{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:23:01Z","timestamp":1789806181560,"version":"4.0.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01- NS109260-01A1"],"award-info":[{"award-number":["R01- NS109260-01A1"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01-AG066597"],"award-info":[{"award-number":["P01-AG066597"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30-AG072979"],"award-info":[{"award-number":["P30-AG072979"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01-AG054519-02"],"award-info":[{"award-number":["R01-AG054519-02"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016954","name":"Institute on Aging, University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2016244S"],"award-info":[{"award-number":["A2016244S"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF-D-619473"],"award-info":[{"award-number":["AARF-D-619473"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF-D-619473-RAPID"],"award-info":[{"award-number":["AARF-D-619473-RAPID"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009456","name":"Wyncote Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00401-022-02472-x","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T16:02:23Z","timestamp":1658592143000},"page":"1103-1116","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"144","author":[{"given":"Sanaz","family":"Arezoumandan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon X.","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katheryn A. Q.","family":"Cousins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn J.","family":"Mechanic-Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire S.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille Y.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Ohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"Ittyerah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey T.","family":"McMillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Yushkevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Q.","family":"Trojanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5599-5098","authenticated-orcid":false,"given":"David J.","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"2472_CR1","doi-asserted-by":"publisher","first-page":"4252","DOI":"10.1073\/pnas.1801093115","volume":"115","author":"DH Adler","year":"2018","unstructured":"Adler DH, Wisse LEM, Ittyerah R et al (2018) Characterizing the human hippocampus in aging and Alzheimer\u2019s disease using a computational atlas derived from ex vivo MRI and histology. Proc Natl Acad Sci U S A 115:4252\u20134257. https:\/\/doi.org\/10.1073\/pnas.1801093115","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2472_CR2","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1093\/brain\/awm213","volume":"130","author":"S Alladi","year":"2007","unstructured":"Alladi S, Xuereb J, Bak T et al (2007) Focal cortical presentations of Alzheimer\u2019s disease. Brain J Neurol 130:2636\u20132645. https:\/\/doi.org\/10.1093\/brain\/awm213","journal-title":"Brain J Neurol"},{"key":"2472_CR3","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","volume":"80","author":"MJ Armstrong","year":"2013","unstructured":"Armstrong MJ, Litvan I, Lang AE et al (2013) Criteria for the diagnosis of corticobasal degeneration. Neurology 80:496\u2013503. https:\/\/doi.org\/10.1212\/WNL.0b013e31827f0fd1","journal-title":"Neurology"},{"key":"2472_CR4","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1046\/j.1365-2559.2003.01601.x","volume":"42","author":"RA Armstrong","year":"2003","unstructured":"Armstrong RA (2003) Quantifying the pathology of neurodegenerative disorders: quantitative measurements, sampling strategies and data analysis. Histopathology 42:521\u2013529. https:\/\/doi.org\/10.1046\/j.1365-2559.2003.01601.x","journal-title":"Histopathology"},{"key":"2472_CR5","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1097\/NEN.0b013e31817275c7","volume":"67","author":"G Basurto-Islas","year":"2008","unstructured":"Basurto-Islas G, Luna-Mu\u00f1oz J, Guillozet-Bongaarts AL et al (2008) Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease. J