{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:17:01Z","timestamp":1785377821733,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,4,9]],"date-time":"2016-04-09T00:00:00Z","timestamp":1460160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Deutsche Arthrosehilfe e.V."},{"name":"Oscar-Helene-Stiftung"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s00402-016-2453-5","type":"journal-article","created":{"date-parts":[[2016,4,9]],"date-time":"2016-04-09T06:23:05Z","timestamp":1460182985000},"page":"891-897","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Cartilage repair surgery for full-thickness defects of the knee in Germany: indications and epidemiological data from the German Cartilage Registry (KnorpelRegister DGOU)"],"prefix":"10.1007","volume":"136","author":[{"given":"Philipp","family":"Niemeyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias J.","family":"Feucht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Fritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Spahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Angele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,9]]},"reference":[{"issue":"4","key":"2453_CR1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00167-009-1028-1","volume":"18","author":"E Basad","year":"2010","unstructured":"Basad E, Ishaque B, Bachmann G, Sturz H, Steinmeyer J (2010) Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: a 2-year randomised study. Knee Surg Sports Traumatol Arthrosc 18(4):519\u2013527","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"7","key":"2453_CR2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00402-015-2235-5","volume":"135","author":"C Becher","year":"2015","unstructured":"Becher C, Ettinger M, Ezechieli M, Kaps C, Ewig M, Smith T (2015) Repair of retropatellar cartilage defects in the knee with microfracture and a cell-free polymer-based implant. Arch Orthop Trauma Surg 135(7):1003\u20131010","journal-title":"Arch Orthop Trauma Surg"},{"issue":"7","key":"2453_CR3","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1002\/art.21148","volume":"52","author":"F Cicuttini","year":"2005","unstructured":"Cicuttini F, Ding C, Wluka A, Davis S, Ebeling PR, Jones G (2005) Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: a prospective study. Arthritis Rheum 52(7):2033\u20132039","journal-title":"Arthritis Rheum"},{"issue":"7","key":"2453_CR4","first-page":"1778","volume":"91","author":"BJ Cole","year":"2009","unstructured":"Cole BJ, Pascual-Garrido C, Grumet RC (2009) Surgical management of articular cartilage defects in the knee. J Bone Joint Surg Am 91(7):1778\u20131790","journal-title":"J Bone Joint Surg Am"},{"issue":"4","key":"2453_CR5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/1947603510373917","volume":"1","author":"CN Engen","year":"2010","unstructured":"Engen CN, Engebretsen L (2010) Knee cartilage defect patients enrolled in randomized controlled trials are not representative of patients in orthopedic practice. Cartilage 1(4):312\u2013319","journal-title":"Cartilage"},{"issue":"2","key":"2453_CR6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/0363546509352157","volume":"38","author":"S Heir","year":"2010","unstructured":"Heir S, Nerhus TK, Rotterud JH, Loken S, Ekeland A, Engebretsen L, Aroen A (2010) Focal cartilage defects in the knee impair quality of life as much as severe osteoarthritis: a comparison of knee injury and osteoarthritis outcome score in 4 patient categories scheduled for knee surgery. Am J Sports Med 38(2):231\u2013237","journal-title":"Am J Sports Med"},{"issue":"7","key":"2453_CR7","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1053\/jars.2002.32839","volume":"18","author":"K Hjelle","year":"2002","unstructured":"Hjelle K, Solheim E, Strand T, Muri R, Brittberg M (2002) Articular cartilage defects in 1,000 knee arthroscopies. Arthroscopy 