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O.A.R. consulted for SciNeuro and has received support from the National Institute of Health, the Department of Defense, the Michael J. Fox Foundation for Parkinson\u2019s Research, and the American Brain Foundation. This research was conducted in compliance with Mayo Clinic conflict of interest. B.J.T. and S.W.S. received research support from Cerevel Therapeutics. B.J.T. is an editorial and advisory board member for Brain, eClinicalMedicine, and the Journal of Neurology, Neurosurgery, and Psychiatry. S.W.S. is a scientific advisory board member of the Lewy Body Dementia Association, Mission MSA, and the GBA1 Canada Initiative, and an editorial board member of JAMA Neurology and the Journal of Parkinson\u2019s Disease.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by The Mayo Clinic Institutional Review Board (PR17-008444\u201308; Biospecimen Protocol IRB# 15\u2013009452), and written informed consent was obtained from all individuals (or next of kin).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"During the preparation of this work, the author used ChatGPT to improve grammar and clarity. After using this tool\/service, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of Generative AI and AI-assisted technologies in the writing process"}}],"article-number":"23"}}