{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:44:26Z","timestamp":1789825466212,"version":"4.0.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s00402-016-2574-x","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T08:33:49Z","timestamp":1476261229000},"page":"1753-1759","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The value of arthroscopic neosynovium biopsies to diagnose periprosthetic knee joint low-grade infection"],"prefix":"10.1007","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5212-9744","authenticated-orcid":false,"given":"Leif","family":"Claassen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Ettinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Frederic","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Budde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Windhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Floerkemeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,12]]},"reference":[{"key":"2574_CR1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/0974909820130103","volume":"47","author":"VK Aggarwal","year":"2013","unstructured":"Aggarwal VK, Rasouli MR, Parvizi J (2013) Periprosthetic joint infection: current concept. Indian J Orthop 47:10\u201317","journal-title":"Indian J Orthop"},{"key":"2574_CR2","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1302\/0301-620X.84B7.13637","volume":"84","author":"R Allum","year":"2002","unstructured":"Allum R (2002) Complications of arthroscopy of the knee. J Bone Jt Surg Br 84:937\u2013945","journal-title":"J Bone Jt Surg Br"},{"key":"2574_CR3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11999-010-1433-2","volume":"469","author":"H Bedair","year":"2011","unstructured":"Bedair H, Ting N, Jacovides C, Saxena A, Moric M, Parvizi J, Della Valle CJ (2011) The Mark Coventry Award: diagnosis of early postoperative TKA infection using synovial fluid analysis. Clin Orthop Relat Res 469:34\u201340","journal-title":"Clin Orthop Relat Res"},{"key":"2574_CR4","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.2106\/JBJS.I.01199","volume":"92","author":"E Berbari","year":"2010","unstructured":"Berbari E, Mabry T, Tsaras G, Spangehl M, Erwin PJ, Murad MH, Steckelberg J, Osmon D (2010) Inflammatory blood laboratory levels as markers of prosthetic joint infection: a systematic review and meta-analysis. J Bone Jt Surg Am 92:2102\u20132109","journal-title":"J Bone Jt Surg Am"},{"key":"2574_CR5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2174\/1874325001509010049","volume":"9","author":"L Claassen","year":"2015","unstructured":"Claassen L, Plaass C, Daniilidis K, Calliess T, von Lewinski G (2015) Two-stage revision total knee arthroplasty in cases of periprosthetic joint infection: an analysis of 50 cases. Open Orthop J 9:49\u201356","journal-title":"Open Orthop J"},{"key":"2574_CR6","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.4081\/or.2014.5437","volume":"6","author":"L Claassen","year":"2014","unstructured":"Claassen L, Radtke K, Ettinger M, Plaass C, von Lewinski G (2014) Preoperative diagnostic for periprosthetic joint infection prior to total knee revision arthroplasty. Orthop Rev (Pavia) 6:5437","journal-title":"Orthop Rev (Pavia)"},{"issue":"8","key":"2574_CR7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.arth.2013.04.051","volume":"28","author":"DF Dalury","year":"2013","unstructured":"Dalury DF, Pomeroy DL, Gorab RS, Adams MJ (2013) Why are total knee arthroplasties being revised? J Arthroplast Volume 28(8):120\u2013121","journal-title":"J Arthroplast"},{"key":"2574_CR8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00003086-199610000-00018","volume":"331","author":"GP Duff","year":"1996","unstructured":"Duff GP, Lachiewicz PF, Kelley SS (1996) Aspiration of the knee joint before revision arthroplasty. Clin Orthop Relat Res 331:132\u2013139","journal-title":"Clin Orthop Relat Res"},{"key":"2574_CR9","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/cid\/civ286","volume":"61","author":"M Ettinger","year":"2015","unstructured":"Ettinger M, Calliess