{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:19:54Z","timestamp":1793387994678,"version":"4.5.0"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000864","name":"michael j. fox foundation for parkinson's research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"name":"lewy body society"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mutations in glucocerebrosidase (\n                    <jats:italic>GBA<\/jats:italic>\n                    ) are the most prevalent genetic risk factor for Lewy body disorders (LBD)\u2014collectively Parkinson\u2019s disease, Parkinson\u2019s disease dementia and dementia with Lewy bodies. Despite this genetic association, it remains unclear how\n                    <jats:italic>GBA<\/jats:italic>\n                    mutations increase susceptibility to develop LBD. We investigated relationships between LBD-specific glucocerebrosidase deficits, GBA-related pathways, and \u03b1-synuclein levels in brain tissue from LBD and controls, with and without\n                    <jats:italic>GBA<\/jats:italic>\n                    mutations. We show that LBD is characterised by altered sphingolipid metabolism with prominent elevation of ceramide species, regardless of\n                    <jats:italic>GBA<\/jats:italic>\n                    mutations. Since extracellular vesicles (EV) could be involved in LBD pathogenesis by spreading disease-linked lipids and proteins, we investigated EV derived from\n                    <jats:italic>post-mortem<\/jats:italic>\n                    cerebrospinal fluid (CSF) and brain tissue from\n                    <jats:italic>GBA<\/jats:italic>\n                    mutation carriers and non-carriers. EV purified from LBD CSF and frontal cortex were heavily loaded with ceramides and neurodegeneration-linked proteins including alpha-synuclein and tau. Our in vitro studies demonstrate that LBD EV constitute a \u201cpathological package\u201d capable of inducing aggregation of wild-type alpha-synuclein, mediated through a combination of alpha-synuclein\u2013ceramide interaction and the presence of pathological forms of alpha-synuclein. Together, our findings indicate that abnormalities in ceramide metabolism are a feature of LBD, constituting a promising source of biomarkers, and that\n                    <jats:italic>GBA<\/jats:italic>\n                    mutations likely accelerate the pathological process occurring in sporadic LBD through endolysosomal deficiency.\n                  <\/jats:p>","DOI":"10.1007\/s00401-021-02367-3","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T23:14:36Z","timestamp":1631488476000},"page":"961-984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders"],"prefix":"10.1007","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2482-2741","authenticated-orcid":false,"given":"Marzena","family":"Kurzawa-Akanbi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seshu","family":"Tammireddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Fabrik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Gliaudelyt\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Doherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Heap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Mate\u010dko-Burmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn M.","family":"Burmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Trost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Lucocq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anda V.","family":"Gherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Fairfoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Burt\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian G.","family":"McKeith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anetta","family":"H\u00e4rtlova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip D.","family":"Whitfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"issue":"3","key":"2367_CR1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1001\/archneur.60.3.387","volume":"60","author":"D Aarsland","year":"2003","unstructured":"Aarsland D, Andersen K, Larsen JP, Lolk A, Kragh-Sorensen P (2003) Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study. Arch Neurol 60(3):387\u2013392","journal-title":"Arch Neurol"},{"issue":"4","key":"2367_CR2","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/mds.25729","volume":"29","author":"SK Abbott","year":"2014","unstructured":"Abbott SK, Li H, Munoz SS, Knoch B, Batterham M, Murphy KE et al (2014) Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson\u2019s disease. Mov Disord 29(4):518\u2013526","journal-title":"Mov Disord"},{"key":"2367_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101430","volume":"30","author":"E Afsar","year":"2020","unstructured":"Afsar E, Kirimlioglu E, Ceker T, Yilmaz C, Demir N, Aslan M (2020) Effect of ER stress on sphingolipid levels and apoptotic pathways in retinal pigment epithelial cells. Redox Biol 30:101430","journal-title":"Redox Biol"},{"issue":"6","key":"2367_CR4","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1001\/jamaneurol.2014.313","volume":"71","author":"RN