{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:52:13Z","timestamp":1793393533209,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["AG057902"],"award-info":[{"award-number":["AG057902"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["RF1AG054156"],"award-info":[{"award-number":["RF1AG054156"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U54NS115266"],"award-info":[{"award-number":["U54NS115266"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01NS086659"],"award-info":[{"award-number":["U01NS086659"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23NS102399"],"award-info":[{"award-number":["K23NS102399"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01-CX001038"],"award-info":[{"award-number":["I01-CX001038"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nick and Lynn Buoniconti Foundation"},{"name":"Clinical and Translational Sciences Institute, Boston University","award":["1UL1TR001430"],"award-info":[{"award-number":["1UL1TR001430"]}]},{"DOI":"10.13039\/100014040","name":"Peer Reviewed Alzheimer\u2019s Research Program","doi-asserted-by":"publisher","award":["AARF-17-529888"],"award-info":[{"award-number":["AARF-17-529888"]}],"id":[{"id":"10.13039\/100014040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["K23AG046377"],"award-info":[{"award-number":["K23AG046377"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG13846"],"award-info":[{"award-number":["P30AG13846"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s00401-020-02197-9","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T21:02:18Z","timestamp":1597093338000},"page":"495-512","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme"],"prefix":"10.1007","volume":"140","author":[{"given":"Michael L.","family":"Alosco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand Russell","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorghos","family":"Tripodis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Baucom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil W.","family":"Kowall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Saltiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee E.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas I.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigid","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Daneshvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph N.","family":"Palmisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Cantu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor E.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor D.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.","family":"McKee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"2197_CR1","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1002\/ana.25245","volume":"83","author":"ML Alosco","year":"2018","unstructured":"Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L et al (2018) Age of first exposure to tackle football and chronic traumatic encephalopathy. Ann Neurol 83:886\u2013901. https:\/\/doi.org\/10.1002\/ana.25245","journal-title":"Ann Neurol"},{"key":"2197_CR2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2244","author":"ML Alosco","year":"2019","unstructured":"Alosco ML, Stein TD, Tripodis Y, Chua AS, Kowall NW, Huber BR et al (2019) Association of white matter rarefaction, arteriolosclerosis, and tau with dementia in chronic traumatic encephalopathy. JAMA Neurol. https:\/\/doi.org\/10.1001\/jamaneurol.2019.2244","journal-title":"JAMA Neurol"},{"key":"2197_CR3","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s10072-018-3686-6","volume":"40","author":"RA Armstrong","year":"2019","unstructured":"Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ (2019) Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change. Neurol Sci 40:529\u2013533. https:\/\/doi.org\/10.1007\/s10072-018-3686-6","journal-title":"Neurol Sci"},{"key":"2197_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/bpa.12757","volume":"30","author":"KF Bieniek","year":"2020","unstructured":"Bieniek KF, Blessing MM, Heckman MG, Diehl NN, Serie AM, Paolini MA 2nd et al (2020) Association between contact sports participation and chronic traumatic encephalopathy: a retrospective cohort study. Brain Pathol 30:63\u201374. https:\/\/doi.org\/10.1111\/bpa.12757","journal-title":"Brain Pathol"},{"key":"2197_CR5","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s00401-015-1502-4","volume":"130","author":"KF Bieniek","year":"2015","unstructured":"Bieniek KF, Ross OA, Cormier KA, Walton RL, Soto-Ortolaza A, Johnston AE et al (2015) Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank. Acta Neuropathol 130:877\u2013889. https:\/\/doi.org\/10.1007\/s00401-015-1502-4","journal-title":"Acta