{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:49:50Z","timestamp":1790696990225,"version":"4.1.0"},"reference-count":136,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R01AG048678-01A1"],"award-info":[{"award-number":["1R01AG048678-01A1"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R01AG059689-01A1"],"award-info":[{"award-number":["1R01AG059689-01A1"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R01NS089932-01A1"],"award-info":[{"award-number":["1R01NS089932-01A1"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chan Zuckerberg Initiative Collaborate Science Award","award":["2018-191983"],"award-info":[{"award-number":["2018-191983"]}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2019060"],"award-info":[{"award-number":["A2019060"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chan Zuckerberg Initiative Collaborative Science Award","award":["2018-191983"],"award-info":[{"award-number":["2018-191983"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tauopathies consist of over 25 different neurodegenerative diseases that include argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick\u2019s disease (PiD). Tauopathies are defined by brain accumulation of microtubule-associated protein tau in fibrillar aggregates, whose prevalence strongly correlates with dementia. Dominant mutations in tau cause neurodegenerative diseases, and most increase its aggregation propensity. Pathogenesis of tauopathies may involve pathological tau conformers that serve as templates to recruit native protein into growing assemblies and also move between brain cells to cause disease progression, similar to prions. Prions adopt pathological conformations, termed \u201cstrains,\u201d that stably propagate in living systems, and create unique patterns of neuropathology. Data from multiple laboratories now suggest that tau acts as a prion. It propagates unique strains indefinitely in cultured cells, and when these are inoculated into mouse models, they create defined neuropathological patterns, which establish a direct link between conformation and disease. In humans, distinct fibril structures are associated with different diseases, but causality has not been established as in mice. Cryo-EM structures of tau fibrils isolated from tauopathy brains reveal distinct fibril cores across disease. Interestingly, the conformation of the tau monomer\u00a0unit within different fibril subtypes from the same patient appears relatively preserved. This is consistent with data that the tau monomer samples an ensemble of conformations that act as distinct pathologic templates in the formation of restricted numbers of strains. The propensity of a tau monomer to adopt distinct conformations appears to be linked to defined local motifs that expose different patterns of amyloidogenic amino acid sequences. The prion hypothesis, which predicts that protein structure dictates resultant disease, has proved particularly useful to understand the diversity of human tauopathies. The challenge now is to develop methods to rapidly classify patients according to the structure of the underlying pathological protein assemblies to achieve more accurate diagnosis and effective therapy.<\/jats:p>","DOI":"10.1007\/s00401-021-02301-7","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T09:03:14Z","timestamp":1617872594000},"page":"57-71","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":138,"title":["Tau strains shape disease"],"prefix":"10.1007","volume":"142","author":[{"given":"Jaime","family":"Vaquer-Alicea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc I.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3061-5850","authenticated-orcid":false,"given":"Lukasz A.","family":"Joachimiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"2301_CR1","doi-asserted-by":"publisher","first-page":"106519","DOI":"10.1016\/j.bpc.2020.106519","volume":"269","author":"ED Agerschou","year":"2020","unstructured":"Agerschou ED, Sch\u00fctzmann MP, Reppert N, W\u00f6rdehoff MM, Shaykhalishahi H, Buell AK, Hoyer W (2020) \u03b2-Turn exchanges in the \u03b1-synuclein segment 44-TKEG-47 reveal high sequence fidelity requirements of amyloid fibril elongation. Biophys Chem 269:106519. https:\/\/doi.org\/10.1016\/j.bpc.2020.106519","journal-title":"Biophys Chem"},{"key":"2301_CR2","doi-asserted-by":"publisher","first-page":"3511","DOI":"10.1002\/anie.201208290","volume":"52","author":"E Akoury","year":"2013","unstructured":"Akoury E, Pickhardt M, Gajda M, Biernat J, Mandelkow E, Zweckstetter M (2013) Mechanistic basis of phenothiazine-driven inhibition of tau aggregation. Angewandte Chemie Int Ed 52:3511\u20133515. https:\/\/doi.org\/10.1002\/anie.201208290","journal-title":"Angewandte Chemie Int Ed"},{"key":"2301_CR3","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.1016\/j.jmb.2018.08.010","volume":"430","author":"YK Al-Hilaly","year":"2018","unstructured":"Al-Hilaly YK, Pollack SJ, Rickard JE, Simpson M, Raulin A-C, Baddeley T, Schellenberger P, Storey JMD, Harrington CR, Wischik CM, Serpell LC (2018) Cysteine-independent inhibition of Alzheimer\u2019s disease-like paired helical filament assembly by leuco-methylthioninium (LMT). J Mol Biol 430:4119\u20134131. https:\/\/doi.org\/10.1016\/j.jmb.2018.08.010","journal-title":"J Mol Biol"},{"key":"2301_CR4","doi-asserted-by":"publisher","first-page":"9340","DOI":"10.1523\/jneurosci.22-21-09340.2002","volume":"22","author":"B Allen","year":"2002","unstructured":"Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, Yoshida H, Holzer M, Craxton M, Emson PC, Atzori C, Migheli A, Crowther RA, Ghetti B, Spillantini MG, Goedert M (2002) Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci 22:9340\u20139351. https:\/\/doi.org\/10.1523\/jneurosci.22-21-09340.2002","journal-title":"J Neurosci"},{"key":"2301_CR5","doi-asserted-by":"publisher","first-page":"6503","DOI":"10.1039\/c9sc00531e","volume":"10","author":"S Ambadipudi","year":"2019","unstructured":"Ambadipudi S, Reddy JG, Biernat J, Mandelkow E, Zweckstetter M (2019) Residue-specific identification of phase separation hot spots of Alzheimer\u2019s-related protein tau. Chem Sci 10:6503\u20136507. https:\/\/doi.org\/10.1039\/c9sc00531e","journal-title":"Chem Sci"},{"key":"2301_CR6","doi-asserted-by":"publisher","first-page":"10626","DOI":"10.1021\/bi00158a027","volume":"31","author":"A Andreadis","year":"1992","unstructured":"Andreadis A, Brown WM, Kosik KS (1992) Structure and novel exons of the human.tau. gene. Biochemistry-us 31:10626\u201310633. https:\/\/doi.org\/10.1021\/bi00158a027","journal-title":"Biochemistry-us"},{"key":"2301_CR7","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.cell.2020.01.027","volume":"180","author":"T Arakhamia","year":"2020","unstructured":"Arakhamia T, Lee CE, Carlomagno Y, Duong DM, Kundinger SR, Wang K, Williams D, DeTure M, Dickson DW, Cook CN, Seyfried NT, Petrucelli L, Fitzpatrick AWP (2020) Posttranslational modifications mediate the structural diversity of Tauopathy strains. Cell 180:633-644.e12. https:\/\/doi.org\/10.1016\/j.cell.2020.01.027","journal-title":"Cell"},{"key":"2301_CR8","doi-asserted-by":"publisher","first-page":"7606","DOI":"10.1039\/c4cp05563b","volume":"17","author":"P Arosio","year":"2015","unstructured":"Arosio P, Knowles TPJ, Linse S (2015) On the lag phase in amyloid fibril formation. Phys Chem Chem Phys 17:7606\u20137618. https:\/\/doi.org\/10.1039\/c4cp05563b","journal-title":"Phys Chem Chem Phys"},{"key":"2301_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/bf02778005","volume":"8","author":"HF Baker","year":"1994","unstructured":"Baker HF, Ridley RM, Duchen LW, Crow TJ, Bruton CJ (1994) Induction of \u03b2(A4)-amyloid in primates by injection of Alzheimer\u2019s disease brain homogenate. Mol Neurobiol 8:25\u201339. https:\/\/doi.org\/10.1007\/bf02778005","journal-title":"Mol