{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:12:52Z","timestamp":1793239972511,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T00:00:00Z","timestamp":1436400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s00402-015-2277-8","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T04:58:00Z","timestamp":1436331480000},"page":"1307-1314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Incidence and risk factors for heterotopic ossification after total hip arthroplasty: a meta-analysis"],"prefix":"10.1007","volume":"135","author":[{"given":"Yanbin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,9]]},"reference":[{"issue":"4","key":"2277_CR1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1302\/0301-620X.89B4.18845","volume":"89","author":"T Board","year":"2007","unstructured":"Board T, Karva A, Board RE et al (2007) The prophylaxis and treatment of heterotopic ossification following lower limb arthroplasty. J Bone Jt Surg Br 89(4):434\u2013440","journal-title":"J Bone Jt Surg Br"},{"issue":"5","key":"2277_CR2","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.ijrobp.2006.03.053","volume":"65","author":"TA Balboni","year":"2006","unstructured":"Balboni TA, Gobezie R, Mamon HJ (2006) Heterotopic ossification: pathophysiology, clinical features, and the role of radiotherapy for prophylaxis. Int J Radiat Oncol Biol Phys 65(5):1289\u20131299","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"2277_CR3","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.arth.2005.08.014","volume":"21","author":"ST Chao","year":"2006","unstructured":"Chao ST, Lee S-Y, Borden LS et al (2006) External beam radiation helps prevent heterotopic bone formation in patients with a history of heterotopic ossification. J Arthroplast 21(5):731\u2013736","journal-title":"J Arthroplast"},{"issue":"2","key":"2277_CR4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0883-5403(97)90058-9","volume":"12","author":"HC Amstutz","year":"1997","unstructured":"Amstutz HC, Fowble VA, Schmalzried TP et al (1997) Short-course indomethacin prevents heterotopic ossification in a high-risk population following total hip arthroplasty. J Arthroplast 12(2):126\u2013132","journal-title":"J Arthroplast"},{"issue":"9","key":"2277_CR5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s004020100287","volume":"121","author":"S Eggli","year":"2001","unstructured":"Eggli S, Woo A (2001) Risk factors for heterotopic ossification in total hip arthroplasty. Arch Orthop Trauma Surg 121(9):531\u2013535","journal-title":"Arch Orthop Trauma Surg"},{"issue":"2","key":"2277_CR6","first-page":"174","volume":"66","author":"S Eggli","year":"2000","unstructured":"Eggli S, Rodriguez J, Ganz R (2000) Heterotopic ossification in total hip arthroplasty: the significance for clinical outcome. Acta Orthop Belg 66(2):174\u2013180","journal-title":"Acta Orthop Belg"},{"issue":"6","key":"2277_CR7","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.arth.2005.10.016","volume":"21","author":"T Higo","year":"2006","unstructured":"Higo T, Mawatari M, Shigematsu M et al (2006) The incidence of heterotopic ossification after cementless total hip arthroplasty. J Arthroplast 21(6):852\u2013856","journal-title":"J Arthroplast"},{"issue":"6","key":"2277_CR8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.5435\/00124635-200211000-00005","volume":"10","author":"R Iorio","year":"2002","unstructured":"Iorio R, Healy WL (2002) Heterotopic ossification after hip and knee arthroplasty: risk factors, prevention, and treatment. J Am Acad Orthop Surg 10(6):409\u2013416","journal-title":"J Am Acad Orthop Surg"},{"issue":"11","key":"2277_CR9","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2106\/JBJS.I.01435","volume":"92","author":"N Hamid","year":"2010","unstructured":"Hamid N, Ashraf N, Bosse MJ et al (2010) Radiation therapy for heterotopic ossification prophylaxis acutely after elbow trauma prospective randomized study. J Bone Jt Surg Am 92(11):2032\u20132038","journal-title":"J Bone Jt Surg Am"},{"issue":"3","key":"2277_CR10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1754-9485.2011.02275.x","volume":"55","author":"MV Mishra","year":"2011","unstructured":"Mishra MV, Austin L, Parvizi J et al (2011) Safety and efficacy of radiation therapy as secondary prophylaxis for heterotopic ossification of non-hip joints. J Med Imaging Radiat Oncol 55(3):333\u2013336","journal-title":"J Med Imaging Radiat Oncol"},{"issue":"2","key":"2277_CR11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/BF00932162","volume":"108","author":"N Pedersen","year":"1989","unstructured":"Pedersen N, Kristensen S, Schmidt S et al (1989) Factors associated with heterotopic bone formation following total hip replacement. Arch Orthop Trauma Surg 