Neuropathol"},{"key":"2197_CR6","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1097\/NEN.0b013e31817d751c","volume":"67","author":"EH Bigio","year":"2008","unstructured":"Bigio EH (2008) Update on recent molecular and genetic advances in frontotemporal lobar degeneration. J Neuropathol Exp Neurol 67:635\u2013648. https:\/\/doi.org\/10.1097\/NEN.0b013e31817d751c","journal-title":"J Neuropathol Exp Neurol"},{"key":"2197_CR7","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239\u2013259. https:\/\/doi.org\/10.1007\/BF00308809","journal-title":"Acta Neuropathol"},{"key":"2197_CR8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","volume":"16","author":"H Braak","year":"1995","unstructured":"Braak H, Braak E (1995) Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16:271\u2013278. https:\/\/doi.org\/10.1016\/0197-4580(95)00021-6","journal-title":"Neurobiol Aging"},{"key":"2197_CR9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00401-010-0789-4","volume":"121","author":"H Braak","year":"2011","unstructured":"Braak H, Del Tredici K (2011) The pathological process underlying Alzheimer's disease in individuals under thirty. Acta Neuropathol 121:171\u2013181. https:\/\/doi.org\/10.1007\/s00401-010-0789-4","journal-title":"Acta Neuropathol"},{"key":"2197_CR10","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1136\/jnnp.33.3.338","volume":"33","author":"B Brownell","year":"1970","unstructured":"Brownell B, Oppenheimer DR, Hughes JT (1970) The central nervous system in motor neurone disease. J Neurol Neurosurg Psychiatry 33:338\u2013357. https:\/\/doi.org\/10.1136\/jnnp.33.3.338","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2197_CR11","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2353\/ajpath.2007.070182","volume":"171","author":"NJ Cairns","year":"2007","unstructured":"Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ et al (2007) TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Am J Pathol 171:227\u2013240. https:\/\/doi.org\/10.2353\/ajpath.2007.070182","journal-title":"Am J Pathol"},{"key":"2197_CR12","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12867","author":"JD Cherry","year":"2020","unstructured":"Cherry JD, Kim SH, Stein TD, Pothast MJ, Nicks R, Meng G et al (2020) Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy. Brain Pathol. https:\/\/doi.org\/10.1111\/bpa.12867","journal-title":"Brain Pathol"},{"key":"2197_CR13","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s40478-016-0382-8","volume":"4","author":"JD Cherry","year":"2016","unstructured":"Cherry JD, Tripodis Y, Alvarez VE, Huber B, Kiernan PT, Daneshvar DH et al (2016) Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy. Acta Neuropathol Commun 4:112. https:\/\/doi.org\/10.1186\/s40478-016-0382-8","journal-title":"Acta Neuropathol Commun"},{"key":"2197_CR14","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1017\/s0033291700049588","volume":"3","author":"JA Corsellis","year":"1973","unstructured":"Corsellis JA, Bruton CJ, Freeman-Browne D (1973) The aftermath of boxing. Psychol Med 3:270\u2013303. https:\/\/doi.org\/10.1017\/s0033291700049588","journal-title":"Psychol Med"},{"key":"2197_CR15","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.jns.2016.10.052","volume":"372","author":"AS de Miranda","year":"2017","unstructured":"de Miranda AS, Zhang CJ, Katsumoto A, Teixeira AL (2017) Hippocampal adult neurogenesis: does the immune system matter? J Neurol Sci 372:482\u2013495. https:\/\/doi.org\/10.1016\/j.jns.2016.10.052","journal-title":"J Neurol Sci"},{"key":"2197_CR16","first-page":"1","volume":"3","author":"DW Dickson","year":"2009","unstructured":"Dickson DW (2009) Neuropathology of non-Alzheimer degenerative disorders. Int J Clin Exp Pathol 3:1\u201323","journal-title":"Int J Clin Exp Pathol"},{"key":"2197_CR17","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3233\/JAD-180688","volume":"66","author":"AJ Ehrenberg","year":"2018","unstructured":"Ehrenberg AJ, Suemoto CK, Franca Resende EP, Petersen C, Leite REP, Rodriguez RD et al (2018) Neuropathologic correlates of psychiatric symptoms in Alzheimer's disease. J Alzheimers Dis 66:115\u2013126. https:\/\/doi.org\/10.3233\/JAD-180688","journal-title":"J Alzheimers Dis"},{"key":"2197_CR18","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1177\/0271678X16679420","volume":"37","author":"F Erdo","year":"2017","unstructured":"Erdo F, Denes L, de Lange E (2017) Age-associated physiological and pathological changes at the blood-brain barrier: a review. J Cereb Blood Flow Metab 37:4\u201324. https:\/\/doi.org\/10.1177\/0271678X16679420","journal-title":"J Cereb Blood Flow