T, Kielstein JT, Sibai J, Bruckner T, Lichtinghagen R, Windhagen H, Lukasz A (2015) Circulating biomarkers for discrimination between aseptic joint failure, low-grade infection, and high-grade septic failure. Clin Infect Dis 61:332\u2013341","journal-title":"Clin Infect Dis"},{"key":"2574_CR10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1055\/s-2004-836252","volume":"143","author":"M Fuerst","year":"2005","unstructured":"Fuerst M, Fink B, Ruther W (2005) The value of preoperative knee aspiration and arthroscopic biopsy in revision total knee arthroplasty. Z Orthop Ihre Grenzgeb 143:36\u201341","journal-title":"Z Orthop Ihre Grenzgeb"},{"key":"2574_CR11","first-page":"411","volume":"61","author":"KL Garvin","year":"2012","unstructured":"Garvin KL, Konigsberg BS (2012) Infection following total knee arthroplasty: prevention and management. Instr Course Lect 61:411\u2013419","journal-title":"Instr Course Lect"},{"issue":"8","key":"2574_CR12","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1007\/s11999-013-2998-3","volume":"471","author":"M Glehr","year":"2013","unstructured":"Glehr M, Friesenbichler J, Hofmann G, Bernhardt GA, Zacherl M, Avian A, Windhager R, Leithner A (2013) Novel biomarkers to detect infection in revision hip and knee arthroplasties. Clin Orthop Relat Res 471(8):2621\u20132628","journal-title":"Clin Orthop Relat Res"},{"key":"2574_CR13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/17453670902805064","volume":"80","author":"E Jamsen","year":"2009","unstructured":"Jamsen E, Stogiannidis I, Malmivaara A, Pajamaki J, Puolakka T, Konttinen YT (2009) Outcome of prosthesis exchange for infected knee arthroplasty: the effect of treatment approach. Acta Orthop 80:67\u201377","journal-title":"Acta Orthop"},{"key":"2574_CR14","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s00402-015-2317-4","volume":"135","author":"V Janz","year":"2015","unstructured":"Janz V, Wassilew GI, Kribus M, Trampuz A, Perka C (2015) Improved identification of polymicrobial infection in total knee arthroplasty through sonicate fluid cultures. Arch Orthop Trauma Surg 135:1453\u20131457","journal-title":"Arch Orthop Trauma Surg"},{"key":"2574_CR15","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s00402-015-2286-7","volume":"135","author":"YH Kim","year":"2015","unstructured":"Kim YH, Park JW, Kim JS, Kim DJ (2015) The outcome of infected total knee arthroplasty: culture-positive versus culture-negative. Arch Orthop Trauma Surg 135:1459\u20131467","journal-title":"Arch Orthop Trauma Surg"},{"key":"2574_CR16","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00402-015-2237-3","volume":"135","author":"IJ Koh","year":"2015","unstructured":"Koh IJ, Han SB, In Y, Oh KJ, Lee DH, Kim TK, Team Knee Multicenter Collaboration (2015) Open debridement and prosthesis retention is a viable treatment option for acute periprosthetic joint infection after total knee arthroplasty. Arch Orthop Trauma Surg 135:847\u2013855","journal-title":"Arch Orthop Trauma Surg"},{"key":"2574_CR17","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.prp.2014.09.017","volume":"210","author":"V Krenn","year":"2014","unstructured":"Krenn V, Morawietz L, Perino G, Kienapfel H, Ascherl R, Hassenpflug GJ, Thomsen M, Thomas P, Huber M, Kendoff D, Baumhoer D, Krukemeyer MG, Natu S, Boettner F, Zustin J, Kolbel B, Ruther W, Kretzer JP, Tiemann A, Trampuz A, Frommelt L, Tichilow R, Soder S, Muller S, Parvizi J, Illgner U, Gehrke T (2014) Revised histopathological consensus classification of joint implant related pathology. Pathol Res Pract 210:779\u2013786","journal-title":"Pathol Res Pract"},{"key":"2574_CR18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00292-011-1418-2","volume":"32","author":"V Krenn","year":"2011","unstructured":"Krenn V, Morawietz L, Jakobs M, Kienapfel H, Ascherl R, Bause L, Kuhn H, Matziolis G, Skutek M, Gehrke T (2011) Joint endoprosthesis pathology. Histopathological diagnostics and classification. Pathologe 32:210\u2013219","journal-title":"Pathologe"},{"key":"2574_CR19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s00132-008-1400-8","volume":"38","author":"V