{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:29:41Z","timestamp":1793464181928,"version":"4.5.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2023_EKEA.38"],"award-info":[{"award-number":["2023_EKEA.38"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PR 1725\/2\u20131"],"award-info":[{"award-number":["PR 1725\/2\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RU 2169\/2\u20131"],"award-info":[{"award-number":["RU 2169\/2\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Myositis Netz","award":["Nelke 2023"],"award-info":[{"award-number":["Nelke 2023"]}]},{"name":"BMBF","award":["01EC1901A"],"award-info":[{"award-number":["01EC1901A"]}]},{"name":"Universit\u00e4tsklinikum D\u00fcsseldorf. Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inclusion body myositis (IBM) is unique across the spectrum of idiopathic inflammatory myopathies (IIM) due to its distinct clinical presentation and refractoriness to current treatment approaches. One explanation for this resistance may be the engagement of cell-autonomous mechanisms that sustain or promote disease progression of IBM independent of inflammatory activity. In this study, we focused on senescence of tissue-resident cells as potential driver of disease. For this purpose, we compared IBM patients to non-diseased controls and immune-mediated necrotizing myopathy patients. Histopathological analysis suggested that cellular senescence is a prominent feature of IBM, primarily affecting non-myogenic cells. In-depth analysis by single nuclei RNA sequencing allowed for the deconvolution and study of muscle-resident cell populations. Among these, we identified a specific cluster of fibro-adipogenic progenitors (FAPs) that demonstrated key hallmarks of senescence, including a pro-inflammatory secretome, expression of p21, increased \u03b2-galactosidase activity, and engagement of senescence pathways. FAP function is required for muscle cell health with changes to their phenotype potentially proving detrimental. In this respect, the transcriptomic landscape of IBM was also characterized by changes to the myogenic compartment demonstrating a pronounced loss of type 2A myofibers and a rarefication of acetylcholine receptor expressing myofibers. IBM muscle cells also engaged a specific pro-inflammatory phenotype defined by intracellular complement activity and the expression of immunogenic surface molecules. Skeletal muscle cell dysfunction may be linked to FAP senescence by a change in the collagen composition of the latter. Senescent FAPs lose collagen type XV expression, which is required to support myofibers\u2019 structural integrity and neuromuscular junction formation in vitro. Taken together, this study demonstrates an altered phenotypical landscape of muscle-resident cells and that FAPs, and not myofibers, are the primary senescent cell type in IBM.<\/jats:p>","DOI":"10.1007\/s00401-023-02637-2","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:02:38Z","timestamp":1695988958000},"page":"725-745","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Senescent fibro-adipogenic progenitors are potential drivers of pathology in inclusion body myositis"],"prefix":"10.1007","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6633-982X","authenticated-orcid":false,"given":"Christopher","family":"Nelke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina B.","family":"Schroeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Theissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Preusse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pawlitzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"R\u00e4uber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Dobelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Cengiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Kleefeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Schoser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Brunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Neuen-Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Zsch\u00fcntzsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven G.","family":"Meuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Stenzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6332-8650","authenticated-orcid":false,"given":"Tobias","family":"Ruck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"2637_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/nan.12380","volume":"43","author":"Y