Alcalay","year":"2014","unstructured":"Alcalay RN, Dinur T, Quinn T, Sakanaka K, Levy O, Waters C et al (2014) Comparison of Parkinson risk in Ashkenazi Jewish patients with Gaucher disease and GBA heterozygotes. JAMA Neurol 71(6):752\u2013757","journal-title":"JAMA Neurol"},{"key":"2367_CR5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.micron.2017.03.019","volume":"99","author":"J Asadi","year":"2017","unstructured":"Asadi J, Ferguson S, Raja H, Hacker C, Marius P, Ward R et al (2017) Enhanced imaging of lipid rich nanoparticles embedded in methylcellulose films for transmission electron microscopy using mixtures of heavy metals. Micron 99:40\u201348","journal-title":"Micron"},{"issue":"11","key":"2367_CR6","first-page":"289","volume":"10","author":"EE Aspholm","year":"2020","unstructured":"Aspholm EE, Matecko-Burmann I, Burmann BM (2020) Keeping alpha-synuclein at bay: a more active role of molecular chaperones in preventing mitochondrial interactions and transition to pathological states? Life (Basel) 10(11):289","journal-title":"Life (Basel)"},{"issue":"4","key":"2367_CR7","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.tins.2016.01.007","volume":"39","author":"M Baudry","year":"2016","unstructured":"Baudry M, Bi X (2016) Calpain-1 and Calpain-2: the Yin and Yang of synaptic plasticity and neurodegeneration. Trends Neurosci 39(4):235\u2013245","journal-title":"Trends Neurosci"},{"issue":"1","key":"2367_CR8","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jmr.2005.08.011","volume":"178","author":"W Bermel","year":"2006","unstructured":"Bermel W, Bertini I, Felli IC, K\u00fcmmerle R, Pierattelli R (2006) Novel 13C direct detection experiments, including extension to the third dimension, to perform the complete assignment of proteins. J Magn Reson 178(1):56\u201364","journal-title":"J Magn Reson"},{"issue":"42","key":"2367_CR9","doi-asserted-by":"publisher","first-page":"15339","DOI":"10.1021\/ja9058525","volume":"131","author":"W Bermel","year":"2009","unstructured":"Bermel W, Bertini I, Felli IC, Pierattelli R (2009) Speeding up 13C direct detection biomolecular NMR spectroscopy. J Am Chem Soc 131(42):15339\u201315345","journal-title":"J Am Chem Soc"},{"issue":"11","key":"2367_CR10","doi-asserted-by":"publisher","first-page":"5450","DOI":"10.3390\/ijms22115450","volume":"22","author":"A Bluhm","year":"2021","unstructured":"Bluhm A, Schrempel S, von Horsten S, Schulze A, Rossner S (2021) Proteolytic alpha-synuclein cleavage in health and disease. Int J Mol Sci 22(11):5450","journal-title":"Int J Mol Sci"},{"key":"2367_CR11","doi-asserted-by":"publisher","first-page":"23430","DOI":"10.3402\/jev.v3.23430","volume":"3","author":"AN Boing","year":"2014","unstructured":"Boing AN, van der Pol E, Grootemaat AE, Coumans FA, Sturk A, Nieuwland R (2014) Single-step isolation of extracellular vesicles by size-exclusion chromatography. J Extracell Vesicles 3:23430","journal-title":"J Extracell Vesicles"},{"issue":"3","key":"2367_CR12","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1021\/acs.analchem.5b04227","volume":"88","author":"M Boutin","year":"2016","unstructured":"Boutin M, Sun Y, Shacka JJ, Auray-Blais C (2016) Tandem mass spectrometry multiplex analysis of glucosylceramide and galactosylceramide isoforms in brain tissues at different stages of Parkinson disease. Anal Chem 88(3):1856\u20131863","journal-title":"Anal Chem"},{"issue":"2","key":"2367_CR13","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici K, Rub U, de Vos RA, Steur ENJ, Braak E (2003) Staging of brain pathology related to sporadic Parkinson\u2019s disease. Neurobiol Aging 24(2):197\u2013211","journal-title":"Neurobiol Aging"},{"key":"2367_CR14","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1146\/annurev-biochem-013118-111518","volume":"88","author":"B Breiden","year":"2019","unstructured":"Breiden B, Sandhoff K (2019) Lysosomal glycosphingolipid storage diseases. Annu Rev Biochem 88:461\u2013485","journal-title":"Annu Rev Biochem"},{"issue":"11","key":"2367_CR15","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1038\/nsmb.2677","volume":"20","author":"BM Burmann","year":"2013","unstructured":"Burmann BM, Wang C, Hiller S (2013) Conformation and dynamics of the periplasmic membrane-protein\u2013chaperone complexes OmpX-Skp and tOmpA-Skp. Nat Struct Mol Biol 20(11):1265\u20131272","journal-title":"Nat Struct Mol Biol"},{"issue":"7788","key":"2367_CR16","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/s41586-019-1808-9","volume":"577","author":"BM Burmann","year":"2020","unstructured":"Burmann BM, Gerez JA, Matecko-Burmann I, Campioni S, Kumari P, Ghosh D et al (2020) Regulation of alpha-synuclein by chaperones in mammalian cells. Nature 577(7788):127\u2013132","journal-title":"Nature"},{"key":"2367_CR17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13024-015-0010-2","volume":"10","author":"D Chiasserini","year":"2015","unstructured":"Chiasserini D, Paciotti S, Eusebi P, Persichetti E, Tasegian A, Kurzawa-Akanbi M et al (2015) Selective