108(2):92\u201395","journal-title":"Arch Orthop Trauma Surg"},{"issue":"3","key":"2277_CR12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2106\/00004623-197759030-00009","volume":"59","author":"MA Ritter","year":"1977","unstructured":"Ritter MA, Vaughan RB (1977) Ectopic ossificationaftertotalhip arthroplasty. Predisposing factors, frequency, and effect on results. J Bone Jt Surg Am 59(3):345\u2013351","journal-title":"J Bone Jt Surg Am"},{"issue":"11","key":"2277_CR13","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00066-003-1088-y","volume":"179","author":"O Koelbl","year":"2003","unstructured":"Koelbl O, Seufert J, Pohl F et al (2003) Preoperative irradiation for prevention of heterotopic ossification following prosthetic total hip replacement. Strahlenther Onkol 179(11):767\u2013773","journal-title":"Strahlenther Onkol"},{"issue":"1","key":"2277_CR14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.5301\/HIP.2012.9057","volume":"22","author":"G Pavlou","year":"2012","unstructured":"Pavlou G, Salhab M, Jallad S et al (2012) Risk factors for heterotopic ossification in primary total hip arthroplasty. Hip Int 22(1):50\u201355","journal-title":"Hip Int"},{"issue":"5","key":"2277_CR15","first-page":"368","volume":"40","author":"K Nayak","year":"1997","unstructured":"Nayak K, Mulliken B, Rorabeck C et al (1997) Prevalence of heterotopic ossification in cemented versus noncemented total hip joint replacement in patients with osteoarthrosis: a randomized clinical trial. Can J Surg 40(5):368\u2013374","journal-title":"Can J Surg"},{"issue":"2","key":"2277_CR16","first-page":"135","volume":"37","author":"I Lieberman","year":"1994","unstructured":"Lieberman I, Moran E, Hastings D et al (1994) Heterotopic ossification after primary cemented and noncemented total hip arthroplasty in patients with osteoarthritis and rheumatoid arthritis. Can J Surg 37(2):135\u2013139","journal-title":"Can J Surg"},{"issue":"2","key":"2277_CR17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2106\/00004623-199173020-00006","volume":"73","author":"W Maloney","year":"1991","unstructured":"Maloney W, Krushell R, Jasty M et al (1991) Incidence of heterotopic ossification after total hip replacement: effect of the type of fixation of the femoral component. J Bone Jt Surg Am 73(2):191\u2013193","journal-title":"J Bone Jt Surg Am"},{"issue":"1","key":"2277_CR18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3928\/01477447-20091124-13","volume":"33","author":"M Kocic","year":"2010","unstructured":"Kocic M, Lazovic M, Mitkovic M et al (2010) Clinical significance of the heterotopic ossification after total hip arthroplasty. Orthopedics 33(1):16","journal-title":"Orthopedics"},{"issue":"1","key":"2277_CR19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0883-5403(96)80161-6","volume":"11","author":"JJ Purtill","year":"1996","unstructured":"Purtill JJ, Eng K, Rothman RH et al (1996) Heterotopic ossification: incidence in cemented versus cementless total hip arthroplasty. J Arthroplast 11(1):58\u201363","journal-title":"J Arthroplast"},{"issue":"3","key":"2277_CR20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00281-011-0240-5","volume":"33","author":"C Zeckey","year":"2011","unstructured":"Zeckey C, Hildebrand F, Frink M et al (2011) Heterotopic ossifications following implant surgery\u2014epidemiology, therapeutical approaches and current concepts. Semin Immunopathol 33(3):273\u2013286","journal-title":"Semin Immunopathol"},{"key":"2277_CR21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00003086-199102000-00005","volume":"263","author":"L Ahrengart","year":"1991","unstructured":"Ahrengart L (1991) Periarticular heterotopic ossification after total hip arthroplasty: risk factors and consequences. Clin Orthop Relat Res 263:49\u201358","journal-title":"Clin Orthop Relat Res"},{"key":"2277_CR22","unstructured":"Wells G, Shea B, O\u2019connell D et al (2000) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses"},{"issue":"9","key":"2277_CR23","doi-asserted-by":"crossref","first-page":"820","DOI":"10.7326\/0003-4819-127-9-199711010-00008","volume":"127","author":"J Lau","year":"1997","unstructured":"Lau J, Ioannidis JP, Schmid CH (1997) Quantitative synthesis in systematic reviews. Ann Intern Med 127(9):820\u2013826","journal-title":"Ann Intern Med"},{"issue":"2","key":"2277_CR24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/0300060513476438","volume":"41","author":"J Wei","year":"2013","unstructured":"Wei J, Yang T-B, Luo W et al (2013) Complications following dorsal versus volar plate fixation of distal radius fracture: a meta-analysis. J Int Med Res 41(2):265\u2013275","journal-title":"J Int Med Res"},{"issue":"6","key":"2277_CR25","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1210\/jc.2011-3058","volume":"97","author":"MT