Metab"},{"key":"2197_CR19","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/jnen\/nlx113","volume":"77","author":"RA Eser","year":"2018","unstructured":"Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK et al (2018) Selective vulnerability of brainstem nuclei in distinct tauopathies: a postmortem study. J Neuropathol Exp Neurol 77:149\u2013161. https:\/\/doi.org\/10.1093\/jnen\/nlx113","journal-title":"J Neuropathol Exp Neurol"},{"key":"2197_CR20","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s41586-019-1026-5","volume":"568","author":"B Falcon","year":"2019","unstructured":"Falcon B, Zivanov J, Zhang W, Murzin AG, Garringer HJ, Vidal R et al (2019) Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature 568:420\u2013423. https:\/\/doi.org\/10.1038\/s41586-019-1026-5","journal-title":"Nature"},{"key":"2197_CR21","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1093\/jnen\/nlz017","volume":"78","author":"SL Forrest","year":"2019","unstructured":"Forrest SL, Kril JJ, Wagner S, Honigschnabl S, Reiner A, Fischer P et al (2019) Chronic traumatic encephalopathy (CTE) is absent from a european community-based aging cohort while cortical aging-related tau astrogliopathy (ARTAG) is highly prevalent. J Neuropathol Exp Neurol 78:398\u2013405. https:\/\/doi.org\/10.1093\/jnen\/nlz017","journal-title":"J Neuropathol Exp Neurol"},{"key":"2197_CR22","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000197389","volume":"32","author":"S Haneuse","year":"2009","unstructured":"Haneuse S, Schildcrout J, Crane P, Sonnen J, Breitner J, Larson E (2009) Adjustment for selection bias in observational studies with application to the analysis of autopsy data. Neuroepidemiology 32:229\u2013239. https:\/\/doi.org\/10.1159\/000197389","journal-title":"Neuroepidemiology"},{"key":"2197_CR23","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1093\/jnen\/nlz045","volume":"78","author":"GL Iverson","year":"2019","unstructured":"Iverson GL, Luoto TM, Karhunen PJ, Castellani RJ (2019) Mild chronic traumatic encephalopathy neuropathology in people with no known participation in contact sports or history of repetitive neurotrauma. J Neuropathol Exp Neurol 78:615\u2013625. https:\/\/doi.org\/10.1093\/jnen\/nlz045","journal-title":"J Neuropathol Exp Neurol"},{"key":"2197_CR24","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1093\/brain\/aww224","volume":"139","author":"BD James","year":"2016","unstructured":"James BD, Wilson RS, Boyle PA, Trojanowski JQ, Bennett DA, Schneider JA (2016) TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia. Brain 139:2983\u20132993. https:\/\/doi.org\/10.1093\/brain\/aww224","journal-title":"Brain"},{"key":"2197_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12916-018-1016-8","volume":"16","author":"KA Jellinger","year":"2018","unstructured":"Jellinger KA, Korczyn AD (2018) Are dementia with Lewy bodies and Parkinson's disease dementia the same disease? BMC Med 16:34. https:\/\/doi.org\/10.1186\/s12916-018-1016-8","journal-title":"BMC Med"},{"key":"2197_CR26","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/ana.24271","volume":"76","author":"BT Kress","year":"2014","unstructured":"Kress BT, Iliff JJ, Xia M, Wang M, Wei HS, Zeppenfeld D et al (2014) Impairment of paravascular clearance pathways in the aging brain. Ann Neurol 76:845\u2013861. https:\/\/doi.org\/10.1002\/ana.24271","journal-title":"Ann Neurol"},{"key":"2197_CR27","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s00401-019-02030-y","volume":"138","author":"EB Lee","year":"2019","unstructured":"Lee EB, Kinch K, Johnson VE, Trojanowski JQ, Smith DH, Stewart W (2019) Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players. Acta Neuropathol 138:389\u2013399. https:\/\/doi.org\/10.1007\/s00401-019-02030-y","journal-title":"Acta Neuropathol"},{"key":"2197_CR28","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1007\/s00401-015-1496-y","volume":"130","author":"H Ling","year":"2015","unstructured":"Ling H, Holton JL, Shaw K, Davey K, Lashley T, Revesz T (2015) Histological evidence of chronic traumatic encephalopathy in a large series of neurodegenerative diseases. Acta Neuropathol 130:891\u2013893. https:\/\/doi.org\/10.1007\/s00401-015-1496-y","journal-title":"Acta Neuropathol"},{"key":"2197_CR29","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00401-017-1680-3","volume":"133","author":"H Ling","year":"2017","unstructured":"Ling H, Morris HR, Neal JW, Lees AJ, Hardy J, Holton JL et al (2017) Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players. Acta Neuropathol 133:337\u2013352. https:\/\/doi.org\/10.1007\/s00401-017-1680-3","journal-title":"Acta Neuropathol"},{"key":"2197_CR30","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/00005072-199601000-00010","volume":"55","author":"I