loss of glucocerebrosidase activity in sporadic Parkinson\u2019s disease and dementia with Lewy bodies. Mol Neurodegener 10:15","journal-title":"Mol Neurodegener"},{"issue":"5","key":"2367_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125204","volume":"10","author":"LN Clark","year":"2015","unstructured":"Clark LN, Chan R, Cheng R, Liu X, Park N, Parmalee N et al (2015) Gene-wise association of variants in four lysosomal storage disorder genes in neuropathologically confirmed Lewy body disease. PLoS ONE 10(5):e0125204","journal-title":"PLoS ONE"},{"issue":"6","key":"2367_CR19","doi-asserted-by":"publisher","first-page":"6707","DOI":"10.18632\/oncotarget.24158","volume":"9","author":"GP Collett","year":"2018","unstructured":"Collett GP, Redman CW, Sargent IL, Vatish M (2018) Endoplasmic reticulum stress stimulates the release of extracellular vesicles carrying danger-associated molecular pattern (DAMP) molecules. Oncotarget 9(6):6707\u20136717","journal-title":"Oncotarget"},{"issue":"5785","key":"2367_CR20","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1126\/science.1129462","volume":"313","author":"AA Cooper","year":"2006","unstructured":"Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B et al (2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson\u2019s models. Science 313(5785):324\u2013328","journal-title":"Science"},{"issue":"7","key":"2367_CR21","doi-asserted-by":"publisher","first-page":"945","DOI":"10.3390\/biom11070945","volume":"11","author":"A Custodia","year":"2021","unstructured":"Custodia A, Aramburu-Nunez M, Correa-Paz C, Posado-Fernandez A, Gomez-Larrauri A, Castillo J et al (2021) Ceramide metabolism and Parkinson\u2019s disease\u2014therapeutic targets. Biomolecules 11(7):945","journal-title":"Biomolecules"},{"issue":"3","key":"2367_CR22","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/BF00197809","volume":"6","author":"F Delaglio","year":"1995","unstructured":"Delaglio F, Grzesiek S, Vuister GW, Zhu G, Pfeifer J, Bax A (1995) NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 6(3):277\u2013293","journal-title":"J Biomol NMR"},{"issue":"10","key":"2367_CR23","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1002\/acn3.338","volume":"3","author":"G Fairfoul","year":"2016","unstructured":"Fairfoul G, McGuire LI, Pal S, Ironside JW, Neumann J, Christie S et al (2016) Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies. Ann Clin Transl Neurol 3(10):812\u2013818","journal-title":"Ann Clin Transl Neurol"},{"issue":"3","key":"2367_CR24","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.stemcr.2016.01.013","volume":"6","author":"HJ Fernandes","year":"2016","unstructured":"Fernandes HJ, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H et al (2016) ER stress and autophagic perturbations lead to elevated extracellular alpha-synuclein in GBA-N370S Parkinson\u2019s iPSC-derived dopamine neurons. Stem Cell Reports 6(3):342\u2013356","journal-title":"Stem Cell Reports"},{"issue":"5","key":"2367_CR25","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3390\/biomedicines9050491","volume":"9","author":"J Fernandez-Irigoyen","year":"2021","unstructured":"Fernandez-Irigoyen J, Cartas-Cejudo P, Iruarrizaga-Lejarreta M, Santamaria E (2021) Alteration in the cerebrospinal fluid lipidome in Parkinson\u2019s disease: a post-mortem pilot study. Biomedicines 9(5):491","journal-title":"Biomedicines"},{"issue":"3","key":"2367_CR26","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.bbrc.2016.08.082","volume":"478","author":"R Ferrazza","year":"2016","unstructured":"Ferrazza R, Cogo S, Melrose H, Bubacco L, Greggio E, Guella G et al (2016) LRRK2 deficiency impacts ceramide metabolism in brain. Biochem Biophys Res Commun 478(3):1141\u20131146","journal-title":"Biochem Biophys Res Commun"},{"key":"2367_CR27","doi-asserted-by":"publisher","first-page":"3827","DOI":"10.1038\/ncomms4827","volume":"5","author":"G Fusco","year":"2014","unstructured":"Fusco G, De Simone A, Gopinath T, Vostrikov V, Vendruscolo M, Dobson CM et al (2014) Direct observation of the three regions in alpha-synuclein that determine its membrane-bound behaviour. Nat Commun 5:3827","journal-title":"Nat Commun"},{"issue":"3","key":"2367_CR28","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/nchembio.1750","volume":"11","author":"C Galvagnion","year":"2015","unstructured":"Galvagnion C, Buell AK, Meisl G, Michaels TC, Vendruscolo M, Knowles TP et al (2015) Lipid vesicles trigger alpha-synuclein aggregation by stimulating primary nucleation. Nat Chem Biol 11(3):229\u2013234","journal-title":"Nat Chem Biol"},{"issue":"26","key":"2367_CR29","doi-asserted-by":"publisher","first-page":"7065","DOI":"10.1073\/pnas.1601899113","volume":"113","author":"C Galvagnion","year":"2016","unstructured":"Galvagnion C, Brown JW, Ouberai MM, Flagmeier P, Vendruscolo M, Buell AK et al (2016) Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of alpha-synuclein. Proc Natl Acad Sci USA 113(26):7065\u20137070","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"2367_CR30","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.molcel.2015.07.012","volume":"59","author":"X