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ACL received consulting fees from AB Science (Paris, France), Desitin (Buckinghamshire, UK), Novartis (Basel, Switzerland), and Teva (Jerusalum, Israel). PVD participated in advisory board meetings of Biogen (Cambridge, MA, US), Cytokinetics (San Francisco, CA, US), Ferrer (Barcelona, Spain), UCB (Brussels, Belgium), Argenx (Ghent, Belgium), Muna Therapeutics (Copenhagen, Denmark), Alector (San Francisco, CA, US), Augustine Therapeutics (Leuven, Belgium), Alexion Therapeutics (Boston, MA, US), and QurAlis (Cambridge, MA, US). LVDB received speaker honorary from UCB (Brussels, Belgium) and Gr\u00fcnenthal (Aachen, Germany), and is head of the Scientific Advisory Board of Augustine Therapeutics (Leuven, Belgium) and is part of the Investment Advisory Board of Droia Ventures (Meise, Belgium). DRT received speaker honorary or travel reimbursement from Novartis Pharma AG (Basel, Switzerland), UCB (Brussels, Belgium), Biogen (Cambridge, MA,\u00a0USA), and GE Healthcare (Amersham, UK), and collaborated with Novartis Pharma AG (Basel, Switzerland), Probiodrug (Halle (Saale), Germany), GE Healthcare (Amersham, UK), and Janssen Pharmaceutical Companies (Beerse, Belgium). The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. DRT serves in the editorial board of Acta Neuropathologica, but was not involved in the handling of this manuscript at any stage.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Human brain and spinal cord tissues were collected in accordance with the applicable laws in Belgium (UZ Leuven) and Germany (Ulm). The recruitment protocols for collecting the human brains were approved by the ethical committees of the University of Ulm (Germany) and of UZ Leuven (Belgium). This study was approved by the UZ Leuven ethical committee (Leuven, Belgium). All animal care and experiments were approved by the KU Leuven Ethical Committee and were carried out according to the Belgian law.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}