{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:08:15Z","timestamp":1788001695545,"version":"build-2784847793"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T00:00:00Z","timestamp":1286841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1007\/s00402-010-1192-2","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T02:27:55Z","timestamp":1287023275000},"page":"657-662","source":"Crossref","is-referenced-by-count":48,"title":["Systemic exposure to tobramycin after local antibiotic treatment with calcium sulphate as carrier material"],"prefix":"10.1007","volume":"131","author":[{"given":"Peter","family":"Wahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Livio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Jacobi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Gautier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Buclin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,12]]},"reference":[{"issue":"11","key":"1192_CR1","first-page":"511","volume":"41","author":"HW Buchholz","year":"1970","unstructured":"Buchholz HW, Engelbrecht H (1970) Depot effects of various antibiotics mixed with Palacos resins. Chirurg 41(11):511\u2013515","journal-title":"Chirurg"},{"key":"1192_CR2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00003086-199310000-00003","volume":"295","author":"JD Blaha","year":"1993","unstructured":"Blaha JD, Calhoun JH, Nelson CL, Henry SL, Seligsnon D et al (1993) Comparison of the clinical efficacy and tolerance of gentamicin PMMA beads on surgical wire versus combined and systemic therapy for osteomyelitis. Clin Orthop Relat Res 295:8\u201312","journal-title":"Clin Orthop Relat Res"},{"issue":"1","key":"1192_CR3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2165\/00003088-199529010-00005","volume":"29","author":"SL Henry","year":"1995","unstructured":"Henry SL, Galloway KP (1995) Local antibacterial therapy for the management of orthopaedic infections: pharmacokinetic considerations. Clin Pharmacokinet 29(1):36\u201345","journal-title":"Clin Pharmacokinet"},{"issue":"6","key":"1192_CR4","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2165\/00003495-200059060-00003","volume":"59","author":"K Kanellakopoulou","year":"2000","unstructured":"Kanellakopoulou K, Giamarellos-Bourboulis EJ (2000) Carrier systems for the local delivery of antibiotics in bone infections. Drugs 59(6):1223\u20131232","journal-title":"Drugs"},{"issue":"1","key":"1192_CR5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/230949900201000110","volume":"10","author":"S Gitelis","year":"2002","unstructured":"Gitelis S, Brebach GT (2002) The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant. J Orthop Surg 10(1):53\u201360","journal-title":"J Orthop Surg"},{"issue":"2","key":"1192_CR6","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1054\/arth.2002.34525","volume":"17","author":"TM Raaij Van","year":"2002","unstructured":"Van Raaij TM, Visser LE, Vulto AG, Verhaar JAN (2002) Acute renal failure after local gentamicin treatment in an infected total knee arthroplasty. J Arthroplasty 17(2):948\u2013950","journal-title":"J Arthroplasty"},{"key":"1192_CR7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/01.blo.0000144476.43661.10","volume":"427","author":"BD Springer","year":"2004","unstructured":"Springer BD, Lee GC, Osmon D, Haidukewych GJ, Hanssen AD, Jacofsky DJ (2004) Systemic safety of high-dose antibiotic-loaded cement spacers after resection of an infected total knee arthroplasty. Clin Orthop Relat Res 427:47\u201351","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"1192_CR8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3109\/17453670902884700","volume":"80","author":"K Anagnostakos","year":"2009","unstructured":"Anagnostakos K, Wilmes P, Schmitt E, Kelm J (2009) Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo. Acta Orthop 80(2):193\u2013197","journal-title":"Acta Orthop"},{"issue":"9","key":"1192_CR9","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/00005131-200210000-00002","volume":"16","author":"MD McKee","year":"2002","unstructured":"McKee MD, Wild LM, Schemitsch EH, Waddell JP (2002) The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: Early results of a prospective trial. J Orthop Trauma 16(9):622\u2013627","journal-title":"J Orthop Trauma"},{"key":"1192_CR10","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1016\/j.biomaterials.2004.06.045","volume":"26","author":"MA Rauschmann","year":"2005","unstructured":"Rauschmann MA, Wichelhaus TA, Stirnal V, Dingeldein E, Zichner L et al (2005) Nanocrystalline hydroxyapatite and calcium sulphate as biodegradable composite carrier material for local delivery of antibiotics in bone infections. Biomaterials 26:2677\u20132684","journal-title":"Biomaterials"},{"key":"1192_CR11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00268172","volume":"9","author":"S Downes","year":"1985","unstructured":"Downes S, Brown AE, Murkherjee S (1985) The clearance of gentamicin from antibiotic-loaded bone cement. Int Orthop 9:205\u2013207","journal-title":"Int Orthop"},{"key":"1192_CR12","first-page":"171","volume":"205","author":"GHIM Walenkamp","year":"1986","unstructured":"Walenkamp GHIM, Vree TB, Van Rens TJG (1986) Gentamicin-PMMA beads: pharmacokinetic and nephrotoxicological study. Clin Orthop Relat Res 205:171\u2013183","journal-title":"Clin Orthop Relat Res"},{"key":"1192_CR13","first-page":"804","volume":"9","author":"H Dreesmann","year":"1892","unstructured":"Dreesmann H (1892) \u00dcber Knochenplombierung. Beitr Klin Chir 9:804\u2013810","journal-title":"Beitr Klin Chir"},{"key":"1192_CR14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0002-9610(59)90305-8","volume":"97","author":"LF Peltier","year":"1959","unstructured":"Peltier LF (1959) The use of plaster of Paris to fill large defects in bone: a preliminary report. Am J Surg 97:311\u2013315","journal-title":"Am J Surg"},{"key":"1192_CR15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00003086-200101000-00008","volume":"382","author":"CM Kelly","year":"2001","unstructured":"Kelly CM, Ross MW, Gitelis S, Hartjen C, Watson JT, Kim PT (2001) The use of a surgical grade calcium sulfate as a bone graft substitute: results of a multicenter trial. Clin Orthop Relat Res 382:42\u201350","journal-title":"Clin Orthop Relat Res"},{"issue":"5","key":"1192_CR16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/000164702321022875","volume":"73","author":"J Petruskevicius","year":"2002","unstructured":"Petruskevicius J, Nielsen S, Kaalund S, Knudsen PR, Overgaard S (2002) No effet of Osteoset\u00ae, a bone graft substitute, on bone healing in humans. A prospective randomized double-blind study. Acta Orthop Scand 73(5):575\u2013578","journal-title":"Acta Orthop Scand"},{"issue":"7","key":"1192_CR17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1177\/107110070602700702","volume":"27","author":"C Bibbo","year":"2006","unstructured":"Bibbo C, Patel DV (2006) The effect of demineralised bone matrix-calcium sulphate with vancomycin in calcaneal fracture healing and infection rates: a prospective study. Foot Ankle Int 27(7):487\u2013493","journal-title":"Foot Ankle Int"},{"key":"1192_CR18","first-page":"238","volume":"73","author":"W Chang","year":"2007","unstructured":"Chang W, Colangeli M, Colangeli S, Di Bella C, Gozzi E, Donati D (2007) Adult osteomyelitis: debridement versus debridement plus Osteoset T\u00ae pellets. Acta Orthop Belg 73:238\u2013244","journal-title":"Acta Orthop Belg"},{"key":"1192_CR19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3928\/01477447-20090501-03","volume":"32","author":"MD Helgeson","year":"2009","unstructured":"Helgeson MD, Potter BK, Tucker CJ, Frisch HM, Shawen SB (2009) Antibiotic-impregnated calcium sulfate use in combat-related open fractures. Orthopedics 32:323\u2013327","journal-title":"Orthopedics"},{"issue":"6","key":"1192_CR20","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3113\/FAI.2009.0486","volume":"30","author":"FG Krause","year":"2009","unstructured":"Krause FG, de Vries G, Meakin C, Kalla TP, Younger AS (2009) Outcome of transmetatarsal amputations in diabetics using antibiotic beads. Foot Ankle Int 30(6):486\u2013493","journal-title":"Foot Ankle Int"},{"key":"1192_CR21","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0736-0266(01)00133-4","volume":"20","author":"CL Nelson","year":"2002","unstructured":"Nelson CL, McLaren SG, Skinner RA, Smeltzer MS, Thomas JR, Olsen KM (2002) The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulphate tobramycin pellets. J Orthop Res 20:643\u2013647","journal-title":"J Orthop Res"},{"key":"1192_CR22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/01.blo.0000175127.37343.0d","volume":"437","author":"TM Turner","year":"2005","unstructured":"Turner TM, Urban RM, Hall DJ, Chye PC, Segreti J, Gitelis S (2005) Local and systemic levels of tobramycin delivered from calcium sulphate bone graft substitute pellets. Clin Orthop Relat Res 437:97\u2013104","journal-title":"Clin Orthop Relat Res"},{"key":"1192_CR23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","volume":"16","author":"DW Cockcroft","year":"1976","unstructured":"Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31\u201341","journal-title":"Nephron"},{"key":"1192_CR24","unstructured":"Livio F, Wahl P, Csajka C, Gautier E, Buclin T Systemic exposure in orthopaedic patients treated with tobramycin-laden bone graft substitute. Br J Clin Pharmacol (submitted)"},{"issue":"1","key":"1192_CR25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1128\/AAC.8.1.58","volume":"8","author":"JG Dahlgren","year":"1975","unstructured":"Dahlgren JG, Anderson ET, Hewitt WL (1975) Gentamicin blood levels: a guide to nephrotoxicity. J Antimicrob Chemother 8(1):58\u201362","journal-title":"J Antimicrob Chemother"},{"key":"1192_CR26","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/clinids\/14.1.320","volume":"14","author":"JP