18(7):730\u2013734","journal-title":"Arthroscopy"},{"issue":"6","key":"2453_CR8","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1053\/joca.2002.0801","volume":"10","author":"EB Hunziker","year":"2002","unstructured":"Hunziker EB (2002) Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthr Cartil 10(6):432\u2013463","journal-title":"Osteoarthr Cartil"},{"issue":"Suppl 1","key":"2453_CR9","doi-asserted-by":"crossref","first-page":"167S","DOI":"10.1177\/0363546509351650","volume":"37","author":"K Mithoefer","year":"2009","unstructured":"Mithoefer K, Hambly K, Della Villa S, Silvers H, Mandelbaum BR (2009) Return to sports participation after articular cartilage repair in the knee: scientific evidence. Am J Sports Med 37(Suppl 1):167S\u2013176S","journal-title":"Am J Sports Med"},{"issue":"1","key":"2453_CR10","first-page":"38","volume":"151","author":"P Niemeyer","year":"2013","unstructured":"Niemeyer P, Andereya S, Angele P, Ateschrang A, Aurich M, Baumann M, Behrens P, Bosch U, Erggelet C, Fickert S et al (2013) Autologous Chondrocyte Implantation (ACI) for Cartilage Defects of the Knee: a Guideline by the Working Group \u201cTissue Regeneration\u201d of the German Society of Orthopaedic Surgery and Traumatology (DGOU). Z Orthop Unfall 151(1):38\u201347","journal-title":"Z Orthop Unfall"},{"issue":"1","key":"2453_CR11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1055\/s-2007-963030","volume":"21","author":"P Niemeyer","year":"2007","unstructured":"Niemeyer P, Kreuz PC, Steinwachs M, Sudkamp NP (2007) Operative treatment of cartilage lesions in the knee joint. Sportverletz Sportschaden 21(1):41\u201350","journal-title":"Sportverletz Sportschaden"},{"issue":"11","key":"2453_CR12","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1177\/0363546508322131","volume":"36","author":"P Niemeyer","year":"2008","unstructured":"Niemeyer P, Pestka JM, Kreuz PC, Erggelet C, Schmal H, Suedkamp NP, Steinwachs M (2008) Characteristic complications after autologous chondrocyte implantation for cartilage defects of the knee joint. Am J Sports Med 36(11):2091\u20132099","journal-title":"Am J Sports Med"},{"issue":"1","key":"2453_CR13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1055\/s-0034-1383222","volume":"153","author":"P Niemeyer","year":"2015","unstructured":"Niemeyer P, Schweigler K, Grotejohann B, Maurer J, Angele P, Aurich M, Becher C, Fay J, Feil R, Fickert S et al (2015) The German Cartilage Registry (KnorpelRegister DGOU) for evaluation of surgical treatment for cartilage defects: experience after 6\u00a0months including first demographic data. Z Orthop Unfall 153(1):67\u201374","journal-title":"Z Orthop Unfall"},{"issue":"6","key":"2453_CR14","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00402-015-2194-x","volume":"135","author":"P Niemeyer","year":"2015","unstructured":"Niemeyer P, Uhl M, Salzmann GM, Morscheid YP, Sudkamp NP, Madry H (2015) Evaluation and analysis of graft hypertrophy by means of arthroscopy, biochemical MRI and osteochondral biopsies in a patient following autologous chondrocyte implantation for treatment of a full-thickness-cartilage defect of the knee. Arch Orthop Trauma Surg 135(6):819\u2013830","journal-title":"Arch Orthop Trauma Surg"},{"issue":"2","key":"2453_CR15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2519\/jospt.1998.28.2.88","volume":"28","author":"EM Roos","year":"1998","unstructured":"Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD (1998) Knee Injury and Osteoarthritis Outcome Score (KOOS)\u2013development of a self-administered outcome measure. J Orthop Sports Phys Ther 28(2):88\u201396","journal-title":"J Orthop Sports Phys Ther"},{"issue":"6","key":"2453_CR16","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1177\/0363546514528093","volume":"42","author":"D Saris","year":"2014","unstructured":"Saris D, Price A, Widuchowski W, Bertrand-Marchand M, Caron J, Drogset JO, Emans P, Podskubka A, Tsuchida A, Kili S et al (2014) Matrix-applied characterized autologous cultured chondrocytes versus microfracture: 