Neuropathol Exp Neurol 67:470\u2013483. https:\/\/doi.org\/10.1097\/NEN.0b013e31817275c7","journal-title":"J Neuropathol Exp Neurol"},{"key":"2472_CR6","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.bbadis.2004.08.014","volume":"1739","author":"LI Binder","year":"2005","unstructured":"Binder LI, Guillozet-Bongaarts AL, Garcia-Sierra F, Berry RW (2005) Tau, tangles, and Alzheimer\u2019s disease. Biochim Biophys Acta BBA - Mol Basis Dis 1739:216\u2013223. https:\/\/doi.org\/10.1016\/j.bbadis.2004.08.014","journal-title":"Biochim Biophys Acta BBA - Mol Basis Dis"},{"key":"2472_CR7","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1007\/BF00293315","volume":"87","author":"E Braak","year":"1994","unstructured":"Braak E, Braak H, Mandelkow EM (1994) A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol (Berl) 87:554\u2013567. https:\/\/doi.org\/10.1007\/BF00293315","journal-title":"Acta Neuropathol (Berl)"},{"key":"2472_CR8","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82:239\u2013259. https:\/\/doi.org\/10.1007\/BF00308809","journal-title":"Acta Neuropathol (Berl)"},{"key":"2472_CR9","doi-asserted-by":"publisher","first-page":"3868","DOI":"10.1523\/JNEUROSCI.2061-21.2022","volume":"42","author":"M Chen","year":"2022","unstructured":"Chen M, Ohm DT, Phillips JS et al (2022) Divergent histopathological networks of frontotemporal degeneration proteinopathy subytpes. J Neurosci Off J Soc Neurosci 42:3868\u20133877. https:\/\/doi.org\/10.1523\/JNEUROSCI.2061-21.2022","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"2472_CR10","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12698","author":"DG Coughlin","year":"2021","unstructured":"Coughlin DG, Grossman M, Trojanowski JQ, Irwin DJ (2021) Hippocampal subfield pathologic Burden in Lewy body diseases versus Alzheimer\u2019s disease. Neuropathol Appl Neurobiol. https:\/\/doi.org\/10.1111\/nan.12698","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2472_CR11","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.jalz.2017.01.014","volume":"13","author":"SJ Crutch","year":"2017","unstructured":"Crutch SJ, Schott JM, Rabinovici GD et al (2017) Consensus classification of posterior cortical atrophy. Alzheimers Dement J Alzheimers Assoc 13:870\u2013884. https:\/\/doi.org\/10.1016\/j.jalz.2017.01.014","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"2472_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-33603-4","author":"HM Duvernoy","year":"2013","unstructured":"Duvernoy HM, Cattin F, Risold P-Y (2013) The human hippocampus: functional anatomy, vascularization and serial sections with MRI, 4. Aufl. https:\/\/doi.org\/10.1007\/978-3-642-33603-4","journal-title":"Aufl"},{"key":"2472_CR13","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1093\/brain\/awz136","volume":"142","author":"NC Firth","year":"2019","unstructured":"Firth NC, Primativo S, Marinescu R-V et al (2019) Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy. Brain 142:2082\u20132095. https:\/\/doi.org\/10.1093\/brain\/awz136","journal-title":"Brain"},{"key":"2472_CR14","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1001\/jamaneurol.2020.0528","volume":"77","author":"AS Fleisher","year":"2020","unstructured":"Fleisher AS, Pontecorvo MJ, Devous MD et al (2020) Positron emission tomography imaging with [18F] flortaucipir and postmortem assessment of Alzheimer disease neuropathologic changes. JAMA Neurol 77:829\u2013839. https:\/\/doi.org\/10.1001\/jamaneurol.2020.0528","journal-title":"JAMA Neurol"},{"key":"2472_CR15","doi-asserted-by":"publisher","first-page":"10032","DOI":"10.1073\/pnas.1630428100","volume":"100","author":"TC Gamblin","year":"2003","unstructured":"Gamblin TC, Chen F, Zambrano A et al (2003) Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer\u2019s disease. Proc Natl Acad Sci U S A 100:10032\u201310037. https:\/\/doi.org\/10.1073\/pnas.1630428100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2472_CR16","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0891-0618(01)00096-5","volume":"22","author":"F Garc\u0131a-Sierra","year":"2001","unstructured":"Garc\u0131a-Sierra