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FTD syndromes often display macroscopic signatures of neurodegeneration at the level of regions and networks, but it is unclear if subregional laminar pathology display patterns unique to proteinopathy or clinical syndrome. We hypothesized that FTLD-tau and FTLD-TDP accumulate pathology in relatively distinct cortical layers independent of clinical syndrome, with greater involvement of lower layers in FTLD-tau. The current study examined 170 patients with either FTLD-tau (<jats:italic>n<\/jats:italic>\u2009=\u200973) or FTLD-TDP (<jats:italic>n<\/jats:italic>\u2009=\u200997) spanning dementia and motor phenotypes in the FTD spectrum. We digitally measured the percent area occupied by tau and TDP-43 pathology in upper layers (I\u2013III), lower layers (IV\u2013VI), and juxtacortical white matter (WM) from isocortical regions in both hemispheres where available. Linear mixed-effects models compared ratios of upper to lower layer pathology between FTLD groups and investigated relationships with regions, WM pathology, and global cognitive impairment while adjusting for demographics. We found lower ratios of layer pathology in FTLD-tau and higher ratios of layer pathology in FTLD-TDP, reflecting lower layer-predominant tau pathology and upper layer-predominant TDP-43 pathology, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). FTLD-tau displayed lower ratios of layer pathology related to greater WM tau pathology (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) and to earlier involved\/severe pathology regions (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). In contrast, FTLD-TDP displayed higher ratios of layer pathology not related to either WM pathology or regional severity. Greater cognitive impairment was associated with higher ratios of layer pathology in FTLD-tau (<jats:italic>p<\/jats:italic>\u2009=\u20090.018), but was not related to ratios of layer pathology in FTLD-TDP. Lower layer-predominant tau pathology and upper layer-predominant TDP-43 pathology are proteinopathy-specific, regardless of clinical syndromes or regional networks that define these syndromes. Thus, patterns of laminar change may provide a useful anatomical framework for investigating how degeneration of select cells and corresponding laminar circuits influence large-scale networks and clinical symptomology in FTLD.<\/jats:p>","DOI":"10.1007\/s00401-021-02402-3","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T09:02:46Z","timestamp":1641632566000},"page":"363-382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Signature laminar distributions of pathology in frontotemporal lobar degeneration"],"prefix":"10.1007","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7930-5434","authenticated-orcid":false,"given":"Daniel T.","family":"Ohm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katheryn A. 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