Gao","year":"2015","unstructured":"Gao X, Carroni M, Nussbaum-Krammer C, Mogk A, Nillegoda NB, Szlachcic A et al (2015) Human Hsp70 disaggregase reverses Parkinson\u2019s-linked alpha-synuclein amyloid fibrils. Mol Cell 59(5):781\u2013793","journal-title":"Mol Cell"},{"issue":"3","key":"2367_CR31","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/ana.23614","volume":"72","author":"ME Gegg","year":"2012","unstructured":"Gegg ME, Burke D, Heales SJ, Cooper JM, Hardy J, Wood NW et al (2012) Glucocerebrosidase deficiency in substantia nigra of Parkinson disease brains. Ann Neurol 72(3):455\u2013463","journal-title":"Ann Neurol"},{"issue":"8","key":"2367_CR32","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1002\/mds.26278","volume":"30","author":"ME Gegg","year":"2015","unstructured":"Gegg ME, Sweet L, Wang BH, Shihabuddin LS, Sardi SP, Schapira AH (2015) No evidence for substrate accumulation in Parkinson brains with GBA mutations. Mov Disord 30(8):1085\u20131089","journal-title":"Mov Disord"},{"issue":"17","key":"2367_CR33","doi-asserted-by":"publisher","first-page":"6373","DOI":"10.3390\/ijms21176373","volume":"21","author":"Y Giesecke","year":"2020","unstructured":"Giesecke Y, Soete S, MacKinnon K, Tsiaras T, Ward M, Althobaiti M et al (2020) Developing electron microscopy tools for profiling plasma lipoproteins using methyl cellulose embedment, machine learning and immunodetection of apolipoprotein B and apolipoprotein(a). Int J Mol Sci 21(17):6373","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2367_CR34","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.1074\/jbc.M114.585703","volume":"290","author":"M Grey","year":"2015","unstructured":"Grey M, Dunning CJ, Gaspar R, Grey C, Brundin P, Sparr E et al (2015) Acceleration of alpha-synuclein aggregation by exosomes. J Biol Chem 290(5):2969\u20132982","journal-title":"J Biol Chem"},{"key":"2367_CR35","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.parkreldis.2017.08.026","volume":"44","author":"LC Guedes","year":"2017","unstructured":"Guedes LC, Chan RB, Gomes MA, Conceicao VA, Machado RB, Soares T et al (2017) Serum lipid alterations in GBA-associated Parkinson\u2019s disease. Park Relat Disord 44:58\u201365","journal-title":"Park Relat Disord"},{"key":"2367_CR36","doi-asserted-by":"publisher","first-page":"25275","DOI":"10.1038\/srep25275","volume":"6","author":"C Hacker","year":"2016","unstructured":"Hacker C, Asadi J, Pliotas C, Ferguson S, Sherry L, Marius P et al (2016) Nanoparticle suspensions enclosed in methylcellulose: a new approach for quantifying nanoparticles in transmission electron microscopy. Sci Rep 6:25275","journal-title":"Sci Rep"},{"issue":"32","key":"2367_CR37","doi-asserted-by":"publisher","first-page":"27855","DOI":"10.1074\/jbc.R111.254359","volume":"286","author":"YA Hannun","year":"2011","unstructured":"Hannun YA, Obeid LM (2011) Many ceramides. J Biol Chem 286(32):27855\u201327862","journal-title":"J Biol Chem"},{"issue":"5","key":"2367_CR38","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.neuron.2019.12.004","volume":"105","author":"MX Henderson","year":"2020","unstructured":"Henderson MX, Sedor S, McGeary I, Cornblath EJ, Peng C, Riddle DM et al (2020) Glucocerebrosidase activity modulates neuronal susceptibility to pathological alpha-synuclein insult. Neuron 105(5):822-836.e7","journal-title":"Neuron"},{"issue":"11","key":"2367_CR39","doi-asserted-by":"publisher","first-page":"4659","DOI":"10.1021\/acschemneuro.9b00476","volume":"10","author":"I Horvath","year":"2019","unstructured":"Horvath I, Blockhuys S, Sulskis D, Holgersson S, Kumar R, Burmann BM et al (2019) Interaction between copper chaperone Atox1 and Parkinson\u2019s disease protein alpha-synuclein includes metal-binding sites and occurs in living cells. ACS Chem Neurosci 10(11):4659\u20134668","journal-title":"ACS Chem Neurosci"},{"issue":"5","key":"2367_CR40","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/humu.20676","volume":"29","author":"KS Hruska","year":"2008","unstructured":"Hruska KS, LaMarca ME, Scott CR, Sidransky E (2008) Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA). Hum Mutat 29(5):567\u2013583","journal-title":"Hum Mutat"},{"issue":"1","key":"2367_CR41","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0014-5793(94)00395-5","volume":"345","author":"R Jakes","year":"1994","unstructured":"Jakes R, Spillantini MG, Goedert M (1994) Identification of two distinct synucleins from human brain. FEBS Lett 345(1):27\u201332","journal-title":"FEBS Lett"},{"issue":"8","key":"2367_CR42","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nmeth900","volume":"3","author":"V Jaravine","year":"2006","unstructured":"Jaravine V, Ibraghimov I, Orekhov VY (2006) Removal of a time barrier for high-resolution multidimensional NMR spectroscopy. Nat Methods 3(8):605\u2013607","journal-title":"Nat Methods"},{"issue":"1","key":"2367_CR43","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12916-018-1016-8","volume":"16","author":"KA Jellinger","year":"2018","unstructured":"Jellinger