McCormack","year":"1992","unstructured":"McCormack JP, Jewesson PJ (1992) A critical reevaluation of the \u201ctherapeutic range\u201d of aminoglycosides. Clin Infect Dis 14:320\u2013339","journal-title":"Clin Infect Dis"},{"key":"1192_CR27","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/jac\/39.6.677","volume":"39","author":"CD Freeman","year":"1997","unstructured":"Freeman CD, Nicolau DP, Belliveau PP, Nightingale CH (1997) Once-daily dosing of aminoglycosides: review and recommendations for clinical practice. J Antimicrob Chemother 39:677\u2013686","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"1192_CR28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2165\/00002512-199710040-00003","volume":"10","author":"K Moerike","year":"1997","unstructured":"Moerike K, Schwab M, Klotz U (1997) Use of aminoglycosides in elderly patients. Pharmacokinetic and clinical considerations. Drugs Aging 10(4):259\u2013277","journal-title":"Drugs Aging"},{"key":"1192_CR29","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0891-5520(03)00057-6","volume":"17","author":"J Turnidge","year":"2003","unstructured":"Turnidge J (2003) Pharmacodynamics and dosing of aminoglycosides. Infect Dis Clin N Am 17:503\u2013528","journal-title":"Infect Dis Clin N Am"},{"issue":"4","key":"1192_CR30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2165\/00003088-199937040-00004","volume":"37","author":"E Triggs","year":"1999","unstructured":"Triggs E, Charles B (1999) Pharmacokinetics and therapeutic drug monitoring of gentamicin in the elderly. Clin Pharmacokinet 37(4):331\u2013341","journal-title":"Clin Pharmacokinet"},{"key":"1192_CR31","first-page":"285","volume-title":"Applied pharmacokinetics and pharmacodynamics\u2014principles of therapeutic drug monitoring","author":"ME Burton","year":"2006","unstructured":"Burton ME, Shaw LM, Schentag JJ, Evans WE (2006) Aminoglycosides. In: Troy D, Hauber M, Remsberg C (eds) Applied pharmacokinetics and pharmacodynamics\u2014principles of therapeutic drug monitoring, 4th edn. Williams and Wilkins, Philadelphia, pp 285\u2013327","edition":"4"},{"issue":"5","key":"1192_CR32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00005131-199505000-00007","volume":"9","author":"T Miclau","year":"1995","unstructured":"Miclau T, Edin ML, Lester GE, Lindsey RW, Dahners LE (1995) Bone toxicity of locally applied aminoglycosides. J Orthop Trauma 9(5):401\u2013406","journal-title":"J Orthop Trauma"},{"key":"1192_CR33","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1302\/0301-620X.85B5.13746","volume":"85","author":"GJ Sterling","year":"2003","unstructured":"Sterling GJ, Crawford S, Potter JH, Koerbin D, Crawford R (2003) The pharmacokinetics of simplex-tobramycin bone cement. J Bone Joint Surg Br 85:646\u2013649","journal-title":"J Bone Joint Surg Br"},{"issue":"1","key":"1192_CR34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/00016470510030355","volume":"76","author":"AJ Swieringa","year":"2005","unstructured":"Swieringa AJ, Tulp NJA (2005) Toxic serum gentamicin levels after the use of gentamicin-loaded sponges in infected total hip arthroplasty. Acta Orthop 76(1):75\u201377","journal-title":"Acta Orthop"},{"key":"1192_CR35","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","volume":"130","author":"AS Levey","year":"1999","unstructured":"Levey AS, Posch JP, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med 130:461\u20137034","journal-title":"Ann Intern Med"},{"issue":"6","key":"1192_CR36","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1532-5415.2007.01196.x","volume":"55","author":"SV Giannelli","year":"2007","unstructured":"Giannelli SV, Patel KV, Windham BG, Pizzarelli F, Ferrucci L, Guralnik JM (2007) Magnitude of under ascertainment of impaired kidney function in older adults with normal serum creatinine. J Am Geriatr Soc 55(6):816\u2013823","journal-title":"J Am Geriatr Soc"},{"key":"1192_CR37","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.bbmt.2009.01.015","volume":"15","author":"T Hahn","year":"2009","unstructured":"Hahn T, Yao S, Dunford LM, Thomas J, Lohr J et al (2009) A comparison of measured creatinine clearance versus calculated glomerular filtration rate for assessment of renal function before autologous and allogenic BMT. Biol Blood Marrow Transplant 15:574\u2013579","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-010-1192-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00402-010-1192-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-010-1192-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T20:20:08Z","timestamp":1685823608000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00402-010-1192-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,12]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["1192"],"URL":"https:\/\/doi.org\/10.1007\/s00402-010-1192-2","relation":{},"ISSN":["0936-8051","1434-3916"],"issn-type":[{"value":"0936-8051","type":"print"},{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,12]]}}}