{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:35:25Z","timestamp":1768091725038,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T00:00:00Z","timestamp":1100736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1007\/s00402-004-0760-8","type":"journal-article","created":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T12:30:53Z","timestamp":1100694653000},"page":"51-55","source":"Crossref","is-referenced-by-count":50,"title":["Factor V Leiden and the prothrombin 20210A gene mutation and osteonecrosis of the knee"],"prefix":"10.1007","volume":"125","author":[{"given":"Anders","family":"Bj\ufffdrkman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella M.","family":"Burtscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hillarp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Besjakov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\ufffdran","family":"Benoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,11,18]]},"reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1302\/0301-620X.65B5.6643563","volume":"65","author":"Aglietti","year":"1983","unstructured":"Aglietti P, Insall JN, Buzzi R, Deschamps G (1983) Idiopathic osteonecrosis of the knee. Aetiology, prognosis and treatment. J Bone Joint Surg Br 65:588?597","journal-title":"J Bone Joint Surg Br"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/art.1780110602","volume":"11","author":"Ahlb","year":"1968","unstructured":"Ahlb\u00e4ck S, Bauer GCH, Bohne WH (1968) Spontaneous osteonecrosis of the knee. Arthritis Rheum 11:705?733","journal-title":"Arthritis Rheum"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1302\/0301-620X.57B3.360","volume":"57","author":"Arnoldi","year":"1975","unstructured":"Arnoldi C, Lemperg R, Linderholm H (1975) Intraosseous hypertension and pain in the knee. J Bone Joint Surg Br 57:360?363","journal-title":"J Bone Joint Surg Br"},{"key":"CR4","first-page":"84","volume":"19","author":"Arruda","year":"1999","unstructured":"Arruda VR, Belangero WD, Ozelo MC, Oliveira GB, Pagnano RG, Volpon JB, Annichino-Bizzacchi JM (1999) Inherited risk factors for thrombophilia among children with Legg-Calv\u00e9-Perthes disease. J Pediatr Orthop 19:84?87","journal-title":"J Pediatr Orthop"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/369064a0","volume":"369","author":"Bertina","year":"1994","unstructured":"Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, Ronde H de, Velden PA van der, Reitsma PH (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369:64?67","journal-title":"Nature"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5435\/00124635-199405000-00006","volume":"2","author":"Ecker","year":"1994","unstructured":"Ecker ML, Lotke PA (1994) Spontaneous osteonecrosis of the knee. J Am Acad Orthop Surg 2:173?178","journal-title":"J Am Acad Orthop Surg"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1055\/s-0037-1616136","volume":"86","author":"Emmerich","year":"2001","unstructured":"Emmerich J, Rosendaal FR, Cattaneo M, Margaglione M, De Stefano V, Cumming T, Arruda V, Hillarp A, Reny JL (2001) Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism: pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Thromb Haemost 86:809?816","journal-title":"Thromb Haemost"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00003086-199705000-00021","volume":"338","author":"Glueck","year":"1997","unstructured":"Glueck CJ, Brandt G, Gruppo R, Crawford A, Roy D, Tracy T, Stroop D, Wang P (1997) Resistance to activated protein C and Legg-Perthes disease. Clin Orthop 338:139?152","journal-title":"Clin Orthop"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00003086-200105000-00004","volume":"386","author":"Glueck","year":"2001","unstructured":"Glueck CJ, Freiberg RA, Fontaine RN, Tracy T, Wang P (2001) Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop 386:19?33","journal-title":"Clin Orthop"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1302\/0301-620X.81B4.9378","volume":"81","author":"Hayek","year":"1999","unstructured":"Hayek S, Kenet G, Lubetsky A, Rosenberg N, Gitel S, Wientroub S (1999) Does thrombophilia play an aetiological role in Legg-Calv\u00e9-Perthes disease? J Bone Joint Surg Br 81:686?890","journal-title":"J Bone Joint Surg Br"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1055\/s-0038-1657674","volume":"78","author":"Hillarp","year":"1997","unstructured":"Hillarp A, Z\u00f6ller B, Svensson PJ, Dahlb\u00e4ck B (1997) The 20210A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis. Thromb Haemost 78:990?992","journal-title":"Thromb Haemost"},{"key":"CR12","unstructured":"Hirota Y, Hotokebuchi T, Sugioka Y (1997) Idiopathic osteonecrosis of the femoral head: nationwide epidemiologic studies in Japan. In: Urbaniak JR, Jones JP Jr (eds) Osteonecrosis: etiology, diagnosis and treatment. American Academy of Orthopaedic Surgeons, Rosemont, pp 51?58"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.2106\/00004623-200209000-00014","volume":"84","author":"Hresko","year":"2002","unstructured":"Hresko T, McDougall PA, Gorlin JB, Vamvakas EC, Kasser JR, Neufeld EJ (2002) Prospective reevaluation of the association between thrombotic diathesis and Legg-Perthes disease. J Bone Joint Surg Am 84:1613?1618","journal-title":"J Bone Joint Surg Am"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00003086-199204000-00006","volume":"277","author":"Jones","year":"1992","unstructured":"Jones JP Jr (1992) Intravascular coagulation and osteonecrosis. Clin