Allenbach","year":"2017","unstructured":"Allenbach Y, Benveniste O, Goebel H-H, Stenzel W (2017) Integrated classification of inflammatory myopathies. Neuropathol Appl Neurobiol 43:62\u201381. https:\/\/doi.org\/10.1111\/nan.12380","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2637_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.nmd.2017.09.016","volume":"28","author":"Y Allenbach","year":"2018","unstructured":"Allenbach Y, Mammen AL, Benveniste O, Stenzel W, Allenbach Y, Amato A et al (2018) 224th ENMC international workshop: clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, the Netherlands, 14\u201316 October 2016. Neuromuscul Disord 28:87\u201399. https:\/\/doi.org\/10.1016\/j.nmd.2017.09.016","journal-title":"Neuromuscul Disord"},{"key":"2637_CR3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.molimm.2017.05.012","volume":"89","author":"G Arbore","year":"2017","unstructured":"Arbore G, Kemper C, Kolev M (2017) Intracellular complement\u2014the complosome\u2014in immune cell regulation. Mol Immunol 89:2\u20139. https:\/\/doi.org\/10.1016\/j.molimm.2017.05.012","journal-title":"Mol Immunol"},{"key":"2637_CR4","doi-asserted-by":"publisher","first-page":"e40","DOI":"10.1016\/S2665-9913(20)30280-0","volume":"3","author":"O Benveniste","year":"2021","unstructured":"Benveniste O, Hogrel J-Y, Belin L, Annoussamy M, Bachasson D, Rigolet A et al (2021) Sirolimus for treatment of patients with inclusion body myositis: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2b trial. Lancet Rheumatol 3:e40\u2013e48. https:\/\/doi.org\/10.1016\/S2665-9913(20)30280-0","journal-title":"Lancet Rheumatol"},{"key":"2637_CR5","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.3389\/fphys.2019.01074","volume":"10","author":"B Biferali","year":"2019","unstructured":"Biferali B, Proietti D, Mozzetta C, Madaro L (2019) Fibro\u2013adipogenic progenitors cross-talk in skeletal muscle: the social network. Front Physiol 10:1074. https:\/\/doi.org\/10.3389\/fphys.2019.01074","journal-title":"Front Physiol"},{"key":"2637_CR6","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.diff.2016.05.007","volume":"92","author":"MA Chapman","year":"2016","unstructured":"Chapman MA, Meza R, Lieber RL (2016) Skeletal muscle fibroblasts in health and disease. Differentiation 92:108\u2013115. https:\/\/doi.org\/10.1016\/j.diff.2016.05.007","journal-title":"Differentiation"},{"key":"2637_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2172-9-43","volume":"9","author":"Y-W Chen","year":"2008","unstructured":"Chen Y-W, Shi R, Geraci N, Shrestha S, Gordish-Dressman H, Pachman LM (2008) Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis. BMC Immunol 9:43. https:\/\/doi.org\/10.1186\/1471-2172-9-43","journal-title":"BMC Immunol"},{"key":"2637_CR8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13395-021-00265-6","volume":"11","author":"O Contreras","year":"2021","unstructured":"Contreras O, Rossi FMV, Theret M (2021) Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors\u2014time for new definitions. Skeletal Muscle 11:16. https:\/\/doi.org\/10.1186\/s13395-021-00265-6","journal-title":"Skeletal Muscle"},{"key":"2637_CR9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13395-020-00236-3","volume":"10","author":"AJ De Micheli","year":"2020","unstructured":"De Micheli AJ, Spector JA, Elemento O, Cosgrove BD (2020) A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations. Skeletal Muscle 10:19. https:\/\/doi.org\/10.1186\/s13395-020-00236-3","journal-title":"Skeletal Muscle"},{"key":"2637_CR10","unstructured":"Dubowitz, Sewry, Oldfors muscle biopsy: a practical approach. 