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M.S.: scientific advisor and shareholder of Heidelberg Epignostix and Halo Dx, a scientific advisor of Arima Genomics, and InnoSIGN, consulted for Servier Pharmaceuticals, and received research funding from Lilly USA. D.C.: inventor on the patent \u2018DNA-methylation based method for classifying tumor species\u2019 (EP3268492B1) filed by Deutsches Krebsforschungszentrum Stiftung des \u00f6ffentlichen Rechts and Ruprecht-Karls-Universit\u00e4t Heidelberg; shareholder in and co-founder of Heidelberg Epignostix GmbH. Other authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the National Institutes of Health Institutional Review Board (IRB ID: 000983\/MOD013986), which granted a waiver of informed consent given the use of existing data, documents, records, or specimens and the minimal risk to subjects.","order":2,"name":"Ethics","label":"Ethics statement","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"20"}}