{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:57:32Z","timestamp":1790042252804,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000874","name":"brain and behavior research foundation","doi-asserted-by":"publisher","award":["28956"],"award-info":[{"award-number":["28956"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS080390"],"award-info":[{"award-number":["R01 NS080390"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS095733"],"award-info":[{"award-number":["R01 NS095733"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002243","name":"National Ataxia Foundation","doi-asserted-by":"publisher","award":["Young Investigator Award"],"award-info":[{"award-number":["Young Investigator Award"]}],"id":[{"id":"10.13039\/100002243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001461","name":"American Philosophical Society","doi-asserted-by":"publisher","award":["Franklin Award"],"award-info":[{"award-number":["Franklin Award"]}],"id":[{"id":"10.13039\/100001461","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s00401-021-02355-7","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T09:03:00Z","timestamp":1628067780000},"page":"761-776","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Evidence of disrupted rhombic lip development in the pathogenesis of Dandy\u2013Walker malformation"],"prefix":"10.1007","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2865-8683","authenticated-orcid":false,"given":"Parthiv","family":"Haldipur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bernardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Aldinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarika","family":"Sivakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Millman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria H.","family":"Sjoboen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Dubocanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Timms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine T.","family":"Plummer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshitij","family":"Mankad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Oztekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Manganaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Guimiot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homa","family":"Adle-Biassette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Kidron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Petrilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferechte","family":"Razavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Glass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cira","family":"Di Gioia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen J.","family":"Millen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"2355_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.siny.2016.04.008","volume":"21","author":"KA Aldinger","year":"2016","unstructured":"Aldinger KA, Doherty D (2016) The genetics of cerebellar malformations. Semin Fetal Neonatal Med 21:321\u2013332. https:\/\/doi.org\/10.1016\/j.siny.2016.04.008","journal-title":"Semin Fetal Neonatal Med"},{"key":"2355_CR2","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/ng.422","volume":"41","author":"KA Aldinger","year":"2009","unstructured":"Aldinger KA, Lehmann OJ, Hudgins L, Chizhikov VV, Bassuk AG, Ades LC (2009) FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation. Nat Genet 41:1037\u20131042. https:\/\/doi.org\/10.1038\/ng.422","journal-title":"Nat Genet"},{"key":"2355_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00872-y","author":"KA Aldinger","year":"2021","unstructured":"Aldinger KA, Thomson Z, Phelps IG, Haldipur P, Deng M, Timms AE et al (2021) Spatial and cell type transcriptional landscape of human cerebellar development. Nat Neurosci. https:\/\/doi.org\/10.1038\/s41593-021-00872-y","journal-title":"Nat Neurosci"},{"key":"2355_CR4","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.ajhg.2019.07.019","volume":"105","author":"KA Aldinger","year":"2019","unstructured":"Aldinger KA, Timms AE, Thomson Z, Mirzaa GM, Bennett JT, Rosenberg AB et al (2019) Redefining the etiologic landscape of cerebellar Malformations. Am