5th edn. ISBN: 978-7020-7471-4. Pages 21-22"},{"key":"2637_CR11","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1073\/pnas.98.3.1194","volume":"98","author":"L Eklund","year":"2001","unstructured":"Eklund L, Piuhola J, Komulainen J, Sormunen R, Ongvarrasopone C, F\u00e1ssler R et al (2001) Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proc Natl Acad Sci USA 98:1194\u20131199. https:\/\/doi.org\/10.1073\/pnas.98.3.1194","journal-title":"Proc Natl Acad Sci USA"},{"key":"2637_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101652","volume":"67","author":"DA Englund","year":"2023","unstructured":"Englund DA, Jolliffe A, Aversa Z, Zhang X, Sturmlechner I, Sakamoto AE et al (2023) p21 induces a senescence program and skeletal muscle dysfunction. Molecular Metabolism 67:101652. https:\/\/doi.org\/10.1016\/j.molmet.2022.101652","journal-title":"Molecular Metabolism"},{"key":"2637_CR13","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.immuni.2021.03.003","volume":"54","author":"J Fri\u0161\u010di\u0107","year":"2021","unstructured":"Fri\u0161\u010di\u0107 J, B\u00f6ttcher M, Reinwald C, Bruns H, Wirth B, Popp S-J et al (2021) The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts. Immunity 54:1002-1021.e10. https:\/\/doi.org\/10.1016\/j.immuni.2021.03.003","journal-title":"Immunity"},{"key":"2637_CR14","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1136\/annrheumdis-2022-eular.2141","volume":"81","author":"N Goel","year":"2022","unstructured":"Goel N, Needham M, Soler-Ferran D, Cotreau MM, Escobar J, Greenberg S (2022) Pos1342 depletion of Klrg1+ T cells in a first-in-human clinical trial of Abc008 in inclusion body myositis (ibm). Ann Rheum Dis 81:1008\u20131009. https:\/\/doi.org\/10.1136\/annrheumdis-2022-eular.2141","journal-title":"Ann Rheum Dis"},{"key":"2637_CR15","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","volume":"179","author":"V Gorgoulis","year":"2019","unstructured":"Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C et al (2019) Cellular senescence: defining a path forward. Cell 179:813\u2013827. https:\/\/doi.org\/10.1016\/j.cell.2019.10.005","journal-title":"Cell"},{"key":"2637_CR16","doi-asserted-by":"publisher","first-page":"e1374","DOI":"10.1212\/WNL.0000000000200013","volume":"98","author":"NA Goyal","year":"2022","unstructured":"Goyal NA, Coulis G, Duarte J, Farahat PK, Mannaa AH, Cauchii J et al (2022) Immunophenotyping of inclusion body myositis blood T and NK cells. Neurology 98:e1374\u2013e1383. https:\/\/doi.org\/10.1212\/WNL.0000000000200013","journal-title":"Neurology"},{"key":"2637_CR17","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41584-019-0186-x","volume":"15","author":"SA Greenberg","year":"2019","unstructured":"Greenberg SA (2019) Inclusion body myositis: clinical features and pathogenesis. Nat Rev Rheumatol 15:257\u2013272. https:\/\/doi.org\/10.1038\/s41584-019-0186-x","journal-title":"Nat Rev Rheumatol"},{"key":"2637_CR18","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1093\/brain\/awz207","volume":"142","author":"SA Greenberg","year":"2019","unstructured":"Greenberg SA, Pinkus JL, Kong SW, Baecher-Allan C, Amato AA, Dorfman DM (2019) Highly differentiated cytotoxic T cells in inclusion body myositis. Brain 142:2590\u20132604. https:\/\/doi.org\/10.1093\/brain\/awz207","journal-title":"Brain"},{"key":"2637_CR19","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70235","volume":"11","author":"A Grimaldi","year":"2022","unstructured":"Grimaldi A, Comai G, Mella S, Tajbakhsh S (2022) Identification of bipotent progenitors that give rise to myogenic and connective tissues in mouse. Elife 11:e70235. https:\/\/doi.org\/10.7554\/eLife.70235","journal-title":"Elife"},{"key":"2637_CR20","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/ncb3225","volume":"17","author":"N Herranz","year":"2015","unstructured":"Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ et al (2015) mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. Nat Cell Biol 17:1205\u20131217. https:\/\/doi.org\/10.1038\/ncb3225","journal-title":"Nat Cell Biol"},{"key":"2637_CR21","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","volume":"47","author":"LJ Hickson","year":"2019","unstructured":"Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK et al (2019) Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMedicine 47:446\u2013456. https:\/\/doi.org\/10.1016\/j.ebiom.2019.08.069","journal-title":"EBioMedicine"},{"key":"2637_CR22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41584-019-0324-5","volume":"16","author":"B Hinz","year":"2020","unstructured":"Hinz B, Lagares D (2020) Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases. Nat Rev Rheumatol 16:11\u201331. https:\/\/doi.org\/10.1038\/s41584-019-0324-5","journal-title":"Nat Rev Rheumatol"},{"key":"2637_CR23","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.molmed.2021.10.003","volume":"28","author":"MW Hogarth","year":"2022","unstructured":"Hogarth MW, Uapinyoying