Neurobiol"},{"key":"2301_CR10","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/s0140-6736(15)00461-4","volume":"386","author":"J Bang","year":"2015","unstructured":"Bang J, Spina S, Miller BL (2015) Frontotemporal dementia. Lancet 386:1672\u20131682. https:\/\/doi.org\/10.1016\/s0140-6736(15)00461-4","journal-title":"Lancet"},{"key":"2301_CR11","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3389\/fnagi.2019.00204","volume":"11","author":"P Barbier","year":"2019","unstructured":"Barbier P, Zejneli O, Martinho M, Lasorsa A, Belle V, Smet-Nocca C, Tsvetkov PO, Devred F, Landrieu I (2019) Role of tau as a microtubule-associated protein: structural and functional aspects. Front Aging Neurosci 11:204. https:\/\/doi.org\/10.3389\/fnagi.2019.00204","journal-title":"Front Aging Neurosci"},{"key":"2301_CR12","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1021\/bi0357006","volume":"43","author":"S Barghorn","year":"2004","unstructured":"Barghorn S, Davies P, Mandelkow E (2004) Tau paired helical filaments from Alzheimer\u2019s disease brain and assembled in vitro are based on \u03b2-structure in the core domain \u2020. Biochemistry-us 43:1694\u20131703. https:\/\/doi.org\/10.1021\/bi0357006","journal-title":"Biochemistry-us"},{"key":"2301_CR13","doi-asserted-by":"publisher","first-page":"7859","DOI":"10.1128\/jvi.68.12.7859-7868.1994","volume":"68","author":"RA Bessen","year":"1994","unstructured":"Bessen RA, Marsh RF (1994) Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy. J Virol 68:7859\u20137868. https:\/\/doi.org\/10.1128\/jvi.68.12.7859-7868.1994","journal-title":"J Virol"},{"key":"2301_CR14","doi-asserted-by":"publisher","unstructured":"Bhat RV, Andersson U, Andersson S, Knerr L, Bauer U, Andersson AS (2018) The conundrum of GSK3 inhibitors: is it the dawn of a new beginning? J Alzheimer\u2019s Dis Preprint. https:\/\/doi.org\/10.3233\/jad-179934","DOI":"10.3233\/jad-179934"},{"key":"2301_CR15","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/39057","volume":"389","author":"ME Bruce","year":"1997","unstructured":"Bruce ME, Will RG, Ironside JW, McConnell I, Drummond D, Suttie A, McCardle L, Chree A, Hope J, Birkett C, Cousens S, Fraser H, Bostock CJ (1997) Transmissions to mice indicate that \u2018new variant\u2019 CJD is caused by the BSE agent. Nature 389:498\u2013501. https:\/\/doi.org\/10.1038\/39057","journal-title":"Nature"},{"key":"2301_CR16","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1038\/s41467-019-10355-1","volume":"10","author":"D Chen","year":"2019","unstructured":"Chen D, Drombosky KW, Hou Z, Sari L, Kashmer OM, Ryder BD, Perez VA, Woodard DR, Lin MM, Diamond MI, Joachimiak LA (2019) Tau local structure shields an amyloid-forming motif and controls aggregation propensity. Nat Commun 10:2493. https:\/\/doi.org\/10.1038\/s41467-019-10355-1","journal-title":"Nat Commun"},{"key":"2301_CR17","doi-asserted-by":"publisher","first-page":"25644","DOI":"10.1074\/jbc.m301663200","volume":"278","author":"CN Chirita","year":"2003","unstructured":"Chirita CN, Necula M, Kuret J (2003) Anionic micelles and vesicles induce tau fibrillization in vitro. J Biol Chem 278:25644\u201325650. https:\/\/doi.org\/10.1074\/jbc.m301663200","journal-title":"J Biol Chem"},{"key":"2301_CR18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/ana.24174","volume":"76","author":"F Cicchetti","year":"2014","unstructured":"Cicchetti F, Lacroix S, Cisbani G, Valli\u00e8res N, Saint-Pierre M, St-Amour I, Tolouei R, Skepper JN, Hauser RA, Mantovani D, Barker RA, Freeman TB (2014) Mutant huntingtin is present in neuronal grafts in huntington disease patients: transfer of mutant huntingtin to normal tissue. Ann Neurol 76:31\u201342. https:\/\/doi.org\/10.1002\/ana.24174","journal-title":"Ann Neurol"},{"key":"2301_CR19","doi-asserted-by":"publisher","first-page":"9535","DOI":"10.1073\/pnas.1301175110","volume":"110","author":"F Clavaguera","year":"2013","unstructured":"Clavaguera F, Akatsu H, Fraser G, Crowther RA, Frank S, Hench J, Probst A, Winkler DT, Reichwald J, Staufenbiel M, Ghetti B, Goedert M, Tolnay M (2013) Brain homogenates from human tauopathies induce tau inclusions in mouse brain. P Natl Acad Sci USA 110:9535\u20139540. https:\/\/doi.org\/10.1073\/pnas.1301175110","journal-title":"P Natl Acad Sci USA"},{"key":"2301_CR20","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/ncb1901","volume":"11","author":"F Clavaguera","year":"2009","unstructured":"Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M (2009) Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 11:909\u2013913. https:\/\/doi.org\/10.1038\/ncb1901","journal-title":"Nat Cell Biol"},{"key":"2301_CR21","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0022-2836(77)90214-5","volume":"116","author":"DW Cleveland","year":"1977","unstructured":"Cleveland DW, Hwo S-Y, Kirschner MW (1977) Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J Mol Biol 116:227\u2013247. https:\/\/doi.org\/10.1016\/0022-2836(77)90214-5","journal-title":"J Mol Biol"},{"key":"2301_CR22","doi-asserted-by":"publisher","first-page":"a006833","DOI":"10.1101\/cshperspect.a006833","volume":"3","author":"DW Colby","year":"2011","unstructured":"Colby DW, Prusiner SB (2011) Prions. Csh Perspect Biol 3:a006833\u2013a006833. https:\/\/doi.org\/10.1101\/cshperspect.a006833","journal-title":"Csh Perspect Biol"},{"key":"2301_CR23","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev.neuro.24.1.519","volume":"24","author":"J Collinge","year":"2001","unstructured":"Collinge J (2001) Prion diseases of humans and animals: their causes and molecular basis. Annu Rev Neurosci 24:519\u2013550. https:\/\/doi.org\/10.1146\/annurev.neuro.24.1.519","journal-title":"Annu Rev Neurosci"},{"key":"2301_CR24","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41582-018-0013-z","volume":"14","author":"EE Congdon","year":"2018","unstructured":"Congdon EE, Sigurdsson EM (2018) Tau-targeting therapies for Alzheimer disease. Nat Rev Neurol 14:399\u2013415. https:\/\/doi.org\/10.1038\/s41582-018-0013-z","journal-title":"Nat Rev Neurol"},{"key":"2301_CR25","doi-asserted-by":"publisher","first-page":"4378","DOI":"10.1073\/pnas.89.10.4378","volume":"89","author":"D Couchie","year":"1992","unstructured":"Couchie D, Mavilia C, Georgieff IS, Liem RK, Shelanski ML, Nunez J (1992) Primary structure of high molecular weight tau present in the peripheral nervous system. Proc Natl Acad Sci 89:4378\u20134381. https:\/\/doi.org\/10.1073\/pnas.89.10.4378","journal-title":"Proc Natl Acad Sci"},{"key":"2301_CR26","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1073\/pnas.88.6.2288","volume":"88","author":"RA Crowther","year":"1991","unstructured":"Crowther RA (1991) Straight and paired helical filaments in Alzheimer disease have a common structural unit. Proc Natl Acad Sci 88:2288\u20132292. https:\/\/doi.org\/10.1073\/pnas.88.6.2288","journal-title":"Proc Natl Acad Sci"},{"key":"2301_CR27","doi-asserted-by":"publisher","first-page":"13010","DOI":"10.1073\/pnas.0903691106","volume":"106","author":"P Desplats","year":"2009","unstructured":"Desplats P, Lee H-J, Bae E-J, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee S-J (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. P Natl Acad Sci USA 106:13010\u201313015. https:\/\/doi.org\/10.1073\/pnas.0903691106","journal-title":"P Natl Acad Sci USA"},{"key":"2301_CR28","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1021\/acschemneuro.9b00326","volume":"10","author":"LR Drake","year":"2019","unstructured":"Drake LR, Pham JM, Desmond TJ, Mossine AV, Lee SJ, Kilbourn MR, Koeppe RA, Brooks AF, Scott PJH (2019) Identification of AV-1451 as a weak, nonselective inhibitor of monoamine oxidase. Acs Chem Neurosci 10:3839\u20133846. https:\/\/doi.org\/10.1021\/acschemneuro.9b00326","journal-title":"Acs Chem Neurosci"},{"key":"2301_CR29","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00401-017-1791-x","volume":"135","author":"C