J Hum Genet 105:606\u2013615. https:\/\/doi.org\/10.1016\/j.ajhg.2019.07.019","journal-title":"Am J Hum Genet"},{"key":"2355_CR5","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1093\/brain\/awp247","volume":"132","author":"AJ Barkovich","year":"2009","unstructured":"Barkovich AJ, Millen KJ, Dobyns WB (2009) A developmental and genetic classification for midbrain-hindbrain malformations. Brain 132:3199\u20133230. https:\/\/doi.org\/10.1093\/brain\/awp247","journal-title":"Brain"},{"key":"2355_CR6","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/ana.21239","volume":"62","author":"AJ Barkovich","year":"2007","unstructured":"Barkovich AJ, Millen KJ, Dobyns WB (2007) A developmental classification of malformations of the brainstem. Ann Neurol 62:625\u2013639. https:\/\/doi.org\/10.1002\/ana.21239","journal-title":"Ann Neurol"},{"key":"2355_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/jnen\/13.1.14","volume":"13","author":"CE Benda","year":"1954","unstructured":"Benda CE (1954) The Dandy-Walker syndrome or the so-called atresia of the foramen Magendie. J Neuropathol Exp Neurol 13:14\u201329. https:\/\/doi.org\/10.1093\/jnen\/13.1.14","journal-title":"J Neuropathol Exp Neurol"},{"key":"2355_CR8","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1002\/pd.4705","volume":"35","author":"S Bernardo","year":"2015","unstructured":"Bernardo S, Vinci V, Saldari M, Servadei F, Silvestri E, Giancotti A et al (2015) Dandy-Walker Malformation: is the \u2018tail sign\u2019 the key sign? Prenat Diagn 35:1358\u20131364. https:\/\/doi.org\/10.1002\/pd.4705","journal-title":"Prenat Diagn"},{"key":"2355_CR9","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1148\/rg.2020200034","volume":"40","author":"SW Cater","year":"2020","unstructured":"Cater SW, Boyd BK, Ghate SV (2020) Abnormalities of the fetal central nervous system: prenatal US diagnosis with postnatal correlation. Radiographics 40:1458\u20131472. https:\/\/doi.org\/10.1148\/rg.2020200034","journal-title":"Radiographics"},{"key":"2355_CR10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.clinimag.2014.10.012","volume":"39","author":"T Chapman","year":"2015","unstructured":"Chapman T, Mahalingam S, Ishak GE, Nixon JN, Siebert J, Dighe MK (2015) Diagnostic imaging of posterior fossa anomalies in the fetus and neonate: part 2, Posterior fossa disorders. Clin Imaging 39:167\u2013175. https:\/\/doi.org\/10.1016\/j.clinimag.2014.10.012","journal-title":"Clin Imaging"},{"key":"2355_CR11","doi-asserted-by":"publisher","first-page":"963","DOI":"10.3174\/ajnr.A5574","volume":"39","author":"G Conte","year":"2018","unstructured":"Conte G, Milani S, Palumbo G, Talenti G, Boito S, Rustico M et al (2018) Prenatal brain MR imaging: reference linear biometric centiles between 20 and 24 gestational weeks. AJNR Am J Neuroradiol 39:963\u2013967. https:\/\/doi.org\/10.3174\/ajnr.A5574","journal-title":"AJNR Am J Neuroradiol"},{"key":"2355_CR12","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1001\/archpedi.1914.02180010416002","volume":"8","author":"W Dandy","year":"1914","unstructured":"Dandy W, Blackfan K (1914) Internal hydrocephalus: an experimental, clinical and pathological study. Am J Dis Child 8:406\u2013482","journal-title":"Am J Dis Child"},{"key":"2355_CR13","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1002\/ajmg.a.35548","volume":"158A","author":"A Delahaye","year":"2012","unstructured":"Delahaye A, Khung-Savatovsky S, Aboura A, Guimiot F, Drunat S, Alessandri JL et al (2012) Pre- and postnatal phenotype of 6p25 deletions involving the FOXC1 gene. Am J Med Genet A 158A:2430\u20132438. https:\/\/doi.org\/10.1002\/ajmg.a.35548","journal-title":"Am J Med Genet A"},{"key":"2355_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S et al (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29:15\u201321. https:\/\/doi.org\/10.1093\/bioinformatics\/bts635","journal-title":"Bioinformatics"},{"key":"2355_CR15","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3389\/fncel.2020.00115","volume":"14","author":"E Gabriel","year":"2020","unstructured":"Gabriel E, Ramani A, Altinisik N, Gopalakrishnan J (2020) Human brain organoids to decode mechanisms of microcephaly. Front Cell