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GE Healthcare holds a license agreement with the University of Pittsburgh based on the PiB-PET technology described in this manuscript. W.E.K.\u00a0is a co-inventor of PiB and, as such, has a financial interest in this license agreement. GE Healthcare provided no grant support for this study and had no role in the design or interpretation of results or preparation of this manuscript. All other authors have no conflicts of interest with PiB-PET and had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. J.C.M. is funded by NIH grants # P30 AG066444; P01AG003991; P01AG026276; U19 AG032438; and U19 AG024904. Neither J.C.M. nor his family owns stock or has equity interest (outside of mutual funds or other externally directed accounts) in any pharmaceutical or biotechnology company. T.L.S.B. has investigator-initiated research funding from the NIH, the Alzheimer\u2019s Association, the Barnes-Jewish Hospital Foundation, and Avid Radiopharmaceuticals (a wholly owned subsidiary of Eli Lilly); participates as a site investigator in clinical trials sponsored by Avid Radiopharmaceuticals, Eli Lilly, Biogen, Eisai, Jaansen, and Roche; serves as an unpaid consultant to Eisai and Siemens; and is on the Speaker\u2019s Bureau for Biogen.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Data are available by request to the Knight ADRC (knightadrc.wustl.edu\/research\/resourcerequest.htm) and the DIAN-Obs (dian.wustl.edu\/our-research\/observational-study\/dian-observational-study-investigator-resources\/data-request-terms-and-instructions\/).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data and materials availability"}}]}}