Orthop 277:41?53","journal-title":"Clin Orthop"},{"key":"CR15","unstructured":"Kirkwood BR (1988) Cohort and case-control studies. In: Kirkwood BR (ed) Essentials of medical statistics. Blackwell Scientific Publications, Oxford, pp 177?183"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"834","DOI":"10.2106\/00004623-200205000-00023","volume":"84","author":"Lieberman","year":"2002","unstructured":"Lieberman JR, Berry DJ, Mont MA, Aaron RK, Callaghan JJ, Rayadhyaksha A, Urbaniak JR (2002) Osteonecrosis of the hip: management in the twenty-first century. J Bone Joint Surg Am 84:834?853","journal-title":"J Bone Joint Surg Am"},{"key":"CR17","unstructured":"Lotke PA (1997) Tibial osteonecrosis. In: Urbaniak JR, Jones JP Jr (eds) Osteonecrosis: etiology, diagnosis and treatment. American Academy of Orthopaedic Surgeons, Rosemont, pp 425?428"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1056\/NEJM199205283262206","volume":"326","author":"Mankin","year":"1992","unstructured":"Mankin HJ (1992) Nontraumatic necrosis of bone (osteonecrosis). N Engl J Med 326:1473?1479","journal-title":"N Engl J Med"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.2106\/00004623-200009000-00008","volume":"82","author":"Mont","year":"2000","unstructured":"Mont MA, Baumgarten KM, Rifai A, Bluemke DA, Jones LC, Hungerford DS (2000) Atraumatic osteonecrosis of the knee. J Bone Joint Surg Am 82:1279?1290","journal-title":"J Bone Joint Surg Am"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00003086-199705000-00019","volume":"338","author":"Mont","year":"1997","unstructured":"Mont MA, Myers TH, Krackow KA, Hungerford DS (1997) Total knee arthroplasty for corticosteroid associated avascular necrosis of the knee. Clin Orthop 338:124?130","journal-title":"Clin Orthop"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2106\/00004623-200204000-00014","volume":"84","author":"Mont","year":"2002","unstructured":"Mont MA, Rifai A, Baumgarten KM, Sheldon M, Hungerford DS (2002) Total knee arthroplasty for osteonecrosis. J Bone Joint Surg Am 84:599?603","journal-title":"J Bone Joint Surg Am"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","volume":"88","author":"Poort","year":"1996","unstructured":"Poort SR, Rosendaal FR, Reitsma PH, Bertina RM (1996) A common genetic variation in the 3?-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88:3698?3703","journal-title":"Blood"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0140-6736(95)91803-5","volume":"346","author":"Rees","year":"1995","unstructured":"Rees DC, Cox M, Clegg JB (1995) World distribution of factor V Leiden. Lancet 346:1133?1134","journal-title":"Lancet"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1080\/000164700317393376","volume":"71","author":"Robertsson","year":"2000","unstructured":"Robertsson O, Dunbar MJ, Knutsson K, Lidgren L (2000) Past incidence and future demand for knee arthroplasty in Sweden. A report from the Swedish knee arthroplasty register regarding the effect of past and future population changes on the number of athroplasties performed. Acta Orthop Scand 71:376?380","journal-title":"Acta Orthop Scand"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1056\/NEJM199402243300801","volume":"330","author":"Svensson","year":"1994","unstructured":"Svensson PJ, Dahlb\u00e4ck B (1994) Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 330:517?522","journal-title":"N Engl J Med"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1046\/j.1365-2796.1997.124140000.x","volume":"241","author":"Svensson","year":"1997","unstructured":"Svensson PJ, Z\u00f6ller B, Mattiasson I, Dahlb\u00e4ck B (1997) The factor VR506Q mutation causing APC resistance is highly prevalent amongst unselected outpatients with clinically suspected deep venous thrombosis. J Int Med 241:379?385","journal-title":"J Int Med"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00003086-200103000-00025","volume":"384","author":"Uchio","year":"2001","unstructured":"Uchio Y, Ochi M, Adachi N, Nishikori T, Kawasaki K (2001) Intraosseous hypertension and venous congestion in osteonecrosis of the knee. Clin Orthop 384:217?223","journal-title":"Clin Orthop"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1302\/0301-620X.82B8.11194","volume":"82","author":"Yamamoto","year":"2000","unstructured":"Yamamoto T, Bullough PG (2000) Spontaneous osteonecrosis of the knee: the result of subchondral insufficiency fracture. J. Bone Joint Surg Am 82:858?866","journal-title":"Bone Joint Surg Am"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1172\/JCI117623","volume":"94","author":"Z","year":"1994","unstructured":"Z\u00f6ller B, Svensson PJ, He X, Dahlb\u00e4ck B (1994) Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. J Clin Invest 94:2521?2524","journal-title":"J Clin Invest"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-004-0760-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00402-004-0760-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-004-0760-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T08:36:27Z","timestamp":1682843787000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00402-004-0760-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,18]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["760"],"URL":"https:\/\/doi.org\/10.1007\/s00402-004-0760-8","relation":{},"ISSN":["0936-8051","1434-3916"],"issn-type":[{"value":"0936-8051","type":"print"},{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,18]]}}}