P, M\u00e1zala DAG, Jaiswal JK (2022) Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease. Trends Mol Med 28:8\u201311. https:\/\/doi.org\/10.1016\/j.molmed.2021.10.003","journal-title":"Trends Mol Med"},{"key":"2637_CR24","doi-asserted-by":"publisher","first-page":"C330","DOI":"10.1152\/ajpcell.00065.2021","volume":"321","author":"L-Y Hu","year":"2021","unstructured":"Hu L-Y, Mileti CJ, Loomis T, Brashear SE, Ahmad S, Chellakudam RR et al (2021) Skeletal muscle progenitors are sensitive to collagen architectural features of fibril size and cross linking. Am J Physiol Cell Physiol 321:C330\u2013C342. https:\/\/doi.org\/10.1152\/ajpcell.00065.2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"2637_CR25","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0888-7543(05)80209-5","volume":"14","author":"K Huebner","year":"1992","unstructured":"Huebner K, Cannizzaro LA, Jabs EW, Kiyirikko S, Manzone H, Pihlajaniemi T et al (1992) Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 \u2192 q22. Genomics 14:220\u2013224. https:\/\/doi.org\/10.1016\/S0888-7543(05)80209-5","journal-title":"Genomics"},{"key":"2637_CR26","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.1074\/jbc.M109.033787","volume":"285","author":"M Hurskainen","year":"2010","unstructured":"Hurskainen M, Ruggiero F, H\u00e4gg P, Pihlajaniemi T, Huhtala P (2010) Recombinant human collagen XV regulates cell adhesion and migration. J Biol Chem 285:5258\u20135265. https:\/\/doi.org\/10.1074\/jbc.M109.033787","journal-title":"J Biol Chem"},{"key":"2637_CR27","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan C-H et al (2021) Inference and analysis of cell-cell communication using cell chat. Nat Commun 12:1088. https:\/\/doi.org\/10.1038\/s41467-021-21246-9","journal-title":"Nat Commun"},{"key":"2637_CR28","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1016\/j.celrep.2017.11.008","volume":"21","author":"RA Jones","year":"2017","unstructured":"Jones RA, Harrison C, Eaton SL, Llavero Hurtado M, Graham LC, Alkhammash L et al (2017) Cellular and molecular anatomy of the human neuromuscular junction. Cell Rep 21:2348\u20132356. https:\/\/doi.org\/10.1016\/j.celrep.2017.11.008","journal-title":"Cell Rep"},{"key":"2637_CR29","doi-asserted-by":"publisher","first-page":"617","DOI":"10.33594\/000000044","volume":"52","author":"SR Kim","year":"2019","unstructured":"Kim SR, Eirin A, Zhang X, Lerman A, Lerman LO (2019) Mitochondrial protection partly mitigates kidney cellular senescence in swine atherosclerotic renal artery stenosis. Cell Physiol Biochem 52:617\u2013632. https:\/\/doi.org\/10.33594\/000000044","journal-title":"Cell Physiol Biochem"},{"key":"2637_CR30","doi-asserted-by":"publisher","first-page":"6375","DOI":"10.1038\/s41467-020-20064-9","volume":"11","author":"M Kim","year":"2020","unstructured":"Kim M, Franke V, Brandt B, Lowenstein ED, Sch\u00f6wel V, Spuler S et al (2020) Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells. Nat Commun 11:6375. https:\/\/doi.org\/10.1038\/s41467-020-20064-9","journal-title":"Nat Commun"},{"key":"2637_CR31","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nri3761","volume":"14","author":"M Kolev","year":"2014","unstructured":"Kolev M, Friec GL, Kemper C (2014) Complement \u2014 tapping into new sites and effector systems. Nat Rev Immunol 14:811\u2013820. https:\/\/doi.org\/10.1038\/nri3761","journal-title":"Nat Rev Immunol"},{"key":"2637_CR32","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1038\/ncb3195","volume":"17","author":"R-M Laberge","year":"2015","unstructured":"Laberge R-M, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L et al (2015) MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol 17:1049\u20131061. https:\/\/doi.org\/10.1038\/ncb3195","journal-title":"Nat Cell Biol"},{"key":"2637_CR33","doi-asserted-by":"publisher","first-page":"12230","DOI":"10.1523\/JNEUROSCI.5518-09.2010","volume":"30","author":"A Latvanlehto","year":"2010","unstructured":"Latvanlehto A, Fox MA, Sormunen R, Tu H, Oikarainen T, Koski A et al (2010) Muscle-derived collagen XIII regulates maturation of the skeletal neuromuscular junction. J Neurosci 30:12230\u201312241. https:\/\/doi.org\/10.1523\/JNEUROSCI.5518-09.2010","journal-title":"J Neurosci"},{"key":"2637_CR34","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13723","volume":"21","author":"M-L