Litvan","year":"1996","unstructured":"Litvan I, Hauw JJ, Bartko JJ, Lantos PL, Daniel SE, Horoupian DS et al (1996) Validity and reliability of the preliminary NINDS neuropathologic criteria for progressive supranuclear palsy and related disorders. J Neuropathol Exp Neurol 55:97\u2013105. https:\/\/doi.org\/10.1097\/00005072-199601000-00010","journal-title":"J Neuropathol Exp Neurol"},{"key":"2197_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-009-0612-2","volume":"119","author":"IR Mackenzie","year":"2010","unstructured":"Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J et al (2010) Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol 119:1\u20134. https:\/\/doi.org\/10.1007\/s00401-009-0612-2","journal-title":"Acta Neuropathol"},{"key":"2197_CR32","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00401-015-1515-z","volume":"131","author":"AC McKee","year":"2016","unstructured":"McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Keene CD, Litvan I et al (2016) The first NINDS\/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathol 131:75\u201386. https:\/\/doi.org\/10.1007\/s00401-015-1515-z","journal-title":"Acta Neuropathol"},{"key":"2197_CR33","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","volume":"68","author":"AC McKee","year":"2009","unstructured":"McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE et al (2009) Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 68:709\u2013735. https:\/\/doi.org\/10.1097\/NEN.0b013e3181a9d503","journal-title":"J Neuropathol Exp Neurol"},{"key":"2197_CR34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/brain\/aws307","volume":"136","author":"AC McKee","year":"2013","unstructured":"McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH et al (2013) The spectrum of disease in chronic traumatic encephalopathy. Brain 136:43\u201364. https:\/\/doi.org\/10.1093\/brain\/aws307","journal-title":"Brain"},{"key":"2197_CR35","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3233\/jad-2006-9s347","volume":"9","author":"IG McKeith","year":"2006","unstructured":"McKeith IG (2006) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop. J Alzheimers Dis 9:417\u2013423. https:\/\/doi.org\/10.3233\/jad-2006-9s347","journal-title":"J Alzheimers Dis"},{"key":"2197_CR36","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/ana.25611","volume":"87","author":"J Mez","year":"2020","unstructured":"Mez J, Daneshvar DH, Abdolmohammadi B, Chua AS, Alosco ML, Kiernan PT et al (2020) Duration of American football play and chronic traumatic encephalopathy. Ann Neurol 87:116\u2013131. https:\/\/doi.org\/10.1002\/ana.25611","journal-title":"Ann Neurol"},{"key":"2197_CR37","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1001\/jama.2017.8334","volume":"318","author":"J Mez","year":"2017","unstructured":"Mez J, Daneshvar DH, Kiernan PT, Abdolmohammadi B, Alvarez VE, Huber BR et al (2017) Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football. JAMA 318:360\u2013370. https:\/\/doi.org\/10.1001\/jama.2017.8334","journal-title":"JAMA"},{"key":"2197_CR38","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13195-015-0148-8","volume":"7","author":"J Mez","year":"2015","unstructured":"Mez J, Solomon TM, Daneshvar DH, Murphy L, Kiernan PT, Montenigro PH et al (2015) Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study. Alzheimers Res Ther 7:62. https:\/\/doi.org\/10.1186\/s13195-015-0148-8","journal-title":"Alzheimers Res Ther"},{"key":"2197_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","volume":"123","author":"TJ Montine","year":"2012","unstructured":"Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW et al (2012) National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol 123:1\u201311. https:\/\/doi.org\/10.1007\/s00401-011-0910-3","journal-title":"Acta Neuropathol"},{"key":"2197_CR40","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/s0197-4580(88)80013-7","volume":"9","author":"AD Mooradian","year":"1988","unstructured":"Mooradian AD (1988) Effect of aging on the blood-brain barrier. Neurobiol Aging 9:31\u201339. https:\/\/doi.org\/10.1016\/s0197-4580(88)80013-7","journal-title":"Neurobiol Aging"},{"key":"2197_CR41","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1097\/00005072-199911000-00004","volume":"58","author":"KL Newell","year":"1999","unstructured":"Newell KL, Hyman BT, Growdon JH, Hedley-Whyte ET (1999) Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease. J Neuropathol Exp Neurol 58:1147\u20131155. https:\/\/doi.org\/10.1097\/00005072-199911000-00004","journal-title":"J Neuropathol Exp Neurol"},{"key":"2197_CR42","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1093\/jnen\/nlw026","volume":"75","author":"A