KA, Korczyn AD (2018) Are dementia with Lewy bodies and Parkinson\u2019s disease dementia the same disease? BMC Med 16(1):34","journal-title":"BMC Med"},{"issue":"2","key":"2367_CR44","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.bbrc.2016.10.019","volume":"480","author":"S Kanemoto","year":"2016","unstructured":"Kanemoto S, Nitani R, Murakami T, Kaneko M, Asada R, Matsuhisa K et al (2016) Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress. Biochem Biophys Res Commun 480(2):166\u2013172","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"2367_CR45","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1002\/pro.2088","volume":"21","author":"L Kang","year":"2012","unstructured":"Kang L, Moriarty GM, Woods LA, Ashcroft AE, Radford SE, Baum J (2012) N-terminal acetylation of alpha-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer. Protein Sci 21(7):911\u2013917","journal-title":"Protein Sci"},{"key":"2367_CR46","volume-title":"The computer aided resonance assignment tutorial","author":"RLJ Keller","year":"2004","unstructured":"Keller RLJ (2004) The computer aided resonance assignment tutorial. Cantina Verlag, Goldau"},{"key":"2367_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.220","volume":"6","author":"MJ Keogh","year":"2016","unstructured":"Keogh MJ, Kurzawa-Akanbi M, Griffin H, Douroudis K, Ayers KL, Hussein RI et al (2016) Exome sequencing in dementia with Lewy bodies. Transl Psychiatry 6:e728","journal-title":"Transl Psychiatry"},{"issue":"1","key":"2367_CR48","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s40478-016-0334-3","volume":"4","author":"AA Khundakar","year":"2016","unstructured":"Khundakar AA, Hanson PS, Erskine D, Lax NZ, Roscamp J, Karyka E et al (2016) Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations. Acta Neuropathol Commun 4(1):66","journal-title":"Acta Neuropathol Commun"},{"issue":"5","key":"2367_CR49","first-page":"185","volume":"3","author":"K Kosaka","year":"1984","unstructured":"Kosaka K, Yoshimura M, Ikeda K, Budka H (1984) Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree\u2013a new disease? Clin Neuropathol 3(5):185\u2013192","journal-title":"Clin Neuropathol"},{"issue":"2","key":"2367_CR50","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/j.1471-4159.2012.07879.x","volume":"123","author":"M Kurzawa-Akanbi","year":"2012","unstructured":"Kurzawa-Akanbi M, Hanson PS, Blain PG, Lett DJ, McKeith IG, Chinnery PF et al (2012) Glucocerebrosidase mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease. J Neurochem 123(2):298\u2013309","journal-title":"J Neurochem"},{"key":"2367_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104876","volume":"141","author":"HA Lashuel","year":"2020","unstructured":"Lashuel HA (2020) Do Lewy bodies contain alpha-synuclein fibrils? And does it matter? A brief history and critical analysis of recent reports. Neurobiol Dis 141:104876","journal-title":"Neurobiol Dis"},{"issue":"1","key":"2367_CR52","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/s41467-018-03111-4","volume":"9","author":"J Lautenschlager","year":"2018","unstructured":"Lautenschlager J, Stephens AD, Fusco G, Strohl F, Curry N, Zacharopoulou M et al (2018) C-terminal calcium binding of alpha-synuclein modulates synaptic vesicle interaction. Nat Commun 9(1):712","journal-title":"Nat Commun"},{"issue":"5","key":"2367_CR53","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1002\/mds.28472","volume":"36","author":"S Lerche","year":"2021","unstructured":"Lerche S, Schulte C, Wurster I, Machetanz G, Roeben B, Zimmermann M et al (2021) The mutation matters: CSF profiles of GCase, sphingolipids, alpha-synuclein in PDGBA. Mov Disord 36(5):1216\u20131228","journal-title":"Mov Disord"},{"issue":"4","key":"2367_CR54","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.cmet.2018.05.019","volume":"28","author":"G Lin","year":"2018","unstructured":"Lin G, Lee PT, Chen K, Mao D, Tan KL, Zuo Z et al (2018) Phospholipase PLA2G6, a Parkinsonism-associated gene, affects Vps26 and Vps35, retromer function, and ceramide levels, similar to alpha-synuclein gain. Cell Metab 28(4):605-618.e6","journal-title":"Cell Metab"},{"issue":"3","key":"2367_CR55","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.neuron.2012.11.033","volume":"77","author":"DA MacLeod","year":"2013","unstructured":"MacLeod DA, Rhinn H, Kuwahara T, Zolin A, Di Paolo G, McCabe BD et al (2013) RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson\u2019s disease risk. Neuron 77(3):425\u2013439","journal-title":"Neuron"},{"issue":"9","key":"2367_CR56","doi-asserted-by":"publisher","first-page":"4971","DOI":"10.1073\/pnas.1913904117","volume":"117","author":"AL Mahul-Mellier","year":"2020","unstructured":"Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F et al (2020) The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proc Natl Acad Sci USA 117(9):4971\u20134982","journal-title":"Proc Natl Acad Sci USA"},{"issue":"25","key":"2367_CR57","doi-asserted-by":"publisher","first-page":"5004","DOI":"10.1021\/bi300642h","volume":"51","author":"AS