F, Wischik CM, Harrington CR et al (2001) Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer\u2019s disease. J Chem Neuroanat 22:65\u201377. https:\/\/doi.org\/10.1016\/S0891-0618(01)00096-5","journal-title":"J Chem Neuroanat"},{"key":"2472_CR17","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1006\/exnr.2002.8014","volume":"177","author":"N Ghoshal","year":"2002","unstructured":"Ghoshal N, Garc\u0131a-Sierra F, Wuu J et al (2002) Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer\u2019s disease. Exp Neurol 177:475\u2013493. https:\/\/doi.org\/10.1006\/exnr.2002.8014","journal-title":"Exp Neurol"},{"key":"2472_CR18","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/ana.25465","volume":"85","author":"LAA Giannini","year":"2019","unstructured":"Giannini LAA, Xie SX, McMillan CT et al (2019) Divergent patterns of TDP-43 and tau pathologies in primary progressive aphasia. Ann Neurol 85:630\u2013643. https:\/\/doi.org\/10.1002\/ana.25465","journal-title":"Ann Neurol"},{"key":"2472_CR19","doi-asserted-by":"publisher","first-page":"682","DOI":"10.3389\/fnins.2019.00682","volume":"13","author":"LAA Giannini","year":"2019","unstructured":"Giannini LAA, Xie SX, Peterson C et al (2019) Empiric methods to account for pre-analytical variability in digital histopathology in frontotemporal lobar degeneration. Front Neurosci 13:682. https:\/\/doi.org\/10.3389\/fnins.2019.00682","journal-title":"Front Neurosci"},{"key":"2472_CR20","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0304-3940(95)11484-E","volume":"189","author":"M Goedert","year":"1995","unstructured":"Goedert M, Jakes R, Vanmechelen E (1995) Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205. Neurosci Lett 189:167\u2013170. https:\/\/doi.org\/10.1016\/0304-3940(95)11484-E","journal-title":"Neurosci Lett"},{"key":"2472_CR21","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","volume":"76","author":"ML Gorno-Tempini","year":"2011","unstructured":"Gorno-Tempini ML, Hillis AE, Weintraub S et al (2011) Classification of primary progressive aphasia and its variants. Neurology 76:1006\u20131014. https:\/\/doi.org\/10.1212\/WNL.0b013e31821103e6","journal-title":"Neurology"},{"key":"2472_CR22","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.neurobiolaging.2004.09.019","volume":"26","author":"AL Guillozet-Bongaarts","year":"2005","unstructured":"Guillozet-Bongaarts AL, Garcia-Sierra F, Reynolds MR et al (2005) Tau truncation during neurofibrillary tangle evolution in Alzheimer\u2019s disease. Neurobiol Aging 26:1015\u20131022. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2004.09.019","journal-title":"Neurobiol Aging"},{"key":"2472_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","volume":"8","author":"BT Hyman","year":"2012","unstructured":"Hyman BT, Phelps CH, Beach TG et al (2012) National Institute on aging\u2013Alzheimer\u2019s association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease. Alzheimers Dement J Alzheimers Assoc 8:1\u201313. https:\/\/doi.org\/10.1016\/j.jalz.2011.10.007","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"2472_CR24","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/B978-0-12-374236-0.10024-0","volume-title":"Hippocampal Formation In: Human Nervous System","author":"R Insausti","year":"2012","unstructured":"Insausti R, Amaral DG (2012) Hippocampal Formation In: Human Nervous System. Elsevier, Amsterdam, pp 896\u2013942"},{"key":"2472_CR25","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1369\/0022155415614303","volume":"64","author":"DJ Irwin","year":"2016","unstructured":"Irwin DJ, Byrne MD, McMillan CT et al (2016) Semi-automated digital image analysis of pick\u2019s disease and TDP-43 Proteinopathy. J Histochem Cytochem Off J Histochem Soc 64:54\u201366. https:\/\/doi.org\/10.1369\/0022155415614303","journal-title":"J Histochem Cytochem Off J Histochem Soc"},{"key":"2472_CR26","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1093\/brain\/aws013","volume":"135","author":"DJ Irwin","year":"2012","unstructured":"Irwin DJ, Cohen TJ, Grossman M et al (2012) Acetylated tau, a novel pathological signature in Alzheimer\u2019s