Drake","year":"2012","unstructured":"Drake MT, Murad MH, Mauck KF et al (2012) Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis. J Clin Endocrinol Metab 97(6):1861\u20131870","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2277_CR26","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00402-013-1723-8","volume":"133","author":"J Chen","year":"2013","unstructured":"Chen J, Cui Y, Li X et al (2013) Risk factors for deep infection after total knee arthroplasty: a meta-analysis. Arch Orthop Trauma Surg 133(5):675\u2013687","journal-title":"Arch Orthop Trauma Surg"},{"issue":"3","key":"2277_CR27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/rheumatology\/27.3.187","volume":"27","author":"H Fahrer","year":"1988","unstructured":"Fahrer H, Koch P, Ballmer P et al (1988) Ectopic ossification following total hip arthroplasty: is diffuse idiopathic skeletal hyperostosis a risk factor? Br J Rheumatol 27(3):187\u2013190","journal-title":"Br J Rheumatol"},{"issue":"1","key":"2277_CR28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/112070000901900108","volume":"19","author":"M Fransen","year":"2009","unstructured":"Fransen M, Neal B, Cameron ID et al (2009) Determinants of heterotopic ossification after total hip replacement surgery. Hip Int 19(1):41\u201346","journal-title":"Hip Int"},{"issue":"6","key":"2277_CR29","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00264-011-1446-9","volume":"36","author":"K Okano","year":"2012","unstructured":"Okano K, Aoyagi K, Osaki M et al (2012) Bone mineral density is not related to heterotopic ossification after total hip arthroplasty. Int Orthop 36(6):1163\u20131166","journal-title":"Int Orthop"},{"issue":"5","key":"2277_CR30","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1055\/s-2004-832310","volume":"142","author":"M Handel","year":"2003","unstructured":"Handel M, Brettschneider J, K\u00f6ck F et al (2003) Risk factors associated with heterotopic ossifications in primary total hip arthroplasty. Z Orthop Ihre Grenzgeb 142(5):564\u2013570","journal-title":"Z Orthop Ihre Grenzgeb"},{"issue":"2","key":"2277_CR31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/17453679308994567","volume":"64","author":"AJ Nollen","year":"1993","unstructured":"Nollen AJ, van Douveren FQ (1993) Ectopic ossification in hip arthroplasty: a retrospective study of predisposing factors in 637 cases. Acta Orthop Scand 64(2):185\u2013187","journal-title":"Acta Orthop Scand"},{"issue":"12","key":"2277_CR32","first-page":"910","volume":"27","author":"L Wu","year":"2007","unstructured":"Wu L, Wu F, Ye K et al (2007) Heterotopic ossification following primary total hip arthroplasty. Chin J Ortho 27(12):910\u2013914","journal-title":"Chin J Ortho"},{"issue":"003","key":"2277_CR33","first-page":"220","volume":"17","author":"Z Wang","year":"2012","unstructured":"Wang Z, Zhou J, Li Z et al (2012) Clinical study on heterotopic ossification after the operation of total hiparthroplasty and revision. Ana Clin 17(003):220\u2013223","journal-title":"Ana Clin"},{"issue":"5","key":"2277_CR34","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3109\/17453678308996614","volume":"54","author":"C Hierton","year":"1983","unstructured":"Hierton C, Blomgren G, Lindgren U (1983) Factors associated with heterotopic bone formation in cemented total hip prostheses. Acta Orthop Scand 54(5):698\u2013702","journal-title":"Acta Orthop Scand"},{"issue":"3","key":"2277_CR35","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0749-0712(21)01180-X","volume":"10","author":"H Hastings 2nd","year":"1994","unstructured":"Hastings H 2nd, Graham TJ (1994) The classification and treatment of heterotopic ossification about the elbow and forearm. Hand Clin 10(3):417\u2013437","journal-title":"Hand Clin"},{"issue":"5","key":"2277_CR36","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.bone.2006.05.023","volume":"39","author":"G Schmidmaier","year":"2006","unstructured":"Schmidmaier G, Herrmann S, Green J et al (2006) Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation. Bone 39(5):1156\u20131163","journal-title":"Bone"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-015-2277-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00402-015-2277-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-015-2277-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T16:28:35Z","timestamp":1652804915000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00402-015-2277-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["2277"],"URL":"https:\/\/doi.org\/10.1007\/s00402-015-2277-8","relation":{},"ISSN":["0936-8051","1434-3916"],"issn-type":[{"value":"0936-8051","type":"print"},{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,9]]}}}