructured":"Rorden C, Brett M (2000) Stereotaxic display of brain lesions. Behav Neurol 12:191\u2013200","journal-title":"Behav Neurol"},{"key":"2075_CR55","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.neuron.2014.04.047","volume":"82","author":"DW Sanders","year":"2014","unstructured":"Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A et al (2014) Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron 82:1271\u20131288","journal-title":"Neuron"},{"key":"2075_CR56","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1001\/jamaneurol.2016.0412","volume":"73","author":"MA Santos-Santos","year":"2016","unstructured":"Santos-Santos MA, Mandelli ML, Binney RJ, Ogar J, Wilson SM, Henry ML et al (2016) Features of patients with nonfluent\/agrammatic primary progressive aphasia with underlying progressive supranuclear palsy pathology or corticobasal degeneration. JAMA Neurol 73:733\u2013742","journal-title":"JAMA Neurol"},{"key":"2075_CR57","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1093\/brain\/awh138","volume":"127","author":"JD Schmahmann","year":"2004","unstructured":"Schmahmann JD, Ko R, MacMore J (2004) The human basis pontis: motor syndromes and topographic organization. Brain 127:1269\u20131291","journal-title":"Brain"},{"key":"2075_CR58","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1523\/JNEUROSCI.17-01-00438.1997","volume":"17","author":"JD Schmahmann","year":"1997","unstructured":"Schmahmann JD, Pandya DN (1997) Anatomic organization of the basilar pontine projections from prefrontal cortices in rhesus monkey. J Neurosci 17:438\u2013458","journal-title":"J Neurosci"},{"key":"2075_CR59","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/cne.902890105","volume":"289","author":"JD Schmahmann","year":"1989","unstructured":"Schmahmann JD, Pandya DN (1989) Anatomical investigation of projections to the basis pontis from posterior parietal association cortices in rhesus monkey. J Comp Neurol 289:53\u201373","journal-title":"J Comp Neurol"},{"key":"2075_CR60","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0304-3940(95)12056-A","volume":"199","author":"JD Schmahmann","year":"1995","unstructured":"Schmahmann JD, Pandya DN (1995) Prefrontal cortex projections to the basilar pons in rhesus monkey: implications for the cerebellar contribution to higher function. Neurosci Lett 199:175\u2013178","journal-title":"Neurosci Lett"},{"key":"2075_CR61","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/cne.903370107","volume":"337","author":"JD Schmahmann","year":"1993","unstructured":"Schmahmann JD, Pandya DN (1993) Prelunate, occipitotemporal, and parahippocampal projections to the basis pontis in rhesus monkey. J Comp Neurol 337:94\u2013112","journal-title":"J Comp Neurol"},{"key":"2075_CR62","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/cne.20286","volume":"478","author":"JD Schmahmann","year":"2004","unstructured":"Schmahmann JD, Rosene DL, Pandya DN (2004) Motor projections to the basis pontis in rhesus monkey. J Comp Neurol 478:248\u2013268","journal-title":"J Comp Neurol"},{"key":"2075_CR63","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024","volume":"62","author":"W Seeley","year":"2009","unstructured":"Seeley W, Crawford R, Zhou J, Miller B, Greicius M (2009) Neurodegenerative diseases target large-scale human brain networks. Neuron 62:42\u201352","journal-title":"Neuron"},{"issue":"8","key":"2075_CR64","doi-asserted-by":"publisher","first-page":"a023622","DOI":"10.1101\/cshperspect.a023622","volume":"9","author":"William W. Seeley","year":"2017","unstructured":"Seeley WW (2017) Mapping neurodegenerative disease onset and progression. Cold Spring Harb Perspect Biol 9","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"2075_CR65","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1006\/nimg.2001.0861","volume":"14","author":"B Stieltjes","year":"2001","unstructured":"Stieltjes B, Kaufmann WE, van Zijl PC, Fredericksen K, Pearlson GD, Solaiyappan M et al (2001) Diffusion tensor imaging and axonal tracking in the human brainstem. Neuroimage 14:723\u2013735","journal-title":"Neuroimage"},{"key":"2075_CR66","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00401-009-0605-1","volume":"119","author":"M Tartaglia","year":"2010","unstructured":"Tartaglia M, Sidhu M, Laluz V, Racine C, Rabinovici G, Creighton K et al (2010) Sporadic corticobasal syndrome due to FTLD-TDP. Acta Neuropathol 119:365\u2013374","journal-title":"Acta Neuropathol"},{"key":"2075_CR67","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1159\/000146902","volume":"137","author":"G Tredici","year":"1990","unstructured":"Tredici G, Barajon I, Pizzini G, Sanguineti I (1990) The organization of corticopontine fibres in man. Acta Anat (Basel) 137:320\u2013323","journal-title":"Acta Anat (Basel)"},{"key":"2075_CR68","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1002\/mds.20478","volume":"20","author":"Y Tsuboi","year":"2005","unstructured":"Tsuboi Y, Josephs KA, Boeve BF, Litvan I, Caselli RJ, Caviness JN et al (2005) Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome. Mov Disord 20:982\u2013988","journal-title":"Mov Disord"},{"key":"2075_CR69","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1111\/ene.12675","volume":"22","author":"JL Whitwell","year":"2015","unstructured":"Whitwell JL, Boeve BF, Weigand SD, Senjem ML, Gunter JL, Baker MC et al (2015) Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images. Eur J Neurol 22:745\u2013752","journal-title":"Eur J Neurol"},{"issue":"Pt 3","key":"2075_CR70","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1093\/brain\/112.3.799","volume":"112","author":"SF Witelson","year":"1989","unstructured":"Witelson SF (1989) Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study. Brain 112(Pt 3):799\u2013835","journal-title":"Brain"},{"key":"2075_CR71","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1074\/jbc.M112.394528","volume":"288","author":"JW Wu","year":"2013","unstructured":"Wu JW, Herman M, Liu L, Simoes S, Acker CM, Figueroa H et al (2013) Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J Biol Chem 288:1856\u20131870","journal-title":"J Biol Chem"},{"key":"2075_CR72","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.neuron.2012.03.004","volume":"73","author":"J Zhou","year":"2012","unstructured":"Zhou J, Gennatas ED, Kramer JH, Miller BL, Seeley WW (2012) Predicting regional neurodegeneration from the healthy brain functional connectome. Neuron 73:1216\u20131227","journal-title":"Neuron"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-019-02075-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-019-02075-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-019-02075-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T02:24:09Z","timestamp":1664418249000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-019-02075-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,21]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["2075"],"URL":"https:\/\/doi.org\/10.1007\/s00401-019-02075-z","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,21]]},"assertion":[{"value":"4 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}