Serrano-Pozo","year":"2016","unstructured":"Serrano-Pozo A, Qian J, Muzikansky A, Monsell SE, Montine TJ, Frosch MP et al (2016) Thal amyloid stages do not significantly impact the correlation between neuropathological change and cognition in the Alzheimer disease continuum. J Neuropathol Exp Neurol 75:516\u2013526. https:\/\/doi.org\/10.1093\/jnen\/nlw026","journal-title":"J Neuropathol Exp Neurol"},{"key":"2197_CR43","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00401-015-1435-y","volume":"130","author":"TD Stein","year":"2015","unstructured":"Stein TD, Montenigro PH, Alvarez VE, Xia W, Crary JF, Tripodis Y et al (2015) Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol 130:21\u201334. https:\/\/doi.org\/10.1007\/s00401-015-1435-y","journal-title":"Acta Neuropathol"},{"key":"2197_CR44","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1212\/WNL.0b013e3182a55f7f","volume":"81","author":"RA Stern","year":"2013","unstructured":"Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO et al (2013) Clinical presentation of chronic traumatic encephalopathy. Neurology 81:1122\u20131129. https:\/\/doi.org\/10.1212\/WNL.0b013e3182a55f7f","journal-title":"Neurology"},{"key":"2197_CR45","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/1467-9868.00293","volume":"63","author":"R Tibshirani","year":"2001","unstructured":"Tibshirani R, Walther G, Hastie T (2001) Estimating the number of clusters in a data set via the gap statistic. J R Stat Soc Ser B (Stat Methodol) 63:411\u2013423","journal-title":"J R Stat Soc Ser B (Stat Methodol)"},{"key":"2197_CR46","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/cen3.12307","volume":"7","author":"JC Udeochu","year":"2016","unstructured":"Udeochu JC, Shea JM, Villeda SA (2016) Microglia communication: Parallels between aging and Alzheimer's disease. Clin Exp Neuroimmunol 7:114\u2013125. https:\/\/doi.org\/10.1111\/cen3.12307","journal-title":"Clin Exp Neuroimmunol"},{"key":"2197_CR47","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/00005072-199501000-00006","volume":"54","author":"JP Vonsattel","year":"1995","unstructured":"Vonsattel JP, Aizawa H, Ge P, DiFiglia M, McKee AC, MacDonald M et al (1995) An improved approach to prepare human brains for research. J Neuropathol Exp Neurol 54:42\u201356. https:\/\/doi.org\/10.1097\/00005072-199501000-00006","journal-title":"J Neuropathol Exp Neurol"},{"key":"2197_CR48","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s00401-007-0311-9","volume":"115","author":"JP Vonsattel","year":"2008","unstructured":"Vonsattel JP, Del Amaya MP, Keller CE (2008) Twenty-first century brain banking. Processing brains for research: the Columbia University methods. Acta Neuropathol 115:509\u2013532. https:\/\/doi.org\/10.1007\/s00401-007-0311-9","journal-title":"Acta Neuropathol"},{"key":"2197_CR49","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1001\/jamapsychiatry.2013.2224","volume":"70","author":"RS Wilson","year":"2013","unstructured":"Wilson RS, Nag S, Boyle PA, Hizel LP, Yu L, Buchman AS et al (2013) Brainstem aminergic nuclei and late-life depressive symptoms. JAMA Psychiatry 70:1320\u20131328. https:\/\/doi.org\/10.1001\/jamapsychiatry.2013.2224","journal-title":"JAMA Psychiatry"},{"key":"2197_CR50","doi-asserted-by":"publisher","first-page":"E8187","DOI":"10.1073\/pnas.1616344113","volume":"113","author":"AL Woerman","year":"2016","unstructured":"Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT et al (2016) Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci USA 113:E8187\u2013E8196. https:\/\/doi.org\/10.1073\/pnas.1616344113","journal-title":"Proc Natl Acad Sci USA"},{"key":"2197_CR51","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1177\/0271678X16676826","volume":"37","author":"CY Xing","year":"2017","unstructured":"Xing CY, Tarumi T, Liu J, Zhang Y, Turner M, Riley J et al (2017) Distribution of cardiac output to the brain across the adult lifespan. J Cereb Blood Flow Metab 37:2848\u20132856. https:\/\/doi.org\/10.1177\/0271678X16676826","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-020-02197-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00401-020-02197-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-020-02197-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T19:43:05Z","timestamp":1628624585000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00401-020-02197-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["2197"],"URL":"https:\/\/doi.org\/10.1007\/s00401-020-02197-9","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,11]]},"assertion":[{"value":"27 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}