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All donors were enrolled in ongoing brain aging studies, with informed consent obtained prior to participation, and all protocols adhered to Institutional Review Board (IRB) guidelines at each institution. All donor subject samples were de-identified before being provided to the University of Texas Medical Branch (UTMB); therefore, no approval was required from the UTMB IRB per CFR \u00a746.101(a). Animals (mice) used procure EM immunogold images were housed in adherence with USDA standards and sacrificed in compliance with UTMB\u2019s Institutional Animal Care and Use Committee (IACUC), as well as UTMB IRB, approved protocols.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"2"}}