disease and other tauopathies. Brain J Neurol 135:807\u2013818. https:\/\/doi.org\/10.1093\/brain\/aws013","journal-title":"Brain J Neurol"},{"key":"2472_CR27","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0022-1759(02)00006-6","volume":"262","author":"M Khuebachova","year":"2002","unstructured":"Khuebachova M, Verzillo V, Skrabana R et al (2002) Mapping the C terminal epitope of the Alzheimer\u2019s disease specific antibody MN423. J Immunol Methods 262:205\u2013215. https:\/\/doi.org\/10.1016\/S0022-1759(02)00006-6","journal-title":"J Immunol Methods"},{"key":"2472_CR28","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2307\/2529876","volume":"38","author":"NM Laird","year":"1982","unstructured":"Laird NM, Ware JH (1982) Random-effects models for longitudinal data. Biometrics 38:963\u2013974. https:\/\/doi.org\/10.2307\/2529876","journal-title":"Biometrics"},{"key":"2472_CR29","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/ana.22424","volume":"70","author":"SE Lee","year":"2011","unstructured":"Lee SE, Rabinovici GD, Mayo MC et al (2011) Clinicopathological correlations in corticobasal degeneration. Ann Neurol 70:327\u2013340. https:\/\/doi.org\/10.1002\/ana.22424","journal-title":"Ann Neurol"},{"key":"2472_CR30","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/j.1750-3639.2007.00117.x","volume":"18","author":"JB Leverenz","year":"2008","unstructured":"Leverenz JB, Hamilton R, Tsuang DW et al (2008) RESEARCH ARTICLE: empiric refinement of the pathologic assessment of lewy-related pathology in the dementia patient. Brain Pathol 18:220\u2013224. https:\/\/doi.org\/10.1111\/j.1750-3639.2007.00117.x","journal-title":"Brain Pathol"},{"key":"2472_CR31","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00401-008-0431-x","volume":"116","author":"J Luna-Mu\u00f1oz","year":"2008","unstructured":"Luna-Mu\u00f1oz J, Peralta-Ramirez J, Ch\u00e1vez-Mac\u00edas L et al (2008) Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer\u2019s disease in tissue imprints. Acta Neuropathol (Berl) 116:507\u2013515. https:\/\/doi.org\/10.1007\/s00401-008-0431-x","journal-title":"Acta Neuropathol (Berl)"},{"key":"2472_CR32","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1111\/nan.12664","volume":"46","author":"KE McAleese","year":"2020","unstructured":"McAleese KE, Walker L, Erskine D et al (2020) Concomitant LATE-NC in Alzheimer\u2019s disease is not associated with increased tau or amyloid-\u03b2 pathological burden. Neuropathol Appl Neurobiol 46:722\u2013734. https:\/\/doi.org\/10.1111\/nan.12664","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2472_CR33","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H et al (2011) The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the national institute on aging-Alzheimer\u2019s association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement J Alzheimers Assoc 7:263\u2013269. https:\/\/doi.org\/10.1016\/j.jalz.2011.03.005","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"2472_CR34","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1093\/brain\/awu024","volume":"137","author":"M-M Mesulam","year":"2014","unstructured":"Mesulam M-M, Weintraub S, Rogalski EJ et al (2014) Asymmetry and heterogeneity of Alzheimer\u2019s and frontotemporal pathology in primary progressive aphasia. Brain J Neurol 137:1176\u20131192. https:\/\/doi.org\/10.1093\/brain\/awu024","journal-title":"Brain J Neurol"},{"key":"2472_CR35","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1002\/alz.12321","volume":"17","author":"CM Moloney","year":"2021","unstructured":"Moloney CM, Lowe VJ, Murray ME (2021) Visualization of neurofibrillary tangle maturity in Alzheimer\u2019s disease: a clinicopathologic perspective for biomarker research. Alzheimers Dement J Alzheimers Assoc 17:1554\u20131574. https:\/\/doi.org\/10.1002\/alz.12321","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"2472_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","volume":"123","author":"TJ Montine","year":"2012","unstructured":"Montine TJ, Phelps CH, Beach TG et al (2012) National institute on aging-Alzheimer\u2019s association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: a practical approach. Acta Neuropathol (Berl) 123:1\u201311. https:\/\/doi.org\/10.1007\/s00401-011-0910-3","journal-title":"Acta Neuropathol (Berl)"},{"key":"2472_CR37","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/S1474-4422(11)70156-9","volume":"10","author":"ME Murray","year":"2011","unstructured":"Murray ME, Graff-Radford NR, Ross OA et al (2011) Neuropathologically defined subtypes of Alzheimer\u2019s disease with distinct clinical characteristics: a retrospective study. Lancet Neurol 10:785\u2013796. https:\/\/doi.org\/10.1016\/S1474-4422(11)70156-9","journal-title":"Lancet Neurol"},{"key":"2472_CR38","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","volume":"71","author":"PT Nelson","year":"2012","unstructured":"Nelson PT, Alafuzoff I, Bigio EH et al (2012) Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 71:362\u2013381. https:\/\/doi.org\/10.1097\/NEN.0b013e31825018f7","journal-title":"J Neuropathol Exp Neurol"},{"key":"2472_CR39","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1093\/brain\/awz099","volume":"142","author":"PT Nelson","year":"2019","unstructured":"Nelson PT, Dickson DW, Trojanowski JQ et al (2019) Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain 142:1503\u20131527. https:\/\/doi.org\/10.1093\/brain\/awz099","journal-title":"Brain"},{"key":"2472_CR40","doi-asserted-by":"publisher","first-page":"5837","DOI":"10.1073\/pnas.88.13.5837","volume":"88","author":"M Novak","year":"1991","unstructured":"Novak M, Jakes R, Edwards PC et al (1991) Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51. Proc Natl Acad Sci U S A 88:5837\u20135841","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2472_CR41","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1093\/brain\/aww027","volume":"139","author":"R Ossenkoppele","year":"2016","unstructured":"Ossenkoppele R, Schonhaut DR, Sch\u00f6ll M et al (2016) Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer\u2019s disease. Brain J Neurol 139:1551\u20131567. https:\/\/doi.org\/10.1093\/brain\/aww027","journal-title":"Brain J Neurol"},{"key":"2472_CR42","doi-asserted-by":"publisher","first-page":"4531","DOI":"10.1073\/pnas.82.13.4531","volume":"82","author":"RC Pearson","year":"1985","unstructured":"Pearson RC, Esiri MM, Hiorns RW et al (1985) Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease. Proc Natl Acad Sci U S A 82:4531\u20134534","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2472_CR43","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00401-019-02036-6","volume":"138","author":"C Petersen","year":"2019","unstructured":"Petersen C, Nolan AL, de Paula Fran\u00e7a Resende E et al (2019) Alzheimer\u2019s disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation. Acta Neuropathol (Berl) 138:597\u2013612. https:\/\/doi.org\/10.1007\/s00401-019-02036-6","journal-title":"Acta Neuropathol (Berl)"},{"key":"2472_CR44","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1002\/hbm.23874","volume":"39","author":"JS Phillips","year":"2018","unstructured":"Phillips JS, Das SR, McMillan CT et al (2018) Tau PET imaging predicts cognition in atypical variants of Alzheimer\u2019s disease. Hum Brain Mapp 39:691\u2013708. https:\/\/doi.org\/10.1002\/hbm.23874","journal-title":"Hum Brain Mapp"},{"key":"2472_CR45","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12456","author":"JS Phillips","year":"2021","unstructured":"Phillips JS, Nitchie FJ, Da Re F et al (2021) Rates of longitudinal change in 18 F-flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer\u2019s disease. Alzheimers Dement J Alzheimers Assoc. https:\/\/doi.org\/10.1002\/alz.12456","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"2472_CR46","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1093\/brain\/awr179","volume":"134","author":"K Rascovsky","year":"2011","unstructured":"Rascovsky K, Hodges JR, Knopman D et al (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain J Neurol 134:2456\u20132477. https:\/\/doi.org\/10.1093\/brain\/awr179","journal-title":"Brain J