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RR receives invention royalties from a patent related to progranulin. KAJ is an Associate Editor of Annals of Clinical and Translational Neurology. The remaining authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Mayo Clinic and University of Antwerp Institutional Review Boards.\u00a0All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. All autopsies were obtained with consent from the legal next-of-kin or someone legally authorized to make this decision and conducted with the explicit assumption that the tissue will be used for diagnostic evaluation and research. 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