Duyckaerts","year":"2017","unstructured":"Duyckaerts C, Sazdovitch V, Ando K, Seilhean D, Privat N, Yilmaz Z, Peckeu L, Amar E, Comoy E, Maceski A, Lehmann S, Brion J-P, Brandel J-P, Ha\u00efk S (2017) Neuropathology of iatrogenic Creutzfeldt-Jakob disease and immunoassay of French cadaver-sourced growth hormone batches suggest possible transmission of tauopathy and long incubation periods for the transmission of Abeta pathology. Acta Neuropathol 135:201\u2013212. https:\/\/doi.org\/10.1007\/s00401-017-1791-x","journal-title":"Acta Neuropathol"},{"key":"2301_CR30","doi-asserted-by":"publisher","first-page":"16607","DOI":"10.1021\/ja305206m","volume":"134","author":"S Elbaum-Garfinkle","year":"2012","unstructured":"Elbaum-Garfinkle S, Rhoades E (2012) Identification of an aggregation-prone structure of tau. J Am Chem Soc 134:16607\u201316613. https:\/\/doi.org\/10.1021\/ja305206m","journal-title":"J Am Chem Soc"},{"key":"2301_CR31","doi-asserted-by":"publisher","first-page":"44739","DOI":"10.1038\/srep44739","volume":"7","author":"NA Eschmann","year":"2017","unstructured":"Eschmann NA, Georgieva ER, Ganguly P, Borbat PP, Rappaport MD, Akdogan Y, Freed JH, Shea J-E, Han S (2017) Signature of an aggregation-prone conformation of tau. Sci Rep UK 7:44739. https:\/\/doi.org\/10.1038\/srep44739","journal-title":"Sci Rep UK"},{"key":"2301_CR32","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41586-018-0454-y","volume":"561","author":"B Falcon","year":"2018","unstructured":"Falcon B, Zhang W, Murzin AG, Murshudov G, Garringer HJ, Vidal R, Crowther RA, Ghetti B, Scheres SHW, Goedert M (2018) Structures of filaments from Pick\u2019s disease reveal a novel tau protein fold. Nature 561:137\u2013140. https:\/\/doi.org\/10.1038\/s41586-018-0454-y","journal-title":"Nature"},{"key":"2301_CR33","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s00401-018-1914-z","volume":"136","author":"B Falcon","year":"2018","unstructured":"Falcon B, Zhang W, Schweighauser M, Murzin AG, Vidal R, Garringer HJ, Ghetti B, Scheres SHW, Goedert M (2018) Tau filaments from multiple cases of sporadic and inherited Alzheimer\u2019s disease adopt a common fold. Acta Neuropathol 136:699\u2013708. https:\/\/doi.org\/10.1007\/s00401-018-1914-z","journal-title":"Acta Neuropathol"},{"key":"2301_CR34","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s41586-019-1026-5","volume":"568","author":"B Falcon","year":"2019","unstructured":"Falcon B, Zivanov J, Zhang W, Murzin AG, Garringer HJ, Vidal R, Crowther RA, Newell KL, Ghetti B, Goedert M, Scheres SHW (2019) Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature 568:420\u2013423. https:\/\/doi.org\/10.1038\/s41586-019-1026-5","journal-title":"Nature"},{"key":"2301_CR35","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/bs.pmbts.2017.06.012","volume":"150","author":"M Fiorini","year":"2017","unstructured":"Fiorini M, Bongianni M, Monaco S, Zanusso G (2017) Biochemical characterization of prions. Prog Mol Biol Transl 150:389\u2013407. https:\/\/doi.org\/10.1016\/bs.pmbts.2017.06.012","journal-title":"Prog Mol Biol Transl"},{"key":"2301_CR36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nature23002","volume":"547","author":"AWP Fitzpatrick","year":"2017","unstructured":"Fitzpatrick AWP, Falcon B, He S, Murzin AG, Murshudov G, Garringer HJ, Crowther RA, Ghetti B, Goedert M, Scheres SHW (2017) Cryo-EM structures of tau filaments from Alzheimer\u2019s disease. Nature 547:185\u2013190. https:\/\/doi.org\/10.1038\/nature23002","journal-title":"Nature"},{"key":"2301_CR37","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0021-9975(73)90024-8","volume":"83","author":"H Fraser","year":"1973","unstructured":"Fraser H, Dickinson AG (1973) Scrapie in mice Agent-strain differences in the distribution and intensity of grey matter vacuolation. J Comp Pathol 83:29\u201340. https:\/\/doi.org\/10.1016\/0021-9975(73)90024-8","journal-title":"J Comp Pathol"},{"key":"2301_CR38","doi-asserted-by":"publisher","first-page":"10223","DOI":"10.1021\/bi980537d","volume":"37","author":"P Friedhoff","year":"1998","unstructured":"Friedhoff P, Schneider A, Mandelkow E-M, Mandelkow E (1998) Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution \u2020. Biochemistry US 37:10223\u201310230. https:\/\/doi.org\/10.1021\/bi980537d","journal-title":"Biochemistry US"},{"key":"2301_CR39","doi-asserted-by":"publisher","first-page":"12845","DOI":"10.1074\/jbc.m808759200","volume":"284","author":"B Frost","year":"2009","unstructured":"Frost B, Jacks RL, Diamond MI (2009) Propagation of tau misfolding from the outside to the inside of a cell. J Biological Chem 284:12845\u201312852. https:\/\/doi.org\/10.1074\/jbc.m808759200","journal-title":"J Biological Chem"},{"key":"2301_CR40","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00401-016-1644-z","volume":"133","author":"JL Furman","year":"2016","unstructured":"Furman JL, Vaquer-Alicea J, White CL, Cairns NJ, Nelson PT, Diamond MI (2016) Widespread tau seeding activity at early Braak stages. Acta Neuropathol 133:91\u2013100. https:\/\/doi.org\/10.1007\/s00401-016-1644-z","journal-title":"Acta Neuropathol"},{"key":"2301_CR41","doi-asserted-by":"publisher","first-page":"599384","DOI":"10.3389\/fneur.2020.599384","volume":"11","author":"J Ganguly","year":"2020","unstructured":"Ganguly J, Jog M (2020) Tauopathy and movement disorders\u2014unveiling the chameleons and mimics. Front Neurol 11:599384. https:\/\/doi.org\/10.3389\/fneur.2020.599384","journal-title":"Front Neurol"},{"key":"2301_CR42","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1016\/s0140-6736(16)31275-2","volume":"388","author":"S Gauthier","year":"2016","unstructured":"Gauthier S, Feldman HH, Schneider LS, Wilcock GK, Frisoni GB, Hardlund JH, Moebius HJ, Bentham P, Kook KA, Wischik DJ, Schelter BO, Davis CS, Staff RT, Bracoud L, Shamsi K, Storey JMD, Harrington CR, Wischik CM (2016) Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer\u2019s disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial. Lancet 388:2873\u20132884. https:\/\/doi.org\/10.1016\/s0140-6736(16)31275-2","journal-title":"Lancet"},{"key":"2301_CR43","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1001\/jamaneurol.2018.2505","volume":"76","author":"GS Gibbons","year":"2018","unstructured":"Gibbons GS, Lee VMY, Trojanowski JQ (2018) Mechanisms of cell-to-cell transmission of pathological tau: a review. JAMA Neurol 76:101. https:\/\/doi.org\/10.1001\/jamaneurol.2018.2505","journal-title":"JAMA Neurol"},{"key":"2301_CR44","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev-neuro-072116-031153","volume":"40","author":"M Goedert","year":"2017","unstructured":"Goedert M, Eisenberg DS, Crowther RA (2017) Propagation of Tau aggregates and neurodegeneration. Annu Rev Neurosci 40:189\u2013210. https:\/\/doi.org\/10.1146\/annurev-neuro-072116-031153","journal-title":"Annu Rev Neurosci"},{"key":"2301_CR45","doi-asserted-by":"publisher","first-page":"4225","DOI":"10.1002\/j.1460-2075.1990.tb07870.x","volume":"9","author":"M Goedert","year":"1990","unstructured":"Goedert M, Jakes R (1990) Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. Embo J 9:4225\u20134230. https:\/\/doi.org\/10.1002\/j.1460-2075.1990.tb07870.x","journal-title":"Embo J"},{"key":"2301_CR46","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/s0014-5793(99)00508-6","volume":"450","author":"M Goedert","year":"1999","unstructured":"Goedert M, Jakes R, Crowther RA (1999) Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments. Febs Lett 450:306\u2013311. https:\/\/doi.org\/10.1016\/s0014-5793(99)00508-6","journal-title":"Febs Lett"},{"key":"2301_CR47","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/383550a0","volume":"383","author":"M Goedert","year":"1996","unstructured":"Goedert M, Jakes R, Spillantini MG, Hasegawa M, Smith MJ, Crowther