{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:41:58Z","timestamp":1783579318881,"version":"3.55.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100010267","name":"BVOT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010267","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s00402-019-03326-0","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T09:04:46Z","timestamp":1576227886000},"page":"1029-1035","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Traumatic brain injury enhances the formation of heterotopic ossification around the hip: an animal model study"],"prefix":"10.1007","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-4127","authenticated-orcid":false,"given":"Joris","family":"Anthonissen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Theressa","family":"Steffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Alessandri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Baranowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pol Maria","family":"Rommens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Victor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"3326_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1302\/2046-3758.23.2000152","volume":"2","author":"MP Sullivan","year":"2013","unstructured":"Sullivan MP, Torres SJ, Mehta S, Ahn J (2013) Heterotopic ossification after central nervous system trauma: a current review. Bone Jt Res 2:51\u201357. https:\/\/doi.org\/10.1302\/2046-3758.23.2000152","journal-title":"Bone Jt Res"},{"key":"3326_CR2","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/j.injury.2007.03.019","volume":"38","author":"LL Simonsen","year":"2007","unstructured":"Simonsen LL, Sonne-Holm S, Krasheninnikoff M, Engberg AW (2007) Symptomatic heterotopic ossification after very severe traumatic brain injury in 114 patients: incidence and risk factors. Injury 38:1146\u20131150. https:\/\/doi.org\/10.1016\/j.injury.2007.03.019","journal-title":"Injury"},{"key":"3326_CR3","first-page":"351","volume":"66","author":"LL Jensen","year":"1987","unstructured":"Jensen LL, Halar E, Little JW, Brooke MM (1987) Neurogenic heterotopic ossification. Am J Phys Med 66:351\u2013363","journal-title":"Am J Phys Med"},{"key":"3326_CR4","doi-asserted-by":"publisher","first-page":"683","DOI":"10.2106\/00004623-197658050-00019","volume":"58","author":"SL Stover","year":"1976","unstructured":"Stover SL, Niemann KM, Miller JM 3rd (1976) Disodium etidronate in the prevention of postoperative recurrence of heterotopic ossification in spinal-cord injury patients. J Bone Jt Surg Am 58:683\u2013688","journal-title":"J Bone Jt Surg Am"},{"key":"3326_CR5","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.ijrobp.2006.03.053","volume":"65","author":"TA Balboni","year":"2006","unstructured":"Balboni TA, Gobezie R, Mamon HJ (2006) Heterotopic ossification: pathophysiology, clinical features, and the role of radiotherapy for prophylaxis. Int J Radiat Oncol Biol Phys 65:1289\u20131299. https:\/\/doi.org\/10.1016\/j.ijrobp.2006.03.053","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"3326_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3233\/NRE-2011-0643","volume":"28","author":"J-AL Aubut","year":"2011","unstructured":"Aubut J-AL, Mehta S, Cullen N et al (2011) A comparison of heterotopic ossification treatment within the traumatic brain and spinal cord injured population: an evidence based systematic review. NeuroRehabilitation 28:151\u2013160. https:\/\/doi.org\/10.3233\/NRE-2011-0643","journal-title":"NeuroRehabilitation"},{"key":"3326_CR7","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1089\/neu.2007.0342","volume":"24","author":"B Chalidis","year":"2007","unstructured":"Chalidis B, Stengel D, Giannoudis PV (2007) Early excision and late excision of heterotopic ossification after traumatic brain injury are equivalent: a systematic review of the literature. J Neurotrauma 24:1675\u20131686. https:\/\/doi.org\/10.1089\/neu.2007.0342","journal-title":"J Neurotrauma"},{"key":"3326_CR8","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1080\/02699050802158235","volume":"22","author":"AM Toffoli","year":"2008","unstructured":"Toffoli AM, Gautschi OP, Frey SP et al (2008) From brain to bone: evidence for the release of osteogenic humoral factors after traumatic brain injury. Brain Inj 22:511\u2013518. https:\/\/doi.org\/10.1080\/02699050802158235","journal-title":"Brain Inj"},{"key":"3326_CR9","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/j.1445-2197.2008.04803.x","volume":"79","author":"OP Gautschi","year":"2009","unstructured":"Gautschi OP, Cadosch D, Frey SP et al (2009) Serum-mediated osteogenic effect in traumatic brain-injured patients. ANZ J Surg 79:449\u2013455. https:\/\/doi.org\/10.1111\/j.1445-2197.2008.04803.x","journal-title":"ANZ J Surg"},{"key":"3326_CR10","doi-asserted-by":"publisher","first-page":"2790","DOI":"10.1007\/s11999-015-4323-9","volume":"473","author":"ZW Lazard","year":"2015","unstructured":"Lazard ZW, Olmsted-Davis EA, Salisbury EA et al (2015) Osteoblasts have a neural origin in heterotopic ossification. Clin Orthop Relat Res 473:2790\u20132806. https:\/\/doi.org\/10.1007\/s11999-015-4323-9","journal-title":"Clin Orthop Relat Res"},{"key":"3326_CR11","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1002\/jcb.23225","volume":"112","author":"E Salisbury","year":"2011","unstructured":"Salisbury E, Rodenberg E, Sonnet C et al (2011) Sensory nerve induced inflammation contributes to heterotopic ossification. J Cell Biochem 112:2748\u20132758. https:\/\/doi.org\/10.1002\/jcb.23225","journal-title":"J Cell Biochem"},{"key":"3326_CR12","first-page":"197","volume":"49","author":"J Anthonissen","year":"2015","unstructured":"Anthonissen J, Ossendorf C, Hock JL et al (2015) A new small-animal model for the study of acquired heterotopic ossification after hip surgery. Acta Orthop Traumatol Turc 49:197\u2013202","journal-title":"Acta Orthop Traumatol Turc"},{"key":"3326_CR13","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0165-0270(91)90104-8","volume":"39","author":"CE Dixon","year":"1991","unstructured":"Dixon CE, Clifton GL, Lighthall JW et al (1991) A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Methods 39:253\u2013262","journal-title":"J Neurosci Methods"},{"key":"3326_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.11.019","author":"J Anthonissen","year":"2015","unstructured":"Anthonissen J, Ossendorf C, Hock JL et al (2015) The role of muscular trauma in the development of heterotopic ossification after hip surgery: an animal-model study in rats. Injury. https:\/\/doi.org\/10.1016\/j.injury.2015.11.019","journal-title":"Injury"},{"key":"3326_CR15","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1097\/00007632-199404000-00002","volume":"19","author":"KJ Renfree","year":"1994","unstructured":"Renfree KJ, Banovac K, Hornicek FJ et al (1994) Evaluation of serum osteoblast mitogenic activity in spinal cord and head injury patients with acute heterotopic ossification. Spine 19:740\u2013746","journal-title":"Spine"},{"key":"3326_CR16","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jot.2017.10.002","volume":"12","author":"H Huang","year":"2018","unstructured":"Huang H, Cheng W-X, Hu Y-P et al (2018) Relationship between heterotopic ossification and traumatic brain injury: why severe traumatic brain injury increases the risk of heterotopic ossification. J Orthop Transl 12:16\u201325. https:\/\/doi.org\/10.1016\/j.jot.2017.10.002","journal-title":"J Orthop Transl"},{"key":"3326_CR17","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s11845-016-1399-5","volume":"185","author":"\u00c9 Smith","year":"2016","unstructured":"Smith \u00c9, Comiskey C, Carroll \u00c1 (2016) Prevalence of and risk factors for osteoporosis in adults with acquired brain injury. Ir J Med Sci 185:473\u2013481. https:\/\/doi.org\/10.1007\/s11845-016-1399-5","journal-title":"Ir J Med Sci"},{"key":"3326_CR18","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1097\/01.phm.0000214275.69286.7a","volume":"85","author":"G Beaupre","year":"2006","unstructured":"Beaupre G, Lew H (2006) Bone-density changes after stroke. Am J Phys Med Rehabil 85:464\u2013472. https:\/\/doi.org\/10.1097\/01.phm.0000214275.69286.7a","journal-title":"Am J Phys Med Rehabil"},{"key":"3326_CR19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1302\/0301-620X.57B1.36","volume":"57","author":"J Chalmers","year":"1975","unstructured":"Chalmers J, Gray DH, Rush J (1975) Observations on the induction of bone in soft tissues. J Bone Jt Surg Br 57:36\u201345","journal-title":"J Bone Jt Surg Br"},{"key":"3326_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3109\/02699058809150942","volume":"2","author":"TA Gennarelli","year":"1988","unstructured":"Gennarelli TA (1988) Heterotopic ossification. Brain Inj 2:175\u2013178","journal-title":"Brain Inj"},{"key":"3326_CR21","first-page":"230","volume":"12","author":"VI Sakellariou","year":"2012","unstructured":"Sakellariou VI, Grigoriou E, Mavrogenis AF et al (2012) Heterotopic ossification following traumatic brain injury and spinal cord injury: insight into the etiology and pathophysiology. J Musculoskelet Neuronal Interact 12:230\u2013240","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"3326_CR22","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1016\/j.injury.2006.08.020","volume":"37","author":"PV Giannoudis","year":"2006","unstructured":"Giannoudis PV, Mushtaq S, Harwood P et al (2006) Accelerated bone healing and excessive callus formation in