Li","year":"2022","unstructured":"Li M-L, Wu S-H, Song B, Yang J, Fan L-Y, Yang Y et al (2022) Single-cell analysis reveals transcriptomic reprogramming in aging primate entorhinal cortex and the relevance with Alzheimer\u2019s disease. Aging Cell 21:e13723. https:\/\/doi.org\/10.1111\/acel.13723","journal-title":"Aging Cell"},{"key":"2637_CR35","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1212\/WNL.0000000000000642","volume":"83","author":"TE Lloyd","year":"2014","unstructured":"Lloyd TE, Mammen AL, Amato AA, Weiss MD, Needham M, Greenberg SA (2014) Evaluation and construction of diagnostic criteria for inclusion body myositis. Neurology 83:426\u2013433. https:\/\/doi.org\/10.1212\/WNL.0000000000000642","journal-title":"Neurology"},{"key":"2637_CR36","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nrrheum.2018.41","volume":"14","author":"IE Lundberg","year":"2018","unstructured":"Lundberg IE, de Visser M, Werth VP (2018) Classification of myositis. Nat Rev Rheumatol 14:269\u2013278. https:\/\/doi.org\/10.1038\/nrrheum.2018.41","journal-title":"Nat Rev Rheumatol"},{"key":"2637_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109634","volume":"36","author":"P Maity","year":"2021","unstructured":"Maity P, Singh K, Krug L, Koroma A, Hainzl A, Bloch W et al (2021) Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging. Cell Rep 36:109634. https:\/\/doi.org\/10.1016\/j.celrep.2021.109634","journal-title":"Cell Rep"},{"key":"2637_CR38","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13344","volume":"20","author":"RI Mart\u00ednez-Zamudio","year":"2021","unstructured":"Mart\u00ednez-Zamudio RI, Dewald HK, Vasilopoulos T, Gittens-Williams L, Fitzgerald-Bocarsly P, Herbig U (2021) Senescence-associated \u03b2-galactosidase reveals the abundance of senescent CD8+ T cells in aging humans. Aging Cell 20:e13344. https:\/\/doi.org\/10.1111\/acel.13344","journal-title":"Aging Cell"},{"key":"2637_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2022.101761","volume":"36","author":"E McLeish","year":"2022","unstructured":"McLeish E, Slater N, Sooda A, Wilson A, Coudert JD, Lloyd TE et al (2022) Inclusion body myositis: the interplay between ageing, muscle degeneration and autoimmunity. Best Pract Res Clin Rheumatol 36:101761. https:\/\/doi.org\/10.1016\/j.berh.2022.101761","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2637_CR40","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.neurobiolaging.2008.08.011","volume":"31","author":"R Morosetti","year":"2010","unstructured":"Morosetti R, Broccolini A, Sancricca C, Gliubizzi C, Gidaro T, Tonali PA et al (2010) Increased aging in primary muscle cultures of sporadic inclusion-body myositis. Neurobiol Aging 31:1205\u20131214. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2008.08.011","journal-title":"Neurobiol Aging"},{"key":"2637_CR41","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1002\/emmm.201202096","volume":"5","author":"C Mozzetta","year":"2013","unstructured":"Mozzetta C, Consalvi S, Saccone V, Tierney M, Diamantini A, Mitchell KJ et al (2013) Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice. EMBO Mol Med 5:626\u2013639. https:\/\/doi.org\/10.1002\/emmm.201202096","journal-title":"EMBO Mol Med"},{"key":"2637_CR42","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13395-021-00279-0","volume":"11","author":"M Murgia","year":"2021","unstructured":"Murgia M, Nogara L, Baraldo M, Reggiani C, Mann M, Schiaffino S (2021) Protein profile of fiber types in human skeletal muscle: a single-fiber proteomics study. Skeletal Muscle 11:24. https:\/\/doi.org\/10.1186\/s13395-021-00279-0","journal-title":"Skeletal Muscle"},{"key":"2637_CR43","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.ebiom.2019.10.034","volume":"49","author":"C Nelke","year":"2019","unstructured":"Nelke C, Dziewas R, Minnerup J, Meuth SG, Ruck T (2019) Skeletal muscle as potential central link between sarcopenia and immune senescence. EBioMedicine 49:381\u2013388. https:\/\/doi.org\/10.1016\/j.ebiom.2019.10.034","journal-title":"EBioMedicine"},{"key":"2637_CR44","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.molmed.2022.07.003","volume":"28","author":"C Nelke","year":"2022","unstructured":"Nelke C, Schroeter CB, Pawlitzki M, Meuth SG, Ruck T (2022) Cellular senescence in neuroinflammatory disease: new therapies for old cells? Trends