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DRT and KS are members of Acta Neuropathologica editorial board. They were not involved in the assessment or decision-making process for this manuscript. CAFvA received honoraria from serving on the scientific advisory board of Biogen, Roche, Novo Nordisk, Biontech, Lilly, Dr. Willmar Schwabe GmbH &Co. KG, and MindAhead UG and has received funding for travel and speaker honoraria from Biogen, Lilly, Novo Nordisk, Roche diagnostics AG, Novartis, Medical Tribune Verlagsgesellschaft mbH, Landesvereinigung f\u00fcr Gesundheit und Akademie f\u00fcr Sozialmedizin Niedersachsen e. V., FomF GmbH | Forum f\u00fcr medizinische Fortbildung and Dr. Willmar Schwabe GmbH &Co. KG has received research support from Roche diagnostics AG. RVs institution has clinical trial agreements (RV as PI) with Alector, Biogen, Denali, J&J, EliLilly, and UCB and consultancy agreements (RV as DSMB member) with AC Immune. 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