Neurosci 14:115. https:\/\/doi.org\/10.3389\/fncel.2020.00115","journal-title":"Front Cell Neurosci"},{"key":"2355_CR16","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1038\/ng1420","volume":"36","author":"I Grinberg","year":"2004","unstructured":"Grinberg I, Northrup H, Ardinger H, Prasad C, Dobyns WB, Millen KJ (2004) Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation. Nat Genet 36:1053\u20131055. https:\/\/doi.org\/10.1038\/ng1420","journal-title":"Nat Genet"},{"key":"2355_CR17","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1750-3639.2010.00459.x","volume":"21","author":"S Guidi","year":"2011","unstructured":"Guidi S, Ciani E, Bonasoni P, Santini D, Bartesaghi R (2011) Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome. Brain Pathol 21:361\u2013373. https:\/\/doi.org\/10.1111\/j.1750-3639.2010.00459.x","journal-title":"Brain Pathol"},{"key":"2355_CR18","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1126\/science.aax7526","volume":"366","author":"P Haldipur","year":"2019","unstructured":"Haldipur P, Aldinger KA, Bernardo S, Deng M, Timms AE, Overman LM et al (2019) Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum. Science 366:454\u2013460. https:\/\/doi.org\/10.1126\/science.aax7526","journal-title":"Science"},{"key":"2355_CR19","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1089\/scd.2011.0206","volume":"21","author":"P Haldipur","year":"2012","unstructured":"Haldipur P, Bharti U, Govindan S, Sarkar C, Iyengar S, Gressens P et al (2012) Expression of Sonic hedgehog during cell proliferation in the human cerebellum. Stem Cells Dev 21:1059\u20131068. https:\/\/doi.org\/10.1089\/scd.2011.0206","journal-title":"Stem Cells Dev"},{"key":"2355_CR20","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20898","author":"P Haldipur","year":"2017","unstructured":"Haldipur P, Dang D, Aldinger KA, Janson OK, Guimiot F, Adle-Biasette H et al (2017) Phenotypic outcomes in Mouse and Human Foxc1 dependent Dandy-Walker cerebellar malformation suggest shared mechanisms. Elife. https:\/\/doi.org\/10.7554\/eLife.20898","journal-title":"Elife"},{"key":"2355_CR21","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03962","author":"P Haldipur","year":"2014","unstructured":"Haldipur P, Gillies GS, Janson OK, Chizhikov VV, Mithal DS, Miller RJ et al (2014) Foxc1 dependent mesenchymal signalling drives embryonic cerebellar growth. Elife. https:\/\/doi.org\/10.7554\/eLife.03962","journal-title":"Elife"},{"key":"2355_CR22","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1002\/bdra.20589","volume":"85","author":"RP Kapur","year":"2009","unstructured":"Kapur RP, Mahony BS, Finch L, Siebert JR (2009) Normal and abnormal anatomy of the cerebellar vermis in midgestational human fetuses. Birth Defects Res A Clin Mol Teratol 85:700\u2013709. https:\/\/doi.org\/10.1002\/bdra.20589","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"2355_CR23","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s12311-015-0724-2","volume":"15","author":"K Leto","year":"2016","unstructured":"Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B et al (2016) Consensus paper: cerebellar development. Cerebellum 15:789\u2013828. https:\/\/doi.org\/10.1007\/s12311-015-0724-2","journal-title":"Cerebellum"},{"key":"2355_CR24","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao Y, Smyth GK, Shi W (2014) featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30:923\u2013930. https:\/\/doi.org\/10.1093\/bioinformatics\/btt656","journal-title":"Bioinformatics"},{"key":"2355_CR25","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1542\/peds.2004-1169","volume":"115","author":"C Limperopoulos","year":"2005","unstructured":"Limperopoulos C, Soul JS, Gauvreau K, Huppi PS, Warfield SK, Bassan H et al (2005) Late gestation cerebellar growth is rapid and impeded by premature birth. Pediatrics 115:688\u2013695. https:\/\/doi.org\/10.1542\/peds.2004-1169","journal-title":"Pediatrics"},{"key":"2355_CR26","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8","journal-title":"Genome Biol"},{"key":"2355_CR27","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1097\/01.AOG.0000200594.85483.8a","volume":"107","author":"JJ Phillips","year":"2006","unstructured":"Phillips