2-year follow-up of a prospective randomized trial. Am J Sports Med 42(6):1384\u20131394","journal-title":"Am J Sports Med"},{"issue":"Suppl 1","key":"2453_CR17","doi-asserted-by":"crossref","first-page":"10S","DOI":"10.1177\/0363546509350694","volume":"37","author":"DB Saris","year":"2009","unstructured":"Saris DB, Vanlauwe J, Victor J, Almqvist KF, Verdonk R, Bellemans J, Luyten FP (2009) Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36\u00a0months in a randomized trial compared to microfracture. Am J Sports Med 37(Suppl 1):10S\u201319S","journal-title":"Am J Sports Med"},{"issue":"2","key":"2453_CR18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/0363546507311095","volume":"36","author":"DB Saris","year":"2008","unstructured":"Saris DB, Vanlauwe J, Victor J, Haspl M, Bohnsack M, Fortems Y, Vandekerckhove B, Almqvist KF, Claes T, Handelberg F et al (2008) Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med 36(2):235\u2013246","journal-title":"Am J Sports Med"},{"issue":"2","key":"2453_CR19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/jor.21521","volume":"30","author":"M Schinhan","year":"2012","unstructured":"Schinhan M, Gruber M, Vavken P, Dorotka R, Samouh L, Chiari C, Gruebl-Barabas R, Nehrer S (2012) Critical-size defect induces unicompartmental osteoarthritis in a stable ovine knee. J Orthop Res 30(2):214\u2013220","journal-title":"J Orthop Res"},{"key":"2453_CR20","doi-asserted-by":"publisher","unstructured":"Solheim E, Krokeide AM, Melteig P, Larsen A, Strand T, Brittberg M (2014) Symptoms and function in patients with articular cartilage lesions in 1000 knee arthroscopies. Knee Surg Sports Traumatol Arthrosc. doi: 10.1007\/s00167-014-3472-9","DOI":"10.1007\/s00167-014-3472-9"},{"issue":"4","key":"2453_CR21","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s00167-009-0974-y","volume":"18","author":"E Solheim","year":"2010","unstructured":"Solheim E, Oyen J, Hegna J, Austgulen OK, Harlem T, Strand T (2010) Microfracture treatment of single or multiple articular cartilage defects of the knee: a 5-year median follow-up of 110 patients. Knee Surg Sports Traumatol Arthrosc 18(4):504\u2013508","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"12","key":"2453_CR22","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1177\/0363546511422220","volume":"39","author":"J Vanlauwe","year":"2011","unstructured":"Vanlauwe J, Saris DB, Victor J, Almqvist KF, Bellemans J, Luyten FP (2011) Tig\/Act, Group EXTS. Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: early treatment matters. Am J Sports Med 39(12):2566\u20132574","journal-title":"Am J Sports Med"},{"issue":"6","key":"2453_CR23","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.injury.2011.06.033","volume":"43","author":"J Vaquero","year":"2012","unstructured":"Vaquero J, Forriol F (2012) Knee chondral injuries: clinical treatment strategies and experimental models. Injury 43(6):694\u2013705","journal-title":"Injury"},{"issue":"3","key":"2453_CR24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.knee.2007.02.001","volume":"14","author":"W Widuchowski","year":"2007","unstructured":"Widuchowski W, Widuchowski J, Trzaska T (2007) Articular cartilage defects: study of 25,124 knee arthroscopies. Knee 14(3):177\u2013182","journal-title":"Knee"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-016-2453-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00402-016-2453-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-016-2453-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T17:42:13Z","timestamp":1559065333000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00402-016-2453-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,9]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["2453"],"URL":"https:\/\/doi.org\/10.1007\/s00402-016-2453-5","relation":{},"ISSN":["0936-8051","1434-3916"],"issn-type":[{"value":"0936-8051","type":"print"},{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,9]]}}}