Mol Med 28:850\u2013863. https:\/\/doi.org\/10.1016\/j.molmed.2022.07.003","journal-title":"Trends Mol Med"},{"key":"2637_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120317","volume":"439","author":"S Noda","year":"2022","unstructured":"Noda S, Murakami A, Kazuta T, Hirano S, Kimura S, Nakanishi H et al (2022) Clinical implication of denervation in sporadic inclusion body myositis. J Neurol Sci 439:120317. https:\/\/doi.org\/10.1016\/j.jns.2022.120317","journal-title":"J Neurol Sci"},{"key":"2637_CR46","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1097\/00005072-199507000-00012","volume":"54","author":"A Oldfors","year":"1995","unstructured":"Oldfors A, Moslemi AR, Fyhr IM, Holme E, Larsson NG, Lindberg C (1995) Mitochondrial DNA deletions in muscle fibers in inclusion body myositis. J Neuropathol Exp Neurol 54:581\u2013587. https:\/\/doi.org\/10.1097\/00005072-199507000-00012","journal-title":"J Neuropathol Exp Neurol"},{"key":"2637_CR47","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1016\/j.celrep.2019.09.033","volume":"29","author":"A-M Opri\u015foreanu","year":"2019","unstructured":"Opri\u015foreanu A-M, Smith HL, Arya S, Webster R, Zhong Z, Eaton-Hart C et al (2019) Interaction of axonal chondrolectin with collagen XIXa1 is necessary for precise neuromuscular junction formation. Cell Rep 29:1082-1098.e10. https:\/\/doi.org\/10.1016\/j.celrep.2019.09.033","journal-title":"Cell Rep"},{"key":"2637_CR48","doi-asserted-by":"publisher","first-page":"16772","DOI":"10.1038\/s41598-020-73194-x","volume":"10","author":"C-H Pai","year":"2020","unstructured":"Pai C-H, Lin S-R, Liu C-H, Pan S-Y, Hsu H, Chen Y-T et al (2020) Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis. Sci Rep 10:16772. https:\/\/doi.org\/10.1038\/s41598-020-73194-x","journal-title":"Sci Rep"},{"key":"2637_CR49","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1002\/mus.21230","volume":"39","author":"KC Parker","year":"2009","unstructured":"Parker KC, Kong SW, Walsh RJ, Salajegheh M, Moghadaszadeh B, Amato AA et al (2009) Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis. Muscle Nerve 39:739\u2013753. https:\/\/doi.org\/10.1002\/mus.21230","journal-title":"Muscle Nerve"},{"key":"2637_CR50","doi-asserted-by":"publisher","first-page":"9393","DOI":"10.18632\/aging.204435","volume":"14","author":"K Perez","year":"2022","unstructured":"Perez K, Ciotlos S, McGirr J, Limbad C, Doi R, Nederveen JP et al (2022) Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence. Aging (Albany NY) 14:9393\u20139422. https:\/\/doi.org\/10.18632\/aging.204435","journal-title":"Aging (Albany NY)"},{"key":"2637_CR51","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.ebiom.2019.05.057","volume":"44","author":"P Petrus","year":"2019","unstructured":"Petrus P, Fernandez TL, Kwon MM, Huang JL, Lei V, Safikhan NS et al (2019) Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation. eBioMedicine 44:489\u2013501. https:\/\/doi.org\/10.1016\/j.ebiom.2019.05.057","journal-title":"eBioMedicine"},{"key":"2637_CR52","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1136\/ard-2022-223792","volume":"82","author":"I Pinal-Fernandez","year":"2023","unstructured":"Pinal-Fernandez I, Quintana A, Milisenda JC, Casal-Dominguez M, Mu\u00f1oz-Braceras S, Derfoul A et al (2023) Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor induced myositis. Ann Rheum Dis 82:829\u2013836. https:\/\/doi.org\/10.1136\/ard-2022-223792","journal-title":"Ann Rheum Dis"},{"key":"2637_CR53","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02438-z","author":"C Preu\u00dfe","year":"2022","unstructured":"Preu\u00dfe C, Paesler B, Nelke C, Cengiz D, M\u00fcntefering T, Roos A et al (2022) Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis. Acta Neuropathol. https:\/\/doi.org\/10.1007\/s00401-022-02438-z","journal-title":"Acta Neuropathol"},{"key":"2637_CR54","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.nmd.2013.08.007","volume":"23","author":"MR Rose","year":"2013","unstructured":"Rose MR, ENMC IBM Working Group (2013) 188th ENMC International Workshop: Inclusion Body Myositis, 2\u20134 December 2011, Naarden, The Netherlands. Neuromuscul Disord 23:1044\u20131055. https:\/\/doi.org\/10.1016\/j.nmd.2013.08.007","journal-title":"Neuromuscul Disord"},{"key":"2637_CR55","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/s41598-019-57110-6","volume":"10","author":"AB