Maltsev","year":"2012","unstructured":"Maltsev AS, Ying J, Bax A (2012) Impact of N-terminal acetylation of alpha-synuclein on its random coil and lipid binding properties. Biochemistry 51(25):5004\u20135013","journal-title":"Biochemistry"},{"issue":"7","key":"2367_CR58","doi-asserted-by":"publisher","first-page":"6112","DOI":"10.1007\/s12035-017-0821-y","volume":"55","author":"R Manek","year":"2018","unstructured":"Manek R, Moghieb A, Yang Z, Kumar D, Kobessiy F, Sarkis GA et al (2018) Protein biomarkers and neuroproteomics characterization of microvesicles\/exosomes from human cerebrospinal fluid following traumatic brain injury. Mol Neurobiol 55(7):6112\u20136128","journal-title":"Mol Neurobiol"},{"issue":"1","key":"2367_CR59","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","volume":"146","author":"JR Mazzulli","year":"2011","unstructured":"Mazzulli JR, Xu YH, Sun Y, Knight AL, McLean PJ, Caldwell GA et al (2011) Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell 146(1):37\u201352","journal-title":"Cell"},{"key":"2367_CR60","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","volume":"89","author":"IG McKeith","year":"2017","unstructured":"McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D et al (2017) Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB consortium. Neurology 89:88\u2013100","journal-title":"Neurology"},{"issue":"9","key":"2367_CR61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073094","volume":"8","author":"MM Mielke","year":"2013","unstructured":"Mielke MM, Maetzler W, Haughey NJ, Bandaru VV, Savica R, Deuschle C et al (2013) Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson\u2019s disease and associated with cognitive impairment: a pilot study. PLoS ONE 8(9):e73094","journal-title":"PLoS ONE"},{"issue":"1","key":"2367_CR62","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nrc3398","volume":"13","author":"SA Morad","year":"2013","unstructured":"Morad SA, Cabot MC (2013) Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer 13(1):51\u201365","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"2367_CR63","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1038\/s41467-017-02196-7","volume":"8","author":"L Morgado","year":"2017","unstructured":"Morgado L, Burmann BM, Sharpe T, Mazur A, Hiller S (2017) The dynamic dimer structure of the chaperone trigger factor. Nat Commun 8(1):1992","journal-title":"Nat Commun"},{"issue":"Pt 3","key":"2367_CR64","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1093\/brain\/awt367","volume":"137","author":"KE Murphy","year":"2014","unstructured":"Murphy KE, Gysbers AM, Abbott SK, Tayebi N, Kim WS, Sidransky E et al (2014) Reduced glucocerebrosidase is associated with increased alpha-synuclein in sporadic Parkinson\u2019s disease. Brain 137(Pt 3):834\u2013848","journal-title":"Brain"},{"issue":"6","key":"2367_CR65","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1001\/jamaneurol.2013.1925","volume":"70","author":"MA Nalls","year":"2013","unstructured":"Nalls MA, Duran R, Lopez G, Kurzawa-Akanbi M, McKeith IG, Chinnery PF et al (2013) A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. JAMA Neurol 70(6):727\u2013735","journal-title":"JAMA Neurol"},{"issue":"1","key":"2367_CR66","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s40478-017-0445-5","volume":"5","author":"J Ngolab","year":"2017","unstructured":"Ngolab J, Trinh I, Rockenstein E, Mante M, Florio J, Trejo M et al (2017) Brain-derived exosomes from dementia with Lewy bodies propagate alpha-synuclein pathology. Acta Neuropathol Commun 5(1):46","journal-title":"Acta Neuropathol Commun"},{"issue":"24","key":"2367_CR67","doi-asserted-by":"publisher","first-page":"9220","DOI":"10.1128\/MCB.01453-06","volume":"26","author":"M Ogata","year":"2006","unstructured":"Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S et al (2006) Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26(24):9220\u20139231","journal-title":"Mol Cell Biol"},{"issue":"51","key":"2367_CR68","doi-asserted-by":"publisher","first-page":"43108","DOI":"10.1074\/jbc.M112.404467","volume":"287","author":"R Perez-Gonzalez","year":"2012","unstructured":"Perez-Gonzalez R, Gauthier SA, Kumar A, Levy E (2012) The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space. J Biol Chem 287(51):43108\u201343115","journal-title":"J Biol Chem"},{"issue":"D1","key":"2367_CR69","doi-asserted-by":"publisher","first-page":"D442","DOI":"10.1093\/nar\/gky1106","volume":"47","author":"Y Perez-Riverol","year":"2019","unstructured":"Perez-Riverol Y, Csordas A, Bai J, Bernal-Llinares M, Hewapathirana S, Kundu DJ et al (2019) The PRIDE database and related tools and resources in 2019: improving support for quantification data. Nucleic Acids Res 47(D1):D442\u2013D450","journal-title":"Nucleic Acids Res"},{"key":"2367_CR70","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3389\/fnins.2019.00330","volume":"13","author":"N Plotegher","year":"2019","unstructured":"Plotegher N, Bubacco L, Greggio E, Civiero L (2019) Ceramides in Parkinson\u2019s disease: from recent evidence to new hypotheses. Front