JJ, Mahony BS, Siebert JR, Lalani T, Fligner CL, Kapur RP (2006) Dandy-Walker malformation complex: correlation between ultrasonographic diagnosis and postmortem neuropathology. Obstet Gynecol 107:685\u2013693. https:\/\/doi.org\/10.1097\/01.AOG.0000200594.85483.8a","journal-title":"Obstet Gynecol"},{"key":"2355_CR28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s12311-015-0699-z","volume":"15","author":"A Poretti","year":"2016","unstructured":"Poretti A, Boltshauser E, Huisman T (2016) Pre- and postnatal neuroimaging of congenital cerebellar abnormalities. Cerebellum 15:5\u20139. https:\/\/doi.org\/10.1007\/s12311-015-0699-z","journal-title":"Cerebellum"},{"key":"2355_CR29","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/cne.901390407","volume":"139","author":"P Rakic","year":"1970","unstructured":"Rakic P, Sidman RL (1970) Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans. J Comp Neurol 139:473\u2013500. https:\/\/doi.org\/10.1002\/cne.901390407","journal-title":"J Comp Neurol"},{"key":"2355_CR30","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1177\/0883073807299862","volume":"22","author":"R Russo","year":"2007","unstructured":"Russo R, Fallet-Bianco C (2007) Isolated posterior cerebellar vermal defect: a morphological study of midsagittal cerebellar vermis in 4 fetuses\u2013early stage of Dandy-Walker continuum or new vermal dysgenesis? J Child Neurol 22:492\u2013500. https:\/\/doi.org\/10.1177\/0883073807299862","journal-title":"J Child Neurol"},{"key":"2355_CR31","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.pediatrneurol.2021.01.002","volume":"117","author":"SD Schlatterer","year":"2021","unstructured":"Schlatterer SD, Sanapo L, du Plessis AJ, Whitehead MT, Mulkey SB (2021) The role of fetal MRI for suspected anomalies of the posterior Fossa. Pediatr Neurol 117:10\u201318. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2021.01.002","journal-title":"Pediatr Neurol"},{"key":"2355_CR32","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1001\/archneurpsyc.1942.02290100083008","volume":"48","author":"JK Taggart","year":"1942","unstructured":"Taggart JK, Walker AE (1942) Congenital Atresia of the foramens of Luschka and Magendie. Arch NeurPsych 48:583\u2013612. https:\/\/doi.org\/10.1001\/archneurpsyc.1942.02290100083008","journal-title":"Arch NeurPsych"},{"key":"2355_CR33","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1093\/bioinformatics\/bty896","volume":"35","author":"R Vera Alvarez","year":"2019","unstructured":"Vera Alvarez R, Pongor LS, Marino-Ramirez L, Landsman D (2019) TPMCalculator: one-step software to quantify mRNA abundance of genomic features. Bioinformatics 35:1960\u20131962. https:\/\/doi.org\/10.1093\/bioinformatics\/bty896","journal-title":"Bioinformatics"},{"key":"2355_CR34","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1177\/0883073809338067","volume":"24","author":"JJ Volpe","year":"2009","unstructured":"Volpe JJ (2009) Cerebellum of the premature infant: rapidly developing, vulnerable, clinically important. J Child Neurol 24:1085\u20131104. https:\/\/doi.org\/10.1177\/0883073809338067","journal-title":"J Child Neurol"},{"key":"2355_CR35","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1002\/uog.11101","volume":"39","author":"P Volpe","year":"2012","unstructured":"Volpe P, Contro E, De Musso F, Ghi T, Farina A, Tempesta A et al (2012) Brainstem-vermis and brainstem-tentorium angles allow accurate categorization of fetal upward rotation of cerebellar vermis. Ultrasound Obstet Gynecol 39:632\u2013635. https:\/\/doi.org\/10.1002\/uog.11101","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-021-02355-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00401-021-02355-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-021-02355-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T15:11:16Z","timestamp":1631027476000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00401-021-02355-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["2355"],"URL":"https:\/\/doi.org\/10.1007\/s00401-021-02355-7","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,4]]},"assertion":[{"value":"1 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}