Rubenstein","year":"2020","unstructured":"Rubenstein AB, Smith GR, Raue U, Begue G, Minchev K, Ruf-Zamojski F et al (2020) Single-cell transcriptional profiles in human skeletal muscle. Sci Rep 10:229. https:\/\/doi.org\/10.1038\/s41598-019-57110-6","journal-title":"Sci Rep"},{"key":"2637_CR56","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1038\/s41467-022-32552-1","volume":"13","author":"D Saul","year":"2022","unstructured":"Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK et al (2022) A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat Commun 13:4827. https:\/\/doi.org\/10.1038\/s41467-022-32552-1","journal-title":"Nat Commun"},{"key":"2637_CR57","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","volume":"177","author":"T Stuart","year":"2019","unstructured":"Stuart T, Butler A, Hoffman P, Hafemeister C, Papalexi E, Mauck WM et al (2019) Comprehensive integration of single-cell data. Cell 177:1888-1902.e21. https:\/\/doi.org\/10.1016\/j.cell.2019.05.031","journal-title":"Cell"},{"key":"2637_CR58","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/wdev.230","volume":"5","author":"J Talbot","year":"2016","unstructured":"Talbot J, Maves L (2016) Skeletal muscle fiber type: using insights from muscle developmental biology to dissect targets for susceptibility and resistance to muscle disease. Wiley Interdiscip Rev Dev Biol 5:518\u2013534. https:\/\/doi.org\/10.1002\/wdev.230","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"2637_CR59","doi-asserted-by":"publisher","first-page":"993","DOI":"10.18632\/oncotarget.26590","volume":"10","author":"BA Teicher","year":"2019","unstructured":"Teicher BA (2019) CD248: a therapeutic target in cancer and fibrotic diseases. Oncotarget 10:993\u20131009. https:\/\/doi.org\/10.18632\/oncotarget.26590","journal-title":"Oncotarget"},{"key":"2637_CR60","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.3390\/diagnostics12102309","volume":"12","author":"Y Valieva","year":"2022","unstructured":"Valieva Y, Ivanova E, Fayzullin A, Kurkov A, Igrunkova A (2022) Senescence-associated \u03b2-galactosidase detection in pathology. Diagnostics (Basel) 12:2309. https:\/\/doi.org\/10.3390\/diagnostics12102309","journal-title":"Diagnostics (Basel)"},{"key":"2637_CR61","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3892\/mmr.2022.12855","volume":"26","author":"F Wen","year":"2022","unstructured":"Wen F, Tang X, Xu L, Qu H (2022) Comparison of single-nucleus and single-cell transcriptomes in hepatocellular carcinoma tissue. Mol Med Rep 26:339. https:\/\/doi.org\/10.3892\/mmr.2022.12855","journal-title":"Mol Med Rep"},{"key":"2637_CR62","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00704-1","author":"EE West","year":"2023","unstructured":"West EE, Kemper C (2023) Complosome\u2014the intracellular complement system. Nat Rev Nephrol. https:\/\/doi.org\/10.1038\/s41581-023-00704-1","journal-title":"Nat Rev Nephrol"},{"key":"2637_CR63","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13578-021-00579-4","volume":"11","author":"W Zhang","year":"2021","unstructured":"Zhang W, Liu Y, Zhang H (2021) Extracellular matrix: an important regulator of cell functions and skeletal muscle development. Cell Biosci 11:65. https:\/\/doi.org\/10.1186\/s13578-021-00579-4","journal-title":"Cell Biosci"},{"key":"2637_CR64","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s43587-022-00250-8","volume":"2","author":"X Zhang","year":"2022","unstructured":"Zhang X, Habiballa L, Aversa Z, Ng YE, Sakamoto AE, Englund DA et al (2022) Characterization of cellular senescence in aging skeletal muscle. Nat Aging 2:601\u2013615. https:\/\/doi.org\/10.1038\/s43587-022-00250-8","journal-title":"Nat Aging"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-023-02637-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00401-023-02637-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-023-02637-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T17:04:10Z","timestamp":1696957450000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00401-023-02637-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["2637"],"URL":"https:\/\/doi.org\/10.1007\/s00401-023-02637-2","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,29]]},"assertion":[{"value":"23 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}