{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:34:40Z","timestamp":1785332080634,"version":"3.55.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82222023"],"award-info":[{"award-number":["82222023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971024"],"award-info":[{"award-number":["81971024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930028"],"award-info":[{"award-number":["81930028"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National-Level Reserve Talent Program of the Chongqing Health Commission","award":["HBRC202402"],"award-info":[{"award-number":["HBRC202402"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"DOI":"10.1007\/s00401-024-02814-x","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T19:02:29Z","timestamp":1729796549000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Autoantibodies to BACE1 promote A\u03b2 accumulation and neurodegeneration in Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"148","author":[{"given":"Ye-Ran","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Le","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Doecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6227-6112","authenticated-orcid":false,"given":"Yan-Jiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"2814_CR1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1159\/000488481","volume":"45","author":"P Alexopoulos","year":"2018","unstructured":"Alexopoulos P, Thierjung N, Grimmer T, Ortner M, Economou P, Assimakopoulos K et al (2018) Cerebrospinal fluid BACE1 activity and sA\u03b2PP\u03b2 as biomarker candidates of Alzheimer\u2019s disease. Dement Geriatr Cogn Disord 45:152\u2013161. https:\/\/doi.org\/10.1159\/000488481","journal-title":"Dement Geriatr Cogn Disord"},{"key":"2814_CR2","doi-asserted-by":"publisher","first-page":"340","DOI":"10.4049\/jimmunol.182.1.340","volume":"182","author":"T Aprahamian","year":"2009","unstructured":"Aprahamian T, Bonegio RG, Richez C, Yasuda K, Chiang LK, Sato K et al (2009) The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol 182:340\u2013346. https:\/\/doi.org\/10.4049\/jimmunol.182.1.340","journal-title":"J Immunol"},{"key":"2814_CR3","doi-asserted-by":"publisher","first-page":"84ra43","DOI":"10.1126\/scitranslmed.3002254","volume":"3","author":"JK Atwal","year":"2011","unstructured":"Atwal JK, Chen Y, Chiu C, Mortensen DL, Meilandt WJ, Liu Y et al (2011) A therapeutic antibody targeting BACE1 inhibits amyloid-beta production in vivo. Sci Transl Med 3:84ra43. https:\/\/doi.org\/10.1126\/scitranslmed.3002254","journal-title":"Sci Transl Med"},{"key":"2814_CR4","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41582-021-00549-x","volume":"17","author":"BM Bettcher","year":"2021","unstructured":"Bettcher BM, Tansey MG, Dorothee G, Heneka MT (2021) Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus. Nat Rev Neurol 17:689\u2013701. https:\/\/doi.org\/10.1038\/s41582-021-00549-x","journal-title":"Nat Rev Neurol"},{"key":"2814_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010453","volume":"18","author":"JA Bristol","year":"2022","unstructured":"Bristol JA, Brand J, Ohashi M, Eichelberg MR, Casco A, Nelson SE et al (2022) Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells. PLoS Pathog 18:e1010453. https:\/\/doi.org\/10.1371\/journal.ppat.1010453","journal-title":"PLoS Pathog"},{"key":"2814_CR6","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","volume":"20","author":"DA Butterfield","year":"2019","unstructured":"Butterfield DA, Halliwell B (2019) Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci 20:148\u2013160. https:\/\/doi.org\/10.1038\/s41583-019-0132-6","journal-title":"Nat Rev Neurosci"},{"key":"2814_CR7","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1080\/20014091111857","volume":"31","author":"EJ Calabrese","year":"2001","unstructured":"Calabrese EJ (2001) Amyloid beta-peptide: biphasic dose responses. Crit Rev Toxicol 31:605\u2013606. https:\/\/doi.org\/10.1080\/20014091111857","journal-title":"Crit