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All experiments using human materials were in compliance with the Helsinki Declaration. Animal experiments were performed in strict accordance with the Regulations for Animal Experiments and Related Activities at Hokkaido University and Fundamental Guidelines for Proper Conduct of Animal Experiment and Related Activities in Academic Research Institutions by the Ministry of Education, Culture, Sports, Science and Technology in Japan, Notice No. 71. Protocols for animal experiments were approved by the Institutional Animal Care and Use Committees of Hokkaido University (14-0170, 19-0025).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}