RA (1996) Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans. Nature 383:550\u2013553. https:\/\/doi.org\/10.1038\/383550a0","journal-title":"Nature"},{"key":"2301_CR48","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1073\/pnas.89.5.1983","volume":"89","author":"M Goedert","year":"1992","unstructured":"Goedert M, Spillantini MG, Crowther RA (1992) Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system. Proc National Acad Sci 89:1983\u20131987. https:\/\/doi.org\/10.1073\/pnas.89.5.1983","journal-title":"Proc National Acad Sci"},{"key":"2301_CR49","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/0896-6273(89)90210-9","volume":"3","author":"M Goedert","year":"1989","unstructured":"Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer\u2019s disease. Neuron 3:519\u2013526. https:\/\/doi.org\/10.1016\/0896-6273(89)90210-9","journal-title":"Neuron"},{"key":"2301_CR50","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.1073\/pnas.85.11.4051","volume":"85","author":"M Goedert","year":"1988","unstructured":"Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A (1988) Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc Natl Acad Sci 85:4051\u20134055. https:\/\/doi.org\/10.1073\/pnas.85.11.4051","journal-title":"Proc Natl Acad Sci"},{"key":"2301_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-pathmechdis-012418-012936","volume":"14","author":"J G\u00f6tz","year":"2018","unstructured":"G\u00f6tz J, Halliday G, Nisbet RM (2018) Molecular pathogenesis of the tauopathies. Annu Rev Pathol Mech Dis 14:1\u201323. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-012418-012936","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"2301_CR52","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/embor.2013.137","volume":"14","author":"G Heilbronner","year":"2013","unstructured":"Heilbronner G, Eisele YS, Langer F, Kaeser SA, Novotny R, Nagarathinam A, Aslund A, Hammarstr\u00f6m P, Nilsson KPR, Jucker M (2013) Seeded strain-like transmission of \u03b2-amyloid morphotypes in APP transgenic mice. Embo Rep 14:1017\u20131022. https:\/\/doi.org\/10.1038\/embor.2013.137","journal-title":"Embo Rep"},{"key":"2301_CR53","doi-asserted-by":"publisher","first-page":"a024026","DOI":"10.1101\/cshperspect.a024026","volume":"7","author":"BB Holmes","year":"2016","unstructured":"Holmes BB, Diamond MI (2016) Cellular models for the study of prions. Csh Perspect Med 7:a024026. https:\/\/doi.org\/10.1101\/cshperspect.a024026","journal-title":"Csh Perspect Med"},{"key":"2301_CR54","doi-asserted-by":"publisher","first-page":"E4376","DOI":"10.1073\/pnas.1411649111","volume":"111","author":"BB Holmes","year":"2014","unstructured":"Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI (2014) Proteopathic tau seeding predicts tauopathy in vivo. P Natl Acad Sci USA 111:E4376\u2013E4385. https:\/\/doi.org\/10.1073\/pnas.1411649111","journal-title":"P Natl Acad Sci USA"},{"key":"2301_CR55","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1126\/science.282.5395.1914","volume":"282","author":"M Hong","year":"1998","unstructured":"Hong M, Zhukareva V, Vogelsberg-Ragaglia V, Wszolek Z, Reed L, Miller BI, Geschwind DH, Bird TD, McKeel D, Goate A, Morris JC, Wilhelmsen KC, Schellenberg GD, Trojanowski JQ, Lee VM-Y (1998) Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science 282:1914\u20131917. https:\/\/doi.org\/10.1126\/science.282.5395.1914","journal-title":"Science"},{"key":"2301_CR56","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/31508","volume":"393","author":"M Hutton","year":"1998","unstructured":"Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P, Che LK, Norton J, Morris JC, Reed LA, Trojanowski J, Basun H, Lannfelt L, Neystat M, Fahn S, Dark F, Tannenberg T, Dodd PR, Hayward N, Kwok JBJ, Schofield PR, Andreadis A, Snowden J, Craufurd D, Neary D, Owen F, Oostra BA, Hardy J, Goate A, van Swieten J, Mann D, Lynch T, Heutink P (1998) Association of missense and 5\u2032-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393:702\u2013705. https:\/\/doi.org\/10.1038\/31508","journal-title":"Nature"},{"key":"2301_CR57","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1523\/jneurosci.2642-12.2013","volume":"33","author":"M Iba","year":"2013","unstructured":"Iba M, Guo JL, McBride JD, Zhang B, Trojanowski JQ, Lee VM-Y (2013) Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer\u2019s-like tauopathy. J Neurosci Off J Soc Neurosci 33:1024\u20131037. https:\/\/doi.org\/10.1523\/jneurosci.2642-12.2013","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"2301_CR58","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1016\/j.parkreldis.2015.09.020","volume":"22","author":"DJ Irwin","year":"2016","unstructured":"Irwin DJ (2016) Tauopathies as clinicopathological entities. Parkinsonism Relat D 22:S29\u2013S33. https:\/\/doi.org\/10.1016\/j.parkreldis.2015.09.020","journal-title":"Parkinsonism Relat D"},{"key":"2301_CR59","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40478-019-0664-z","volume":"7","author":"S Jadhav","year":"2019","unstructured":"Jadhav S, Avila J, Sch\u00f6ll M, Kovacs GG, K\u00f6vari E, Skrabana R, Evans LD, Kontsekova E, Malawska B, de Silva R, Buee L, Zilka N (2019) A walk through tau therapeutic strategies. Acta Neuropathol Commun 7:22. https:\/\/doi.org\/10.1186\/s40478-019-0664-z","journal-title":"Acta Neuropathol Commun"},{"key":"2301_CR60","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/nature15369","volume":"525","author":"Z Jaunmuktane","year":"2015","unstructured":"Jaunmuktane Z, Mead S, Ellis M, Wadsworth JDF, Nicoll AJ, Kenny J, Launchbury F, Linehan J, Richard-Loendt A, Walker AS, Rudge P, Collinge J, Brandner S (2015) Evidence for human transmission of amyloid-\u03b2 pathology and cerebral amyloid angiopathy. Nature 525:247\u2013250. https:\/\/doi.org\/10.1038\/nature15369","journal-title":"Nature"},{"key":"2301_CR61","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s00401-016-1582-9","volume":"132","author":"I Jeon","year":"2016","unstructured":"Jeon I, Cicchetti F, Cisbani G, Lee S, Li E, Bae J, Lee N, Li L, Im W, Kim M, Kim HS, Oh S-H, Kim T-A, Ko JJ, Aub\u00e9 B, Oueslati A, Kim YJ, Song J (2016) Human-to-mouse prion-like propagation of mutant huntingtin protein. Acta Neuropathol 132:577\u2013592. https:\/\/doi.org\/10.1007\/s00401-016-1582-9","journal-title":"Acta Neuropathol"},{"key":"2301_CR62","doi-asserted-by":"publisher","unstructured":"Jones M, Neary D (2016) Hodges\u2019 Frontotemporal Dementia. 30\u201343. https:\/\/doi.org\/10.1017\/cbo9781316091586.006","DOI":"10.1017\/cbo9781316091586.006"},{"key":"2301_CR63","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/s41593-018-0238-6","volume":"21","author":"M Jucker","year":"2018","unstructured":"Jucker M, Walker LC (2018) Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases. Nat Neurosci 21:1341\u20131349. https:\/\/doi.org\/10.1038\/s41593-018-0238-6","journal-title":"Nat Neurosci"},{"key":"2301_CR64","doi-asserted-by":"publisher","first-page":"10347","DOI":"10.1002\/anie.201501714","volume":"54","author":"H Kadavath","year":"2015","unstructured":"Kadavath H, Jaremko M, Jaremko \u0141, Biernat J, Mandelkow E, Zweckstetter M (2015) Folding of the tau protein on microtubules. Angewandte Chem Int Ed 54:10347\u201310351. https:\/\/doi.org\/10.1002\/anie.201501714","journal-title":"Angewandte Chem Int Ed"},{"key":"2301_CR65","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/s0014-5793(96)01386-5","volume":"399","author":"T Kampers","year":"1996","unstructured":"Kampers T, Friedhoff P, Biernat J, Mandelkow E-M, Mandelkow E (1996) RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments. Febs Lett 399:344\u2013349. https:\/\/doi.org\/10.1016\/s0014-5793(96)01386-5","journal-title":"Febs Lett"},{"key":"2301_CR66","doi-asserted-by":"publisher","first-page":"3606","DOI":"10.1523\/jneurosci.20-10-03606.2000","volume":"20","author":"MD