Rev Toxicol"},{"key":"2814_CR8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.dadm.2016.03.002","volume":"3","author":"CA DeMarshall","year":"2016","unstructured":"DeMarshall CA, Nagele EP, Sarkar A, Acharya NK, Godsey G, Goldwaser EL et al (2016) Detection of Alzheimer\u2019s disease at mild cognitive impairment and disease progression using autoantibodies as blood-based biomarkers. Alzheimers Dement (Amst) 3:51\u201362. https:\/\/doi.org\/10.1016\/j.dadm.2016.03.002","journal-title":"Alzheimers Dement (Amst)"},{"key":"2814_CR9","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/j.1471-4159.2011.07629.x","volume":"120","author":"J Deng","year":"2012","unstructured":"Deng J, Hou H, Giunta B, Mori T, Wang Y-J, Fernandez F et al (2012) Autoreactive-A\u03b2 antibodies promote APP \u03b2-secretase processing. J Neurochem 120:732\u2013740. https:\/\/doi.org\/10.1111\/j.1471-4159.2011.07629.x","journal-title":"J Neurochem"},{"key":"2814_CR10","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1146\/annurev-immunol-020711-075041","volume":"31","author":"B Diamond","year":"2013","unstructured":"Diamond B, Honig G, Mader S, Brimberg L, Volpe BT (2013) Brain-reactive antibodies and disease. Annu Rev Immunol 31:345\u2013385. https:\/\/doi.org\/10.1146\/annurev-immunol-020711-075041","journal-title":"Annu Rev Immunol"},{"key":"2814_CR11","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S1474-4422(13)70014-0","volume":"12","author":"R Dodel","year":"2013","unstructured":"Dodel R, Rominger A, Bartenstein P, Barkhof F, Blennow K, Forster S et al (2013) Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer\u2019s disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial. Lancet Neurol 12:233\u2013243. https:\/\/doi.org\/10.1016\/S1474-4422(13)70014-0","journal-title":"Lancet Neurol"},{"key":"2814_CR12","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/s41591-020-0938-9","volume":"26","author":"S Dujardin","year":"2020","unstructured":"Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV et al (2020) Tau molecular diversity contributes to clinical heterogeneity in Alzheimer\u2019s disease. Nat Med 26:1256\u20131263. https:\/\/doi.org\/10.1038\/s41591-020-0938-9","journal-title":"Nat Med"},{"key":"2814_CR13","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1017\/S1041610209009405","volume":"21","author":"KA Ellis","year":"2009","unstructured":"Ellis KA, Bush AI, Darby D, De Fazio D, Foster J, Hudson P et al (2009) The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer\u2019s disease. Int Psychogeriatr 21:672\u2013687. https:\/\/doi.org\/10.1017\/S1041610209009405","journal-title":"Int Psychogeriatr"},{"key":"2814_CR14","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1212\/WNL.0b013e3181ae7aaf","volume":"73","author":"H Fillit","year":"2009","unstructured":"Fillit H, Hess G, Hill J, Bonnet P, Toso C (2009) IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders. Neurology 73:180\u2013185. https:\/\/doi.org\/10.1212\/WNL.0b013e3181ae7aaf","journal-title":"Neurology"},{"key":"2814_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41583-021-00533-w","volume":"23","author":"GB Frisoni","year":"2022","unstructured":"Frisoni GB, Altomare D, Thal DR, Ribaldi F, van der Kant R, Ossenkoppele R et al (2022) The probabilistic model of Alzheimer disease: the amyloid hypothesis revised. Nat Rev Neurosci 23:53\u201366. https:\/\/doi.org\/10.1038\/s41583-021-00533-w","journal-title":"Nat Rev Neurosci"},{"key":"2814_CR16","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3389\/fnins.2014.00235","volume":"8","author":"JP Fuller","year":"2014","unstructured":"Fuller JP, Stavenhagen JB, Teeling JL (2014) New roles for Fc receptors in neurodegeneration-the impact on Immunotherapy for Alzheimer\u2019s Disease. Front Neurosci 8:235. https:\/\/doi.org\/10.3389\/fnins.2014.00235","journal-title":"Front Neurosci"},{"key":"2814_CR17","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00702-021-02316-0","volume":"128","author":"N