Neurol"},{"key":"2472_CR47","doi-asserted-by":"publisher","unstructured":"Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer\u2019s disease presenting as logopenic progressive aphasia | Elsevier Enhanced Reader. https:\/\/doi.org\/10.1016\/j.bandl.2013.02.003","DOI":"10.1016\/j.bandl.2013.02.003"},{"key":"2472_CR48","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/ana.410230212","volume":"23","author":"ML Schmidt","year":"1988","unstructured":"Schmidt ML, Gur RE, Gur RC, Trojanowski JQ (1988) Intraneuronal and extracellular neurofibrillary tangles exhibit mutually exclusive cytoskeletal antigens. Ann Neurol 23:184\u2013189. https:\/\/doi.org\/10.1002\/ana.410230212","journal-title":"Ann Neurol"},{"key":"2472_CR49","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","volume":"69","author":"JA Schneider","year":"2007","unstructured":"Schneider JA, Arvanitakis Z, Bang W, Bennett DA (2007) Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69:2197\u20132204. https:\/\/doi.org\/10.1212\/01.wnl.0000271090.28148.24","journal-title":"Neurology"},{"key":"2472_CR50","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1006\/exnr.1995.1025","volume":"133","author":"G Smale","year":"1995","unstructured":"Smale G, Nichols NR, Brady DR et al (1995) Evidence for apoptotic cell death in Alzheimer\u2019s disease. Exp Neurol 133:225\u2013230. https:\/\/doi.org\/10.1006\/exnr.1995.1025","journal-title":"Exp Neurol"},{"key":"2472_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102913","volume":"33","author":"MD Tisdall","year":"2022","unstructured":"Tisdall MD, Ohm DT, Lobrovich R et al (2022) Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology. NeuroImage Clin 33:102913. https:\/\/doi.org\/10.1016\/j.nicl.2021.102913","journal-title":"NeuroImage Clin"},{"key":"2472_CR52","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.jalz.2013.06.003","volume":"10","author":"JB Toledo","year":"2014","unstructured":"Toledo JB, Van Deerlin VM, Lee EB et al (2014) A platform for discovery: the university of pennsylvania integrated neurodegenerative disease biobank. Alzheimers Dement J Alzheimers Assoc 10:477-484.e1. https:\/\/doi.org\/10.1016\/j.jalz.2013.06.003","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"2472_CR53","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa068","author":"RA Townley","year":"2020","unstructured":"Townley RA, Graff-Radford J, Mantyh WG et al (2020) Progressive dysexecutive syndrome due to Alzheimer\u2019s disease: a description of 55 cases and comparison to other phenotypes. Brain Commun. https:\/\/doi.org\/10.1093\/braincomms\/fcaa068","journal-title":"Brain Commun"},{"key":"2472_CR54","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/S1474-4422(10)70306-9","volume":"10","author":"WM van der Flier","year":"2011","unstructured":"van der Flier WM, Pijnenburg YA, Fox NC, Scheltens P (2011) Early-onset versus late-onset Alzheimer\u2019s disease: the case of the missing APOE \u025b4 allele. Lancet Neurol 10:280\u2013288. https:\/\/doi.org\/10.1016\/S1474-4422(10)70306-9","journal-title":"Lancet Neurol"},{"key":"2472_CR55","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/S1474-4422(12)70200-4","volume":"11","author":"JL Whitwell","year":"2012","unstructured":"Whitwell JL, Dickson DW, Murray ME et al (2012) Neuroimaging correlates of pathologically defined subtypes of Alzheimer\u2019s disease: a case-control study. Lancet Neurol 11:868\u2013877. https:\/\/doi.org\/10.1016\/S1474-4422(12)70200-4","journal-title":"Lancet Neurol"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-022-02472-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00401-022-02472-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-022-02472-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T14:04:48Z","timestamp":1667743488000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00401-022-02472-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,23]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2472"],"URL":"https:\/\/doi.org\/10.1007\/s00401-022-02472-x","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,23]]},"assertion":[{"value":"25 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}