Neurosci 13:330","journal-title":"Front Neurosci"},{"issue":"12","key":"2367_CR71","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W et al (2015) MDS clinical diagnostic criteria for Parkinson\u2019s disease. Mov Disord 30(12):1591\u20131601","journal-title":"Mov Disord"},{"issue":"6","key":"2367_CR72","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nrm3984","volume":"16","author":"PM Quiros","year":"2015","unstructured":"Quiros PM, Langer T, Lopez-Otin C (2015) New roles for mitochondrial proteases in health, ageing and disease. Nat Rev Mol Cell Biol 16(6):345\u2013359","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"2367_CR73","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.1093\/brain\/awx285","volume":"140","author":"LA Robak","year":"2017","unstructured":"Robak LA, Jansen IE, van Rooij J, Uitterlinden AG, Kraaij R, Jankovic J et al (2017) Excessive burden of lysosomal storage disorder gene variants in Parkinson\u2019s disease. Brain 140(12):3191\u20133203","journal-title":"Brain"},{"issue":"16","key":"2367_CR74","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1093\/hmg\/ddi240","volume":"14","author":"I Ron","year":"2005","unstructured":"Ron I, Horowitz M (2005) ER retention and degradation as the molecular basis underlying Gaucher disease heterogeneity. Hum Mol Genet 14(16):2387\u20132398","journal-title":"Hum Mol Genet"},{"issue":"19","key":"2367_CR75","doi-asserted-by":"publisher","first-page":"3771","DOI":"10.1093\/hmg\/ddq292","volume":"19","author":"I Ron","year":"2010","unstructured":"Ron I, Rapaport D, Horowitz M (2010) Interaction between parkin and mutant glucocerebrosidase variants: a possible link between Parkinson disease and Gaucher disease. Hum Mol Genet 19(19):3771\u20133781","journal-title":"Hum Mol Genet"},{"key":"2367_CR76","volume-title":"Molecular cloning: a laboratory manual","author":"J Sambrook","year":"1989","unstructured":"Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, vol 2. Cold Spring Harbor Laboratory, Cold Spring Harbor"},{"issue":"29","key":"2367_CR77","doi-asserted-by":"publisher","first-page":"12101","DOI":"10.1073\/pnas.1108197108","volume":"108","author":"SP Sardi","year":"2011","unstructured":"Sardi SP, Clarke J, Kinnecom C, Tamsett TJ, Li L, Stanek LM et al (2011) CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy. Proc Natl Acad Sci USA 108(29):12101\u201312106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"2367_CR78","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1002\/jnr.23798","volume":"94","author":"G Scesa","year":"2016","unstructured":"Scesa G, Moyano AL, Bongarzone ER, Givogri MI (2016) Port-to-port delivery: mobilization of toxic sphingolipids via extracellular vesicles. J Neurosci Res 94(11):1333\u20131340","journal-title":"J Neurosci Res"},{"issue":"4","key":"2367_CR79","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s10858-005-4425-x","volume":"33","author":"P Schanda","year":"2005","unstructured":"Schanda P, Kup\u010de E, Brutscher B (2005) SOFAST-HMQC experiments for recording two-dimensional heteronuclear correlation spectra of proteins within a few seconds. J Biomol NMR 33(4):199\u2013211","journal-title":"J Biomol NMR"},{"key":"2367_CR80","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.parkreldis.2019.11.015","volume":"73","author":"K Senkevich","year":"2020","unstructured":"Senkevich K, Gan-Or Z (2020) Autophagy lysosomal pathway dysfunction in Parkinson\u2019s disease; evidence from human genetics. Park Relat Disord 73:60\u201371","journal-title":"Park Relat Disord"},{"issue":"7","key":"2367_CR81","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1038\/s41593-019-0423-2","volume":"22","author":"SH Shahmoradian","year":"2019","unstructured":"Shahmoradian SH, Lewis AJ, Genoud C, Hench J, Moors TE, Navarro PP et al (2019) Lewy pathology in Parkinson\u2019s disease consists of crowded organelles and lipid membranes. Nat Neurosci 22(7):1099\u20131109","journal-title":"Nat Neurosci"},{"issue":"17","key":"2367_CR82","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","volume":"361","author":"E Sidransky","year":"2009","unstructured":"Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER et al (2009) Multicenter analysis of glucocerebrosidase mutations in Parkinson\u2019s disease. N Engl J Med 361(17):1651\u20131661","journal-title":"N Engl J Med"},{"issue":"16","key":"2367_CR83","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.1111\/febs.15327","volume":"287","author":"G Soto-Heredero","year":"2020","unstructured":"Soto-Heredero G, de Las Heras MMG, Gabande-Rodriguez E, Oller J, Mittelbrunn M (2020) Glycolysis\u2014a key player in the inflammatory response. FEBS J 287(16):3350\u20133369","journal-title":"FEBS J"},{"issue":"34","key":"2367_CR84","doi-asserted-by":"publisher","first-page":"26279","DOI":"10.1074\/jbc.M110.134775","volume":"285","author":"K Strauss","year":"2010","unstructured":"Strauss K, Goebel C, Runz H, Mobius W, Weiss S, Feussner I et al (2010) Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease. J Biol Chem 285(34):26279\u201326288","journal-title":"J