Hansen","year":"2021","unstructured":"Hansen N, Malchow B, Zerr I, Stocker W, Wiltfang J, Timaus C (2021) Neural cell-surface and intracellular autoantibodies in patients with cognitive impairment from a memory clinic cohort. J Neural Transm (Vienna) 128:357\u2013369. https:\/\/doi.org\/10.1007\/s00702-021-02316-0","journal-title":"J Neural Transm (Vienna)"},{"key":"2814_CR18","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1002\/ana.10208","volume":"51","author":"RM Holsinger","year":"2002","unstructured":"Holsinger RM, McLean CA, Beyreuther K, Masters CL, Evin G (2002) Increased expression of the amyloid precursor beta-secretase in Alzheimer\u2019s disease. Ann Neurol 51:783\u2013786. https:\/\/doi.org\/10.1002\/ana.10208","journal-title":"Ann Neurol"},{"key":"2814_CR19","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-022-00869-y","author":"JM Jian","year":"2022","unstructured":"Jian JM, Fan DY, Tian DY, Cheng Y, Sun PY, Tan CR et al (2022) Naturally-occurring antibodies against Bim are decreased in Alzheimer\u2019s disease and attenuate AD-type pathology in a mouse model. Neurosci Bull. https:\/\/doi.org\/10.1007\/s12264-022-00869-y","journal-title":"Neurosci Bull"},{"key":"2814_CR20","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s12640-015-9589-x","volume":"29","author":"SS Jiao","year":"2016","unstructured":"Jiao SS, Bu XL, Liu YH, Zhu C, Wang QH, Shen LL et al (2016) Sex dimorphism profile of Alzheimer\u2019s disease-type pathologies in an app\/ps1 mouse model. Neurotox Res 29:256\u2013266. https:\/\/doi.org\/10.1007\/s12640-015-9589-x","journal-title":"Neurotox Res"},{"key":"2814_CR21","doi-asserted-by":"publisher","first-page":"5225","DOI":"10.1073\/pnas.1422998112","volume":"112","author":"SS Jiao","year":"2015","unstructured":"Jiao SS, Yao XQ, Liu YH, Wang QH, Zeng F, Lu JJ et al (2015) Edaravone alleviates Alzheimer\u2019s disease-type pathologies and cognitive deficits. Proc Natl Acad Sci U S A 112:5225\u20135230. https:\/\/doi.org\/10.1073\/pnas.1422998112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2814_CR22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00401-017-1721-y","volume":"134","author":"WS Jin","year":"2017","unstructured":"Jin WS, Shen LL, Bu XL, Zhang WW, Chen SH, Huang ZL et al (2017) Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP\/PS1 mouse model. Acta Neuropathol 134:207\u2013220. https:\/\/doi.org\/10.1007\/s00401-017-1721-y","journal-title":"Acta Neuropathol"},{"key":"2814_CR23","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.7150\/thno.72126","volume":"12","author":"G Kocurova","year":"2022","unstructured":"Kocurova G, Ricny J, Ovsepian SV (2022) Autoantibodies targeting neuronal proteins as biomarkers for neurodegenerative diseases. Theranostics 12:3045\u20133056. https:\/\/doi.org\/10.7150\/thno.72126","journal-title":"Theranostics"},{"key":"2814_CR24","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1212\/WNL.0b013e318217e7a4","volume":"76","author":"J Li","year":"2011","unstructured":"Li J, Wang YJ, Zhang M, Xu ZQ, Gao CY, Fang CQ et al (2011) Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease. Neurology 76:1485\u20131491. https:\/\/doi.org\/10.1212\/WNL.0b013e318217e7a4","journal-title":"Neurology"},{"key":"2814_CR25","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.expneurol.2013.08.004","volume":"248","author":"L Liu","year":"2013","unstructured":"Liu L, Martin R, Kohler G, Chan C (2013) Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes. Exp Neurol 248:482\u2013490. https:\/\/doi.org\/10.1016\/j.expneurol.2013.08.004","journal-title":"Exp Neurol"},{"key":"2814_CR26","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12974-015-0379-4","volume":"12","author":"YH Liu","year":"2015","unstructured":"Liu YH, Bu XL, Liang CR, Wang YR, Zhang T, Jiao SS et al (2015) An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect. J Neuroinflammation 12:153. https:\/\/doi.org\/10.1186\/s12974-015-0379-4","journal-title":"J