patients with femoral fracture and head injury. Injury 37:S18\u2013S24. https:\/\/doi.org\/10.1016\/j.injury.2006.08.020","journal-title":"Injury"},{"key":"3326_CR23","doi-asserted-by":"publisher","first-page":"645","DOI":"10.2106\/JBJS.I.00097","volume":"92","author":"D Cadosch","year":"2010","unstructured":"Cadosch D, Toffoli AM, Gautschi OP et al (2010) Serum after traumatic brain injury increases proliferation and supports expression of osteoblast markers in muscle cells. J Bone Jt Surg Am 92:645\u2013653. https:\/\/doi.org\/10.2106\/JBJS.I.00097","journal-title":"J Bone Jt Surg Am"},{"key":"3326_CR24","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.injury.2004.08.028","volume":"36","author":"J Morley","year":"2005","unstructured":"Morley J, Marsh S, Drakoulakis E et al (2005) Does traumatic brain injury result in accelerated fracture healing? Injury 36:363\u2013368. https:\/\/doi.org\/10.1016\/j.injury.2004.08.028","journal-title":"Injury"},{"key":"3326_CR25","doi-asserted-by":"publisher","first-page":"e204842","DOI":"10.1155\/2015\/204842","volume":"2015","author":"M Hofman","year":"2015","unstructured":"Hofman M, Koopmans G, Kobbe P et al (2015) Improved fracture healing in patients with concomitant traumatic brain injury: proven or not? Improved fracture healing in patients with concomitant traumatic brain injury: proven or not? Mediat Inflamm Mediat Inflamm 2015:e204842. https:\/\/doi.org\/10.1155\/2015\/204842","journal-title":"Mediat Inflamm Mediat Inflamm"},{"key":"3326_CR26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s002239900686","volume":"65","author":"BY Klein","year":"1999","unstructured":"Klein BY, Shohami E, Reikhinshtein Y et al (1999) Serum-mediated osteogenic effects of head injury on cultured rat marrow stromal cells. Calcif Tissue Int 65:217\u2013222. https:\/\/doi.org\/10.1007\/s002239900686","journal-title":"Calcif Tissue Int"},{"key":"3326_CR27","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1089\/neu.2006.0166","volume":"24","author":"OP Gautschi","year":"2007","unstructured":"Gautschi OP, Toffoli AM, Joesbury KA et al (2007) Osteoinductive effect of cerebrospinal fluid from brain-injured patients. J Neurotrauma 24:154\u2013162. https:\/\/doi.org\/10.1089\/neu.2006.0166","journal-title":"J Neurotrauma"},{"key":"3326_CR28","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/exnr.2001.7728","volume":"172","author":"B Dattatreyamurty","year":"2001","unstructured":"Dattatreyamurty B, Roux E, Horbinski C et al (2001) Cerebrospinal fluid contains biologically active bone morphogenetic protein-7. Exp Neurol 172:273\u2013281. https:\/\/doi.org\/10.1006\/exnr.2001.7728","journal-title":"Exp Neurol"},{"key":"3326_CR29","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/00024382-199511000-00001","volume":"4","author":"T Kossmann","year":"1995","unstructured":"Kossmann T, Hans VH, Imhof HG et al (1995) Intrathecal and serum interleukin-6 and the acute-phase response in patients with severe traumatic brain injuries. Shock Augusta Ga 4:311\u2013317","journal-title":"Shock Augusta Ga"},{"key":"3326_CR30","first-page":"20","volume":"121","author":"JG De Lee","year":"1976","unstructured":"De Lee JG, Charnley J (1976) Radiological demarcation of cemented sockets in total hip replacement. Clin Orthop 121:20\u201332","journal-title":"Clin Orthop"},{"key":"3326_CR31","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/jor.22309","volume":"31","author":"WF Mourad","year":"2013","unstructured":"Mourad WF, Packianathan S, Shourbaji RA et al (2013) The influence of pregnancy on heterotopic ossification post-displaced acetabular fractures surgical repair. J Orthop Res 31:944\u2013948. https:\/\/doi.org\/10.1002\/jor.22309","journal-title":"J Orthop Res"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-019-03326-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00402-019-03326-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-019-03326-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T00:23:06Z","timestamp":1607732586000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00402-019-03326-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,13]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["3326"],"URL":"https:\/\/doi.org\/10.1007\/s00402-019-03326-0","relation":{},"ISSN":["0936-8051","1434-3916"],"issn-type":[{"value":"0936-8051","type":"print"},{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,13]]},"assertion":[{"value":"12 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"In support of their research for or preparation of this manuscript, the corresponding author received a grant from the Belgian Society for Orthopedics and Traumatology (BVOT). None of the authors received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}