Krenn","year":"2009","unstructured":"Krenn V, Otto M, Morawietz L, Hopf T, Jakobs M, Klauser W, Schwantes B, Gehrke T (2009) Histopathologic diagnostics in endoprosthetics: periprosthetic neosynovialitis, hypersensitivity reaction, and arthrofibrosis. Orthopade 38:520\u2013530","journal-title":"Orthopade"},{"key":"2574_CR20","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1007\/s11999-010-1619-7","volume":"469","author":"SK Kusuma","year":"2011","unstructured":"Kusuma SK, Ward J, Jacofsky M, Sporer SM, Della Valle CJ (2011) What is the role of serological testing between stages of two-stage reconstruction of the infected prosthetic knee? Clin Orthop Relat Res 469:1002\u20131008","journal-title":"Clin Orthop Relat Res"},{"key":"2574_CR21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0883-5403(03)00453-4","volume":"19","author":"R Malhotra","year":"2004","unstructured":"Malhotra R, Morgan DA (2004) Role of core biopsy in diagnosing infection before revision hip arthroplasty. J Arthroplast 19:78\u201387","journal-title":"J Arthroplast"},{"key":"2574_CR22","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/1471-2474-14-222","volume":"14","author":"JP Masters","year":"2013","unstructured":"Masters JP, Smith NA, Foguet P, Reed M, Parsons H, Sprowson AP (2013) A systematic review of the evidence for single stage and two stage revision of infected knee replacement. BMC Musculoskelet Disord 14:222","journal-title":"BMC Musculoskelet Disord"},{"key":"2574_CR23","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1136\/jcp.2005.027458","volume":"59","author":"L Morawietz","year":"2006","unstructured":"Morawietz L, Classen RA, Schroder JH, Dynybil C, Perka C, Skwara A, Neidel J, Gehrke T, Frommelt L, Hansen T, Otto M, Barden B, Aigner T, Stiehl P, Schubert T, Meyer-Scholten C, Konig A, Strobel P, Rader CP, Kirschner S, Lintner F, Ruther W, Bos I, Hendrich C, Kriegsmann J, Krenn V (2006) Proposal for a histopathological consensus classification of the periprosthetic interface membrane. J Clin Pathol 59:591\u2013597","journal-title":"J Clin Pathol"},{"key":"2574_CR24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00292-004-0710-9","volume":"25","author":"L Morawietz","year":"2004","unstructured":"Morawietz L, Gehrke T, Classen RA, Barden B, Otto M, Hansen T, Aigner T, Stiehl P, Neidel J, Schroder JH, Frommelt L, Schubert T, Meyer-Scholten C, Konig A, Strobel P, Rader C, Kirschner S, Lintner F, Ruther W, Skwara A, Bos I, Kriegsmann J, Krenn V (2004) Proposal for the classification of the periprosthetic membrane from loosened hip and knee endoprostheses. Pathologe 25:375\u2013384","journal-title":"Pathologe"},{"key":"2574_CR25","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1007\/s11999-010-1308-6","volume":"468","author":"SM Mortazavi","year":"2010","unstructured":"Mortazavi SM, Schwartzenberger J, Austin MS, Purtill JJ, Parvizi J (2010) Revision total knee arthroplasty infection: incidence and predictors. Clin Orthop Relat Res 468:2052\u20132059","journal-title":"Clin Orthop Relat Res"},{"key":"2574_CR26","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1007\/s11999-011-1971-2","volume":"469","author":"J Parvizi","year":"2011","unstructured":"Parvizi J, Jacovides C, Zmistowski B, Jung KA (2011) Definition of periprosthetic joint infection: is there a consensus? Clin Orthop Relat Res 469:3022\u20133030","journal-title":"Clin Orthop Relat Res"},{"key":"2574_CR27","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1007\/s11999-008-0471-5","volume":"466","author":"J Parvizi","year":"2008","unstructured":"Parvizi J, Ghanem E, Sharkey P, Aggarwal A, Burnett RS, Barrack RL (2008) Diagnosis of infected total knee: findings of a multicenter database. Clin Orthop Relat Res 466:2628\u20132633","journal-title":"Clin Orthop Relat Res"},{"key":"2574_CR28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00003086-200111000-00003","volume":"392","author":"G Peersman","year":"2001","unstructured":"Peersman G, Laskin