Kane","year":"2000","unstructured":"Kane MD, Lipinski WJ, Callahan MJ, Bian F, Durham RA, Schwarz RD, Roher AE, Walker LC (2000) Evidence for seeding of \u03b2-amyloid by intracerebral infusion of Alzheimer brain extracts in \u03b2-amyloid precursor protein-transgenic mice. J Neurosci 20:3606\u20133611. https:\/\/doi.org\/10.1523\/jneurosci.20-10-03606.2000","journal-title":"J Neurosci"},{"key":"2301_CR67","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.neuron.2016.09.055","volume":"92","author":"SK Kaufman","year":"2016","unstructured":"Kaufman SK, Sanders DW, Thomas TL, Ruchinskas AJ, Vaquer-Alicea J, Sharma AM, Miller TM, Diamond MI (2016) Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo. Neuron 92:796\u2013812. https:\/\/doi.org\/10.1016\/j.neuron.2016.09.055","journal-title":"Neuron"},{"key":"2301_CR68","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00401-018-1855-6","volume":"136","author":"SK Kaufman","year":"2018","unstructured":"Kaufman SK, Tredici KD, Thomas TL, Braak H, Diamond MI (2018) Tau seeding activity begins in the transentorhinal\/entorhinal regions and anticipates phospho-tau pathology in Alzheimer\u2019s disease and PART. Acta Neuropathol 136:57\u201367. https:\/\/doi.org\/10.1007\/s00401-018-1855-6","journal-title":"Acta Neuropathol"},{"key":"2301_CR69","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1126\/science.aat1780","volume":"360","author":"EH Kellogg","year":"2018","unstructured":"Kellogg EH, Hejab NMA, Poepsel S, Downing KH, DiMaio F, Nogales E (2018) Near-atomic model of microtubule-tau interactions. Science 360:1242\u20131246. https:\/\/doi.org\/10.1126\/science.aat1780","journal-title":"Science"},{"key":"2301_CR70","doi-asserted-by":"publisher","first-page":"14851","DOI":"10.1021\/bi9911839","volume":"38","author":"ME King","year":"1999","unstructured":"King ME, Ahuja V, Binder LI, Kuret J (1999) Ligand-dependent tau filament formation: implications for Alzheimer\u2019s disease progression \u2020. Biochemistry-us 38:14851\u201314859. https:\/\/doi.org\/10.1021\/bi9911839","journal-title":"Biochemistry-us"},{"key":"2301_CR71","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/alzrt278","volume":"6","author":"E Kontsekova","year":"2014","unstructured":"Kontsekova E, Zilka N, Kovacech B, Novak P, Novak M (2014) First-in-man tau vaccine targeting structural determinants essential for pathological tau\u2013tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer\u2019s disease model. Alzheimer\u2019s Res Ther 6:44. https:\/\/doi.org\/10.1186\/alzrt278","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"2301_CR72","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nm1747","volume":"14","author":"JH Kordower","year":"2008","unstructured":"Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW (2008) Lewy body\u2013like pathology in long-term embryonic nigral transplants in Parkinson\u2019s disease. Nat Med 14:504\u2013506. https:\/\/doi.org\/10.1038\/nm1747","journal-title":"Nat Med"},{"key":"2301_CR73","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/nan.12208","volume":"41","author":"GG Kovacs","year":"2015","unstructured":"Kovacs GG (2015) Invited review: neuropathology of tauopathies: principles and practice: neuropathology of tauopathies. Neuropath Appl Neuro 41:3\u201323. https:\/\/doi.org\/10.1111\/nan.12208","journal-title":"Neuropath Appl Neuro"},{"key":"2301_CR74","doi-asserted-by":"publisher","unstructured":"Kovacs GG (2017) Chapter 25 Tauopathies. Handb Clin Neurol 145:355\u2013368. https:\/\/doi.org\/10.1016\/b978-0-12-802395-2.00025-0","DOI":"10.1016\/b978-0-12-802395-2.00025-0"},{"key":"2301_CR75","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1136\/jclinpath-2019-205952","volume":"72","author":"GG Kovacs","year":"2019","unstructured":"Kovacs GG (2019) Molecular pathology of neurodegenerative diseases: principles and practice. J Clin Pathol 72:725. https:\/\/doi.org\/10.1136\/jclinpath-2019-205952","journal-title":"J Clin Pathol"},{"key":"2301_CR76","doi-asserted-by":"publisher","unstructured":"Kraus A, Hoyt F, Schwartz CL, Hansen B, Hughson AG, Artikis E, Race B, Caughey B (2021) Structure of an infectious mammalian prion. Biorxiv 2021.02.14.431014. https:\/\/doi.org\/10.1101\/2021.02.14.431014","DOI":"10.1101\/2021.02.14.431014"},{"key":"2301_CR77","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13195-017-0325-z","volume":"9","author":"L Lemoine","year":"2017","unstructured":"Lemoine L, Gillberg P-G, Svedberg M, Stepanov V, Jia Z, Huang J, Nag S, Tian H, Ghetti B, Okamura N, Higuchi M, Halldin C, Nordberg A (2017) Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains. Alzheimer\u2019s Res Ther 9:96. https:\/\/doi.org\/10.1186\/s13195-017-0325-z","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"2301_CR78","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/s41380-018-0342-8","volume":"24","author":"A Leuzy","year":"2019","unstructured":"Leuzy A, Chiotis K, Lemoine L, Gillberg P-G, Almkvist O, Rodriguez-Vieitez E, Nordberg A (2019) Tau PET imaging in neurodegenerative tauopathies\u2014still a challenge. Mol Psychiatr 24:1112\u20131134. https:\/\/doi.org\/10.1038\/s41380-018-0342-8","journal-title":"Mol Psychiatr"},{"key":"2301_CR79","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/78078","volume":"25","author":"J Lewis","year":"2000","unstructured":"Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Slegtenhorst MV, Gwinn-Hardy K, Murphy MP, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin W-L, Yen S-H, Dickson DW, Davies P, Hutton M (2000) Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet 25:402\u2013405. https:\/\/doi.org\/10.1038\/78078","journal-title":"Nat Genet"},{"key":"2301_CR80","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/nm1746","volume":"14","author":"J-Y Li","year":"2008","unstructured":"Li J-Y, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ, Lashley T, Quinn NP, Rehncrona S, Bj\u00f6rklund A, Widner H, Revesz T, Lindvall O, Brundin P (2008) Lewy bodies in grafted neurons in subjects with Parkinson\u2019s disease suggest host-to-graft disease propagation. Nat Med 14:501\u2013503. https:\/\/doi.org\/10.1038\/nm1746","journal-title":"Nat Med"},{"key":"2301_CR81","doi-asserted-by":"publisher","unstructured":"Lovestone S, Boada M, Dubois B, H\u00fcll M, Rinne JO, Huppertz H-J, Calero M, Andr\u00e9s MV, G\u00f3mez-Carrillo B, Le\u00f3n T, Ser T del, investigators for the A (2015) A Phase II Trial of Tideglusib in Alzheimer\u2019s Disease. J Alzheimer\u2019s Dis 45:75\u201388 https:\/\/doi.org\/10.3233\/jad-141959","DOI":"10.3233\/jad-141959"},{"key":"2301_CR82","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1084\/jem.20112457","volume":"209","author":"KC Luk","year":"2012","unstructured":"Luk KC, Kehm VM, Zhang B, O\u2019Brien P, Trojanowski JQ, Lee VMY (2012) Intracerebral inoculation of pathological \u03b1-synuclein initiates a rapidly progressive neurodegenerative \u03b1-synucleinopathy in mice. J Exp Med 209:975\u2013986. https:\/\/doi.org\/10.1084\/jem.20112457","journal-title":"J Exp Med"},{"key":"2301_CR83","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/284353a0","volume":"284","author":"A Mareck","year":"1980","unstructured":"Mareck A, Fellous A, Francon J, Nunez J (1980) Changes in composition and activity of microtubule-associated proteins during brain development. Nature 284:353\u2013355. https:\/\/doi.org\/10.1038\/284353a0","journal-title":"Nature"},{"key":"2301_CR84","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/fbp.0000000000000133","volume":"26","author":"V Melis","year":"2015","unstructured":"Melis V, Magbagbeolu M, Rickard JE, Horsley D, Davidson K, Harrington KA, Goatman K, Goatman EA, Deiana S, Close SP, Zabke C, Stamer K, Dietze S, Schwab K, Storey JMD, Harrington CR, Wischik CM, Theuring F, Riedel G (2015) Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models. Behav Pharmacol 26:353\u2013368. https:\/\/doi.org\/10.1097\/fbp.0000000000000133","journal-title":"Behav Pharmacol"},{"key":"2301_CR85","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1126\/science.1131864","volume":"313","author":"M Meyer-Luehmann","year":"2006","unstructured":"Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret J-M, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M (2006) exogenous induction of cerebral-amyloidogenesis is governed by agent and host. Science 313:1781\u20131784. https:\/\/doi.org\/10.1126\/science.1131864","journal-title":"Science"},{"key":"2301_CR86","doi-asserted-by":"publisher","first-page":"e36584","DOI":"10.7554\/elife.36584","volume":"7","author":"H Mirbaha","year":"2018","unstructured":"Mirbaha H, Chen D, Morazova OA, Ruff KM, Sharma AM, Liu X, Goodarzi M, Pappu RV, Colby DW, Mirzaei H, Joachimiak LA, Diamond MI (2018) Inert and seed-competent tau monomers suggest structural origins of aggregation. Elife 7:e36584. https:\/\/doi.org\/10.7554\/elife.36584","journal-title":"Elife"},{"key":"2301_CR87","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1371\/journal.pbio.1000034","volume":"7","author":"MD Mukrasch","year":"2009","unstructured":"Mukrasch MD, Bibow S, Korukottu J, Jeganathan S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M (2009) Structural polymorphism of 441-residue tau at single residue resolution. Plos Biol 7:e34. https:\/\/doi.org\/10.1371\/journal.pbio.1000034","journal-title":"Plos Biol"},{"key":"2301_CR88","doi-asserted-by":"publisher","first-page":"9676","DOI":"10.1074\/jbc.ra120.013478","volume":"295","author":"E Nachman","year":"2020","unstructured":"Nachman E, Wentink AS, Madiona K, Bousset L, Katsinelos T, Allinson K, Kampinga H, McEwan WA, Jahn TR, Melki R, Mogk A, Bukau B, Nussbaum-Krammer C (2020) Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species. J Biol Chem 295:9676\u20139690. https:\/\/doi.org\/10.1074\/jbc.ra120.013478","journal-title":"J Biol Chem"},{"key":"2301_CR89","doi-asserted-by":"publisher","unstructured":"Neumann M, Kovacs GG, MacKenzie IRA (2016) Hodges\u2019 frontotemporal dementia. 165\u2013184. https:\/\/doi.org\/10.1017\/cbo9781316091586.016","DOI":"10.1017\/cbo9781316091586.016"},{"key":"2301_CR90","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0169-328x(86)90033-1","volume":"1","author":"RL Neve","year":"1986","unstructured":"Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (1986) Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. Mol Brain Res 1:271\u2013280. https:\/\/doi.org\/10.1016\/0169-328x(86)90033-1","journal-title":"Mol Brain Res"},{"key":"2301_CR91","doi-asserted-by":"publisher","first-page":"63","DOI":"10.14283\/jpad.2018.45","volume":"6","author":"P Novak","year":"2019","unstructured":"Novak P, Zilka N, Zilkova M, Kovacech B, Skrabana R, Ondrus M, Fialova L, Kontsekova E, Otto M, Novak M (2019) AADvac1, an active immunotherapy for Alzheimer\u2019s disease and non alzheimer tauopathies: an overview of preclinical and clinical development. J Prev Alzheimer\u2019s Dis 6:63\u201369. https:\/\/doi.org\/10.14283\/jpad.2018.45","journal-title":"J Prev Alzheimer\u2019s Dis"},{"key":"2301_CR92","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1073\/pnas.1715483115","volume":"115","author":"Y Ohhashi","year":"2018","unstructured":"Ohhashi Y, Yamaguchi Y, Kurahashi H, Kamatari YO, Sugiyama S, Uluca B, Piechatzek T, Komi Y, Shida T, M\u00fcller H, Hanashima S, Heise H, Kuwata K, Tanaka M (2018) Molecular basis for diversification of yeast prion strain conformation. P Natl Acad Sci USA 115:2389\u20132394. https:\/\/doi.org\/10.1073\/pnas.1715483115","journal-title":"P Natl Acad Sci USA"},{"key":"2301_CR93","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s40336-018-0290-y","volume":"6","author":"N Okamura","year":"2018","unstructured":"Okamura N, Harada R, Ishiki A, Kikuchi A, Nakamura T, Kudo Y (2018) The development and validation of tau PET tracers: current status and future directions. Clin Transl Imaging 6:305\u2013316. https:\/\/doi.org\/10.1007\/s40336-018-0290-y","journal-title":"Clin Transl Imaging"},{"key":"2301_CR94","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1046\/j.1471-4159.1996.67031183.x","volume":"67","author":"M P\u00e9rez","year":"1996","unstructured":"P\u00e9rez M, Valpuesta JM, Medina M, de Garcini EM, Avila J (1996) Polymerization of \u03c4 into filaments in the presence of heparin: the minimal sequence required for \u03c4-\u03c4 interaction. J Neurochem 67:1183\u20131190. https:\/\/doi.org\/10.1046\/j.1471-4159.1996.67031183.x","journal-title":"J Neurochem"},{"key":"2301_CR95","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1126\/science.1105850","volume":"307","author":"AT Petkova","year":"2005","unstructured":"Petkova AT, Leapman RD, Guo Z, Yau W-M, Mattson MP, Tycko R (2005) Self-propagating, molecular-level polymorphism in Alzheimer\u2019s-amyloid fibrils. Science 307:262\u2013265. https:\/\/doi.org\/10.1126\/science.1105850","journal-title":"Science"},{"key":"2301_CR96","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1002\/ana.410430617","volume":"43","author":"P Poorkaj","year":"1998","unstructured":"Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD (1998) Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol 43:815\u2013825. https:\/\/doi.org\/10.1002\/ana.410430617","journal-title":"Ann Neurol"},{"key":"2301_CR97","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1056\/nejm198403083101021","volume":"310","author":"SB Prusiner","year":"1984","unstructured":"Prusiner SB (1984) Some speculations about prions, amyloid, and Alzheimer\u2019s disease. New Engl J Med 310:661\u2013663. https:\/\/doi.org\/10.1056\/nejm198403083101021","journal-title":"New Engl J Med"},{"key":"2301_CR98","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-018-0790-y","volume":"564","author":"SA Purro","year":"2018","unstructured":"Purro SA, Farrow MA, Linehan J, Nazari T, Thomas DX, Chen Z, Mengel D, Saito T, Saido T, Rudge P, Brandner S, Walsh DM, Collinge J (2018) Transmission of amyloid-\u03b2 protein pathology from cadaveric pituitary growth hormone. Nature 564:415\u2013419. https:\/\/doi.org\/10.1038\/s41586-018-0790-y","journal-title":"Nature"},{"key":"2301_CR99","doi-asserted-by":"publisher","first-page":"13018","DOI":"10.1073\/pnas.1713215114","volume":"114","author":"J Rasmussen","year":"2017","unstructured":"Rasmussen J, Mahler J, Beschorner N, Kaeser SA, H\u00e4sler LM, Baumann F, Nystr\u00f6m S, Portelius E, Blennow K, Lashley T, Fox NC, Sepulveda-Falla D, Glatzel M, Oblak AL, Ghetti B, Nilsson KPR, Hammarstr\u00f6m P, Staufenbiel M, Walker LC, Jucker M (2017) Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer\u2019s disease. Proc National Acad Sci 114:13018\u201313023. https:\/\/doi.org\/10.1073\/pnas.1713215114","journal-title":"Proc National Acad Sci"},{"key":"2301_CR100","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/bs.pmbts.2017.06.009","volume":"150","author":"JR Requena","year":"2017","unstructured":"Requena JR, Wille H (2017) The structure of the infectious prion protein and its propagation. Prog Mol Biol Transl 150:341\u2013359. https:\/\/doi.org\/10.1016\/bs.pmbts.2017.06.009","journal-title":"Prog Mol Biol Transl"},{"key":"2301_CR101","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00401-017-1703-0","volume":"134","author":"DL Ritchie","year":"2017","unstructured":"Ritchie DL, Adlard P, Peden AH, Lowrie S, Grice ML, Burns K, Jackson RJ, Yull H, Keogh MJ, Wei W, Chinnery PF, Head MW, Ironside JW (2017) Amyloid-\u03b2 accumulation in the CNS in human growth hormone recipients in the UK. Acta Neuropathol 134:221\u2013240. https:\/\/doi.org\/10.1007\/s00401-017-1703-0","journal-title":"Acta Neuropathol"},{"key":"2301_CR102","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13024-017-0162-3","volume":"12","author":"L