Biol Chem"},{"key":"2367_CR85","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1093\/brain\/awv346","volume":"139","author":"A Stuendl","year":"2015","unstructured":"Stuendl A, Kunadt M, Kruse N, Bartels C, Moebius W, Danzer KM et al (2015) Induction of alpha-synuclein aggregate formation by CSF exosomes from patients with Parkinson\u2019s disease and dementia with Lewy bodies. Brain 139:481\u2013494","journal-title":"Brain"},{"issue":"5","key":"2367_CR86","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/S0022-2275(20)32121-0","volume":"40","author":"Y Takagi","year":"1999","unstructured":"Takagi Y, Kriehuber E, Imokawa G, Elias PM, Holleran WM (1999) Beta-glucocerebrosidase activity in mammalian stratum corneum. J Lipid Res 40(5):861\u2013869","journal-title":"J Lipid Res"},{"issue":"7588","key":"2367_CR87","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nature16531","volume":"530","author":"FX Theillet","year":"2016","unstructured":"Theillet FX, Binolfi A, Bekei B, Martorana A, Rose HM, Stuiver M et al (2016) Structural disorder of monomeric alpha-synuclein persists in mammalian cells. Nature 530(7588):45\u201350","journal-title":"Nature"},{"issue":"5867","key":"2367_CR88","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1126\/science.1153124","volume":"319","author":"K Trajkovic","year":"2008","unstructured":"Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F et al (2008) Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319(5867):1244\u20131247","journal-title":"Science"},{"issue":"2","key":"2367_CR89","doi-asserted-by":"publisher","first-page":"12034","DOI":"10.1002\/jev2.12034","volume":"10","author":"CL Ugalde","year":"2020","unstructured":"Ugalde CL, Gordon SE, Shambrook M, Kenari AN, Coleman BM, Perugini MA et al (2020) An intact membrane is essential for small extracellular vesicle-induced modulation of alpha-synuclein fibrillization. J Extracell Vesicles 10(2):12034","journal-title":"J Extracell Vesicles"},{"key":"2367_CR90","doi-asserted-by":"publisher","first-page":"31242","DOI":"10.3402\/jev.v5.31242","volume":"5","author":"R Vogel","year":"2016","unstructured":"Vogel R, Coumans FA, Maltesen RG, Boing AN, Bonnington KE, Broekman ML et al (2016) A standardized method to determine the concentration of extracellular vesicles using tunable resistive pulse sensing. J Extracell Vesicles 5:31242","journal-title":"J Extracell Vesicles"},{"issue":"34","key":"2367_CR91","doi-asserted-by":"publisher","first-page":"9587","DOI":"10.1073\/pnas.1610099113","volume":"113","author":"W Wang","year":"2016","unstructured":"Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T et al (2016) Caspase-1 causes truncation and aggregation of the Parkinson\u2019s disease-associated protein alpha-synuclein. Proc Natl Acad Sci USA 113(34):9587\u20139592","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"2367_CR92","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1021\/ja055336t","volume":"128","author":"G Wider","year":"2006","unstructured":"Wider G, Dreier L (2006) Measuring protein concentrations by NMR spectroscopy. J Am Chem Soc 128(8):2571\u20132576","journal-title":"J Am Chem Soc"},{"issue":"3","key":"2367_CR93","doi-asserted-by":"publisher","first-page":"0191815","DOI":"10.1371\/journal.pone.0191815","volume":"13","author":"PL Wood","year":"2018","unstructured":"Wood PL, Tippireddy S, Feriante J, Woltjer RL (2018) Augmented frontal cortex diacylglycerol levels in Parkinson\u2019s disease and Lewy body disease. PLoS ONE 13(3):0191815","journal-title":"PLoS ONE"},{"key":"2367_CR94","doi-asserted-by":"publisher","first-page":"e1350","DOI":"10.1038\/cddis.2014.307","volume":"5","author":"L Zondler","year":"2014","unstructured":"Zondler L, Miller-Fleming L, Repici M, Goncalves S, Tenreiro S, Rosado-Ramos R et al (2014) DJ-1 interactions with alpha-synuclein attenuate aggregation and cellular toxicity in models of Parkinson\u2019s disease. Cell Death Dis 5:e1350","journal-title":"Cell Death Dis"},{"issue":"1","key":"2367_CR95","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.neuron.2017.12.012","volume":"97","author":"F Zunke","year":"2018","unstructured":"Zunke F, Moise AC, Belur NR, Gelyana E, Stojkovska I, Dzaferbegovic H et al (2018) Reversible conformational conversion of alpha-synuclein into toxic assemblies by glucosylceramide. Neuron 97(1):92\u201310710","journal-title":"Neuron"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-021-02367-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00401-021-02367-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-021-02367-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T05:05:52Z","timestamp":1675659952000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00401-021-02367-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,13]]},"references-count":95,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2367"],"URL":"https:\/\/doi.org\/10.1007\/s00401-021-02367-3","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,13]]},"assertion":[{"value":"14 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}