Neuroinflammation"},{"key":"2814_CR27","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb0457","author":"YH Liu","year":"2021","unstructured":"Liu YH, Wang J, Li QX, Fowler CJ, Zeng F, Deng J et al (2021) Association of naturally occurring antibodies to \u03b2-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer\u2019s disease. Sci Adv. https:\/\/doi.org\/10.1126\/sciadv.abb0457","journal-title":"Sci Adv"},{"key":"2814_CR28","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/j.drudis.2013.07.020","volume":"18","author":"YH Liu","year":"2013","unstructured":"Liu YH, Zeng F, Wang YR, Zhou HD, Giunta B, Tan J et al (2013) Immunity and Alzheimer\u2019s disease: immunological perspectives on the development of novel therapies. Drug Discov Today 18:1212\u20131220. https:\/\/doi.org\/10.1016\/j.drudis.2013.07.020","journal-title":"Drug Discov Today"},{"key":"2814_CR29","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/s41582-021-00545-1","volume":"17","author":"E McDade","year":"2021","unstructured":"McDade E, Voytyuk I, Aisen P, Bateman RJ, Carrillo MC, De Strooper B et al (2021) The case for low-level BACE1 inhibition for the prevention of Alzheimer disease. Nat Rev Neurol 17:703\u2013714. https:\/\/doi.org\/10.1038\/s41582-021-00545-1","journal-title":"Nat Rev Neurol"},{"key":"2814_CR30","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12974-016-0601-z","volume":"13","author":"T Minett","year":"2016","unstructured":"Minett T, Classey J, Matthews FE, Fahrenhold M, Taga M, Brayne C et al (2016) Microglial immunophenotype in dementia with Alzheimer\u2019s pathology. J Neuroinflammation 13:135. https:\/\/doi.org\/10.1186\/s12974-016-0601-z","journal-title":"J Neuroinflammation"},{"key":"2814_CR31","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.jalz.2017.01.018","volume":"13","author":"EC Mormino","year":"2017","unstructured":"Mormino EC, Papp KV, Rentz DM, Donohue MC, Amariglio R, Quiroz YT et al (2017) Early and late change on the preclinical Alzheimer\u2019s cognitive composite in clinically normal older individuals with elevated amyloid beta. Alzheimers Dement 13:1004\u20131012. https:\/\/doi.org\/10.1016\/j.jalz.2017.01.018","journal-title":"Alzheimers Dement"},{"key":"2814_CR32","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3233\/JAD-2011-110098","volume":"25","author":"RG Nagele","year":"2011","unstructured":"Nagele RG, Clifford PM, Siu G, Levin EC, Acharya NK, Han M et al (2011) Brain-reactive autoantibodies prevalent in human sera increase intraneuronal amyloid-\u03b2(1\u201342) deposition. J Alzheimers Dis 25:605\u2013622. https:\/\/doi.org\/10.3233\/JAD-2011-110098","journal-title":"J Alzheimers Dis"},{"key":"2814_CR33","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3233\/JAD-215542","volume":"87","author":"R Nicsanu","year":"2022","unstructured":"Nicsanu R, Cervellati C, Benussi L, Squitti R, Zanardini R, Rosta V et al (2022) Increased serum beta-secretase 1 activity is an early marker of Alzheimer\u2019s disease. J Alzheimers Dis 87:433\u2013441. https:\/\/doi.org\/10.3233\/JAD-215542","journal-title":"J Alzheimers Dis"},{"key":"2814_CR34","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1002\/path.4491","volume":"235","author":"C Paquet","year":"2015","unstructured":"Paquet C, Amin J, Mouton-Liger F, Nasser M, Love S, Gray F et al (2015) Effect of active Abeta immunotherapy on neurons in human Alzheimer\u2019s disease. J Pathol 235:721\u2013730. https:\/\/doi.org\/10.1002\/path.4491","journal-title":"J Pathol"},{"key":"2814_CR35","doi-asserted-by":"publisher","first-page":"4987","DOI":"10.1007\/s12035-022-02885-5","volume":"59","author":"H Qiu","year":"2022","unstructured":"Qiu H, Liu X (2022) Echinacoside improves cognitive impairment by inhibiting abeta deposition through the pi3k\/akt\/nrf2\/ppargamma signaling pathways in app\/ps1 mice. Mol Neurobiol 59:4987\u20134999. https:\/\/doi.org\/10.1007\/s12035-022-02885-5","journal-title":"Mol