Saint-Aubert","year":"2017","unstructured":"Saint-Aubert L, Lemoine L, Chiotis K, Leuzy A, Rodriguez-Vieitez E, Nordberg A (2017) Tau PET imaging: present and future directions. Mol Neurodegener 12:19. https:\/\/doi.org\/10.1186\/s13024-017-0162-3","journal-title":"Mol Neurodegener"},{"key":"2301_CR103","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.jalz.2016.01.003","volume":"12","author":"K Sander","year":"2016","unstructured":"Sander K, Lashley T, Gami P, Gendron T, Lythgoe MF, Rohrer JD, Schott JM, Revesz T, Fox NC, \u00c5rstad E (2016) Characterization of tau positron emission tomography tracer [18F]AV-1451 binding to postmortem tissue in Alzheimer\u2019s disease, primary tauopathies, and other dementias. Alzheimer\u2019s Dementia 12:1116\u20131124. https:\/\/doi.org\/10.1016\/j.jalz.2016.01.003","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2301_CR104","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.neuron.2014.04.047","volume":"82","author":"DW Sanders","year":"2014","unstructured":"Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, Barker SJ, Foley AC, Thorpe JR, Serpell LC, Miller TM, Grinberg LT, Seeley WW, Diamond MI (2014) Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron 82:1271\u20131288. https:\/\/doi.org\/10.1016\/j.neuron.2014.04.047","journal-title":"Neuron"},{"key":"2301_CR105","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.neuron.2016.01.026","volume":"89","author":"DW Sanders","year":"2016","unstructured":"Sanders DW, Kaufman SK, Holmes BB, Diamond MI (2016) Prions and protein assemblies that convey biological information in health and disease. Neuron 89:433\u2013448. https:\/\/doi.org\/10.1016\/j.neuron.2016.01.026","journal-title":"Neuron"},{"key":"2301_CR106","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.sbi.2020.05.011","volume":"64","author":"SH Scheres","year":"2020","unstructured":"Scheres SH, Zhang W, Falcon B, Goedert M (2020) Cryo-EM structures of tau filaments. Curr Opin Struc Biol 64:17\u201325. https:\/\/doi.org\/10.1016\/j.sbi.2020.05.011","journal-title":"Curr Opin Struc Biol"},{"key":"2301_CR107","doi-asserted-by":"publisher","first-page":"15137","DOI":"10.1073\/pnas.96.26.15137","volume":"96","author":"MR Scott","year":"1999","unstructured":"Scott MR, Will R, Ironside J, Nguyen H-OB, Tremblay P, DeArmond SJ, Prusiner SB (1999) Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans. Proc National Acad Sci 96:15137\u201315142. https:\/\/doi.org\/10.1073\/pnas.96.26.15137","journal-title":"Proc National Acad Sci"},{"key":"2301_CR108","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.nbd.2009.05.025","volume":"35","author":"L Seren\u00f3","year":"2009","unstructured":"Seren\u00f3 L, Coma M, Rodr\u00edguez M, S\u00e1nchez-Ferrer P, S\u00e1nchez MB, Gich I, Agull\u00f3 JM, P\u00e9rez M, Avila J, Guardia-Laguarta C, Clarim\u00f3n J, Lle\u00f3 A, G\u00f3mez-Isla T (2009) A novel GSK-3\u03b2 inhibitor reduces Alzheimer\u2019s pathology and rescues neuronal loss in vivo. Neurobiol Dis 35:359\u2013367. https:\/\/doi.org\/10.1016\/j.nbd.2009.05.025","journal-title":"Neurobiol Dis"},{"key":"2301_CR109","doi-asserted-by":"publisher","first-page":"7025","DOI":"10.1038\/ncomms8025","volume":"6","author":"SL Shammas","year":"2015","unstructured":"Shammas SL, Garcia GA, Kumar S, Kjaergaard M, Horrocks MH, Shivji N, Mandelkow E, Knowles TPJ, Mandelkow E, Klenerman D (2015) A mechanistic model of tau amyloid aggregation based on direct observation of oligomers. Nat Commun 6:7025. https:\/\/doi.org\/10.1038\/ncomms8025","journal-title":"Nat Commun"},{"key":"2301_CR110","doi-asserted-by":"publisher","first-page":"e37813","DOI":"10.7554\/elife.37813","volume":"7","author":"AM Sharma","year":"2018","unstructured":"Sharma AM, Thomas TL, Woodard DR, Kashmer OM, Diamond MI (2018) Tau monomer encodes strains. Elife 7:e37813. https:\/\/doi.org\/10.7554\/elife.37813","journal-title":"Elife"},{"key":"2301_CR111","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-0516-y","author":"T Shida","year":"2020","unstructured":"Shida T, Kamatari YO, Yoda T, Yamaguchi Y, Feig M, Ohhashi Y, Sugita Y, Kuwata K, Tanaka M (2020) Short disordered protein segment regulates cross-species transmission of a yeast prion. Nat Chem Biol. https:\/\/doi.org\/10.1038\/s41589-020-0516-y","journal-title":"Nat Chem Biol"},{"key":"2301_CR112","doi-asserted-by":"publisher","first-page":"12560","DOI":"10.1021\/bi060964o","volume":"45","author":"N Sibille","year":"2006","unstructured":"Sibille N, Sillen A, Leroy A, Wieruszeski J-M, Mulloy B, Landrieu I, Lippens G (2006) Structural impact of heparin binding to full-length tau as studied by NMR spectroscopy \u2020. Biochemistry US 45:12560\u201312572. https:\/\/doi.org\/10.1021\/bi060964o","journal-title":"Biochemistry US"},{"key":"2301_CR113","doi-asserted-by":"publisher","first-page":"855","DOI":"10.3233\/jad-189010","volume":"66","author":"EM Sigurdsson","year":"2018","unstructured":"Sigurdsson EM (2018) Tau Immunotherapies for Alzheimer\u2019s disease and related tauopathies: progress and potential pitfalls. J Alzheimer\u2019s Dis 66:855\u2013856. https:\/\/doi.org\/10.3233\/jad-189010","journal-title":"J Alzheimer\u2019s Dis"},{"key":"2301_CR114","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1007\/s10571-006-9083-3","volume":"26","author":"R Skrabana","year":"2006","unstructured":"Skrabana R, Sevcik J, Novak M (2006) Intrinsically disordered proteins in the neurodegenerative processes: formation of tau protein paired helical filaments and their analysis. Cell Mol Neurobiol 26:1083\u20131095. https:\/\/doi.org\/10.1007\/s10571-006-9083-3","journal-title":"Cell Mol Neurobiol"},{"key":"2301_CR115","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/s1474-4422(13)70090-5","volume":"12","author":"MG Spillantini","year":"2013","unstructured":"Spillantini MG, Goedert M (2013) Tau pathology and neurodegeneration. Lancet Neurol 12:609\u2013622. https:\/\/doi.org\/10.1016\/s1474-4422(13)70090-5","journal-title":"Lancet Neurol"},{"key":"2301_CR116","doi-asserted-by":"publisher","first-page":"7737","DOI":"10.1073\/pnas.95.13.7737","volume":"95","author":"MG Spillantini","year":"1998","unstructured":"Spillantini MG, Murrell JR, Goedert M, Farlow MR, Klug A, Ghetti B (1998) Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci 95:7737\u20137741. https:\/\/doi.org\/10.1073\/pnas.95.13.7737","journal-title":"Proc Natl Acad Sci"},{"key":"2301_CR117","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s00441-018-2814-1","volume":"373","author":"JA Steiner","year":"2018","unstructured":"Steiner JA, Quansah E, Brundin P (2018) The concept of alpha-synuclein as a prion-like protein: ten years after. Cell Tissue Res 373:161\u2013173. https:\/\/doi.org\/10.1007\/s00441-018-2814-1","journal-title":"Cell Tissue Res"},{"key":"2301_CR118","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/s1474-4422(17)30037-6","volume":"16","author":"BE Stopschinski","year":"2017","unstructured":"Stopschinski BE, Diamond MI (2017) The prion model for progression and diversity of neurodegenerative diseases. Lancet Neurol 16:323\u2013332. https:\/\/doi.org\/10.1016\/s1474-4422(17)30037-6","journal-title":"Lancet Neurol"},{"key":"2301_CR119","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/s41374-019-0197-x","volume":"99","author":"KH Strang","year":"2019","unstructured":"Strang KH, Golde TE, Giasson BI (2019) MAPT mutations, tauopathy, and mechanisms of neurodegeneration. Lab Invest 99:912\u2013928. https:\/\/doi.org\/10.1038\/s41374-019-0197-x","journal-title":"Lab Invest"},{"key":"2301_CR120","doi-asserted-by":"publisher","unstructured":"Theunis C, Crespo-Biel N, Gafner V, Pihlgren M, L\u00f3pez-Deber MP, Reis P, Hickman DT, Adolfsson O, Chuard N, Ndao DM, Borghgraef P, Devijver H, Leuven FV, Pfeifer A, Muhs A (2013) Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in