{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:35:55Z","timestamp":1791776155099,"version":"4.3.4"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Chenevert Family Foundation, Inc."},{"name":"Martin J. Gavin Endowment at Connecticut Children\u2019s Medical Center"},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["P30CA034196"],"award-info":[{"award-number":["P30CA034196"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Supratentorial ependymoma (ST-EPN) is a type of malignant brain tumor mainly seen in children. Since 2014, it has been known that an intrachromosomal fusion\n                    <jats:italic>C11orf95-RELA<\/jats:italic>\n                    is an oncogenic driver in ST-EPN [Parker et al. Nature 506:451\u2013455 (2014); Pietsch et al. Acta Neuropathol 127:609\u2013611 (2014)] but the molecular mechanisms of oncogenesis are unclear. Here we show that the C11orf95 component of the fusion protein dictates DNA binding activity while the RELA component is required for driving the expression of ependymoma-associated genes. Epigenomic characterizations using ChIP-seq and HiChIP approaches reveal that C11orf95-RELA modulates chromatin states and mediates chromatin interactions, leading to transcriptional reprogramming in ependymoma cells. Our findings provide important characterization of the molecular underpinning of\n                    <jats:italic>C11orf95-RELA<\/jats:italic>\n                    fusion and shed light on potential therapeutic targets for\n                    <jats:italic>C11orf95-RELA<\/jats:italic>\n                    subtype ependymoma.\n                  <\/jats:p>","DOI":"10.1007\/s00401-020-02225-8","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T10:32:09Z","timestamp":1599733929000},"page":"951-960","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["C11orf95-RELA reprograms 3D epigenome in supratentorial ependymoma"],"prefix":"10.1007","volume":"140","author":[{"given":"Jacqueline Jufen","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Jillette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Wu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9173-8366","authenticated-orcid":false,"given":"Ching C.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"2225_CR1","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s13059-015-0767-1","volume":"16","author":"KC Akdemir","year":"2015","unstructured":"Akdemir KC, Chin L (2015) HiCPlotter integrates genomic data with interaction matrices. 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