R, Davis J, Peterson M (2001) Infection in total knee replacement: a retrospective review of 6489 total knee replacements. Clin Orthop Relat Res 392:15\u201323","journal-title":"Clin Orthop Relat Res"},{"key":"2574_CR29","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1007\/s00167-012-1885-x","volume":"20","author":"CL Romano","year":"2012","unstructured":"Romano CL, Gala L, Logoluso N, Romano D, Drago L (2012) Two-stage revision of septic knee prosthesis with articulating knee spacers yields better infection eradication rate than one-stage or two-stage revision with static spacers. Knee Surg Sports Traumatol Arthrosc 20:2445\u20132453","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"2574_CR30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00264-010-1014-8","volume":"35","author":"M Schindler","year":"2011","unstructured":"Schindler M, Christofilopoulos P, Wyssa B, Belaieff W, Garzoni C, Bernard L, Lew D, Hoffmeyer P, Uckay I (2011) Poor performance of microbiological sampling in the prediction of recurrent arthroplasty infection. Int Orthop 35:647\u2013654","journal-title":"Int Orthop"},{"key":"2574_CR31","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2214\/AJR.10.5160","volume":"196","author":"MW Squire","year":"2011","unstructured":"Squire MW, Della Valle CJ, Parvizi J (2011) Preoperative diagnosis of periprosthetic joint infection: role of aspiration. AJR Am J Roentgenol 196:875\u2013879","journal-title":"AJR Am J Roentgenol"},{"key":"2574_CR32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.knee.2014.10.005","volume":"22","author":"J Stammers","year":"2015","unstructured":"Stammers J, Kahane S, Ranawat V, Miles J, Pollock R, Carrington RW, Briggs T, Skinner JA (2015) Outcomes of infected revision knee arthroplasty managed by two-stage revision in a tertiary referral centre. Knee 22:56\u201362","journal-title":"Knee"},{"issue":"1","key":"2574_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10195-014-0294-y","volume":"16","author":"M Vasso","year":"2014","unstructured":"Vasso M, Schiavone Panni A (2014) Low-grade periprosthetic knee infection: diagnosis and management. J Orthop Traumatol Volume 16(1):1\u20137","journal-title":"J Orthop Traumatol"},{"key":"2574_CR34","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.arth.2003.11.011","volume":"19","author":"JL Williams","year":"2004","unstructured":"Williams JL, Norman P, Stockley I (2004) The value of hip aspiration versus tissue biopsy in diagnosing infection before exchange hip arthroplasty surgery. J Arthroplasty 19:582\u2013586","journal-title":"J Arthroplasty"},{"key":"2574_CR35","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.arth.2011.09.026","volume":"26","author":"Workgroup Convened by the Musculoskeletal Infection Society","year":"2011","unstructured":"Workgroup Convened by the Musculoskeletal Infection Society (2011) New definition for periprosthetic joint infection. J Arthroplast 26:1136\u20131138","journal-title":"J Arthroplast"},{"issue":"9","key":"2574_CR36","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.arth.2013.02.021","volume":"28","author":"B Zmistowski","year":"2013","unstructured":"Zmistowski B, Tetreault MW, Alijanipour P, Chen AF, Della Valle CJ, Parvizi J (2013) Recurrent periprosthetic joint infection: persistent or new infection? J Arthroplast 28(9):1486\u20131489","journal-title":"J Arthroplast"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-016-2574-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00402-016-2574-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-016-2574-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T09:56:42Z","timestamp":1568455002000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00402-016-2574-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,12]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["2574"],"URL":"https:\/\/doi.org\/10.1007\/s00402-016-2574-x","relation":{},"ISSN":["0936-8051","1434-3916"],"issn-type":[{"value":"0936-8051","type":"print"},{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,12]]}}}