Neurobiol"},{"key":"2814_CR36","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1212\/WNL.0000000000003904","volume":"88","author":"NR Relkin","year":"2017","unstructured":"Relkin NR, Thomas RG, Rissman RA, Brewer JB, Rafii MS, van Dyck CH et al (2017) A phase 3 trial of IV immunoglobulin for Alzheimer disease. Neurology 88:1768\u20131775. https:\/\/doi.org\/10.1212\/WNL.0000000000003904","journal-title":"Neurology"},{"key":"2814_CR37","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W et al (2015) limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43:e47. https:\/\/doi.org\/10.1093\/nar\/gkv007","journal-title":"Nucleic Acids Res"},{"key":"2814_CR38","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","volume":"11","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, Oshlack A (2010) A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol 11:R25. https:\/\/doi.org\/10.1186\/gb-2010-11-3-r25","journal-title":"Genome Biol"},{"key":"2814_CR39","doi-asserted-by":"publisher","first-page":"5115","DOI":"10.1021\/acs.jproteome.1c00630","volume":"20","author":"P San Segundo-Acosta","year":"2021","unstructured":"San Segundo-Acosta P, Montero-Calle A, Jernbom-Falk A, Alonso-Navarro M, Pin E, Andersson E et al (2021) Multiomics profiling of Alzheimer\u2019s disease serum for the identification of autoantibody biomarkers. J Proteome Res 20:5115\u20135130. https:\/\/doi.org\/10.1021\/acs.jproteome.1c00630","journal-title":"J Proteome Res"},{"key":"2814_CR40","doi-asserted-by":"publisher","first-page":"9796","DOI":"10.1523\/JNEUROSCI.23-30-09796.2003","volume":"23","author":"M Sastre","year":"2003","unstructured":"Sastre M, Dewachter I, Landreth GE, Willson TM, Klockgether T, van Leuven F et al (2003) Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci 23:9796\u20139804. https:\/\/doi.org\/10.1523\/JNEUROSCI.23-30-09796.2003","journal-title":"J Neurosci"},{"key":"2814_CR41","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1073\/pnas.0503839103","volume":"103","author":"M Sastre","year":"2006","unstructured":"Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P et al (2006) Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci USA 103:443\u2013448. https:\/\/doi.org\/10.1073\/pnas.0503839103","journal-title":"Proc Natl Acad Sci USA"},{"key":"2814_CR42","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/s0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens P, De Strooper B, Kivipelto M, Holstege H, Ch\u00e9telat G, Teunissen CE et al (2021) Alzheimer\u2019s disease. Lancet 397:1577\u20131590. https:\/\/doi.org\/10.1016\/s0140-6736(20)32205-4","journal-title":"Lancet"},{"key":"2814_CR43","doi-asserted-by":"publisher","first-page":"5489","DOI":"10.1021\/bi501529x","volume":"54","author":"J Sgrignani","year":"2015","unstructured":"Sgrignani J, Olsson S, Ekonomiuk D, Genini D, Krause R, Catapano CV et al (2015) Molecular determinants for unphosphorylated STAT3 dimerization determined by integrative modeling. Biochemistry 54:5489\u20135501. https:\/\/doi.org\/10.1021\/bi501529x","journal-title":"Biochemistry"},{"key":"2814_CR44","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.biopsych.2017.02.007","volume":"83","author":"Y Shen","year":"2018","unstructured":"Shen Y, Wang H, Sun Q, Yao H, Keegan AP, Mullan M et al (2018) Increased plasma beta-secretase 1 may predict conversion to Aalzheimer\u2019s disease dementia in individuals with mild cognitive impairment. Biol Psychiatry 83:447\u2013455. https:\/\/doi.org\/10.1016\/j.biopsych.2017.02.007","journal-title":"Biol Psychiatry"},{"key":"2814_CR45","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1750-1172-8-45","volume":"8","author":"TK Sigdel","year":"2013","unstructured":"Sigdel TK, Shoemaker LD, Chen R, Li L, Butte AJ, Sarwal MM et al (2013) Immune response profiling identifies autoantibodies specific to Moyamoya patients. Orphanet J Rare Dis 8:45. https:\/\/doi.org\/10.1186\/1750-1172-8-45","journal-title":"Orphanet J Rare Dis"},{"key":"2814_CR46","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1111\/ene.14290","volume":"27","author":"BZ Wang","year":"2020","unstructured":"Wang BZ, Zailan FZ, Wong BYX, Ng KP, Kandiah N (2020) Identification of novel candidate autoantibodies in Alzheimer\u2019s disease. Eur J Neurol 27:2292\u20132296. https:\/\/doi.org\/10.1111\/ene.14290","journal-title":"Eur J Neurol"},{"key":"2814_CR47","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.3233\/JAD-220775","volume":"90","author":"YR Wang","year":"2022","unstructured":"Wang YR, Wang MT, Zeng XQ, Liu YH, Wang YJ (2022) Associations of naturally occurring antibodies to presenilin-1 with brain amyloid-beta load and cognitive impairment in Alzheimer\u2019s disease. J Alzheimers Dis 90:1493\u20131500. https:\/\/doi.org\/10.3233\/JAD-220775","journal-title":"J Alzheimers Dis"},{"key":"2814_CR48","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00401-015-1477-1","volume":"130","author":"Y Xiang","year":"2015","unstructured":"Xiang Y, Bu XL, Liu YH, Zhu C, Shen LL, Jiao SS et al (2015) Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer\u2019s disease. Acta Neuropathol 130:487\u2013499. https:\/\/doi.org\/10.1007\/s00401-015-1477-1","journal-title":"Acta Neuropathol"},{"key":"2814_CR49","doi-asserted-by":"publisher","first-page":"6864","DOI":"10.1038\/srep06864","volume":"4","author":"Y Xiang","year":"2014","unstructured":"Xiang Y, Meng S, Wang J, Li S, Liu J, Li H et al (2014) Two novel DNA motifs are essential for BACE1 gene transcription. Sci Rep 4:6864. https:\/\/doi.org\/10.1038\/srep06864","journal-title":"Sci Rep"},{"key":"2814_CR50","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3233\/JAD-200362","volume":"77","author":"M Zhang","year":"2020","unstructured":"Zhang M, Zhong X, Shi H, Vanmechelen E, De Vos A, Liu S et al (2020) BACE1 and other Alzheimer\u2019s-related biomarkers in cerebrospinal fluid and plasma distinguish Alzheimer\u2019s disease patients from cognitively-impaired neurosyphilis patients. J Alzheimers Dis 77:313\u2013322. https:\/\/doi.org\/10.3233\/JAD-200362","journal-title":"J Alzheimers Dis"},{"key":"2814_CR51","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/ageing\/32.2.205","volume":"32","author":"H Zhou","year":"2003","unstructured":"Zhou H, Deng J, Li J, Wang Y, Zhang M, He H (2003) Study of the relationship between cigarette smoking, alcohol drinking and cognitive impairment among elderly people in China. Age Ageing 32:205\u2013210","journal-title":"Age Ageing"},{"key":"2814_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2024.102654","volume":"240","author":"F Zhu","year":"2024","unstructured":"Zhu F, He P, Jiang W, Afridi SK, Xu H, Alahmad M et al (2024) Astrocyte-secreted C3 signaling impairs neuronal development and cognition in autoimmune diseases. Prog Neurobiol 240:102654. https:\/\/doi.org\/10.1016\/j.pneurobio.2024.102654","journal-title":"Prog Neurobiol"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-024-02814-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00401-024-02814-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-024-02814-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T19:02:45Z","timestamp":1729796565000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00401-024-02814-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2814"],"URL":"https:\/\/doi.org\/10.1007\/s00401-024-02814-x","relation":{},"ISSN":["1432-0533"],"issn-type":[{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]},"assertion":[{"value":"25 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institutional Review Board of Daping Hospital, Third Military Medical University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This study was conducted under the animal welfare guidelines of the Third Military Medical University, China. Furthermore, the use of the APPswe\/PS1dE9 mouse model was approved by the Ethics Committee of the Daing Hospital, Third Military Medical University (reference number YYLS2018.129).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}],"article-number":"57"}}