Tau.P301L mice that model tauopathy. Plos One 8:e72301. https:\/\/doi.org\/10.1371\/journal.pone.0072301","DOI":"10.1371\/journal.pone.0072301"},{"key":"2301_CR121","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1471-4159.2009.05996.x","volume":"109","author":"PW Thompson","year":"2009","unstructured":"Thompson PW, Ye L, Morgenstern JL, Sue L, Beach TG, Judd DJ, Shipley NJ, Libri V, Lockhart A (2009) Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer\u2019s disease pathologies. J Neurochem 109:623\u2013630. https:\/\/doi.org\/10.1111\/j.1471-4159.2009.05996.x","journal-title":"J Neurochem"},{"key":"2301_CR122","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13195-019-0470-7","volume":"11","author":"RM Tsai","year":"2019","unstructured":"Tsai RM, Bejanin A, Lesman-Segev O, LaJoie R, Visani A, Bourakova V, O\u2019Neil JP, Janabi M, Baker S, Lee SE, Perry DC, Bajorek L, Karydas A, Spina S, Grinberg LT, Seeley WW, Ramos EM, Coppola G, Gorno-Tempini ML, Miller BL, Rosen HJ, Jagust W, Boxer AL, Rabinovici GD (2019) 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes. Alzheimer\u2019s Res Ther 11:13. https:\/\/doi.org\/10.1186\/s13195-019-0470-7","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"2301_CR123","doi-asserted-by":"publisher","first-page":"977","DOI":"10.3390\/molecules25040977","volume":"25","author":"BC Uzuegbunam","year":"2020","unstructured":"Uzuegbunam BC, Librizzi D, Yousefi BH (2020) PET radiopharmaceuticals for Alzheimer\u2019s disease and parkinson\u2019s disease diagnosis, the current and future landscape. Molecules 25:977. https:\/\/doi.org\/10.3390\/molecules25040977","journal-title":"Molecules"},{"key":"2301_CR124","doi-asserted-by":"publisher","first-page":"134919","DOI":"10.1016\/j.neulet.2020.134919","volume":"731","author":"L VandeVrede","year":"2020","unstructured":"VandeVrede L, Boxer AL, Polydoro M (2020) Targeting tau: clinical trials and novel therapeutic approaches. Neurosci Lett 731:134919. https:\/\/doi.org\/10.1016\/j.neulet.2020.134919","journal-title":"Neurosci Lett"},{"key":"2301_CR125","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1146\/annurev-biochem-061516-045049","volume":"88","author":"J Vaquer-Alicea","year":"2019","unstructured":"Vaquer-Alicea J, Diamond MI (2019) Propagation of protein aggregation in neurodegenerative diseases. Annu Rev Biochem 88:785\u2013810. https:\/\/doi.org\/10.1146\/annurev-biochem-061516-045049","journal-title":"Annu Rev Biochem"},{"key":"2301_CR126","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s00401-010-0735-5","volume":"121","author":"JDF Wadsworth","year":"2010","unstructured":"Wadsworth JDF, Collinge J (2010) Molecular pathology of human prion disease. Acta Neuropathol 121:69\u201377. https:\/\/doi.org\/10.1007\/s00401-010-0735-5","journal-title":"Acta Neuropathol"},{"key":"2301_CR127","doi-asserted-by":"publisher","unstructured":"Wagner FF, Benajiba L, Campbell AJ, We\u00efwer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ, Stone RM, Kaya T, Shi X, Robers MB, Machleidt T, Wilkinson J, Hermine O, Kung A, Stein AJ, Lakshminarasimhan D, Hemann MT, Scolnick E, Zhang Y-L, Pan JQ, Stegmaier K, Holson EB (2018) Exploiting an Asp-Glu \u201cswitch\u201d in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med 10:eaam8460. https:\/\/doi.org\/10.1126\/scitranslmed.aam8460","DOI":"10.1126\/scitranslmed.aam8460"},{"key":"2301_CR128","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/s0196-9781(02)00059-1","volume":"23","author":"LC Walker","year":"2002","unstructured":"Walker LC, Callahan MJ, Bian F, Durham RA, Roher AE, Lipinski WJ (2002) Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic mice. Peptides 23:1241\u20131247. https:\/\/doi.org\/10.1016\/s0196-9781(02)00059-1","journal-title":"Peptides"},{"key":"2301_CR129","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1016\/j.ajpath.2012.08.031","volume":"181","author":"BM Wegenast-Braun","year":"2012","unstructured":"Wegenast-Braun BM, Skodras A, Bayraktar G, Mahler J, Fritschi SK, Klingstedt T, Mason JJ, Hammarstr\u00f6m P, Nilsson KPR, Liebig C, Jucker M (2012) Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes. Am J Pathol 181:1953\u20131960. https:\/\/doi.org\/10.1016\/j.ajpath.2012.08.031","journal-title":"Am J Pathol"},{"key":"2301_CR130","first-page":"2181","volume":"150","author":"DM Wilson","year":"1997","unstructured":"Wilson DM, Binder LI (1997) Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer\u2019s disease. Am J Pathol 150:2181\u20132195","journal-title":"Am J Pathol"},{"key":"2301_CR131","doi-asserted-by":"publisher","first-page":"11213","DOI":"10.1073\/pnas.93.20.11213","volume":"93","author":"CM Wischik","year":"1996","unstructured":"Wischik CM, Edwards PC, Lai RY, Roth M, Harrington CR (1996) Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. Proc Natl Acad Sci 93:11213\u201311218. https:\/\/doi.org\/10.1073\/pnas.93.20.11213","journal-title":"Proc Natl Acad Sci"},{"key":"2301_CR132","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s40478-018-0535-z","volume":"6","author":"MC Wren","year":"2018","unstructured":"Wren MC, Lashley T, \u00c5rstad E, Sander K (2018) Large inter- and intra-case variability of first generation tau PET ligand binding in neurodegenerative dementias. Acta Neuropathol Commun 6:34. https:\/\/doi.org\/10.1186\/s40478-018-0535-z","journal-title":"Acta Neuropathol Commun"},{"key":"2301_CR133","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.neuron.2013.07.046","volume":"80","author":"K Yanamandra","year":"2013","unstructured":"Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM (2013) Anti-Tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron 80:402\u2013414. https:\/\/doi.org\/10.1016\/j.neuron.2013.07.046","journal-title":"Neuron"},{"key":"2301_CR134","doi-asserted-by":"publisher","first-page":"e43584","DOI":"10.7554\/elife.43584","volume":"8","author":"W Zhang","year":"2019","unstructured":"Zhang W, Falcon B, Murzin AG, Fan J, Crowther RA, Goedert M, Scheres SH (2019) Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer\u2019s and Pick\u2019s diseases. Elife 8:e43584. https:\/\/doi.org\/10.7554\/elife.43584","journal-title":"Elife"},{"key":"2301_CR135","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2043-0","author":"W Zhang","year":"2020","unstructured":"Zhang W, Tarutani A, Newell KL, Murzin AG, Matsubara T, Falcon B, Vidal R, Garringer HJ, Shi Y, Ikeuchi T, Murayama S, Ghetti B, Hasegawa M, Goedert M, Scheres SHW (2020) Novel tau filament fold in corticobasal degeneration. Nature. https:\/\/doi.org\/10.1038\/s41586-020-2043-0","journal-title":"Nature"},{"key":"2301_CR136","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.bpj.2017.01.024","volume":"112","author":"J Zhao","year":"2017","unstructured":"Zhao J, Huvent I, Lippens G, Eliezer D, Zhang A, Li Q, Tessier P, Linhardt RJ, Zhang F, Wang C (2017) Glycan determinants of heparin-tau interaction. Biophys J 112:921\u2013932. https:\/\/doi.org\/10.1016\/j.bpj.2017.01.024","journal-title":"Biophys J"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-021-02301-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00401-021-02301-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-021-02301-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T04:06:40Z","timestamp":1624248400000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00401-021-02301-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":136,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["2301"],"URL":"https:\/\/doi.org\/10.1007\/s00401-021-02301-7","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]},"assertion":[{"value":"17 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"One of the authors (MID) is a co-inventor of an anti-tau therapeutic antibody (ABBV-8E12) that is in clinical trials.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}